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The map label for this gene is pgi

Identifier: 52840996

GI number: 52840996

Start: 829724

End: 831226

Strand: Direct

Name: pgi

Synonym: lpg0759

Alternate gene names: 52840996

Gene position: 829724-831226 (Clockwise)

Preceding gene: 52840995

Following gene: 52840997

Centisome position: 24.42

GC content: 35.26

Gene sequence:

>1503_bases
TTGATGATTAGAAATAGCATGAAGTCTCACACAGAATTATTGTCATGGAATTTGCTTCAAAAAGAAGCGGATAGAGTGCG
TCTAAATTCAGATTCTCTAACATGCGTTGTTCCGGATTCCAACAATTATGAATCCAGTAAACAGATCAATTGTATTGAGT
ACGACTATTCCAGGCAGAGAGTAAACAGAACCATCATTGATTTGCTTATCGATTTGGCTAATGAAGTCAAATTACAAGAA
AAAATTGATAACTTAATCAATGGTAAAAAAATCAATATCAGCGAAAACAGGCCTGCACTACATACTGCACTTAGGGACTT
AGGTAATAAATCGATAATGATTGATGGACTGGATATTATGTCCGCAGTTATAAATACTCGTGAAAAAATTAAAGTTATAT
CCAATCAGATCAGAGAAAAGAAGTGGCTGGGCCATTCAGGTCTACCAATAACTGATATTGTAAACATAGGTATTGGCGGC
TCGGATTTAGGTCCTCGTGTATGCATCAATGCCCTGTCTAATTATATTTCCAAAGAATTTAATTATCATTTTATCTCAGA
TGTTGATCCGGCCAGTTTTAACGATGTTATTGCAAAAATTAATCCGCAAACCACCTTATTTATTGTTTCTTCCAAATCAT
TTACTACAAAAGAAACTCTATTAAATGCCAGAAAAGCTTTTGCATTGTATGAGGATACGGCCTCTATCGATCAACATTTT
ATAGCTGTAACCGCACATCCGGAAAGAGCTTATCAAATGGGTATTAAAACTGTTTTACCGATTTGGGATTGGGTTGGTGG
TCGATTTTCTTTTTGTTCCGCAGTTAATTTAATTACTGCGATTGCAATTGGTTATGAACAATTTGTTGAATTGCTGGCTG
GTGCCCATGATGTCGATACTCATGTCCAATTTACTGATTTTAAAAATAATATTCCTGTGCTAATGGCTTTAATCGGTATA
TGGAATAACAATTTTTTGAATATTCATAATTTACTTATTCTTACCTATTCAAAAAAACTGGAGTACTTTGTTCCTTATGT
ACAACAGCTGGATATGGAGAGTAATGGGAAGTCCATTGATGTGAATGGAAGTATGGTAGATTACGCCACTGGACCTATCG
TTTGGGGTGGATTAGGAAATCAGGCACAGCATAGCTATTTTCAATTATTATGTCAGGGTACGCATCGATGTGTTGGTGAT
TTTATTACTTTGAAAACTAATGATGAGCATGAGATTAATTCCATGTGTCATTATAAAATGAAAGTTTTAAGTGAGGGAAT
TCAAACAATTGAAAATCCTTATGGGTATATTCCTGGCAATATGCCAATGAATCATCTCATTTTGTCAGATTGTTCTCCTT
ATACATTAGGGGCTCTGGTGGCACTCTATGAACATAAGATTTTTGTACAAAGTGTGATATGGAATATTAACCCATTCGAT
CAGCCCGGTATTGAAAGCGCCAAGAGTGCTCACAGAGAAATCACATTATCAAGCGAATCATAA

Upstream 100 bases:

>100_bases
TTCATAAATTATCAAATACAGTTCATCATTACTTAACACGGTATGAGCGCGAAATTAATATTTAATAAATTGAAAATAAT
CAGGTAACATAGACTTTATT

Downstream 100 bases:

>100_bases
AGGGGCGCTCAATGCTATAAATTAGTTTAATTATTAAACTAAACTTTATATTTTATTGACATTATCAACGTATTTTAATG
TATTACTTCAATAAACTTGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MMIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRVNRTIIDLLIDLANEVKLQE
KIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGG
SDLGPRVCINALSNYISKEFNYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHF
IAVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGI
WNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGD
FITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFD
QPGIESAKSAHREITLSSES

Sequences:

>Translated_500_residues
MMIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRVNRTIIDLLIDLANEVKLQE
KIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGG
SDLGPRVCINALSNYISKEFNYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHF
IAVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGI
WNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGD
FITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFD
QPGIESAKSAHREITLSSES
>Mature_500_residues
MMIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRVNRTIIDLLIDLANEVKLQE
KIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGG
SDLGPRVCINALSNYISKEFNYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHF
IAVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGI
WNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGD
FITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFD
QPGIESAKSAHREITLSSES

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=506, Percent_Identity=37.3517786561265, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI296080693, Length=473, Percent_Identity=34.8837209302326, Blast_Score=305, Evalue=8e-83,
Organism=Escherichia coli, GI1790457, Length=509, Percent_Identity=40.0785854616896, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71996708, Length=505, Percent_Identity=37.029702970297, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI71996703, Length=505, Percent_Identity=37.029702970297, Blast_Score=342, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6319673, Length=496, Percent_Identity=37.5, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24651916, Length=473, Percent_Identity=39.9577167019027, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24651914, Length=473, Percent_Identity=39.9577167019027, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI17737445, Length=473, Percent_Identity=39.9577167019027, Blast_Score=356, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 56284; Mature: 56284

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQR
CCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHH
VNRTIIDLLIDLANEVKLQEKIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHH
SAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGSDLGPRVCINALSNYISKEF
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCC
NYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHF
CEEEECCCCCCCCHHHHEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEECCHHCCCCEE
IAVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDT
EEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
HVQFTDFKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSID
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEE
VNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKM
CCCCEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
KVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFD
HHHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
QPGIESAKSAHREITLSSES
CCCCHHHHHHCCEEEECCCC
>Mature Secondary Structure
MMIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQR
CCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHH
VNRTIIDLLIDLANEVKLQEKIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHH
SAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGSDLGPRVCINALSNYISKEF
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCC
NYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHF
CEEEECCCCCCCCHHHHEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEECCHHCCCCEE
IAVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDT
EEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
HVQFTDFKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSID
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEE
VNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKM
CCCCEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
KVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFD
HHHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
QPGIESAKSAHREITLSSES
CCCCHHHHHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA