Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 39997665

GI number: 39997665

Start: 2832260

End: 2833444

Strand: Reverse

Name: iscS [H]

Synonym: GSU2570

Alternate gene names: 39997665

Gene position: 2833444-2832260 (Counterclockwise)

Preceding gene: 39997666

Following gene: 308513324

Centisome position: 74.29

GC content: 68.02

Gene sequence:

>1185_bases
ATGAGTGAAGCCCCCGCGGGCACTGTCCCGCTGATCTATCTGGACCACAACGCGACGACGCCGACGCACCCCTTGGTGGT
GGAGGCGTTGTTGCCGTTTCTGGGGGAGCGGTTCGGCAATCCGTCCAGCATCCATTGGGCCGGCCGGGCCGTGAAGGGGG
CCGTGGAGGAGGCCCGCGAGGCGGTGGCCGAACTGGCGGGATGCGAGCCGGGTGAGGTGGTTTTCACCGGGTCGGGCTCC
GAGGCCGACAATATGGCCGTGAAAGGAGTGGCCTCGTCCCTCCGGAAGCGGGGCAACCATATCATCGCCACCCGGGTGGA
GCATCCGGCCGTGGCCAATTCCTGCCGCTACCTGGAGCACGGCGGATACGAGGTAACCTGGCTCGACGTGGACCGGGACG
GTATCCTGGACCCGACGCGGGTGGAAGAGGCCATCACGGAGCGGACCATTCTCGTCACGGCCATGTATGCCAACAACGAG
ACCGGCGTGCTGCTGCCGGTGGCGGAAATCGGCGAGATCGCCCGGCGGCACCGGGTGCCCTTTCACTGCGACGCCGTCCA
GGCCCTGGGCAAGGTCCCCCTGGAGTTCCGCGCCACCGGCGCGTCGCTCATGGCGCTCTCGGCCCACAAGGTTTACGGTC
CCAAGGGGGTGGGGGCGCTGGTGATCCGGCGTGGCACAACCTGCCACCCGCTGGTGCACGGCGGCTCCCAGGAGCGCAAT
CGCCGGGCCGGAACCGAGAACGTGGCCGGCATCGTGGGCTTTGGCCAAGCGTGCCGACTGGCGCGGGAATCCCTGGCCGA
CGAGACAGCGCGGGTTTGTCGCCTGCGGGACCGGCTGGAGGAGGGAATCCTCGGCCGGGTGCCCGGCGCGCGGGTGAACG
GCCATCGGCAGTTCCGGCTGCCGAATACGAGCAATATCAGCTTTGAAGGTGTGACCGCTGATACGCTGCTCATGGCTCTG
GACCTGGCCGGGATCGCCGTGTCGTCGGGGTCCGCGTGCAGTTCCGGCACCCTGCGACATTCGCCGGTGCTGGCCGCCAT
GGGGCTGTCCCCGCAGGAGGCCGGCGGAGCCGTGCGCTTTTCCTTGGGACTGGGAAATACGGATCAGGAGATCGACCGGG
TGCTGACGGTGCTGCCGGAGATCGTCGAACGGGTGAAACGAGGTGGAGATGGCAGAGAAGCATAG

Upstream 100 bases:

>100_bases
GGGAGATGCTCGGCGAGCGGATCAGGACGTTCCTGGATTCCATCACCCTGGAGGACTTGGTGCGGGACGCCCGCCGACGG
CCCGGCGAGAGTGAGGATCA

Downstream 100 bases:

>100_bases
ACAGCGCATCGTCATCGCCATGAGCGGCGGGGTGGACTCGTCGGTGGCGGCGGCGCTTCTGAAGGAAGAGGGGCACGAGG
TCATCGGCATCTCCATGCAG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSEAPAGTVPLIYLDHNATTPTHPLVVEALLPFLGERFGNPSSIHWAGRAVKGAVEEAREAVAELAGCEPGEVVFTGSGS
EADNMAVKGVASSLRKRGNHIIATRVEHPAVANSCRYLEHGGYEVTWLDVDRDGILDPTRVEEAITERTILVTAMYANNE
TGVLLPVAEIGEIARRHRVPFHCDAVQALGKVPLEFRATGASLMALSAHKVYGPKGVGALVIRRGTTCHPLVHGGSQERN
RRAGTENVAGIVGFGQACRLARESLADETARVCRLRDRLEEGILGRVPGARVNGHRQFRLPNTSNISFEGVTADTLLMAL
DLAGIAVSSGSACSSGTLRHSPVLAAMGLSPQEAGGAVRFSLGLGNTDQEIDRVLTVLPEIVERVKRGGDGREA

Sequences:

>Translated_394_residues
MSEAPAGTVPLIYLDHNATTPTHPLVVEALLPFLGERFGNPSSIHWAGRAVKGAVEEAREAVAELAGCEPGEVVFTGSGS
EADNMAVKGVASSLRKRGNHIIATRVEHPAVANSCRYLEHGGYEVTWLDVDRDGILDPTRVEEAITERTILVTAMYANNE
TGVLLPVAEIGEIARRHRVPFHCDAVQALGKVPLEFRATGASLMALSAHKVYGPKGVGALVIRRGTTCHPLVHGGSQERN
RRAGTENVAGIVGFGQACRLARESLADETARVCRLRDRLEEGILGRVPGARVNGHRQFRLPNTSNISFEGVTADTLLMAL
DLAGIAVSSGSACSSGTLRHSPVLAAMGLSPQEAGGAVRFSLGLGNTDQEIDRVLTVLPEIVERVKRGGDGREA
>Mature_393_residues
SEAPAGTVPLIYLDHNATTPTHPLVVEALLPFLGERFGNPSSIHWAGRAVKGAVEEAREAVAELAGCEPGEVVFTGSGSE
ADNMAVKGVASSLRKRGNHIIATRVEHPAVANSCRYLEHGGYEVTWLDVDRDGILDPTRVEEAITERTILVTAMYANNET
GVLLPVAEIGEIARRHRVPFHCDAVQALGKVPLEFRATGASLMALSAHKVYGPKGVGALVIRRGTTCHPLVHGGSQERNR
RAGTENVAGIVGFGQACRLARESLADETARVCRLRDRLEEGILGRVPGARVNGHRQFRLPNTSNISFEGVTADTLLMALD
LAGIAVSSGSACSSGTLRHSPVLAAMGLSPQEAGGAVRFSLGLGNTDQEIDRVLTVLPEIVERVKRGGDGREA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=42.0634920634921, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI156713448, Length=412, Percent_Identity=33.252427184466, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI48994898, Length=380, Percent_Identity=43.1578947368421, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1789175, Length=395, Percent_Identity=26.0759493670886, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=25, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=380, Percent_Identity=42.3684210526316, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17533177, Length=321, Percent_Identity=34.2679127725857, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=40.9921671018277, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=43.1216931216931, Blast_Score=284, Evalue=7e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41813; Mature: 41682

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAPAGTVPLIYLDHNATTPTHPLVVEALLPFLGERFGNPSSIHWAGRAVKGAVEEARE
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHH
AVAELAGCEPGEVVFTGSGSEADNMAVKGVASSLRKRGNHIIATRVEHPAVANSCRYLEH
HHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCC
GGYEVTWLDVDRDGILDPTRVEEAITERTILVTAMYANNETGVLLPVAEIGEIARRHRVP
CCEEEEEEEECCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCEEEEHHHHHHHHHHCCCC
FHCDAVQALGKVPLEFRATGASLMALSAHKVYGPKGVGALVIRRGTTCHPLVHGGSQERN
CCHHHHHHHHCCCEEEECCCCEEEEEEHHHCCCCCCCCEEEEECCCCCCHHCCCCCHHHH
RRAGTENVAGIVGFGQACRLARESLADETARVCRLRDRLEEGILGRVPGARVNGHRQFRL
HCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
PNTSNISFEGVTADTLLMALDLAGIAVSSGSACSSGTLRHSPVLAAMGLSPQEAGGAVRF
CCCCCCEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEECCCHHHCCCEEEE
SLGLGNTDQEIDRVLTVLPEIVERVKRGGDGREA
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEAPAGTVPLIYLDHNATTPTHPLVVEALLPFLGERFGNPSSIHWAGRAVKGAVEEARE
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHH
AVAELAGCEPGEVVFTGSGSEADNMAVKGVASSLRKRGNHIIATRVEHPAVANSCRYLEH
HHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCC
GGYEVTWLDVDRDGILDPTRVEEAITERTILVTAMYANNETGVLLPVAEIGEIARRHRVP
CCEEEEEEEECCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCEEEEHHHHHHHHHHCCCC
FHCDAVQALGKVPLEFRATGASLMALSAHKVYGPKGVGALVIRRGTTCHPLVHGGSQERN
CCHHHHHHHHCCCEEEECCCCEEEEEEHHHCCCCCCCCEEEEECCCCCCHHCCCCCHHHH
RRAGTENVAGIVGFGQACRLARESLADETARVCRLRDRLEEGILGRVPGARVNGHRQFRL
HCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
PNTSNISFEGVTADTLLMALDLAGIAVSSGSACSSGTLRHSPVLAAMGLSPQEAGGAVRF
CCCCCCEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEECCCHHHCCCEEEE
SLGLGNTDQEIDRVLTVLPEIVERVKRGGDGREA
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA