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The map label for this gene is nuoF [H]

Identifier: 39998530

GI number: 39998530

Start: 3786573

End: 3787844

Strand: Reverse

Name: nuoF [H]

Synonym: GSU3441

Alternate gene names: 39998530

Gene position: 3787844-3786573 (Counterclockwise)

Preceding gene: 39998531

Following gene: 39998529

Centisome position: 99.31

GC content: 66.59

Gene sequence:

>1272_bases
ATGGAACAGGTTCTCTTCCGACATAACCGTCCCGGCCGGTGCGTAACCTTTGCCGAGTACCGGGCGGAGGGAGGCTTCGC
GGCCCTGGAGAAGGCCCTTTCCGGCATGTCGCCCAACGATGTCCAGCAGGTGGTGATCGACGCCAATCTGCGGGGCCGGG
GCGGGGCCGGGTTCCCCACCGGGAAGAAGTGGTCCTTCGTGCCGCGGGACATCCCAGGCCCCCGTTATCTCATCTGTAAC
TGCGACGAGATGGAGCCGGGCACCTACAAGGACCGGATACTCCTGGAGGCGAACCCCTATTCTCTGGTGGAGGGGATGAC
CCTGGCCGCTTATGCCATCGGTGTGGCCCATGCCTTCATCTTCATCCGCCGCGGCTACGAAGAGGCGGCGGAGAATTGCC
GGCGCGCCATTGCCGAGGCAAAGGAAGCGGGCCTGCTGGGGAAGAACATCCTCGGCTCCGGTTTCTCCCTGGACCTGGAC
GTCCACCAGTCCGCCGGGCGTTACATCTGTGGCGAGGAAACAGCCCTCATGAACGCGCTGGAGGGGAGGCGGGCCAACCC
GCGGAGCAAACCCCCCTTCCCGGCAGTGAAAGGGCTCTGGGGGCGCCCCACGGTGGTGAACAACGTGGAGACCCTGGCCA
ACATCCCGGCTATCGTGGCCAACGGCGCCGCCTGGTTCAAGGGGCTGGCGAGAATCTCCGAAGCGGCCGGTACCAAGCTC
TTCTGCGTGAGCGGACATGTGAACAACGCCGCCTGCTTCGAGCTTCCCCTGGGGATGAGCCTGGGCGAGATCATCGACGG
CCCCTGCGGCGGCATGCTGCCGGGGCGGGAGTTCAAGGCGTGCATACCCGGCGGGGCGTCCACGCCGTTCTTTACCCGGG
AGCACTGGAACGTCCCCATGGACTTCGATGCCGTGGCAAGGGCCGGCTCCCGGCTCGGCACCGGCGGCATCGTGGTCTTC
GACCGGAACACCTGCATGGTGGCGGCAACCCTGAACCTGGTGTCCTTTTACGCTCGGGAGTCGTGCGGCTGGTGTACCCC
CTGCCGGGAAGGGCTCCCCTTTGTGAAGGACGTCCTGGCCCGGATCGAGGCGGGCGCCGGGCGGGAGGAGCACATCGCCA
TCCTGCGGGAGCATGTCCAGTACCTGAACTACGCCTTCTGTCCCCTGGCCCCCGGTGCCATGGGGCCGGTGGAGGGGCTC
CTGCGGCTCTTCGAGGACGAGATCCGGGAGCACATCGTGATGGGGCGCTGCCCCCTCGGAGGAAAGGGATGA

Upstream 100 bases:

>100_bases
TGAAGGACATTCTTGTTGAGCAATAAGACCCCCCTCGGTCCCCCCTGCCTTGTAGGGGGAAGCGAACGAGAGCGAAGCAG
GGGGGTGAACAAAGGGGTAA

Downstream 100 bases:

>100_bases
CGGCACCATCTGACGATTTCGGCGGCCTCGTGACCCGGGCCACGAGGCTTTGGACGGGCAATTTCGGCAATCTCCTCGTC
CTCTCCCTGGTCTTCTCCCT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MEQVLFRHNRPGRCVTFAEYRAEGGFAALEKALSGMSPNDVQQVVIDANLRGRGGAGFPTGKKWSFVPRDIPGPRYLICN
CDEMEPGTYKDRILLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKEAGLLGKNILGSGFSLDLD
VHQSAGRYICGEETALMNALEGRRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARISEAAGTKL
FCVSGHVNNAACFELPLGMSLGEIIDGPCGGMLPGREFKACIPGGASTPFFTREHWNVPMDFDAVARAGSRLGTGGIVVF
DRNTCMVAATLNLVSFYARESCGWCTPCREGLPFVKDVLARIEAGAGREEHIAILREHVQYLNYAFCPLAPGAMGPVEGL
LRLFEDEIREHIVMGRCPLGGKG

Sequences:

>Translated_423_residues
MEQVLFRHNRPGRCVTFAEYRAEGGFAALEKALSGMSPNDVQQVVIDANLRGRGGAGFPTGKKWSFVPRDIPGPRYLICN
CDEMEPGTYKDRILLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKEAGLLGKNILGSGFSLDLD
VHQSAGRYICGEETALMNALEGRRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARISEAAGTKL
FCVSGHVNNAACFELPLGMSLGEIIDGPCGGMLPGREFKACIPGGASTPFFTREHWNVPMDFDAVARAGSRLGTGGIVVF
DRNTCMVAATLNLVSFYARESCGWCTPCREGLPFVKDVLARIEAGAGREEHIAILREHVQYLNYAFCPLAPGAMGPVEGL
LRLFEDEIREHIVMGRCPLGGKG
>Mature_423_residues
MEQVLFRHNRPGRCVTFAEYRAEGGFAALEKALSGMSPNDVQQVVIDANLRGRGGAGFPTGKKWSFVPRDIPGPRYLICN
CDEMEPGTYKDRILLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKEAGLLGKNILGSGFSLDLD
VHQSAGRYICGEETALMNALEGRRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARISEAAGTKL
FCVSGHVNNAACFELPLGMSLGEIIDGPCGGMLPGREFKACIPGGASTPFFTREHWNVPMDFDAVARAGSRLGTGGIVVF
DRNTCMVAATLNLVSFYARESCGWCTPCREGLPFVKDVLARIEAGAGREEHIAILREHVQYLNYAFCPLAPGAMGPVEGL
LRLFEDEIREHIVMGRCPLGGKG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=379, Percent_Identity=45.910290237467, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI20149568, Length=379, Percent_Identity=45.910290237467, Blast_Score=312, Evalue=3e-85,
Organism=Escherichia coli, GI1788620, Length=401, Percent_Identity=53.1172069825436, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17531727, Length=369, Percent_Identity=43.6314363143631, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI19920794, Length=371, Percent_Identity=45.2830188679245, Blast_Score=314, Evalue=6e-86,
Organism=Drosophila melanogaster, GI45550452, Length=372, Percent_Identity=44.6236559139785, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24653819, Length=382, Percent_Identity=36.3874345549738, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24653817, Length=358, Percent_Identity=35.4748603351955, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45682; Mature: 45682

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQVLFRHNRPGRCVTFAEYRAEGGFAALEKALSGMSPNDVQQVVIDANLRGRGGAGFPT
CCCCCCCCCCCCCEEEEHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
GKKWSFVPRDIPGPRYLICNCDEMEPGTYKDRILLEANPYSLVEGMTLAAYAIGVAHAFI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FIRRGYEEAAENCRRAIAEAKEAGLLGKNILGSGFSLDLDVHQSAGRYICGEETALMNAL
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCCCEECCCHHHHHHHH
EGRRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARISEAAGTKL
HCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCEE
FCVSGHVNNAACFELPLGMSLGEIIDGPCGGMLPGREFKACIPGGASTPFFTREHWNVPM
EEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCEECCCCCCCCCEECCCCCCCC
DFDAVARAGSRLGTGGIVVFDRNTCMVAATLNLVSFYARESCGWCTPCREGLPFVKDVLA
CHHHHHHCCCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHH
RIEAGAGREEHIAILREHVQYLNYAFCPLAPGAMGPVEGLLRLFEDEIREHIVMGRCPLG
HHHCCCCCHHHHHHHHHHHHHHCEECCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCC
GKG
CCC
>Mature Secondary Structure
MEQVLFRHNRPGRCVTFAEYRAEGGFAALEKALSGMSPNDVQQVVIDANLRGRGGAGFPT
CCCCCCCCCCCCCEEEEHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
GKKWSFVPRDIPGPRYLICNCDEMEPGTYKDRILLEANPYSLVEGMTLAAYAIGVAHAFI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FIRRGYEEAAENCRRAIAEAKEAGLLGKNILGSGFSLDLDVHQSAGRYICGEETALMNAL
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCCCCEECCCHHHHHHHH
EGRRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARISEAAGTKL
HCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCEE
FCVSGHVNNAACFELPLGMSLGEIIDGPCGGMLPGREFKACIPGGASTPFFTREHWNVPM
EEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCEECCCCCCCCCEECCCCCCCC
DFDAVARAGSRLGTGGIVVFDRNTCMVAATLNLVSFYARESCGWCTPCREGLPFVKDVLA
CHHHHHHCCCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHH
RIEAGAGREEHIAILREHVQYLNYAFCPLAPGAMGPVEGLLRLFEDEIREHIVMGRCPLG
HHHCCCCCHHHHHHHHHHHHHHCEECCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCC
GKG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]