| Definition | Geobacter sulfurreducens PCA chromosome, complete genome. |
|---|---|
| Accession | NC_002939 |
| Length | 3,814,139 |
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The map label for this gene is ppiA [H]
Identifier: 39998408
GI number: 39998408
Start: 3645704
End: 3646300
Strand: Reverse
Name: ppiA [H]
Synonym: GSU3319
Alternate gene names: 39998408
Gene position: 3646300-3645704 (Counterclockwise)
Preceding gene: 39998409
Following gene: 39998407
Centisome position: 95.6
GC content: 62.31
Gene sequence:
>597_bases ATGTTCAAGAGACTGATCATCGCCCTGCTCATGAGCGGGCTGTTCGGCGCACTGCTCCTGGCCGGCAACGCCGATGCCGC CGACAAGGCGGCCAAGGCCGCCAATCCCGTGGTGGTTATGGAGACGAGCCTCGGCAAGATCGCCGTGGAGCTCTACCCGG ACAAGGCGCCGGCCACGGTGAAGAACGTTCTCGACTACGTCAAGAGCGGCTTCTACGATGGCACCATCTTCCACCGGGTC ATCCCCGGCTTCATGATCCAGGGAGGCGGCTTCACCACCGACCGGAAACAGAAGGAGACCAGGGCTCCGATCAAGAACGA GGCGGACAACGGCCTCAAGAACGACCGGGGTACCATTGCCATGGCCCGCACCGCCAGCCCCGACAGCGCCACGGCCCAGT TCTTCATCAACTTGGTGAACAACGAAAACCTGAACCGTCCCCGCCCCGACGGCTACGGCTACGCGGTGTTCGGCAAGGTG ATCGAGGGGATGGATGTGGTTGACAAGATTGCCGCCTCCCCCACCCAGCGTCTCAACATGCTCTTCGCCAACATACCGGT GACGCCGGTGGTCATCACCTCCGTCAAGATCCGGTAA
Upstream 100 bases:
>100_bases CGTCACCCTGGTCATGCGGAAGGCTTGACCTTTCCCGGGGAAGTGCCTATATAATAATTCGTTTGCAGCACACCGTCTTT AGGTTTCCCGGAGGTTGTAC
Downstream 100 bases:
>100_bases CCCGGCACTACGACTCGCATACCACCAGGCGCCCTGACGGGCGCCTTTTTTTGTGATATACCTCCAGGTGCGGCCCTGCC GCCAGATCACCGGGCGAGGT
Product: peptidyl-prolyl cis-trans isomerase A
Products: NA
Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]
Number of amino acids: Translated: 198; Mature: 198
Protein sequence:
>198_residues MFKRLIIALLMSGLFGALLLAGNADAADKAAKAANPVVVMETSLGKIAVELYPDKAPATVKNVLDYVKSGFYDGTIFHRV IPGFMIQGGGFTTDRKQKETRAPIKNEADNGLKNDRGTIAMARTASPDSATAQFFINLVNNENLNRPRPDGYGYAVFGKV IEGMDVVDKIAASPTQRLNMLFANIPVTPVVITSVKIR
Sequences:
>Translated_198_residues MFKRLIIALLMSGLFGALLLAGNADAADKAAKAANPVVVMETSLGKIAVELYPDKAPATVKNVLDYVKSGFYDGTIFHRV IPGFMIQGGGFTTDRKQKETRAPIKNEADNGLKNDRGTIAMARTASPDSATAQFFINLVNNENLNRPRPDGYGYAVFGKV IEGMDVVDKIAASPTQRLNMLFANIPVTPVVITSVKIR >Mature_198_residues MFKRLIIALLMSGLFGALLLAGNADAADKAAKAANPVVVMETSLGKIAVELYPDKAPATVKNVLDYVKSGFYDGTIFHRV IPGFMIQGGGFTTDRKQKETRAPIKNEADNGLKNDRGTIAMARTASPDSATAQFFINLVNNENLNRPRPDGYGYAVFGKV IEGMDVVDKIAASPTQRLNMLFANIPVTPVVITSVKIR
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Periplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI7706339, Length=139, Percent_Identity=38.8489208633094, Blast_Score=83, Evalue=1e-16, Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=37.984496124031, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=32.484076433121, Blast_Score=80, Evalue=9e-16, Organism=Homo sapiens, GI19557636, Length=140, Percent_Identity=34.2857142857143, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI310110104, Length=147, Percent_Identity=38.0952380952381, Blast_Score=78, Evalue=4e-15, Organism=Homo sapiens, GI10863927, Length=147, Percent_Identity=38.7755102040816, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI310129267, Length=147, Percent_Identity=36.734693877551, Blast_Score=75, Evalue=3e-14, Organism=Homo sapiens, GI310120620, Length=147, Percent_Identity=36.734693877551, Blast_Score=75, Evalue=3e-14, Organism=Homo sapiens, GI4505991, Length=195, Percent_Identity=31.7948717948718, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI5454154, Length=181, Percent_Identity=32.0441988950276, Blast_Score=72, Evalue=2e-13, Organism=Homo sapiens, GI5031987, Length=152, Percent_Identity=37.5, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI22547212, Length=133, Percent_Identity=35.3383458646617, Blast_Score=71, Evalue=5e-13, Organism=Homo sapiens, GI7657473, Length=133, Percent_Identity=35.3383458646617, Blast_Score=71, Evalue=5e-13, Organism=Homo sapiens, GI22547215, Length=133, Percent_Identity=35.3383458646617, Blast_Score=71, Evalue=5e-13, Organism=Homo sapiens, GI169214050, Length=165, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=6e-13, Organism=Homo sapiens, GI239751853, Length=148, Percent_Identity=35.1351351351351, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI113428306, Length=148, Percent_Identity=35.1351351351351, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI256017253, Length=145, Percent_Identity=35.8620689655172, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI221139811, Length=145, Percent_Identity=35.8620689655172, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI256017251, Length=145, Percent_Identity=35.8620689655172, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI310127646, Length=148, Percent_Identity=33.7837837837838, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI310114371, Length=148, Percent_Identity=33.7837837837838, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI310119221, Length=148, Percent_Identity=33.7837837837838, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI4758950, Length=188, Percent_Identity=35.6382978723404, Blast_Score=67, Evalue=9e-12, Organism=Escherichia coli, GI1789763, Length=197, Percent_Identity=54.3147208121827, Blast_Score=196, Evalue=6e-52, Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=56.441717791411, Blast_Score=184, Evalue=2e-48, Organism=Caenorhabditis elegans, GI71980590, Length=136, Percent_Identity=38.9705882352941, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI71980594, Length=136, Percent_Identity=38.9705882352941, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17539496, Length=134, Percent_Identity=39.5522388059701, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=28.9156626506024, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=32.3943661971831, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17559074, Length=147, Percent_Identity=36.734693877551, Blast_Score=70, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17552780, Length=139, Percent_Identity=38.8489208633094, Blast_Score=70, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17566266, Length=160, Percent_Identity=35, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI71997782, Length=127, Percent_Identity=33.8582677165354, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17565860, Length=174, Percent_Identity=33.9080459770115, Blast_Score=66, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17506307, Length=159, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6321848, Length=138, Percent_Identity=37.6811594202899, Blast_Score=67, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6320510, Length=194, Percent_Identity=32.9896907216495, Blast_Score=66, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6320359, Length=135, Percent_Identity=37.037037037037, Blast_Score=65, Evalue=6e-12, Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=33.5294117647059, Blast_Score=87, Evalue=6e-18, Organism=Drosophila melanogaster, GI19922912, Length=139, Percent_Identity=37.410071942446, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24652460, Length=145, Percent_Identity=31.7241379310345, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI45549139, Length=142, Percent_Identity=38.0281690140845, Blast_Score=73, Evalue=1e-13, Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=27.6073619631902, Blast_Score=70, Evalue=8e-13, Organism=Drosophila melanogaster, GI24664125, Length=142, Percent_Identity=36.6197183098592, Blast_Score=68, Evalue=4e-12, Organism=Drosophila melanogaster, GI21357783, Length=142, Percent_Identity=36.6197183098592, Blast_Score=68, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 21346; Mature: 21346
Theoretical pI: Translated: 10.12; Mature: 10.12
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 3.5 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MFKRLIIALLMSGLFGALLLAGNADAADKAAKAANPVVVMETSLGKIAVELYPDKAPATV CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCHHH KNVLDYVKSGFYDGTIFHRVIPGFMIQGGGFTTDRKQKETRAPIKNEADNGLKNDRGTIA HHHHHHHHCCCCCCHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEE MARTASPDSATAQFFINLVNNENLNRPRPDGYGYAVFGKVIEGMDVVDKIAASPTQRLNM EEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH LFANIPVTPVVITSVKIR HHHCCCCCEEEEEEEECC >Mature Secondary Structure MFKRLIIALLMSGLFGALLLAGNADAADKAAKAANPVVVMETSLGKIAVELYPDKAPATV CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCHHH KNVLDYVKSGFYDGTIFHRVIPGFMIQGGGFTTDRKQKETRAPIKNEADNGLKNDRGTIA HHHHHHHHCCCCCCHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEE MARTASPDSATAQFFINLVNNENLNRPRPDGYGYAVFGKVIEGMDVVDKIAASPTQRLNM EEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH LFANIPVTPVVITSVKIR HHHCCCCCEEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 10984043; 8581173 [H]