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The map label for this gene is gltT [H]

Identifier: 52840955

GI number: 52840955

Start: 783098

End: 784345

Strand: Reverse

Name: gltT [H]

Synonym: lpg0718

Alternate gene names: 52840955

Gene position: 784345-783098 (Counterclockwise)

Preceding gene: 52840956

Following gene: 52840954

Centisome position: 23.08

GC content: 38.78

Gene sequence:

>1248_bases
GTGGTAACTCAATTCAATACGCTTAAATCCTATATTTTCCCCATCATTTTGCTCTTATCTATTTTACTTGGTGGGTTAAC
AGGATATGTTTTTAATCAAAACGTTGCCTGGTTAAAACCCTTTGGCGATATTTTTCTTAATTTGATTTTTACTACCATCG
TTCCCCTAATTTTTTTCAGTGTATCCTCAGCGATTGCAAGAACTGGTTCTATTGGCAAATTAGGCAAAATATTCTACTCA
ATGACAGTCATATTCTTATTTACAGGAATAGTTGCTGCAATTTATGCCCTTTTCGTAGTTTTACTTTTCCCTCCAGCGCA
AAACATGCCCATTCTCTTGGAAAGTTCAAAGCAACTCTCTCCGACAAATCTCCCTGAACGCTTGATTGAGATTTTTACTG
TACCTGAATTTTCAAAATTATTCTCCCATGAGCATATTCTGGCATTAGTCCTTTTTTCAATCCTGGTAGGATTGGCTGTA
GCCCATTCAAAAGATAAAGGTACAATTTTTAATTCCTTCTTAAAAGCAGGAGAAGATGTATTCATGTCAGTATTTCGCCT
GATTATGTATTATGCTCCCATCGGTTTTTTTGCCTATTTTGCAGTAATAGTAAGCGAAATAGGCCCCCAATTAATGGAAA
ATTATTTACGCATTGCCATACTCTACTATACCGCTTCAGTGTTCTACTTTTTCTTCGCCTTAACTGCCTATGCTTATTTG
GCGGGAAAATCCCAGGGTATCCGGCTATTCTGGGGAAATATTTTCCTTCCTGCAGCGACCTCCATAGCAACTTGTAGTAG
TGCCGCCAGTATTCCTGCCAACTTAATGGCAACCAAATCCATGCGCATCCCTGCTGAAATCTATGAAACATCAATACCCT
TAGGCTCCATAATTCATAAAGATGGATCAGTCATGGGCGGTGTTTTTAAAATTGCCTTTTTATTCGGGATCTTTCATTTA
CCTTTTGCCAGCTTGCCCGTTCTTATGATGGCATTGGGAGTTTCTTTGTTGGTAGGAACAGTAATGGGAGCGATTCCTAG
TGGCGGGATGTTAGGAGAATTGTTAATTTTGTCAGTGTATGGTTTTCCACCTTCTGTTTTAATTGCAGTTGCTGCTATTA
GCATCATCATTGATCCCATAGCGACAATGGTCAACGTAACAAGCAATAGTGTTTGCAGCATGATGATTGCACGTCTGGTC
GAAGGTAAAAATTGGTTTCTCAGATCCTCCGATGAAAATAACCTATAA

Upstream 100 bases:

>100_bases
CCTCCTTACAGTCATGGCTCAACTTAACTCATTATTCTATACGTGACTGTAAGGAACAAATGGCACAAACTGGATTATTT
AAAAGAAAGGATGTCTTCTC

Downstream 100 bases:

>100_bases
TCTAAGGTATGTTTAATATAAAAAGCACATATTAAATTTTCATTATCCCATATGTGCAATATAAAAGCATTTTTTGGAGG
GAATAGTAATGAAAAAAATA

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MVTQFNTLKSYIFPIILLLSILLGGLTGYVFNQNVAWLKPFGDIFLNLIFTTIVPLIFFSVSSAIARTGSIGKLGKIFYS
MTVIFLFTGIVAAIYALFVVLLFPPAQNMPILLESSKQLSPTNLPERLIEIFTVPEFSKLFSHEHILALVLFSILVGLAV
AHSKDKGTIFNSFLKAGEDVFMSVFRLIMYYAPIGFFAYFAVIVSEIGPQLMENYLRIAILYYTASVFYFFFALTAYAYL
AGKSQGIRLFWGNIFLPAATSIATCSSAASIPANLMATKSMRIPAEIYETSIPLGSIIHKDGSVMGGVFKIAFLFGIFHL
PFASLPVLMMALGVSLLVGTVMGAIPSGGMLGELLILSVYGFPPSVLIAVAAISIIIDPIATMVNVTSNSVCSMMIARLV
EGKNWFLRSSDENNL

Sequences:

>Translated_415_residues
MVTQFNTLKSYIFPIILLLSILLGGLTGYVFNQNVAWLKPFGDIFLNLIFTTIVPLIFFSVSSAIARTGSIGKLGKIFYS
MTVIFLFTGIVAAIYALFVVLLFPPAQNMPILLESSKQLSPTNLPERLIEIFTVPEFSKLFSHEHILALVLFSILVGLAV
AHSKDKGTIFNSFLKAGEDVFMSVFRLIMYYAPIGFFAYFAVIVSEIGPQLMENYLRIAILYYTASVFYFFFALTAYAYL
AGKSQGIRLFWGNIFLPAATSIATCSSAASIPANLMATKSMRIPAEIYETSIPLGSIIHKDGSVMGGVFKIAFLFGIFHL
PFASLPVLMMALGVSLLVGTVMGAIPSGGMLGELLILSVYGFPPSVLIAVAAISIIIDPIATMVNVTSNSVCSMMIARLV
EGKNWFLRSSDENNL
>Mature_415_residues
MVTQFNTLKSYIFPIILLLSILLGGLTGYVFNQNVAWLKPFGDIFLNLIFTTIVPLIFFSVSSAIARTGSIGKLGKIFYS
MTVIFLFTGIVAAIYALFVVLLFPPAQNMPILLESSKQLSPTNLPERLIEIFTVPEFSKLFSHEHILALVLFSILVGLAV
AHSKDKGTIFNSFLKAGEDVFMSVFRLIMYYAPIGFFAYFAVIVSEIGPQLMENYLRIAILYYTASVFYFFFALTAYAYL
AGKSQGIRLFWGNIFLPAATSIATCSSAASIPANLMATKSMRIPAEIYETSIPLGSIIHKDGSVMGGVFKIAFLFGIFHL
PFASLPVLMMALGVSLLVGTVMGAIPSGGMLGELLILSVYGFPPSVLIAVAAISIIIDPIATMVNVTSNSVCSMMIARLV
EGKNWFLRSSDENNL

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=25.4237288135593, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789947, Length=306, Percent_Identity=23.8562091503268, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788024, Length=306, Percent_Identity=23.202614379085, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996953, Length=426, Percent_Identity=22.5352112676056, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71983106, Length=459, Percent_Identity=20.479302832244, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983099, Length=459, Percent_Identity=20.479302832244, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=401, Percent_Identity=19.9501246882793, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583025, Length=448, Percent_Identity=20.9821428571429, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137668, Length=448, Percent_Identity=20.9821428571429, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583023, Length=448, Percent_Identity=20.9821428571429, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45286; Mature: 45286

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]