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The map label for this gene is purE

Identifier: 52840473

GI number: 52840473

Start: 250165

End: 250665

Strand: Reverse

Name: purE

Synonym: lpg0218

Alternate gene names: 52840473

Gene position: 250665-250165 (Counterclockwise)

Preceding gene: 52840474

Following gene: 52840472

Centisome position: 7.38

GC content: 45.51

Gene sequence:

>501_bases
ATGAAACCCATTTTAATAGGTCTAATTATGGGTTCTCAAAGTGATTGGCAAACATTAATCCATGCCGCCCACACACTGGA
TGCGCTAAACATTGGCTATGAGGCAGAAATTGTCTCCGCTCATAGGACACCGGACAAACTTTTCCGGTATGCCGAACAGG
CTGAGGCAAGAGGTTTGGAAGTGATTATTGCTGGTGCAGGAGGAGCGGCTCATCTCCCTGGCATGGTAGCAGCCAAAACA
TCTTTGCCTGTTTTAGGTGTCCCAGTCATGTCACAAACTTTAAACGGCGTCGATTCCTTGCTATCCATTGTGCAAATGCC
TGCGGGGATACCTGTAGGCACTTTATCGATAGGTAAAGCAGGTGCCATCAACTCCGCACTGTTTGCAGCCGCAATTCTTG
CTAATAAATATCCTGATATTCGAGCTGCCTTAAAACACTATAGAGAACAACAAACACAAAAAGTGCTCGACAATCCAAAC
CCTAAAGAGGAAAAGTCATGA

Upstream 100 bases:

>100_bases
AATTTGCTGAGCAAAGGTATTGTCCTTATTGTAATCCTTAACCGTTTGCGAGAATCAAGTCCATGGTATGTTATAAACAT
TCAAACAAGAGAGGCACATT

Downstream 100 bases:

>100_bases
AACTTGGTATTCTAGGTGGTGGCCAACTTGCAAGAATGTTGGCATTAGCAGCATATCCCTTAGGGATTAACACTGTCTGC
CTGGATCCCAGCCCTGATGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit PurE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKPILIGLIMGSQSDWQTLIHAAHTLDALNIGYEAEIVSAHRTPDKLFRYAEQAEARGLEVIIAGAGGAAHLPGMVAAKT
SLPVLGVPVMSQTLNGVDSLLSIVQMPAGIPVGTLSIGKAGAINSALFAAAILANKYPDIRAALKHYREQQTQKVLDNPN
PKEEKS

Sequences:

>Translated_166_residues
MKPILIGLIMGSQSDWQTLIHAAHTLDALNIGYEAEIVSAHRTPDKLFRYAEQAEARGLEVIIAGAGGAAHLPGMVAAKT
SLPVLGVPVMSQTLNGVDSLLSIVQMPAGIPVGTLSIGKAGAINSALFAAAILANKYPDIRAALKHYREQQTQKVLDNPN
PKEEKS
>Mature_166_residues
MKPILIGLIMGSQSDWQTLIHAAHTLDALNIGYEAEIVSAHRTPDKLFRYAEQAEARGLEVIIAGAGGAAHLPGMVAAKT
SLPVLGVPVMSQTLNGVDSLLSIVQMPAGIPVGTLSIGKAGAINSALFAAAILANKYPDIRAALKHYREQQTQKVLDNPN
PKEEKS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=161, Percent_Identity=60.8695652173913, Blast_Score=171, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324702, Length=156, Percent_Identity=48.7179487179487, Blast_Score=138, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17528; Mature: 17528

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPILIGLIMGSQSDWQTLIHAAHTLDALNIGYEAEIVSAHRTPDKLFRYAEQAEARGLE
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCEE
VIIAGAGGAAHLPGMVAAKTSLPVLGVPVMSQTLNGVDSLLSIVQMPAGIPVGTLSIGKA
EEEECCCCCHHCCCHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GAINSALFAAAILANKYPDIRAALKHYREQQTQKVLDNPNPKEEKS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKPILIGLIMGSQSDWQTLIHAAHTLDALNIGYEAEIVSAHRTPDKLFRYAEQAEARGLE
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCEE
VIIAGAGGAAHLPGMVAAKTSLPVLGVPVMSQTLNGVDSLLSIVQMPAGIPVGTLSIGKA
EEEECCCCCHHCCCHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GAINSALFAAAILANKYPDIRAALKHYREQQTQKVLDNPNPKEEKS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]