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The map label for this gene is accC

Identifier: 52840707

GI number: 52840707

Start: 504183

End: 505532

Strand: Reverse

Name: accC

Synonym: lpg0462

Alternate gene names: 52840707

Gene position: 505532-504183 (Counterclockwise)

Preceding gene: 52840708

Following gene: 52840706

Centisome position: 14.88

GC content: 42.07

Gene sequence:

>1350_bases
CTGTTTATGCTCAGTAAAATAGTTATTGCTAATCGAGGCGAAATTGCGCTTCGTATACTGCGTGCTTGTAAAGAACTTGG
CATTCAGACTGTTGCTGTTCACTCTGATGTAGACAAAGATTTATTGCACGTTCGCCTGGCTGATGAAACCGTATGCATAG
GCCCTGCACCTGCCCAAAAAAGCTATCTCAATATTCCTGCAATTATATCTGCGGCAGAAATTACTGATGCAGTAGCGATA
CATCCAGGTTATGGATTTTTATCAGAAAATGCCGATTTTGCAGATATTGTTGAGCAAAGCGGTTTCCGTTTTATTGGCCC
ACGCGGCGACTCCATTCGTCTTATGGGGGATAAAGTTTCCGCGATTGCTGCCATGAAAGCGGCAGGAGTACCCTGTGTTC
CCGGTTCAGACGGTCCTTTAGGAGATGACGACAACAAAAATCTCGAGTTGGCGCGAAAAATTGGTTATCCAATCATTATC
AAAGCAGCCGGCGGCGGTGGTGGACGTGGCATGAGAGTCGTTCATAGCGAATCCAATTTACTTAGTGCTATTGCGTTAAC
CCGAAGCGAAGCAAAAGCCGCTTTCAATAACCCGATAGTTTACATGGAAAAATTTCTGGAAAATCCTCGCCATGTTGAAT
TCCAAGTCCTTGGTGATGGGAAAGGGCATGCTATACATTTGGGTGAGCGTGATTGCTCGATGCAAAGACGACATCAAAAA
GTCGTAGAAGAAGCTCCGGCTCCAGGAATCACTCCTGAATTAAGAGAAGAAATTGGCGCGTCAGTGATTAAAGCTTGCAA
AGAGTTACAATACCGAGGTGCTGGAACCTTTGAATTTTTATTTCAAGATGGTTGTTTTTATTTCATCGAAATGAATACGC
GCATTCAGGTTGAGCATCCAGTAACTGAAATGATCACTGGGATTGATTTAATTAAGGAACAAATCAAAATTGCCAGCGAT
ATTCCTCTGACATTAACCCAAAAAGATATTAAATTACGCGGCCATGCTATTGAATGCCGAATCAATGCGGAAGATCCAAG
GAATTTTATGCCCTCTCCTGGAACCATAAAATTACTTCATCAACCAGGAGGCCCAGGCATTCGTTTTGATTCTCACATCT
ACAGCAGCTATGTTGTTCCACCTAATTACGATTCCATGATAGGAAAATTAATAAGTTATGGGGCAACAAGAGCAGAAGCG
ATTGCCAGGATGCGTAATGCCCTTGATGAAATTATCATTGATGGCATAAAGACAAATATTGAATTACACCAACGTATTCT
TCATGACAAATCTTTTATGGAAGGTGGCACAAACATTCACTATCTAGAAAAAATGCTCAAGGATTCATAG

Upstream 100 bases:

>100_bases
AATTGAAGCCGATCGTGCTGGGAAAATTGTTGAAATCTTGGTAAAAAACGGGGATCCTGTTGAATATGACCAGGCCTTGT
TTATTATAGAATAGAGAGGC

Downstream 100 bases:

>100_bases
CGTGTGGTTTCAACTAAAAATAGAACATTGTCCTAATGACAAGATTGAAGAAATAACCGAGGAACTCGAAGAATGCGGTG
CCTTGTCCATCACACTCACA

Product: acetyl CoA carboxylase, biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFMLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSYLNIPAIISAAEITDAVAI
HPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIII
KAAGGGGGRGMRVVHSESNLLSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQK
VVEEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVTEMITGIDLIKEQIKIASD
IPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQPGGPGIRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEA
IARMRNALDEIIIDGIKTNIELHQRILHDKSFMEGGTNIHYLEKMLKDS

Sequences:

>Translated_449_residues
MFMLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSYLNIPAIISAAEITDAVAI
HPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIII
KAAGGGGGRGMRVVHSESNLLSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQK
VVEEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVTEMITGIDLIKEQIKIASD
IPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQPGGPGIRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEA
IARMRNALDEIIIDGIKTNIELHQRILHDKSFMEGGTNIHYLEKMLKDS
>Mature_449_residues
MFMLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQKSYLNIPAIISAAEITDAVAI
HPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVSAIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIII
KAAGGGGGRGMRVVHSESNLLSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQK
VVEEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHPVTEMITGIDLIKEQIKIASD
IPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLHQPGGPGIRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEA
IARMRNALDEIIIDGIKTNIELHQRILHDKSFMEGGTNIHYLEKMLKDS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=48.5260770975057, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=46.7706013363029, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=449, Percent_Identity=46.7706013363029, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI295821183, Length=449, Percent_Identity=46.7706013363029, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=47.4387527839644, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=47.4387527839644, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=47.4387527839644, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=30.3501945525292, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=30.2912621359223, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=74.5495495495496, Blast_Score=668, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=177, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=45.823927765237, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=45.7013574660633, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=44.8660714285714, Blast_Score=351, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=28.2208588957055, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997168, Length=518, Percent_Identity=27.4131274131274, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71997163, Length=518, Percent_Identity=27.4131274131274, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.0835214446953, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.1964285714286, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.3125, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=31.7919075144509, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=472, Percent_Identity=33.2627118644068, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24651757, Length=423, Percent_Identity=46.0992907801418, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=46.4285714285714, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=385, Percent_Identity=45.1948051948052, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=28.4872298624754, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=28.4872298624754, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=28.4872298624754, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=28.4872298624754, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49244; Mature: 49244

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQK
CCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCC
SYLNIPAIISAAEITDAVAIHPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVS
CCCCCHHHEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEEEECCHHH
AIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKAAGGGGGRGMRVVHSESNL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCH
LSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQK
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHH
VVEEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHP
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCEEEECCC
VTEMITGIDLIKEQIKIASDIPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLH
HHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEE
QPGGPGIRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIARMRNALDEIIIDGIKTNI
CCCCCCCEECCHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCH
ELHQRILHDKSFMEGGTNIHYLEKMLKDS
HHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFMLSKIVIANRGEIALRILRACKELGIQTVAVHSDVDKDLLHVRLADETVCIGPAPAQK
CCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCC
SYLNIPAIISAAEITDAVAIHPGYGFLSENADFADIVEQSGFRFIGPRGDSIRLMGDKVS
CCCCCHHHEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEEEECCHHH
AIAAMKAAGVPCVPGSDGPLGDDDNKNLELARKIGYPIIIKAAGGGGGRGMRVVHSESNL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCH
LSAIALTRSEAKAAFNNPIVYMEKFLENPRHVEFQVLGDGKGHAIHLGERDCSMQRRHQK
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHH
VVEEAPAPGITPELREEIGASVIKACKELQYRGAGTFEFLFQDGCFYFIEMNTRIQVEHP
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCEEEECCC
VTEMITGIDLIKEQIKIASDIPLTLTQKDIKLRGHAIECRINAEDPRNFMPSPGTIKLLH
HHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEE
QPGGPGIRFDSHIYSSYVVPPNYDSMIGKLISYGATRAEAIARMRNALDEIIIDGIKTNI
CCCCCCCEECCHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCH
ELHQRILHDKSFMEGGTNIHYLEKMLKDS
HHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]