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The map label for this gene is gcvPA [H]

Identifier: 52840371

GI number: 52840371

Start: 133978

End: 135348

Strand: Reverse

Name: gcvPA [H]

Synonym: lpg0116

Alternate gene names: 52840371

Gene position: 135348-133978 (Counterclockwise)

Preceding gene: 52840372

Following gene: 52840370

Centisome position: 3.98

GC content: 44.13

Gene sequence:

>1371_bases
ATGCCTTATATTCCACACACGCCCGATGATACCAAAGAGATGCTAGAGGCAATTGGTGCTCAAGACATTCAGGATTTATT
TGATGAAATACCAGCTTCTTTGCAATATGCAGGATTTCAAAATATCCCTGCTGGCATTAACGAAATGGAAATGTTGAAAG
AAGCCCAGAATCAAGCCCAAAAGAATCGCAACGGTATATGTTTTATTGGTGCTGGATGTTATGAGCATCATATTCCAGCA
GCCGTGTGGGATATTGCATCTCGCGGTGAATTTTTAACTGCCTACACACCCTATCAAGCTGAGGCCAGCCAGGGAACTTT
GCAATTATTGTATGAATATCAAACCATGATCTGTGAGTTGACCGGCATGGAAGTATCCAATGCGTCAATGTATGACGGAG
CAACTGCGTTAGCTGAAGCAGTACTCATGGCAGTCCGCCTTAATAAACACAGTAAAACCAACAGAGTACTGATTGCAGGC
ACAGTTCATCCTTTTTATCGCGAAACCATTGAAACGATAGTACGTAATCAGCATATTGAAGTCATCACCCTCCCTTTTGA
TGAACAGCAAGGAATCACTAATCTTGGCTCTCTCAATCAATACACCGGAGAAGATATTACAGCTTTGGTCATAGCCCAAC
CGAATTTCTTTGGTTGCCTCGAACAAGTCGATAAAATGACTTCCTGGGCACATCATAACAAAACAATCAGTGTAGCTTGT
GTTAACCCGACTTCATTGGCTTTATTAAAACCGCCCGGCTCATGGGGAGAACATGGGGTAGACATCGTATGCGGTGAAGG
ACAACCTTTAGGCTCACCTATGGCATCAGGAGGCCCTTATTTTGGTTTTCTGAGCACCCGTATGGCCCATGTCAGACAAA
TGCCCGGAAGAATAATTGGCCGCACGGTAGACAAGGATGGAAAAACCGGTTTTAGTTTAACTCTCCAGGCAAGAGAACAG
CATATTCGGCGTGCTAAAGCCACTTCAAACATATGCACCAACCAGGGTTTACTTGTAACAGCAGCAACTATCTATATGAG
TCTTTTAGGACCGGAAGGTCTAAGCCAAGTGGCAACTCAATGCCATCAAAATACTCATGAATTGATTACTGCCTTAACAC
AAATCGAGGGGGTAGAACTGGCATTCAAAGCTCCGTTTTTCCATGAAGCATTGATTAAACTAAACCAACCAGTTCAGTCC
GTATTGCAACAACTAGCCGACGCTGGAATTGCTGGAGGTTACGCACCGGAACAACACTACCCTCAGCTAGCCAATACGCT
GTTAGTTTGTGCGACAGAGGTGCGTACTGCAGAGGATATCGCGAAATATGCAAAAACATTAAAAACCATAATGTCCAAGC
GAGGTGCCTGA

Upstream 100 bases:

>100_bases
AAGGCTGGCTCGTGAAGCTAAAGCCCAGCCATCCTGATGAAATCAAAAGCCTGTTAAGTGATGAGCAATATCAAAATGAG
ATAGCTGAGGAAAATTAATC

Downstream 100 bases:

>100_bases
TGTTTATTGTGCAATTAACCTATTTAGTTCCCATCAATGAAGTAAACAAATATCTGCAGGCACACAGGGAGTTTCTAGAT
TACCACTACAAACAAGGGTT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MPYIPHTPDDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQKNRNGICFIGAGCYEHHIPA
AVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICELTGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAG
TVHPFYRETIETIVRNQHIEVITLPFDEQQGITNLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIGRTVDKDGKTGFSLTLQAREQ
HIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQCHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQS
VLQQLADAGIAGGYAPEQHYPQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA

Sequences:

>Translated_456_residues
MPYIPHTPDDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQKNRNGICFIGAGCYEHHIPA
AVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICELTGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAG
TVHPFYRETIETIVRNQHIEVITLPFDEQQGITNLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIGRTVDKDGKTGFSLTLQAREQ
HIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQCHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQS
VLQQLADAGIAGGYAPEQHYPQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA
>Mature_455_residues
PYIPHTPDDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQKNRNGICFIGAGCYEHHIPAA
VWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICELTGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAGT
VHPFYRETIETIVRNQHIEVITLPFDEQQGITNLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVACV
NPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIGRTVDKDGKTGFSLTLQAREQH
IRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQCHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQSV
LQQLADAGIAGGYAPEQHYPQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=404, Percent_Identity=33.6633663366337, Blast_Score=215, Evalue=7e-56,
Organism=Escherichia coli, GI1789269, Length=371, Percent_Identity=35.0404312668464, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17535605, Length=385, Percent_Identity=36.3636363636364, Blast_Score=208, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=413, Percent_Identity=32.4455205811138, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24645648, Length=365, Percent_Identity=34.7945205479452, Blast_Score=224, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49821; Mature: 49690

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYIPHTPDDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQ
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
KNRNGICFIGAGCYEHHIPAAVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICEL
HCCCCEEEEECCHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAGTVHPFYRETIETIVRNQHIE
CCCEECCCCHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
VITLPFDEQQGITNLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
EEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIG
ECCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHC
RTVDKDGKTGFSLTLQAREQHIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQ
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
CHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQSVLQQLADAGIAGGYAPEQHY
HHCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHH
PQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PYIPHTPDDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQ
CCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
KNRNGICFIGAGCYEHHIPAAVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICEL
HCCCCEEEEECCHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAGTVHPFYRETIETIVRNQHIE
CCCEECCCCHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
VITLPFDEQQGITNLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
EEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIG
ECCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHC
RTVDKDGKTGFSLTLQAREQHIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQ
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
CHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQSVLQQLADAGIAGGYAPEQHY
HHCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHH
PQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA