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The map label for this gene is atoC [H]

Identifier: 39997676

GI number: 39997676

Start: 2842690

End: 2844060

Strand: Reverse

Name: atoC [H]

Synonym: GSU2581

Alternate gene names: 39997676

Gene position: 2844060-2842690 (Counterclockwise)

Preceding gene: 39997678

Following gene: 39997675

Centisome position: 74.57

GC content: 67.4

Gene sequence:

>1371_bases
ATGACCGCTCCGAAGATTCTTGCCGTCGACGATGACGAGCTTTCTCTCTTGATGCTGGAGAACCTGCTGGCCGATGCGGG
ATTCGCCCCCCTGACCGCGGTCAGCGGCGCACAGGCGCTGGCGCTGTTGGAGCGGGAGCATGTGGACCTGCTCATCTCCG
ACCTGATCATGGAGGGGATGAACGGTCTGGAACTCCTGGATCGGGTCAGGGAGCGCTACCCGAACGTGCCGGTCATCGTG
GTCACGGCCCGGGGGAGCGTGGAGAGCGCCGTGGAGGCCATGCGGCGGGGCGCCTACGACTACCTGGCAAAGCCCTTCAA
CCCCGAGGTGCTGAGGATCACGCTCCAGCGGGCCCTGGACTATCACCACGTGGTCCGCGAGAACGAGCAGATCACGGGGC
TGTTGCGCGAGCGGTTCACCTTCCAGAGCATCGTTACGGTGAATCCGGCCATGAAGAAGCTGCTGGAGCTGGCCGCCAGG
GTGGCTGCGGCGCGGCAGACCACGGTGGCCATCTACGGCGAAAGCGGCTCGGGCAAGGAGGTGCTGGCGCGGGCCATCCA
CTTTGCCGGCAAAGGGCTGCCCGCCGGATTCGTGGCGGTCAACTGCGCGGCCGTGCCCGAGCACTTGCTGGAGAGCGAGC
TGTTCGGCCACGTGCGGGGGGCCTTCACCGGGGCCGACCGGGATCGGGAGGGAAAGTTCAGTCTGGCCCGCGGCGGCACG
CTTCTGCTGGACGAGATCGGCGACATGCCCCTGCCGCTCCAGGCCAAGTTGCTGAGAGTCCTCCAGGAGCGCGTGTTCGA
AAAGATCGGCAGCAATACCCCCATCTCGACGGATTGCCGCGTTATCGTGGCCACCAACCGCAACCTGGCCGACATGGTGG
CGGCCGGCCGCTTCCGCGAAGACCTCTATCACCGGATCAACGTGTTTCCCTTGGTCATTCCGCCTCTGCGGGAGCGCACC
GACGACATCCCGCTCCTGTGCGAGCACGTCCTCGACCAGCTGCGGCAGCACCTGGGCAAGCCGCTGCCCGGCATCTCCCA
GAAGGCCATGGACGCCATGCTGGCCCACGGCTGGCCGGGCAATGTGCGGGAGTTGCGCAACTGCCTGGAGCGCGCCGCGA
TCCTGACCGACGGCGAGCTGATCCGGCCCGAGCACCTGGGGTTCGGCGCGGCCGGAGCCCCTGCCCGGGAAACATCTGCC
GGACCGGCGCCCGACACGGTGCAGTACGCCCTGGCGCTGCCCGTTGACCAGTTGTCGCTCCATGCCCTCACCGAGCGGAT
CATGGCCATCACCCTGGAGCGCTGCGGCGGCAACAAGTCCAGGGCGGCCCAGCTCCTCAGGATCGACCGCAAGGCATTCT
ACCGGGGCTGA

Upstream 100 bases:

>100_bases
TCATGAGGGGATGTTCCCCGTTATCATCTCAAGTCCCGGGGGGAATTGTCCGATATAATATCTGGTATGTCCATTTTGCC
GGGACGAGGTTCACCATCCC

Downstream 100 bases:

>100_bases
CCCCGCGCCGCGCTCCCCCTGCAGCACCCCCCTCATCCCCCACTGTTCCATTTTGCCCCACTCTGTCCCTCAGGGGGACG
CTCCTTCTGTTGTTGTTCGG

Product: sigma-54 dependent transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTAPKILAVDDDELSLLMLENLLADAGFAPLTAVSGAQALALLEREHVDLLISDLIMEGMNGLELLDRVRERYPNVPVIV
VTARGSVESAVEAMRRGAYDYLAKPFNPEVLRITLQRALDYHHVVRENEQITGLLRERFTFQSIVTVNPAMKKLLELAAR
VAAARQTTVAIYGESGSGKEVLARAIHFAGKGLPAGFVAVNCAAVPEHLLESELFGHVRGAFTGADRDREGKFSLARGGT
LLLDEIGDMPLPLQAKLLRVLQERVFEKIGSNTPISTDCRVIVATNRNLADMVAAGRFREDLYHRINVFPLVIPPLRERT
DDIPLLCEHVLDQLRQHLGKPLPGISQKAMDAMLAHGWPGNVRELRNCLERAAILTDGELIRPEHLGFGAAGAPARETSA
GPAPDTVQYALALPVDQLSLHALTERIMAITLERCGGNKSRAAQLLRIDRKAFYRG

Sequences:

>Translated_456_residues
MTAPKILAVDDDELSLLMLENLLADAGFAPLTAVSGAQALALLEREHVDLLISDLIMEGMNGLELLDRVRERYPNVPVIV
VTARGSVESAVEAMRRGAYDYLAKPFNPEVLRITLQRALDYHHVVRENEQITGLLRERFTFQSIVTVNPAMKKLLELAAR
VAAARQTTVAIYGESGSGKEVLARAIHFAGKGLPAGFVAVNCAAVPEHLLESELFGHVRGAFTGADRDREGKFSLARGGT
LLLDEIGDMPLPLQAKLLRVLQERVFEKIGSNTPISTDCRVIVATNRNLADMVAAGRFREDLYHRINVFPLVIPPLRERT
DDIPLLCEHVLDQLRQHLGKPLPGISQKAMDAMLAHGWPGNVRELRNCLERAAILTDGELIRPEHLGFGAAGAPARETSA
GPAPDTVQYALALPVDQLSLHALTERIMAITLERCGGNKSRAAQLLRIDRKAFYRG
>Mature_455_residues
TAPKILAVDDDELSLLMLENLLADAGFAPLTAVSGAQALALLEREHVDLLISDLIMEGMNGLELLDRVRERYPNVPVIVV
TARGSVESAVEAMRRGAYDYLAKPFNPEVLRITLQRALDYHHVVRENEQITGLLRERFTFQSIVTVNPAMKKLLELAARV
AAARQTTVAIYGESGSGKEVLARAIHFAGKGLPAGFVAVNCAAVPEHLLESELFGHVRGAFTGADRDREGKFSLARGGTL
LLDEIGDMPLPLQAKLLRVLQERVFEKIGSNTPISTDCRVIVATNRNLADMVAAGRFREDLYHRINVFPLVIPPLRERTD
DIPLLCEHVLDQLRQHLGKPLPGISQKAMDAMLAHGWPGNVRELRNCLERAAILTDGELIRPEHLGFGAAGAPARETSAG
PAPDTVQYALALPVDQLSLHALTERIMAITLERCGGNKSRAAQLLRIDRKAFYRG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=458, Percent_Identity=43.0131004366812, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=42.4107142857143, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=43.1111111111111, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=37.5809935205184, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI87082117, Length=253, Percent_Identity=49.0118577075099, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789087, Length=282, Percent_Identity=46.8085106382979, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1789233, Length=233, Percent_Identity=50.2145922746781, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87082152, Length=266, Percent_Identity=44.3609022556391, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786524, Length=339, Percent_Identity=40.4129793510324, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87081872, Length=299, Percent_Identity=36.4548494983278, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1787583, Length=246, Percent_Identity=40.2439024390244, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789828, Length=246, Percent_Identity=37.3983739837398, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081858, Length=251, Percent_Identity=33.0677290836653, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1789809, Length=107, Percent_Identity=38.3177570093458, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082012, Length=130, Percent_Identity=32.3076923076923, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI145693157, Length=110, Percent_Identity=34.5454545454545, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=109, Percent_Identity=35.7798165137615, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790552, Length=129, Percent_Identity=34.1085271317829, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790863, Length=113, Percent_Identity=32.7433628318584, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49974; Mature: 49842

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKILAVDDDELSLLMLENLLADAGFAPLTAVSGAQALALLEREHVDLLISDLIMEGM
CCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
NGLELLDRVRERYPNVPVIVVTARGSVESAVEAMRRGAYDYLAKPFNPEVLRITLQRALD
CHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
YHHVVRENEQITGLLRERFTFQSIVTVNPAMKKLLELAARVAAARQTTVAIYGESGSGKE
HHHHHHCCHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHH
VLARAIHFAGKGLPAGFVAVNCAAVPEHLLESELFGHVRGAFTGADRDREGKFSLARGGT
HHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCE
LLLDEIGDMPLPLQAKLLRVLQERVFEKIGSNTPISTDCRVIVATNRNLADMVAAGRFRE
EEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
DLYHRINVFPLVIPPLRERTDDIPLLCEHVLDQLRQHLGKPLPGISQKAMDAMLAHGWPG
HHHHHHCCEEEECCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
NVRELRNCLERAAILTDGELIRPEHLGFGAAGAPARETSAGPAPDTVQYALALPVDQLSL
CHHHHHHHHHHHHHCCCCCEECHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHH
HALTERIMAITLERCGGNKSRAAQLLRIDRKAFYRG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAPKILAVDDDELSLLMLENLLADAGFAPLTAVSGAQALALLEREHVDLLISDLIMEGM
CCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
NGLELLDRVRERYPNVPVIVVTARGSVESAVEAMRRGAYDYLAKPFNPEVLRITLQRALD
CHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
YHHVVRENEQITGLLRERFTFQSIVTVNPAMKKLLELAARVAAARQTTVAIYGESGSGKE
HHHHHHCCHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHH
VLARAIHFAGKGLPAGFVAVNCAAVPEHLLESELFGHVRGAFTGADRDREGKFSLARGGT
HHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCE
LLLDEIGDMPLPLQAKLLRVLQERVFEKIGSNTPISTDCRVIVATNRNLADMVAAGRFRE
EEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
DLYHRINVFPLVIPPLRERTDDIPLLCEHVLDQLRQHLGKPLPGISQKAMDAMLAHGWPG
HHHHHHCCEEEECCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
NVRELRNCLERAAILTDGELIRPEHLGFGAAGAPARETSAGPAPDTVQYALALPVDQLSL
CHHHHHHHHHHHHHCCCCCEECHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHH
HALTERIMAITLERCGGNKSRAAQLLRIDRKAFYRG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]