Click here to switch to the map view.

The map label for this gene is ffh

Identifier: 52840645

GI number: 52840645

Start: 438585

End: 439961

Strand: Reverse

Name: ffh

Synonym: lpg0400

Alternate gene names: 52840645

Gene position: 439961-438585 (Counterclockwise)

Preceding gene: 52840646

Following gene: 52840644

Centisome position: 12.95

GC content: 42.63

Gene sequence:

>1377_bases
ATGTTTGATAATTTAACCGAACGCTTAACCCGAACCTTTAAAAATTTGCGAGGCCAAGGCCGCCTGACGGAAGACAATAT
CCAACATGCCTTGCGTGAAGTAAGACTGTCTCTTATTGAAGCAGACGTGGCTTTGCCTGTTATCAAAGAGTTTATTGAGC
AAGTAAAGCAAAAGTCTCTTGGGCAGGAAGTCTTAACCAGTTTAAATCCCGATCAGGCATTCATTAAAATCGTGCATGAT
GAACTCATTCACGTCATGGGCAATGAGCGGGTTGAACTTGATTACAAAACCCAACCGCCTGCTGTCTTTTTAATGGCCGG
CTTACAAGGTTCTGGTAAAACAACGAGTACAGCAAAACTCGCCCGTTATTTGAAAGAAACCGAAAATAAAAAAGTCATGA
TGGCAAGCGTTGACGTATACAGACCAGCCGCCATACACCAACTGAAAGTATTAGCCGAACAAATTGACGTCGCCTTCTTT
GATTCAGACCCTAATGAGCAACCAATAAAAATAGCTCAAAAGGCATTGGAAAGCGCCAGAAAACAGTATGTTGACGTTCT
CATTCTCGATACAGCAGGGCGCCTGCACGTTGATGAAGACATGATGTCTGAAATCAAGTCTTTGCATAAAGCAGTCAATC
CAATCGAAACCCTTTTTGTCGTTGACAGCATGACAGGACAAGACGCTGCCAATACTGCAAAAGCATTTCATGAAGCCCTC
CCTCTGACTGGTGTGATTTTGACCAAAACGGACGGCGATGCTCGAGGAGGAGCGGCGCTATCTGTCAAACAAATCACAGG
GAAACCTATAAAATTTATAGGGAGTGGTGAAAAAATAGAAGCCTTGGAACCCTTTCACCCTGAACGGATTGCATCAAGAA
TATTGGGGATGGGAGATATTTTAACTCTCATTGAAGAGGTAGAGCGCAAAGCCGACAAACAAGCCAGCGAAAAACTGGCC
AAAAAATTAAAAAAAGGGAAAGGGTTTGACTTGGAGGATTTCAAACAACAATTATTGCAAATGAACAATATGGGGGGTAT
CTCCGGGATGATGAGCAAATTACCCGGAGTGGGGCAATTGCCAAAGCAAGCCATGCAGCAAGTGAATGACAAGGCGATGG
CTCAAACCATTGCAATCATTAACTCTATGACTCCCAAAGAACGCCGTATACCCAAAATTATTGTAGGCTCACGTAAAAAA
CGCATAGCTTTAGGCTCTGGAACTCAAATTCAGGATGTCAACAGACTATTAAAACAATTTGAACAGATGCAAAAGATGAT
GAAAAAATTTACCAAACCAGGCGGAATGCAGAAAATGATGAGAGGAATTGGTGGCATGGCCGGATTGAAAGGCATGTTTC
CAGATGATTTAAAATAA

Upstream 100 bases:

>100_bases
TTCACTGCTATCGATTAGAGCTAATCATTAATGCGCTCTTCTCTGTGGTATACTTTTAACTCTCTATGTTATAGTAGTCA
TTTTTTGGGTACTACTCACT

Downstream 100 bases:

>100_bases
TTCGTAAGAATTACTTCACATGTCGATGTAATTTTCGTACAATACACGGCATTTTTATGTAACCACTCTAACAGTAGAGG
AAAATAATGGTCGTTATACG

Product: signal recognition particle protein Ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFDNLTERLTRTFKNLRGQGRLTEDNIQHALREVRLSLIEADVALPVIKEFIEQVKQKSLGQEVLTSLNPDQAFIKIVHD
ELIHVMGNERVELDYKTQPPAVFLMAGLQGSGKTTSTAKLARYLKETENKKVMMASVDVYRPAAIHQLKVLAEQIDVAFF
DSDPNEQPIKIAQKALESARKQYVDVLILDTAGRLHVDEDMMSEIKSLHKAVNPIETLFVVDSMTGQDAANTAKAFHEAL
PLTGVILTKTDGDARGGAALSVKQITGKPIKFIGSGEKIEALEPFHPERIASRILGMGDILTLIEEVERKADKQASEKLA
KKLKKGKGFDLEDFKQQLLQMNNMGGISGMMSKLPGVGQLPKQAMQQVNDKAMAQTIAIINSMTPKERRIPKIIVGSRKK
RIALGSGTQIQDVNRLLKQFEQMQKMMKKFTKPGGMQKMMRGIGGMAGLKGMFPDDLK

Sequences:

>Translated_458_residues
MFDNLTERLTRTFKNLRGQGRLTEDNIQHALREVRLSLIEADVALPVIKEFIEQVKQKSLGQEVLTSLNPDQAFIKIVHD
ELIHVMGNERVELDYKTQPPAVFLMAGLQGSGKTTSTAKLARYLKETENKKVMMASVDVYRPAAIHQLKVLAEQIDVAFF
DSDPNEQPIKIAQKALESARKQYVDVLILDTAGRLHVDEDMMSEIKSLHKAVNPIETLFVVDSMTGQDAANTAKAFHEAL
PLTGVILTKTDGDARGGAALSVKQITGKPIKFIGSGEKIEALEPFHPERIASRILGMGDILTLIEEVERKADKQASEKLA
KKLKKGKGFDLEDFKQQLLQMNNMGGISGMMSKLPGVGQLPKQAMQQVNDKAMAQTIAIINSMTPKERRIPKIIVGSRKK
RIALGSGTQIQDVNRLLKQFEQMQKMMKKFTKPGGMQKMMRGIGGMAGLKGMFPDDLK
>Mature_458_residues
MFDNLTERLTRTFKNLRGQGRLTEDNIQHALREVRLSLIEADVALPVIKEFIEQVKQKSLGQEVLTSLNPDQAFIKIVHD
ELIHVMGNERVELDYKTQPPAVFLMAGLQGSGKTTSTAKLARYLKETENKKVMMASVDVYRPAAIHQLKVLAEQIDVAFF
DSDPNEQPIKIAQKALESARKQYVDVLILDTAGRLHVDEDMMSEIKSLHKAVNPIETLFVVDSMTGQDAANTAKAFHEAL
PLTGVILTKTDGDARGGAALSVKQITGKPIKFIGSGEKIEALEPFHPERIASRILGMGDILTLIEEVERKADKQASEKLA
KKLKKGKGFDLEDFKQQLLQMNNMGGISGMMSKLPGVGQLPKQAMQQVNDKAMAQTIAIINSMTPKERRIPKIIVGSRKK
RIALGSGTQIQDVNRLLKQFEQMQKMMKKFTKPGGMQKMMRGIGGMAGLKGMFPDDLK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=32.1507760532151, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI226371618, Length=393, Percent_Identity=32.824427480916, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=39.375, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI295424842, Length=314, Percent_Identity=26.1146496815287, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI23308697, Length=314, Percent_Identity=26.1146496815287, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=64.7058823529412, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1789874, Length=220, Percent_Identity=37.2727272727273, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=30.9794988610478, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=295, Percent_Identity=29.1525423728814, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=436, Percent_Identity=32.1100917431193, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=311, Percent_Identity=26.6881028938907, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647949, Length=462, Percent_Identity=30.0865800865801, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24641198, Length=318, Percent_Identity=24.8427672955975, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50828; Mature: 50828

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTERLTRTFKNLRGQGRLTEDNIQHALREVRLSLIEADVALPVIKEFIEQVKQKSL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLTSLNPDQAFIKIVHDELIHVMGNERVELDYKTQPPAVFLMAGLQGSGKTTSTAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHH
ARYLKETENKKVMMASVDVYRPAAIHQLKVLAEQIDVAFFDSDPNEQPIKIAQKALESAR
HHHHHHCCCCEEEEEECCHHCHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHH
KQYVDVLILDTAGRLHVDEDMMSEIKSLHKAVNPIETLFVVDSMTGQDAANTAKAFHEAL
HHHHEEEEEECCCCEEECHHHHHHHHHHHHHHCHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVILTKTDGDARGGAALSVKQITGKPIKFIGSGEKIEALEPFHPERIASRILGMGDI
CCCEEEEEECCCCCCCCCEEEEHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCHHHH
LTLIEEVERKADKQASEKLAKKLKKGKGFDLEDFKQQLLQMNNMGGISGMMSKLPGVGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
PKQAMQQVNDKAMAQTIAIINSMTPKERRIPKIIVGSRKKRIALGSGTQIQDVNRLLKQF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHEECCCCCEEECCCCCCHHHHHHHHHHH
EQMQKMMKKFTKPGGMQKMMRGIGGMAGLKGMFPDDLK
HHHHHHHHHHCCCCCHHHHHHHCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MFDNLTERLTRTFKNLRGQGRLTEDNIQHALREVRLSLIEADVALPVIKEFIEQVKQKSL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLTSLNPDQAFIKIVHDELIHVMGNERVELDYKTQPPAVFLMAGLQGSGKTTSTAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHH
ARYLKETENKKVMMASVDVYRPAAIHQLKVLAEQIDVAFFDSDPNEQPIKIAQKALESAR
HHHHHHCCCCEEEEEECCHHCHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHH
KQYVDVLILDTAGRLHVDEDMMSEIKSLHKAVNPIETLFVVDSMTGQDAANTAKAFHEAL
HHHHEEEEEECCCCEEECHHHHHHHHHHHHHHCHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVILTKTDGDARGGAALSVKQITGKPIKFIGSGEKIEALEPFHPERIASRILGMGDI
CCCEEEEEECCCCCCCCCEEEEHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCHHHH
LTLIEEVERKADKQASEKLAKKLKKGKGFDLEDFKQQLLQMNNMGGISGMMSKLPGVGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
PKQAMQQVNDKAMAQTIAIINSMTPKERRIPKIIVGSRKKRIALGSGTQIQDVNRLLKQF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHEECCCCCEEECCCCCCHHHHHHHHHHH
EQMQKMMKKFTKPGGMQKMMRGIGGMAGLKGMFPDDLK
HHHHHHHHHHCCCCCHHHHHHHCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]