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The map label for this gene is mtnA

Identifier: 39998468

GI number: 39998468

Start: 3714645

End: 3715685

Strand: Reverse

Name: mtnA

Synonym: GSU3379

Alternate gene names: 39998468

Gene position: 3715685-3714645 (Counterclockwise)

Preceding gene: 39998469

Following gene: 39998467

Centisome position: 97.42

GC content: 63.88

Gene sequence:

>1041_bases
ATGTCCTTCAGAACCATAGAGTGGCGCGACGACAAGGTTGTCATGATCGACCAGACCCGCCTGCCCGGCGAGGAGGTCTA
CTGCGAGTACGCCGATTACAAGAGCGTGGCCGAGGCGATACGGGGGATGGTCATCCGGGGCGCACCAGCCATCGGGGTGG
CGGCGGCCATGGGGGTGGCTCTGGGTGCCCGGGAGATCATCGCCGACACCTACGAATCGTTTTTCCGGCAGATGGAGAAT
GTCTGCGATGTCATGGCCCGCACCCGCCCCACAGCGGTGAACCTCTTCTGGGCCATTGAGCGAATGAAGCGGGTGGCGGA
CGAGAACCGGGACAAGCCCCTGGACCAATTGCGCGAAATTCTCAAGACCGAGGCGATCCGGATCGAGCAGGAAGACTTGG
AGCTCTGTAAGGCCATCGGTCGGCACGGGGCGGCGTTGATTCCCGAGGGGGCCACGGTCCTGACCCACTGCAACGCCGGA
GGGCTTGCCACGGCCGGTTACGGTACGGCCCTAGGGGTCATCCGCGCGGCCCACGATGCTGGGAAAAAGATCCAGGTGTT
CGCCGACGAGACCCGTCCGTGGCTCCAGGGGGCGCGGCTCACCGCCTGGGAGCTCATGAAGGATGGCATCCCGGTGACTC
TCATTTCCGACAACATGGCCGGCTTTTTCATGAAACGGGGCGAGATTGCCTGCTGCGTCGTGGGGGCCGATCGGATCGCC
GCCAACGGCGACACGGCAAACAAGATCGGGACTTACAGCGTGGCGGTCCTGGCCAAGGAGAACAACATCCCCTTTTACGT
GGCTGCTCCCACCACCACTCTCGATCTCTCGCTGGAGAATGGCGACCAGATCCCCATCGAGGAGCGTCATTCCCGTGAGG
TGACCCATCTGCACGGGTTCCCGGTGGCGCCCGAGGGAATCCGGGTTCGTAACCCGGCGTTCGACGTGACGCCTGCCCGC
TACATATCCGCCATCATCACCGAGCAGGGGGTAGTGAGCGGTGACTACGTCACCGGCCTTCGGGGCCTCGTGGCGCCATG
A

Upstream 100 bases:

>100_bases
GTGGGCCAGGTGATGCGGGCCTCCAAGGGGAAGGCCAACCCGGCGGTGGTGAATGAGCTGCTGATGAAGAAGCTGAAAGG
CTAAATACGACGAGGTTCCC

Downstream 100 bases:

>100_bases
GCCGCGGCAGCGAGTTCATCCGGCGGATCGAGGAGGCCCTGGCCGCCGCTACGGACAGCGGCAGCGATCAACCCCTCACG
GAACTCCTTGAAAAGGAAGG

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSFRTIEWRDDKVVMIDQTRLPGEEVYCEYADYKSVAEAIRGMVIRGAPAIGVAAAMGVALGAREIIADTYESFFRQMEN
VCDVMARTRPTAVNLFWAIERMKRVADENRDKPLDQLREILKTEAIRIEQEDLELCKAIGRHGAALIPEGATVLTHCNAG
GLATAGYGTALGVIRAAHDAGKKIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEIACCVVGADRIA
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTTTLDLSLENGDQIPIEERHSREVTHLHGFPVAPEGIRVRNPAFDVTPAR
YISAIITEQGVVSGDYVTGLRGLVAP

Sequences:

>Translated_346_residues
MSFRTIEWRDDKVVMIDQTRLPGEEVYCEYADYKSVAEAIRGMVIRGAPAIGVAAAMGVALGAREIIADTYESFFRQMEN
VCDVMARTRPTAVNLFWAIERMKRVADENRDKPLDQLREILKTEAIRIEQEDLELCKAIGRHGAALIPEGATVLTHCNAG
GLATAGYGTALGVIRAAHDAGKKIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEIACCVVGADRIA
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTTTLDLSLENGDQIPIEERHSREVTHLHGFPVAPEGIRVRNPAFDVTPAR
YISAIITEQGVVSGDYVTGLRGLVAP
>Mature_345_residues
SFRTIEWRDDKVVMIDQTRLPGEEVYCEYADYKSVAEAIRGMVIRGAPAIGVAAAMGVALGAREIIADTYESFFRQMENV
CDVMARTRPTAVNLFWAIERMKRVADENRDKPLDQLREILKTEAIRIEQEDLELCKAIGRHGAALIPEGATVLTHCNAGG
LATAGYGTALGVIRAAHDAGKKIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEIACCVVGADRIAA
NGDTANKIGTYSVAVLAKENNIPFYVAAPTTTLDLSLENGDQIPIEERHSREVTHLHGFPVAPEGIRVRNPAFDVTPARY
ISAIITEQGVVSGDYVTGLRGLVAP

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=354, Percent_Identity=42.090395480226, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI23943880, Length=343, Percent_Identity=36.734693877551, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4503503, Length=226, Percent_Identity=30.5309734513274, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI78000158, Length=270, Percent_Identity=23.3333333333333, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI78000156, Length=270, Percent_Identity=23.3333333333333, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI187607323, Length=275, Percent_Identity=23.2727272727273, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=322, Percent_Identity=37.888198757764, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557123, Length=180, Percent_Identity=30.5555555555556, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6325375, Length=395, Percent_Identity=34.6835443037975, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322878, Length=210, Percent_Identity=29.0476190476191, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357667, Length=353, Percent_Identity=43.0594900849858, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24651647, Length=353, Percent_Identity=43.0594900849858, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21358605, Length=225, Percent_Identity=26.2222222222222, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_GEOSL (Q746Y8)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954419.1
- HSSP:   Q9X013
- ProteinModelPortal:   Q746Y8
- SMR:   Q746Y8
- GeneID:   2688214
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3379
- NMPDR:   fig|243231.1.peg.3357
- TIGR:   GSU3379
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK829258
- BioCyc:   GSUL243231:GSU_3379-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37747; Mature: 37615

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: ACT_SITE 237-237 BINDING 89-89 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRTIEWRDDKVVMIDQTRLPGEEVYCEYADYKSVAEAIRGMVIRGAPAIGVAAAMGVA
CCCEEEEECCCEEEEEECCCCCCHHEEEEHHHHHHHHHHHHCEEEECCCHHHHHHHHHHH
LGAREIIADTYESFFRQMENVCDVMARTRPTAVNLFWAIERMKRVADENRDKPLDQLREI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKTEAIRIEQEDLELCKAIGRHGAALIPEGATVLTHCNAGGLATAGYGTALGVIRAAHDA
HHHHHHEECHHHHHHHHHHCCCCCEECCCCCEEEEECCCCCCEECCCHHHHHHHHHHHCC
GKKIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEIACCVVGADRIA
CCEEEEEECCCCHHHCCCCCHHHHHHHCCCCEEEECCCCCCCEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTTTLDLSLENGDQIPIEERHSREVTHLHGF
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCEEEECCC
PVAPEGIRVRNPAFDVTPARYISAIITEQGVVSGDYVTGLRGLVAP
CCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SFRTIEWRDDKVVMIDQTRLPGEEVYCEYADYKSVAEAIRGMVIRGAPAIGVAAAMGVA
CCEEEEECCCEEEEEECCCCCCHHEEEEHHHHHHHHHHHHCEEEECCCHHHHHHHHHHH
LGAREIIADTYESFFRQMENVCDVMARTRPTAVNLFWAIERMKRVADENRDKPLDQLREI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LKTEAIRIEQEDLELCKAIGRHGAALIPEGATVLTHCNAGGLATAGYGTALGVIRAAHDA
HHHHHHEECHHHHHHHHHHCCCCCEECCCCCEEEEECCCCCCEECCCHHHHHHHHHHHCC
GKKIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEIACCVVGADRIA
CCEEEEEECCCCHHHCCCCCHHHHHHHCCCCEEEECCCCCCCEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENNIPFYVAAPTTTLDLSLENGDQIPIEERHSREVTHLHGF
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCEEEECCC
PVAPEGIRVRNPAFDVTPARYISAIITEQGVVSGDYVTGLRGLVAP
CCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA