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The map label for this gene is hemH

Identifier: 52840670

GI number: 52840670

Start: 464892

End: 465890

Strand: Reverse

Name: hemH

Synonym: lpg0425

Alternate gene names: 52840670

Gene position: 465890-464892 (Counterclockwise)

Preceding gene: 52840671

Following gene: 52840669

Centisome position: 13.71

GC content: 39.44

Gene sequence:

>999_bases
CTGATGAGACGTGGTTTATTACTGTTAAATCTTGGCACTCCCAATAATGCAGATATCAGGGCGGTAAAGTTATATTTGCG
TGAATTTCTTACTGACAAAAGAGTAATAGACTTACCAACTATCCCGCGCTATATCCTGGTATATTGTTTGATCTTACCCT
TTAGATCGCCAAAATCAGCCCAGGCTTACCAATCAATATGGACTGAAAAAGGCTCTCCGCTTTTGTATCACAGCCAAAAT
CTAGTGACAAAATTACAGTCCGCACTCAAGGATGAGTACAAAATTGCTTTGGGAATGCGCTATGGAACTCCATCAATTAC
AACAGCACTTGCAGAATTAAAAGATTGCCATTCCCTTACCATTTTACCCTTATTTCCTCAATATTCTTCTGCTGCTACAG
GTTCAGCCATTGAAAAAACCTTATCCCATTTGGCAAACCAGGAAATTATTCCATCAATTAAAATCATTCGAGATTTCTAC
CAAAGACCAGAATACATCCAGGCGCAAGCTAAAATTATGAAGCCTTATATTAAAGACAATTTCCACCTTCTTTTTAGCTA
CCACGGAATTCCCGAACGGCATATTCACAAAAGCGGGTGCGATACGCTTTGCCCCCAAACATGCACACCCATATACGATA
AAAATCAAGCATGTTATAGGGCTCAATGCTATCAGACCAGTCTATTACTGGCAAAAGAATTGCAATTAGGCACTCACCAA
TACACAACCGCCTTCCAATCCAGACTTGGGAAAACTCCATGGATAAAACCTTATACCGATGAAATTTTTGCCGAACTAAT
AAGCAAAGGAATTAAAAACATTGTGGTCTCCTGCCCATCTTTTGTCGCAGATTGCCTGGAAACTCTTGAGGAAATAGGAA
TTCGTGCAAAAGAACAGTGGGAAAAACTTGGCGGTGAGCAATTTATATTAACTCCTTGCATGAACGATCATCCTGAGTGG
ATCAAAGCAATTCAAAGTATTGTTAACGAGCAATTTTAA

Upstream 100 bases:

>100_bases
GATGTGATAAACTATTAAGCGCGGCAGTATAACTAATATTTATGCTGCTGCGTCCATCAACTTGAGGTATTATGTCCTTC
ATTTTATAACTGGACTTTAG

Downstream 100 bases:

>100_bases
CCTGCCGTCTTACTGATTTAACCATCGGCAGTCGCAATAAAATTATGTTTCACATTAAATATTTATTGCAAAACAATAAA
TATTTAATAAAATACGCATG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MMRRGLLLLNLGTPNNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQN
LVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSHLANQEIIPSIKIIRDFY
QRPEYIQAQAKIMKPYIKDNFHLLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQ
YTTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWEKLGGEQFILTPCMNDHPEW
IKAIQSIVNEQF

Sequences:

>Translated_332_residues
MMRRGLLLLNLGTPNNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQN
LVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSHLANQEIIPSIKIIRDFY
QRPEYIQAQAKIMKPYIKDNFHLLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQ
YTTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWEKLGGEQFILTPCMNDHPEW
IKAIQSIVNEQF
>Mature_332_residues
MMRRGLLLLNLGTPNNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQN
LVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSHLANQEIIPSIKIIRDFY
QRPEYIQAQAKIMKPYIKDNFHLLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQ
YTTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWEKLGGEQFILTPCMNDHPEW
IKAIQSIVNEQF

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Escherichia coli, GI1786681, Length=331, Percent_Identity=38.0664652567976, Blast_Score=219, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17864156, Length=353, Percent_Identity=26.0623229461756, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37936; Mature: 37936

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRGLLLLNLGTPNNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCHH
QAYQSIWTEKGSPLLYHSQNLVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLT
HHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCEE
ILPLFPQYSSAATGSAIEKTLSHLANQEIIPSIKIIRDFYQRPEYIQAQAKIMKPYIKDN
EEEECCCCCCCCCHHHHHHHHHHHCCCHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
FHLLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQ
EEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
YTTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQW
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHH
EKLGGEQFILTPCMNDHPEWIKAIQSIVNEQF
HHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMRRGLLLLNLGTPNNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCHH
QAYQSIWTEKGSPLLYHSQNLVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLT
HHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCEE
ILPLFPQYSSAATGSAIEKTLSHLANQEIIPSIKIIRDFYQRPEYIQAQAKIMKPYIKDN
EEEECCCCCCCCCHHHHHHHHHHHCCCHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
FHLLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQ
EEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
YTTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQW
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHH
EKLGGEQFILTPCMNDHPEWIKAIQSIVNEQF
HHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA