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The map label for this gene is uvrA [H]

Identifier: 39998414

GI number: 39998414

Start: 3652846

End: 3655659

Strand: Direct

Name: uvrA [H]

Synonym: GSU3325

Alternate gene names: 39998414

Gene position: 3652846-3655659 (Clockwise)

Preceding gene: 39998412

Following gene: 39998423

Centisome position: 95.77

GC content: 63.04

Gene sequence:

>2814_bases
ATGGCACACGACACCATCATCGTCAAAGGCGCGTGCGAACATAACCTCAAGTGCATCGACGTGGAGATCCCTCGGGACAA
GCTCGTCGTCATCACCGGCATTTCCGGGTCGGGAAAATCGACCCTGGCCTTCGATACCATCTATGCCGAAGGGCAGCGCC
GCTACGTGGAATCCCTCTCGGCCTATGCCCGCCAGTTTCTGGAGCAGATGGAGAAGCCCGACGTGGAATCCATTGAGGGG
CTTTCCCCTGCCATCTCCATCGAACAGAAGACCACCAGCCGCAACCCCCGCTCCACCGTGGGAACCGTCACCGAGATCTA
CGACTACCTTCGGCTCCTCTTCGCCCGCGTCGGCCACCCCCACTGCTATGAATGCGGCAAACCGATCACCTCCCAGACTG
TCTCCCAGATGGTGGACCAGATCATGGCCTTGCCCGCCGGAACCAGGCTTCAGCTTCTCTCGCCCATGGTCCGGGGTCGC
AAGGGGGAGTACCGCAAGGAACTGGCCCAGTTGCGCAAGGACGGCTTCGCCCGGGTCATCGTGGATGGCGTGCAGCATGA
GCTGGCCGAGGAGATTCACCTCGACAAAAACAAGAAACACGATATCGATATCGTGGTGGATCGACTCATTATCAAGGAGG
GAATCGAGCGGCGCCTGGCCGACTCCCTGGAAACGGCCCTGAACCACGCGGAAGGGGTGGTAAAGGTCCAGGTCGTGGAC
GGCGACACCATCCTTTTCTCCGAGGCACTGGCCTGCATCGACTGCGGCATCTCCTACCCCGAGATGACCCCCCGGATGTT
CTCATTCAACAACCCCTACGGCGCCTGCCCCGACTGCACCGGCCTCGGCACGCGGATGTACTTCGACGAGGAACTGGTCG
TGCCGAACCCGGAACTCTCCATCCGCGAAGGAGCCATCGCCCCATGGGAGAAACGGCTCTCGGCCTGGTACCACATGACT
CTGGACGCCCTGGCCAAGGCCTTTGACTTCGACATCCGGACCCCCTTCAAAGAGCTCTCTCCCCGGGTGCGCGAGGTGAT
CCTGCGCGGATCCAAAGGCGAAAAAGTTGAGTTCTGGTGGGAAGAGGACGGTGGGCGGCGTCACACCTACACCAAGGAAT
TCGAAGGGGTCATCCCCAATCTGGAGCGGCGCTACCGGGAAAGCGACTCGGAGCAGGTGCGGGAAGAGCTGGAGCGCTAC
ATGAACGTAATGCCCTGCCCCACCTGCCAGGGGGCGCGCCTGAAGCGCGAGGCCCTTCACGTGAAGGTGGCGGAGCGGGA
CATCCGTCAGGTAACCGCTCTCTCCATCAAGGACGCCTTGGAGTTTTTCGCCTCCCTCACGCTCACCCCGAAAGAGGAGG
AGATCGCCCGCCGCATCCTGAAAGAAATCAGGGAGCGGCTCCACTTCCTAGTTAACGTGGGACTCGACTACCTGTCCCTG
GACCGGACCTCGGGCACCCTCTCCGGCGGTGAAGGGCAGCGGATCCGGCTCGCCACCCAGATCGGCTCCAGCCTCGTGGG
GGTTCTCTACATCCTGGACGAGCCCTCCATCGGCCTGCACCAGCGGGACAACGGCCGACTGTTGCAGACCCTCAAGCACC
TGCGCGACATCGGCAACACGGTGCTGGTGGTGGAGCACGACGAGGAGACGATCCTGGAGGCGGACCACGTGCTCGACATG
GGGCCCGGCGCCGGTGAGCACGGGGGCCGCGTGGTGGCCCAGGGAACCCCGGCGGAGATCATGGCGAACCCCGAGTCCCT
CACGGGCCGCTATCTCTCAGGAGAGCTCACCATCGCCGTGCCTAAAAAGCGGCGCAAGCCCAAGCGCTTCATCACCGTGG
AGGGAGCCGCGGAAAACAACCTGAAGGATGTCACCGTCGACATCCCCCTCGGTGTCATGACCTGCGTCACCGGGGTGTCC
GGGTCGGGCAAATCGACACTCGTGATCGACACCCTCTACAAAGTCCTGGGCCAGCGGCTCTACCGGAGCCGGGAGCGGGC
CGGCGCAGTACGCGACATCCGGGGACTGGAACAACTGGACAAGGTCATCAACATCGACCAGTCGCCCATCGGCCGCACGC
CGCGCTCGAACCCCGCCACCTACACCGGGGTCTTCGCCGATATCCGGGATCTCTTCGCCCAACTCCCCGAATCCAAGGTG
CGGGGCTATAAGCCGGGGCGCTACTCGTTCAACGTGAAGGGGGGACGGTGCGAGGCCTGCGCCGGGGACGGGATCATCAA
GATCGAGATGCACTTTCTCCCCGATGTCTACGTCCAGTGTGAGGTCTGCAAGGGAGCCCGCTATAACCGCGAGACCCTGG
AGGTTACCTACAAGGGGAAATCCATCGCGCAGGTCCTGGACATGACCGTTTCGGAGGCCCTGCGCTTCCTGGAGAACATC
CCGAAGGTCAAGGCAAAGCTCCAGACCCTGGAGGAGGTGGGGCTCGGCTACATCCGCCTGGGCCAATCGGCCACGACCCT
ATCCGGCGGCGAGGCCCAGCGGGTGAAACTGGCCAAGGAACTGGCGCGCCGGGCCACCGGCCGAACCATCTACATCCTCG
ACGAGCCCACCACCGGCCTTCACTTCCACGACATCGCCAAGCTCCTGGAGGTGCTAAGAAAACTGGTGGAGGGGGGAAAT
ACCATCGTCATCATCGAGCACAACCTGGACGTCATCAAGACCGCCGATTACATCATCGACCTGGGCCCCGAAGGGGGCGA
CCGGGGCGGCGAGGTGATCGCCACCGGCACACCTGAGGAGGTGGCCAAGGTGACACGGTCCTACACGGGACAGTATTTGC
GGAAGATGCTGTGA

Upstream 100 bases:

>100_bases
CGGGGACAGCGCGAAAGCCCCTCAGCAATTCGATTATGTGGTATAGTGAGCTCTTGCGTCCGGCCCTCCGGCGCCAGCAT
GCATTACCCACGGGAGCACC

Downstream 100 bases:

>100_bases
AGAGGCGGGATAACGGCGGGGGAAGGAGAGCTACTCCTCCCCCTCGGGGATGTCGATCGGCATTTTCTGCAGACGTTTGA
AGTAGAAGTTTTGGCCGTAG

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 937; Mature: 936

Protein sequence:

>937_residues
MAHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEQMEKPDVESIEG
LSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCYECGKPITSQTVSQMVDQIMALPAGTRLQLLSPMVRGR
KGEYRKELAQLRKDGFARVIVDGVQHELAEEIHLDKNKKHDIDIVVDRLIIKEGIERRLADSLETALNHAEGVVKVQVVD
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDEELVVPNPELSIREGAIAPWEKRLSAWYHMT
LDALAKAFDFDIRTPFKELSPRVREVILRGSKGEKVEFWWEEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVREELERY
MNVMPCPTCQGARLKREALHVKVAERDIRQVTALSIKDALEFFASLTLTPKEEEIARRILKEIRERLHFLVNVGLDYLSL
DRTSGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHLRDIGNTVLVVEHDEETILEADHVLDM
GPGAGEHGGRVVAQGTPAEIMANPESLTGRYLSGELTIAVPKKRRKPKRFITVEGAAENNLKDVTVDIPLGVMTCVTGVS
GSGKSTLVIDTLYKVLGQRLYRSRERAGAVRDIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
RGYKPGRYSFNVKGGRCEACAGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGKSIAQVLDMTVSEALRFLENI
PKVKAKLQTLEEVGLGYIRLGQSATTLSGGEAQRVKLAKELARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGN
TIVIIEHNLDVIKTADYIIDLGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKML

Sequences:

>Translated_937_residues
MAHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEQMEKPDVESIEG
LSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCYECGKPITSQTVSQMVDQIMALPAGTRLQLLSPMVRGR
KGEYRKELAQLRKDGFARVIVDGVQHELAEEIHLDKNKKHDIDIVVDRLIIKEGIERRLADSLETALNHAEGVVKVQVVD
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDEELVVPNPELSIREGAIAPWEKRLSAWYHMT
LDALAKAFDFDIRTPFKELSPRVREVILRGSKGEKVEFWWEEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVREELERY
MNVMPCPTCQGARLKREALHVKVAERDIRQVTALSIKDALEFFASLTLTPKEEEIARRILKEIRERLHFLVNVGLDYLSL
DRTSGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHLRDIGNTVLVVEHDEETILEADHVLDM
GPGAGEHGGRVVAQGTPAEIMANPESLTGRYLSGELTIAVPKKRRKPKRFITVEGAAENNLKDVTVDIPLGVMTCVTGVS
GSGKSTLVIDTLYKVLGQRLYRSRERAGAVRDIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
RGYKPGRYSFNVKGGRCEACAGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGKSIAQVLDMTVSEALRFLENI
PKVKAKLQTLEEVGLGYIRLGQSATTLSGGEAQRVKLAKELARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGN
TIVIIEHNLDVIKTADYIIDLGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKML
>Mature_936_residues
AHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLEQMEKPDVESIEGL
SPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCYECGKPITSQTVSQMVDQIMALPAGTRLQLLSPMVRGRK
GEYRKELAQLRKDGFARVIVDGVQHELAEEIHLDKNKKHDIDIVVDRLIIKEGIERRLADSLETALNHAEGVVKVQVVDG
DTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDEELVVPNPELSIREGAIAPWEKRLSAWYHMTL
DALAKAFDFDIRTPFKELSPRVREVILRGSKGEKVEFWWEEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVREELERYM
NVMPCPTCQGARLKREALHVKVAERDIRQVTALSIKDALEFFASLTLTPKEEEIARRILKEIRERLHFLVNVGLDYLSLD
RTSGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHLRDIGNTVLVVEHDEETILEADHVLDMG
PGAGEHGGRVVAQGTPAEIMANPESLTGRYLSGELTIAVPKKRRKPKRFITVEGAAENNLKDVTVDIPLGVMTCVTGVSG
SGKSTLVIDTLYKVLGQRLYRSRERAGAVRDIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKVR
GYKPGRYSFNVKGGRCEACAGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGKSIAQVLDMTVSEALRFLENIP
KVKAKLQTLEEVGLGYIRLGQSATTLSGGEAQRVKLAKELARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGNT
IVIIEHNLDVIKTADYIIDLGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKML

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=940, Percent_Identity=60, Blast_Score=1127, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 104570; Mature: 104439

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLS
CCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHH
AYARQFLEQMEKPDVESIEGLSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHP
HHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCYECGKPITSQTVSQMVDQIMALPAGTRLQLLSPMVRGRKGEYRKELAQLRKDGFARVI
CHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHH
VDGVQHELAEEIHLDKNKKHDIDIVVDRLIIKEGIERRLADSLETALNHAEGVVKVQVVD
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDEELVVPNPELS
CCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEECCEEECCCCCCC
IREGAIAPWEKRLSAWYHMTLDALAKAFDFDIRTPFKELSPRVREVILRGSKGEKVEFWW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHCCCCCCEEEEEE
EEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVREELERYMNVMPCPTCQGARLKREALH
ECCCCCCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VKVAERDIRQVTALSIKDALEFFASLTLTPKEEEIARRILKEIRERLHFLVNVGLDYLSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEE
DRTSGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHLRDIGNT
CCCCCCCCCCCCCEEEEHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCE
VLVVEHDEETILEADHVLDMGPGAGEHGGRVVAQGTPAEIMANPESLTGRYLSGELTIAV
EEEEECCCHHHHHHHHHEECCCCCCCCCCEEEECCCCHHEEECCHHHCCEEECCEEEEEE
PKKRRKPKRFITVEGAAENNLKDVTVDIPLGVMTCVTGVSGSGKSTLVIDTLYKVLGQRL
CCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
YRSRERAGAVRDIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCHHHH
RGYKPGRYSFNVKGGRCEACAGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGK
CCCCCCCEEEECCCCEECEECCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEEEEECCH
SIAQVLDMTVSEALRFLENIPKVKAKLQTLEEVGLGYIRLGQSATTLSGGEAQRVKLAKE
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHH
LARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGNTIVIIEHNLDVIKTADYIID
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCEEEE
LGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKML
ECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
AHDTIIVKGACEHNLKCIDVEIPRDKLVVITGISGSGKSTLAFDTIYAEGQRRYVESLS
CCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHH
AYARQFLEQMEKPDVESIEGLSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHP
HHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCYECGKPITSQTVSQMVDQIMALPAGTRLQLLSPMVRGRKGEYRKELAQLRKDGFARVI
CHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHH
VDGVQHELAEEIHLDKNKKHDIDIVVDRLIIKEGIERRLADSLETALNHAEGVVKVQVVD
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GDTILFSEALACIDCGISYPEMTPRMFSFNNPYGACPDCTGLGTRMYFDEELVVPNPELS
CCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEECCEEECCCCCCC
IREGAIAPWEKRLSAWYHMTLDALAKAFDFDIRTPFKELSPRVREVILRGSKGEKVEFWW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHCCCCCCEEEEEE
EEDGGRRHTYTKEFEGVIPNLERRYRESDSEQVREELERYMNVMPCPTCQGARLKREALH
ECCCCCCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VKVAERDIRQVTALSIKDALEFFASLTLTPKEEEIARRILKEIRERLHFLVNVGLDYLSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEE
DRTSGTLSGGEGQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNGRLLQTLKHLRDIGNT
CCCCCCCCCCCCCEEEEHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCE
VLVVEHDEETILEADHVLDMGPGAGEHGGRVVAQGTPAEIMANPESLTGRYLSGELTIAV
EEEEECCCHHHHHHHHHEECCCCCCCCCCEEEECCCCHHEEECCHHHCCEEECCEEEEEE
PKKRRKPKRFITVEGAAENNLKDVTVDIPLGVMTCVTGVSGSGKSTLVIDTLYKVLGQRL
CCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
YRSRERAGAVRDIRGLEQLDKVINIDQSPIGRTPRSNPATYTGVFADIRDLFAQLPESKV
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCHHHH
RGYKPGRYSFNVKGGRCEACAGDGIIKIEMHFLPDVYVQCEVCKGARYNRETLEVTYKGK
CCCCCCCEEEECCCCEECEECCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEEEEECCH
SIAQVLDMTVSEALRFLENIPKVKAKLQTLEEVGLGYIRLGQSATTLSGGEAQRVKLAKE
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHH
LARRATGRTIYILDEPTTGLHFHDIAKLLEVLRKLVEGGNTIVIIEHNLDVIKTADYIID
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCEEEE
LGPEGGDRGGEVIATGTPEEVAKVTRSYTGQYLRKML
ECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]