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The map label for this gene is gcvT

Identifier: 229270459

GI number: 229270459

Start: 135762

End: 136844

Strand: Reverse

Name: gcvT

Synonym: lpg0118

Alternate gene names: 229270459

Gene position: 136844-135762 (Counterclockwise)

Preceding gene: 52840375

Following gene: 52840372

Centisome position: 4.03

GC content: 44.97

Gene sequence:

>1083_bases
ATGACTGCTAAAACTCCTCTTCACACTACGCACTTAGCATGTGGTGCCAAAATGGTGGATTTCCATGGTTGGGATATGCC
TCTTCATTATGGATCTCAGTTAAACGAACATCATGCTGTCAGAAACGATGCTGGCATGTTTGATGTCTCACATATGACCA
TCGTTGATATTTTAGGCGCCGGTGGCCGTCAATTTCTGCGCAAACTGCTAACCAACGATGTCGATCAAATTACTCATAAT
GGAAAAGCCCTATACAGCTGTATGTGTAATGAACACGGCGGAATTATAGATGACCTGATTGTATATCAACGCGCTTCCGA
TAATTACCGAGTGGTACTTAATTCGGCAACCAGGCAAAATGATGTGGCCTGGATTCGCGCAAAAAGTGAAGGATTTGCTG
TTGGCTTACAAGAAAGGCGCGAATTATCAATGCTCGCTGTACAAGGTCCAAATGCCATAGCGAAAACATTGAGTATTCTT
GCACCCGCCCATGTAGATGCCGTTTCGACTCTTACCTCTTTCGAATGCGTTGATGTGGATCACTGGTTTTTTGCTCGCAC
CGGCTATACGGGGGAAGATGGCCTTGAAATCATTGTCCCTAATGAATTTGTTACCCAACTCTGGAATGATCTCCTGCATG
CTGGAGTAACGCCATGTGGATTAGGGGCCAGAGATACCCTGAGATTAGAGGCAGGAATGCTTCTTTACGGCCAGGATATG
GATGAAACAACAACCCCACTGGAATCTGGTTTGGCCTGGACAGTAAAGTGGGAGCCGGAAGATAGAGGATTTATCGGAAT
GGGCGCTTTGGTTTCTCAAAAGCAACAAGGAATTAAACGTAAAATGGTTGGTTTAACCTTGTTGGACAAAGGCATTATGC
GTCATGGCCAAAAGGTTATTATTGAAGGCTGCCCTGATGGAATTATCACAAGCGGCAGCTATTCTCCTACCCTGCAGCAA
TCTATAGCTTTGGCACGAGTTCCCATGGAAACAGGGGAACAAGTACTTGTTGATATACGCGGAAAGTTAATCCCTGCAAA
AGTAGGGAAGCCTCGCTTTATCAAACAAGGAAAACCTGTTTAA

Upstream 100 bases:

>100_bases
CCAGGGAGAGGATCATGCAAAAAAATCAAATTGGAAACCTCGCAAAATTAATCCCAACAGGTATAATCACATCCAATAAG
TGATAAAAAAAGGAAATGCA

Downstream 100 bases:

>100_bases
ATTTTAGTAATATTAATATTAAGGATATAAAAAATGAATGATTTGAAATTCACAACAACCCATGAATGGCTGAGAGAAGA
TGAGGAAGAGGTCACAGTAG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGAGGRQFLRKLLTNDVDQITHN
GKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQNDVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSIL
APAHVDAVSTLTSFECVDVDHWFFARTGYTGEDGLEIIVPNEFVTQLWNDLLHAGVTPCGLGARDTLRLEAGMLLYGQDM
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVIIEGCPDGIITSGSYSPTLQQ
SIALARVPMETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV

Sequences:

>Translated_360_residues
MTAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGAGGRQFLRKLLTNDVDQITHN
GKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQNDVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSIL
APAHVDAVSTLTSFECVDVDHWFFARTGYTGEDGLEIIVPNEFVTQLWNDLLHAGVTPCGLGARDTLRLEAGMLLYGQDM
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVIIEGCPDGIITSGSYSPTLQQ
SIALARVPMETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV
>Mature_359_residues
TAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGAGGRQFLRKLLTNDVDQITHNG
KALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQNDVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSILA
PAHVDAVSTLTSFECVDVDHWFFARTGYTGEDGLEIIVPNEFVTQLWNDLLHAGVTPCGLGARDTLRLEAGMLLYGQDMD
ETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVIIEGCPDGIITSGSYSPTLQQS
IALARVPMETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=364, Percent_Identity=37.3626373626374, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI257796258, Length=349, Percent_Identity=37.2492836676218, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI257796254, Length=359, Percent_Identity=33.7047353760446, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI257796256, Length=310, Percent_Identity=36.1290322580645, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24797151, Length=328, Percent_Identity=30.1829268292683, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI197927446, Length=346, Percent_Identity=25.4335260115607, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21361378, Length=346, Percent_Identity=25.4335260115607, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI194306651, Length=392, Percent_Identity=24.234693877551, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789272, Length=364, Percent_Identity=55.2197802197802, Blast_Score=406, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=35.1351351351351, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32563613, Length=319, Percent_Identity=23.8244514106583, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71994045, Length=341, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994052, Length=341, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=377, Percent_Identity=34.2175066312997, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=36.0215053763441, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28571104, Length=277, Percent_Identity=28.158844765343, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130091, Length=406, Percent_Identity=25.1231527093596, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39515; Mature: 39384

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGA
CCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEECHHHEEHHHCC
GGRQFLRKLLTNDVDQITHNGKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQN
CHHHHHHHHHHCCHHHHHCCCCEEEEEHHCCCCCHHHHHHHEEECCCCEEEEEECCCCCC
DVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSILAPAHVDAVSTLTSFECVDVD
CEEEEEECCCCEEECHHHHCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHCCEEECCC
HWFFARTGYTGEDGLEIIVPNEFVTQLWNDLLHAGVTPCGLGARDTLRLEAGMLLYGQDM
CEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEECCC
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVI
CCCCCHHHCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IEGCPDGIITSGSYSPTLQQSIALARVPMETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV
EECCCCCEEECCCCCHHHHHHHHHHCCCHHCCCEEEEEECCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAKTPLHTTHLACGAKMVDFHGWDMPLHYGSQLNEHHAVRNDAGMFDVSHMTIVDILGA
CCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEECHHHEEHHHCC
GGRQFLRKLLTNDVDQITHNGKALYSCMCNEHGGIIDDLIVYQRASDNYRVVLNSATRQN
CHHHHHHHHHHCCHHHHHCCCCEEEEEHHCCCCCHHHHHHHEEECCCCEEEEEECCCCCC
DVAWIRAKSEGFAVGLQERRELSMLAVQGPNAIAKTLSILAPAHVDAVSTLTSFECVDVD
CEEEEEECCCCEEECHHHHCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHCCEEECCC
HWFFARTGYTGEDGLEIIVPNEFVTQLWNDLLHAGVTPCGLGARDTLRLEAGMLLYGQDM
CEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEECCC
DETTTPLESGLAWTVKWEPEDRGFIGMGALVSQKQQGIKRKMVGLTLLDKGIMRHGQKVI
CCCCCHHHCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
IEGCPDGIITSGSYSPTLQQSIALARVPMETGEQVLVDIRGKLIPAKVGKPRFIKQGKPV
EECCCCCEEECCCCCHHHHHHHHHHCCCHHCCCEEEEEECCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA