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The map label for this gene is bioF

Identifier: 39997723

GI number: 39997723

Start: 2900426

End: 2901601

Strand: Reverse

Name: bioF

Synonym: GSU2629

Alternate gene names: 39997723

Gene position: 2901601-2900426 (Counterclockwise)

Preceding gene: 39997728

Following gene: 39997722

Centisome position: 76.07

GC content: 68.54

Gene sequence:

>1176_bases
GTGACGCGAAGCATTGCCGGAGAATTGCAGCAACTCAGGGAACAGGGCCTTTACCGGAGCCTGCGGACCGTCGCAGGGAG
CCAAGGGAGTCGGGTCGTGGCGGAGGGGAGGGAGGTGGTGCTCCTCTGCTCCAACAATTACCTGGGACTGGCCGACCACC
CCAGCCTCAAACGGGCGGCCGTGGAGGCCGTGGAGCGCTACGGCACGGGCAGCGGAGCCTCGCGGCTCGTCTCCGGCACC
ATGGAACTCCATGCAGCCCTGGAGGAACGGCTTGCCCGGTTCAAGGGGACCGAGGCGGCGCTGGTCTTCAATTCGGGGTA
CGCGGCCAACAGCGGCATCATCCCTGCCCTGGTCGGCCGGGGCGACGTGGTGTTCTCGGACCGGCTCAATCATGCAAGCA
TCGTGGACGGATGCCTGCTCTCCCGCGCCCGGTTCGTTCGCTACCCCCACAACGACATGAACGCCCTGGAGCGGCTCCTG
GCCGAGCACCGGGGCGCCGGCCGCATGCTCATCGTCACCGACGGCGTCTTCAGCATGGACGGCGATCTGGCCCCGCTCCC
CGCATTGGTGGCGCTCAAGCGGCAGTACGGCGCGCTGCTTATGGTGGACGACGCTCACGGCACCGGGGTGCTGGGGGAGA
GCGGGCGGGGGAGCGCCGAACAGTTCGAGGTGGCGGCCGACATCGATCTCCAGATGGGGACCCTCGGCAAGGCCCTTGGT
GGCTTCGGTGCCTATGTCGCCGCCTCCGCCGAGGTGGTGGAACTGCTCATAAACCGGGCCCGCAGCTTCATCTTCTCCAC
GTCGCTCCCCCCGGCGGTCCTGGCAGCGGCCCGGGCCGCCCTGGACTTGGTTGACTCCCCCGAAGGTAAAGCGCTGCGTC
GCCGTCTGGCCCGCTCCGCCGCTCTGTTCCGGGACGCGCTGCAGGAGGCCGGCTTCGACACCATGGGGAGCGAAACCCAG
ATCGTTCCTGCCCTCGTGGGCGAGGCCGAACCGGCCATGACCTTTACCCGGCGGCTCCTTGAGGAGGGATTCTACGTCCA
GGGCATTCGCCCCCCCACGGTGCCGGCCGGCACCTGCCGTCTCCGCTGTACTCTCATGGCGACCCACGACGAGTCCGACC
TGGAGCGCGCCGTGGCCGCCATGGCGCGGATCGGCAAAGAACTGGGCATTGTGTGA

Upstream 100 bases:

>100_bases
AAAGCCATGACCATTGTCAACCTGTATTCTCGGCTTGGTTGACGATTCGGGGGACACTGTGCTAAAAATTGACTCCTGGG
GAAAATGCCGGGAGGACAGC

Downstream 100 bases:

>100_bases
CCCGAGGTATCATGCCGTTTCTTCAAATAGACCATAACCTGACGATTCATTATGACGACGAGGGGGACGGCTTCCCCCTG
GTGCTCGTCCACGGCTGGGC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTRSIAGELQQLREQGLYRSLRTVAGSQGSRVVAEGREVVLLCSNNYLGLADHPSLKRAAVEAVERYGTGSGASRLVSGT
MELHAALEERLARFKGTEAALVFNSGYAANSGIIPALVGRGDVVFSDRLNHASIVDGCLLSRARFVRYPHNDMNALERLL
AEHRGAGRMLIVTDGVFSMDGDLAPLPALVALKRQYGALLMVDDAHGTGVLGESGRGSAEQFEVAADIDLQMGTLGKALG
GFGAYVAASAEVVELLINRARSFIFSTSLPPAVLAAARAALDLVDSPEGKALRRRLARSAALFRDALQEAGFDTMGSETQ
IVPALVGEAEPAMTFTRRLLEEGFYVQGIRPPTVPAGTCRLRCTLMATHDESDLERAVAAMARIGKELGIV

Sequences:

>Translated_391_residues
MTRSIAGELQQLREQGLYRSLRTVAGSQGSRVVAEGREVVLLCSNNYLGLADHPSLKRAAVEAVERYGTGSGASRLVSGT
MELHAALEERLARFKGTEAALVFNSGYAANSGIIPALVGRGDVVFSDRLNHASIVDGCLLSRARFVRYPHNDMNALERLL
AEHRGAGRMLIVTDGVFSMDGDLAPLPALVALKRQYGALLMVDDAHGTGVLGESGRGSAEQFEVAADIDLQMGTLGKALG
GFGAYVAASAEVVELLINRARSFIFSTSLPPAVLAAARAALDLVDSPEGKALRRRLARSAALFRDALQEAGFDTMGSETQ
IVPALVGEAEPAMTFTRRLLEEGFYVQGIRPPTVPAGTCRLRCTLMATHDESDLERAVAAMARIGKELGIV
>Mature_390_residues
TRSIAGELQQLREQGLYRSLRTVAGSQGSRVVAEGREVVLLCSNNYLGLADHPSLKRAAVEAVERYGTGSGASRLVSGTM
ELHAALEERLARFKGTEAALVFNSGYAANSGIIPALVGRGDVVFSDRLNHASIVDGCLLSRARFVRYPHNDMNALERLLA
EHRGAGRMLIVTDGVFSMDGDLAPLPALVALKRQYGALLMVDDAHGTGVLGESGRGSAEQFEVAADIDLQMGTLGKALGG
FGAYVAASAEVVELLINRARSFIFSTSLPPAVLAAARAALDLVDSPEGKALRRRLARSAALFRDALQEAGFDTMGSETQI
VPALVGEAEPAMTFTRRLLEEGFYVQGIRPPTVPAGTCRLRCTLMATHDESDLERAVAAMARIGKELGIV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=385, Percent_Identity=39.7402597402597, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI284448556, Length=411, Percent_Identity=37.2262773722628, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI83977442, Length=385, Percent_Identity=34.025974025974, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI83977440, Length=385, Percent_Identity=34.025974025974, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI83977444, Length=385, Percent_Identity=34.025974025974, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=35.2617079889807, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=34.7945205479452, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4502025, Length=399, Percent_Identity=31.328320802005, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI40316939, Length=399, Percent_Identity=31.328320802005, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI5454084, Length=281, Percent_Identity=36.2989323843416, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=44.0203562340967, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=44.4759206798867, Blast_Score=268, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71994529, Length=394, Percent_Identity=37.8172588832487, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=32.3369565217391, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=30.6849315068493, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=30.6849315068493, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71982617, Length=271, Percent_Identity=32.4723247232472, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71982625, Length=271, Percent_Identity=32.4723247232472, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320438, Length=406, Percent_Identity=33.9901477832512, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=33.972602739726, Blast_Score=195, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6323954, Length=261, Percent_Identity=34.4827586206897, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24662918, Length=394, Percent_Identity=38.8324873096447, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI17137420, Length=329, Percent_Identity=34.9544072948328, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24653280, Length=329, Percent_Identity=32.5227963525836, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24653276, Length=329, Percent_Identity=32.5227963525836, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24653278, Length=329, Percent_Identity=32.5227963525836, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI17136286, Length=366, Percent_Identity=31.9672131147541, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_GEOSL (Q749W3)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953674.1
- HSSP:   P0AB77
- ProteinModelPortal:   Q749W3
- SMR:   Q749W3
- GeneID:   2685566
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2629
- NMPDR:   fig|243231.1.peg.2612
- TIGR:   GSU2629
- HOGENOM:   HBG649839
- OMA:   QGIRPPT
- ProtClustDB:   CLSK828920
- BioCyc:   GSUL243231:GSU_2629-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 41593; Mature: 41462

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 19-19 BINDING 131-131 BINDING 178-178 BINDING 353-353

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSIAGELQQLREQGLYRSLRTVAGSQGSRVVAEGREVVLLCSNNYLGLADHPSLKRAA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCEECCCCCCHHHHHH
VEAVERYGTGSGASRLVSGTMELHAALEERLARFKGTEAALVFNSGYAANSGIIPALVGR
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCC
GDVVFSDRLNHASIVDGCLLSRARFVRYPHNDMNALERLLAEHRGAGRMLIVTDGVFSMD
CCEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEECC
GDLAPLPALVALKRQYGALLMVDDAHGTGVLGESGRGSAEQFEVAADIDLQMGTLGKALG
CCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHEEEEECCCCHHHHHHHHHH
GFGAYVAASAEVVELLINRARSFIFSTSLPPAVLAAARAALDLVDSPEGKALRRRLARSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ALFRDALQEAGFDTMGSETQIVPALVGEAEPAMTFTRRLLEEGFYVQGIRPPTVPAGTCR
HHHHHHHHHCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCEE
LRCTLMATHDESDLERAVAAMARIGKELGIV
EEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRSIAGELQQLREQGLYRSLRTVAGSQGSRVVAEGREVVLLCSNNYLGLADHPSLKRAA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCEECCCCCCHHHHHH
VEAVERYGTGSGASRLVSGTMELHAALEERLARFKGTEAALVFNSGYAANSGIIPALVGR
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCC
GDVVFSDRLNHASIVDGCLLSRARFVRYPHNDMNALERLLAEHRGAGRMLIVTDGVFSMD
CCEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEECC
GDLAPLPALVALKRQYGALLMVDDAHGTGVLGESGRGSAEQFEVAADIDLQMGTLGKALG
CCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHEEEEECCCCHHHHHHHHHH
GFGAYVAASAEVVELLINRARSFIFSTSLPPAVLAAARAALDLVDSPEGKALRRRLARSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ALFRDALQEAGFDTMGSETQIVPALVGEAEPAMTFTRRLLEEGFYVQGIRPPTVPAGTCR
HHHHHHHHHCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCEE
LRCTLMATHDESDLERAVAAMARIGKELGIV
EEEEEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA