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The map label for this gene is norM [H]

Identifier: 39998219

GI number: 39998219

Start: 3429286

End: 3430644

Strand: Direct

Name: norM [H]

Synonym: GSU3129

Alternate gene names: 39998219

Gene position: 3429286-3430644 (Clockwise)

Preceding gene: 39998218

Following gene: 39998224

Centisome position: 89.91

GC content: 66.0

Gene sequence:

>1359_bases
ATGGCGAAGAGAGGGTTCAGGGCACGGTACGCAAGGGAACGGAGCAAACGCGCCTCCATCCGCCGCAACGTTATGAACCT
GTCGCTGCCGGTACTCCTGTCCTCGCTCTTCCAGCGGCTCGTGGCCATCGTCGACATCTTTCTCGTGGGGGGGCTGGGAG
CCGCGGCCATTGCCGCCACGGGACTCGGCCAGCTTCTCGTGTTCGTGACGATGACCGTGTTCTGGGGGCTTGCCACCGGC
ACCACGGTAGTGATCGCCCACCTCCGGGGGGCGGGACAGCGCCGGGAAGCGCGGCGGGCGGCCTTTGCGGCGAGTCTCGC
CTGCGCCGGCATGACGGCGGCGGCCTCCGCGCTCGGCTGGTTCTTCAGCGACGACCTGGCCGCGTTCCTCGGTGCCCGGG
ACGACGTGCTCCACCTGGCAGCCGGCTATACCCGGCTGGTCTTCCTCTATCTTGCCTTTACCACTGGCCTCAACATCCTT
TCGGCCATCATGCACGGCATCGGCAACACCCGCACGCCCATGCAGGCCATTATCTTGGTCAACATTCTCCACGTGCTCAT
CGCCTGGCCCCTCATCTACGGCAAGCTCGGTCTCCCCGCCATGGGGGTCACCGGCGCGGCCATCGCCATCAATGCTTCCG
AGGCCATCGGCTTTCTCTACCTGCTGGTGCAAGCCCTGAGGCTGGACTACATCCGCATCGGCCGACCCGACACGGGACTC
ATGGGCCGCATCTGGCGAGTGGGGTGGCCCGTGGCCCTGGAGCGAATTGCCCAGCAGGGGGGACAGCTCTTCTACTCGAA
ATTCATCATCGGCTACGGCACCGCCGCCTACGCAGCTCACCAGATCGGACTCTCCATCGAATCCCTGTCCTTCATGCCGG
GTGCGGGCATGGGGATCGCCGCCGCCACCCTCATGGGACAGGCCCTGGGGGCAAAAAAATACCGCCGGGCGCGGATCAGC
CATCGTGAGGCCCTGCGCCTGGCGGTTATTGTCATGGGGACCATGGCGGCCGTCTTCCTGACAGTACCCGGGCCGCTCAT
CGGGCTCTTCACCCGGGACCCGGCGGTCATCGAAAACGGCATTGTGTTCCTGCGGCTGGTGGCCTTCGCCCAAGTGCCGT
TGGCCCTCTCCTTCGTCTATGCCGGGAGCCTGCGCGGCACCGGCGACACCTTCTACGTCTTCCTGGTCACCCTCGGCGTC
ATGTGGGGGGTGCGGGTCTTTCTCTCATGGGTGGCGTCCGACTGGTGCCACCTTTCCCTCTACGCCGTCTGGGGCGTCTT
CGTCATCGACTGGTACGTGCGAGCCGCCGCCTTCTGGTGGCGGTACCGCCAGCGGGACCTGCACGCGGTCATCATCTGA

Upstream 100 bases:

>100_bases
TACGGGATCATCGCACCATCCGGGCGGGCCAAGAATTTCGTTCTGAACATGGCCGGGGAACTGGAACTCGGTGACTGACA
GGGAGGCTTAAGAAGAACGG

Downstream 100 bases:

>100_bases
ACCGAAGCGGGCGCGGCTTCGACATCGTGAAGGCCCGCCCCGTTCCCTACTTCTGCACCCACCTGCCGTTCTGGAGCTGT
ATCCACCACCCCGGCCGGGC

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAKRGFRARYARERSKRASIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATG
TTVVIAHLRGAGQRREARRAAFAASLACAGMTAAASALGWFFSDDLAAFLGARDDVLHLAAGYTRLVFLYLAFTTGLNIL
SAIMHGIGNTRTPMQAIILVNILHVLIAWPLIYGKLGLPAMGVTGAAIAINASEAIGFLYLLVQALRLDYIRIGRPDTGL
MGRIWRVGWPVALERIAQQGGQLFYSKFIIGYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARIS
HREALRLAVIVMGTMAAVFLTVPGPLIGLFTRDPAVIENGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGV
MWGVRVFLSWVASDWCHLSLYAVWGVFVIDWYVRAAAFWWRYRQRDLHAVII

Sequences:

>Translated_452_residues
MAKRGFRARYARERSKRASIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATG
TTVVIAHLRGAGQRREARRAAFAASLACAGMTAAASALGWFFSDDLAAFLGARDDVLHLAAGYTRLVFLYLAFTTGLNIL
SAIMHGIGNTRTPMQAIILVNILHVLIAWPLIYGKLGLPAMGVTGAAIAINASEAIGFLYLLVQALRLDYIRIGRPDTGL
MGRIWRVGWPVALERIAQQGGQLFYSKFIIGYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARIS
HREALRLAVIVMGTMAAVFLTVPGPLIGLFTRDPAVIENGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGV
MWGVRVFLSWVASDWCHLSLYAVWGVFVIDWYVRAAAFWWRYRQRDLHAVII
>Mature_451_residues
AKRGFRARYARERSKRASIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATGT
TVVIAHLRGAGQRREARRAAFAASLACAGMTAAASALGWFFSDDLAAFLGARDDVLHLAAGYTRLVFLYLAFTTGLNILS
AIMHGIGNTRTPMQAIILVNILHVLIAWPLIYGKLGLPAMGVTGAAIAINASEAIGFLYLLVQALRLDYIRIGRPDTGLM
GRIWRVGWPVALERIAQQGGQLFYSKFIIGYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARISH
REALRLAVIVMGTMAAVFLTVPGPLIGLFTRDPAVIENGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGVM
WGVRVFLSWVASDWCHLSLYAVWGVFVIDWYVRAAAFWWRYRQRDLHAVII

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=444, Percent_Identity=28.6036036036036, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI48994890, Length=401, Percent_Identity=25.1870324189526, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320545, Length=418, Percent_Identity=23.9234449760766, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49090; Mature: 48959

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRGFRARYARERSKRASIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLGQLLVFVTMTVFWGLATGTTVVIAHLRGAGQRREARRAAFAASLACAGMTAAASALGW
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFSDDLAAFLGARDDVLHLAAGYTRLVFLYLAFTTGLNILSAIMHGIGNTRTPMQAIILV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NILHVLIAWPLIYGKLGLPAMGVTGAAIAINASEAIGFLYLLVQALRLDYIRIGRPDTGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEECCCCCCH
MGRIWRVGWPVALERIAQQGGQLFYSKFIIGYGTAAYAAHQIGLSIESLSFMPGAGMGIA
HHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCHHH
AATLMGQALGAKKYRRARISHREALRLAVIVMGTMAAVFLTVPGPLIGLFTRDPAVIENG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCC
IVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGVMWGVRVFLSWVASDWCHLSL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAVWGVFVIDWYVRAAAFWWRYRQRDLHAVII
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure 
AKRGFRARYARERSKRASIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAAT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLGQLLVFVTMTVFWGLATGTTVVIAHLRGAGQRREARRAAFAASLACAGMTAAASALGW
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFSDDLAAFLGARDDVLHLAAGYTRLVFLYLAFTTGLNILSAIMHGIGNTRTPMQAIILV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NILHVLIAWPLIYGKLGLPAMGVTGAAIAINASEAIGFLYLLVQALRLDYIRIGRPDTGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEECCCCCCH
MGRIWRVGWPVALERIAQQGGQLFYSKFIIGYGTAAYAAHQIGLSIESLSFMPGAGMGIA
HHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCHHH
AATLMGQALGAKKYRRARISHREALRLAVIVMGTMAAVFLTVPGPLIGLFTRDPAVIENG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCC
IVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGVMWGVRVFLSWVASDWCHLSL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAVWGVFVIDWYVRAAAFWWRYRQRDLHAVII
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]