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The map label for this gene is thyX

Identifier: 39998196

GI number: 39998196

Start: 3409808

End: 3410506

Strand: Reverse

Name: thyX

Synonym: GSU3106

Alternate gene names: 39998196

Gene position: 3410506-3409808 (Counterclockwise)

Preceding gene: 39998197

Following gene: 39998195

Centisome position: 89.42

GC content: 64.23

Gene sequence:

>699_bases
ATGAAAATTGCCCTCCTCCAGCATACTCCCGATCCTGAAGCCGCCGTGGCGCTCGCGGCGCGGCTCTGCTACGCCTCCGT
CGGCATCGATGAGTTGCGGGAAAAGCTTTCCGCCTCGGACGTGACGGCGTTCCTTGACAAGATCATGTCGCTTGGGCATC
AGTCGGTGCTGGAGCATGCATCGTTCACCTTCGGCATCGAGGGGATTTCCCGGGCCGCCAGCCACCAGCTCGTGCGCCAC
CGCATCGCCTCTTATTCACAGCAGTCCCAGCGCTACGTGACCTTCCGCGGTGACGGCTTCCCCCGGGTTGTGCCCGGGAG
CGTATCCGCCACGGAGAAGCGCCGGCAGGTGTTCGAATCGGCCATGCAGGCCTGCGCCGATGCCTACCGGGCTCTGGTGG
ACGACGGGGTTCCCGCCGAAGATGCCCGTTTCGTCCTCCCCAACGCCGCGGAGACGAAGATCATAGTGACCATGAATGCC
CGTGAGCTCATTCACTTTTTCGGCCTCCGCTGCTGCGAGCGGGCCCAGTGGGAAATCCGGGCGCTGGCGGTGGAGATGCT
GCGGCTTGTGAAGGGCGTTGCCCCCACCATTTTCCGGGATGCCGGTCCCGGCTGCCTGACCGGCCCCTGCCCCGAAGGAG
GCATGACCTGCGGGAAAGCAGCGGAGGTGAAACGGTTGTTCAGGGAGATGTCCATATGA

Upstream 100 bases:

>100_bases
CGGCATGTAACATGGCCTCCGGCCATGCGGTTCCAGTGGAAGGGGATTTTGTCCAGGGCGAAATCCCCTTTGTTTTTAGT
CTCTGGTTGGCGACGACAGT

Downstream 100 bases:

>100_bases
CGCAACGGCTGAGAATGTTTCTGGTGCAGCTGCTCCTGGTTGCCGAACGGATCAATGTGGGCGGGCAGGCCGTGCTGGAA
GGGGTGATGATGCGTGCCCC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKIALLQHTPDPEAAVALAARLCYASVGIDELREKLSASDVTAFLDKIMSLGHQSVLEHASFTFGIEGISRAASHQLVRH
RIASYSQQSQRYVTFRGDGFPRVVPGSVSATEKRRQVFESAMQACADAYRALVDDGVPAEDARFVLPNAAETKIIVTMNA
RELIHFFGLRCCERAQWEIRALAVEMLRLVKGVAPTIFRDAGPGCLTGPCPEGGMTCGKAAEVKRLFREMSI

Sequences:

>Translated_232_residues
MKIALLQHTPDPEAAVALAARLCYASVGIDELREKLSASDVTAFLDKIMSLGHQSVLEHASFTFGIEGISRAASHQLVRH
RIASYSQQSQRYVTFRGDGFPRVVPGSVSATEKRRQVFESAMQACADAYRALVDDGVPAEDARFVLPNAAETKIIVTMNA
RELIHFFGLRCCERAQWEIRALAVEMLRLVKGVAPTIFRDAGPGCLTGPCPEGGMTCGKAAEVKRLFREMSI
>Mature_232_residues
MKIALLQHTPDPEAAVALAARLCYASVGIDELREKLSASDVTAFLDKIMSLGHQSVLEHASFTFGIEGISRAASHQLVRH
RIASYSQQSQRYVTFRGDGFPRVVPGSVSATEKRRQVFESAMQACADAYRALVDDGVPAEDARFVLPNAAETKIIVTMNA
RELIHFFGLRCCERAQWEIRALAVEMLRLVKGVAPTIFRDAGPGCLTGPCPEGGMTCGKAAEVKRLFREMSI

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_GEOSL (Q748A9)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954147.1
- ProteinModelPortal:   Q748A9
- SMR:   Q748A9
- GeneID:   2688454
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3106
- NMPDR:   fig|243231.1.peg.3085
- TIGR:   GSU3106
- HOGENOM:   HBG458114
- OMA:   TSHQLVR
- ProtClustDB:   PRK00847
- BioCyc:   GSUL243231:GSU_3106-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 25384; Mature: 25384

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIALLQHTPDPEAAVALAARLCYASVGIDELREKLSASDVTAFLDKIMSLGHQSVLEHA
CEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SFTFGIEGISRAASHQLVRHRIASYSQQSQRYVTFRGDGFPRVVPGSVSATEKRRQVFES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AMQACADAYRALVDDGVPAEDARFVLPNAAETKIIVTMNARELIHFFGLRCCERAQWEIR
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
ALAVEMLRLVKGVAPTIFRDAGPGCLTGPCPEGGMTCGKAAEVKRLFREMSI
HHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIALLQHTPDPEAAVALAARLCYASVGIDELREKLSASDVTAFLDKIMSLGHQSVLEHA
CEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SFTFGIEGISRAASHQLVRHRIASYSQQSQRYVTFRGDGFPRVVPGSVSATEKRRQVFES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AMQACADAYRALVDDGVPAEDARFVLPNAAETKIIVTMNARELIHFFGLRCCERAQWEIR
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
ALAVEMLRLVKGVAPTIFRDAGPGCLTGPCPEGGMTCGKAAEVKRLFREMSI
HHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA