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The map label for this gene is hisB [H]

Identifier: 39998188

GI number: 39998188

Start: 3401904

End: 3402491

Strand: Reverse

Name: hisB [H]

Synonym: GSU3098

Alternate gene names: 39998188

Gene position: 3402491-3401904 (Counterclockwise)

Preceding gene: 39998189

Following gene: 39998187

Centisome position: 89.21

GC content: 59.69

Gene sequence:

>588_bases
ATGTCCCGGAAAGCCACCATTGAGCGCGTCACCAAGGAAACCCAGATCAAGCTCTCCCTTGAAATAGACGGGACGGGCGA
GGCGAAGATCTGTACCTCCGTGCCGTTTCTCGACCATATGCTCGACCTCTTTGCCCGCCACGGGCTCTTCAATCTTCAGG
TGGACGCCACGGGGGACATCGATATCGATTTTCACCACACGGTGGAGGACATCGGCATCGTCCTCGGCCAGGCGCTCAAG
GAGGCCTTGGGCGACAAGAAGGGGATCAGGCGCTACGGCCAAGCCACAGTCCCCATGGACGAAACCCTTGCCAGCGTGGC
GGTGGACATCTCGGGGCGCCCCTACCTCGTCTACCACGTCTCTCTGCCCAAGGTGAAGATCGGCGAGTTTGACGTGGAAC
TGGTGCGGGAATTTTTTCAGGCCGTGGTAAACAACCTGGGCGCCAACATCCATGTGAACGTCATGTACGGCGACAATGTC
CATCACATCGTCGAGGCGTGCTTCAAGGCGTTTGCCCGGGCCGTGGACCAGGCAACCCAGGTGGACTCCCGGATTCAGGG
GGTCATGTCGACGAAGGGCAAGCTCTGA

Upstream 100 bases:

>100_bases
CATGGCATGAGGATTTCCATCGGCACGCGGGAGGAGATGGAGGCGACTCTCGCCGCCCTGAAAGAGATTGGCTAACTTCG
ATTCCCACGAGGAGGGTTCC

Downstream 100 bases:

>100_bases
TATGACCAAGATTGCAATTATCGACTACGGCATGGGGAATCTCCGGTCGGTCCAGAAGGGGTTCGAGAAGGTGGGCTTCG
AGGCGGTTGTGACTGCCGAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSRKATIERVTKETQIKLSLEIDGTGEAKICTSVPFLDHMLDLFARHGLFNLQVDATGDIDIDFHHTVEDIGIVLGQALK
EALGDKKGIRRYGQATVPMDETLASVAVDISGRPYLVYHVSLPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNV
HHIVEACFKAFARAVDQATQVDSRIQGVMSTKGKL

Sequences:

>Translated_195_residues
MSRKATIERVTKETQIKLSLEIDGTGEAKICTSVPFLDHMLDLFARHGLFNLQVDATGDIDIDFHHTVEDIGIVLGQALK
EALGDKKGIRRYGQATVPMDETLASVAVDISGRPYLVYHVSLPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNV
HHIVEACFKAFARAVDQATQVDSRIQGVMSTKGKL
>Mature_194_residues
SRKATIERVTKETQIKLSLEIDGTGEAKICTSVPFLDHMLDLFARHGLFNLQVDATGDIDIDFHHTVEDIGIVLGQALKE
ALGDKKGIRRYGQATVPMDETLASVAVDISGRPYLVYHVSLPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVH
HIVEACFKAFARAVDQATQVDSRIQGVMSTKGKL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=46.1139896373057, Blast_Score=167, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=35.9447004608295, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21521; Mature: 21390

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKATIERVTKETQIKLSLEIDGTGEAKICTSVPFLDHMLDLFARHGLFNLQVDATGDI
CCCCHHHHHHCCCEEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCEEEEEEECCCCE
DIDFHHTVEDIGIVLGQALKEALGDKKGIRRYGQATVPMDETLASVAVDISGRPYLVYHV
EECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCEEEEEEE
SLPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVHHIVEACFKAFARAVDQATQ
ECCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VDSRIQGVMSTKGKL
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRKATIERVTKETQIKLSLEIDGTGEAKICTSVPFLDHMLDLFARHGLFNLQVDATGDI
CCCHHHHHHCCCEEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCEEEEEEECCCCE
DIDFHHTVEDIGIVLGQALKEALGDKKGIRRYGQATVPMDETLASVAVDISGRPYLVYHV
EECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCEEEEEEE
SLPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVHHIVEACFKAFARAVDQATQ
ECCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VDSRIQGVMSTKGKL
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA