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The map label for this gene is hisC

Identifier: 39998189

GI number: 39998189

Start: 3402517

End: 3403569

Strand: Reverse

Name: hisC

Synonym: GSU3099

Alternate gene names: 39998189

Gene position: 3403569-3402517 (Counterclockwise)

Preceding gene: 39998190

Following gene: 39998188

Centisome position: 89.24

GC content: 62.49

Gene sequence:

>1053_bases
ATGCTTCCCTTTCGCTCAAATATTGCCGCCATGGCAGGCTATGTCCCCGGTTACCAACCTCCGGACGTGGCGTCGTGGAT
CAAGCTGAACACCAATGAGAACCCCTATCCGCCGTCGCCCGAGGTGGTGAAGGCAATCCTGGCGGAGTTAGGGGGTGACG
GGGCGCTCCTGCGCACCTATCCCAGCGCTTCGAGCCAGGTGCTGCGGGAGACCGTGGGCGAGCTGTTCGGCTTCGATCCC
GCGTGGATCATCATGGCCAACGGCTCTGACGAGGTCCTCAATAACCTGATACGGGCCTTTGCCGGCGAGGGGGAGGAAAT
TGGCTACGTGCATCCCTCCTACTCCTACTACGCGACCCTGGCCGAAATCCAGGGGGCACGGGTGCGGACTTTCGGCCTTA
CGGATGACCTTCGCATTGCCGGTTTTCCCGGCCGCTACGAGGGAAAGCTCTTCTTCCTGACCACCCCGAATTCGCCGCTG
GGCTTCGCTTTTCCCCTTGCCTACATCGAGGAACTGGCAACCCGCTGTGCCGGGGTCCTGGTGGTTGACGAGGCCTATGC
CGATTTCGCCGACGGTGATGCCTTGGATCTGGTGCGGCGACACGAGAACGTGGTCGTGACCCGTACCCTGTCCAAGAGCT
ATTCCCTGGCCGGGATGCGGCTTGGTTTCGCCGTGGCCCGTCCGGCGGTGATTGCGGCCCTGGACAAGATCCGCGATCAC
TATAACCTTGACCGTCTCGCCCAGGCCGCCTGCGTGGCCTCCCTGCGGGATCAGACATACTTTGCCGGGTGTACCCGCCT
GATCCGCGAGACCCGCGAGTGGTTTTCCGCTGAAATCCGGACGCTCGGCTACGAGGTGATCCCCTCCCAGGGGAACTTCG
TGTTTGCCGCGCCGCCGGACCGTGACGGTAAACGGGTCTACGACGGCCTCTACTCCCGAAAGATCCTGGTTCGTCATTTC
TCCGACCCGCTCCTGGCCCATGGCATGAGGATTTCCATCGGCACGCGGGAGGAGATGGAGGCGACTCTCGCCGCCCTGAA
AGAGATTGGCTAA

Upstream 100 bases:

>100_bases
GGCCGCGACATCGTCAGTATTGCCGAGATGGAGGGGCTGGAGGCCCACGGCAGGTCGGTAAGCATCCGCCTGAAATAACG
AGAAACGACAGGAGCGCGCC

Downstream 100 bases:

>100_bases
CTTCGATTCCCACGAGGAGGGTTCCATGTCCCGGAAAGCCACCATTGAGCGCGTCACCAAGGAAACCCAGATCAAGCTCT
CCCTTGAAATAGACGGGACG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MLPFRSNIAAMAGYVPGYQPPDVASWIKLNTNENPYPPSPEVVKAILAELGGDGALLRTYPSASSQVLRETVGELFGFDP
AWIIMANGSDEVLNNLIRAFAGEGEEIGYVHPSYSYYATLAEIQGARVRTFGLTDDLRIAGFPGRYEGKLFFLTTPNSPL
GFAFPLAYIEELATRCAGVLVVDEAYADFADGDALDLVRRHENVVVTRTLSKSYSLAGMRLGFAVARPAVIAALDKIRDH
YNLDRLAQAACVASLRDQTYFAGCTRLIRETREWFSAEIRTLGYEVIPSQGNFVFAAPPDRDGKRVYDGLYSRKILVRHF
SDPLLAHGMRISIGTREEMEATLAALKEIG

Sequences:

>Translated_350_residues
MLPFRSNIAAMAGYVPGYQPPDVASWIKLNTNENPYPPSPEVVKAILAELGGDGALLRTYPSASSQVLRETVGELFGFDP
AWIIMANGSDEVLNNLIRAFAGEGEEIGYVHPSYSYYATLAEIQGARVRTFGLTDDLRIAGFPGRYEGKLFFLTTPNSPL
GFAFPLAYIEELATRCAGVLVVDEAYADFADGDALDLVRRHENVVVTRTLSKSYSLAGMRLGFAVARPAVIAALDKIRDH
YNLDRLAQAACVASLRDQTYFAGCTRLIRETREWFSAEIRTLGYEVIPSQGNFVFAAPPDRDGKRVYDGLYSRKILVRHF
SDPLLAHGMRISIGTREEMEATLAALKEIG
>Mature_350_residues
MLPFRSNIAAMAGYVPGYQPPDVASWIKLNTNENPYPPSPEVVKAILAELGGDGALLRTYPSASSQVLRETVGELFGFDP
AWIIMANGSDEVLNNLIRAFAGEGEEIGYVHPSYSYYATLAEIQGARVRTFGLTDDLRIAGFPGRYEGKLFFLTTPNSPL
GFAFPLAYIEELATRCAGVLVVDEAYADFADGDALDLVRRHENVVVTRTLSKSYSLAGMRLGFAVARPAVIAALDKIRDH
YNLDRLAQAACVASLRDQTYFAGCTRLIRETREWFSAEIRTLGYEVIPSQGNFVFAAPPDRDGKRVYDGLYSRKILVRHF
SDPLLAHGMRISIGTREEMEATLAALKEIG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=28.9634146341463, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788722, Length=235, Percent_Identity=28.0851063829787, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=27.8551532033426, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_GEOSL (P61000)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954140.1
- ProteinModelPortal:   P61000
- SMR:   P61000
- GeneID:   2688464
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3099
- NMPDR:   fig|243231.1.peg.3078
- TIGR:   GSU3099
- HOGENOM:   HBG646350
- OMA:   DKIRDHY
- ProtClustDB:   CLSK829109
- BioCyc:   GSUL243231:GSU_3099-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38517; Mature: 38517

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFRSNIAAMAGYVPGYQPPDVASWIKLNTNENPYPPSPEVVKAILAELGGDGALLRTY
CCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEC
PSASSQVLRETVGELFGFDPAWIIMANGSDEVLNNLIRAFAGEGEEIGYVHPSYSYYATL
CCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHH
AEIQGARVRTFGLTDDLRIAGFPGRYEGKLFFLTTPNSPLGFAFPLAYIEELATRCAGVL
HHHCCCEEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCEE
VVDEAYADFADGDALDLVRRHENVVVTRTLSKSYSLAGMRLGFAVARPAVIAALDKIRDH
EEECHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YNLDRLAQAACVASLRDQTYFAGCTRLIRETREWFSAEIRTLGYEVIPSQGNFVFAAPPD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCC
RDGKRVYDGLYSRKILVRHFSDPLLAHGMRISIGTREEMEATLAALKEIG
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPFRSNIAAMAGYVPGYQPPDVASWIKLNTNENPYPPSPEVVKAILAELGGDGALLRTY
CCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEC
PSASSQVLRETVGELFGFDPAWIIMANGSDEVLNNLIRAFAGEGEEIGYVHPSYSYYATL
CCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHH
AEIQGARVRTFGLTDDLRIAGFPGRYEGKLFFLTTPNSPLGFAFPLAYIEELATRCAGVL
HHHCCCEEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCEE
VVDEAYADFADGDALDLVRRHENVVVTRTLSKSYSLAGMRLGFAVARPAVIAALDKIRDH
EEECHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YNLDRLAQAACVASLRDQTYFAGCTRLIRETREWFSAEIRTLGYEVIPSQGNFVFAAPPD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCC
RDGKRVYDGLYSRKILVRHFSDPLLAHGMRISIGTREEMEATLAALKEIG
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA