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The map label for this gene is ppx [H]

Identifier: 39997654

GI number: 39997654

Start: 2821751

End: 2823292

Strand: Reverse

Name: ppx [H]

Synonym: GSU2559

Alternate gene names: 39997654

Gene position: 2823292-2821751 (Counterclockwise)

Preceding gene: 39997655

Following gene: 39997647

Centisome position: 74.02

GC content: 65.95

Gene sequence:

>1542_bases
GTGACCCACAACCGGCTGGCCGCCATCGATATCGGGACCAACTCCATCCGCTGCATCGTGGTGGAGGTGACCAGGAACGG
CAAATTTCGCGTTCTGGACGACGAGAAGGCCACCGTGCGCCTGGGCGAAGGGATGGCCGCCAGCGGCACCATCTCGCCGG
CGGCCTGGGAGCGTGCCGTTACGGCGCTTGGCCGGATGAAGAAGATCGTGGACGGCTACGGGGTCAAGGTGGTGGAGGCG
GTTGCCACCAGCGCCGTGCGCCGTGCCGCAAACGGCGAGGAGTTCATCCGGACCGTGGAGGAGACGGTCGGGGTCAGGGT
GGCGGTGATCAGCGGCGAGGAGGAGGCGGAACTGGCCGCCCTCTCGGTGCGGAACCATTTCGACATGGAGGGGGTCCGCT
ACGCCATGGTGGACATCGGCGGCGGCAGCCTTGAAATCGTCACGGCGCTCGGGACCCATATCGAGGATATCCACTCCCTG
GAGCTCGGGGCCGTGGTCCTGACCGAACGCTTCGTCCGGAGCGATCCCCCGCGCCAGGCTGACCTGGACAGGCTGCGCAA
ACACGTGCGCGCGTCGCTGAAGGAGTCACTGGGCGCCGAGTGGGGACACCTCCAGAGCCTGGTGGGCTCCGGCGGCACCA
TCACGTCTATCGCCGCCATGGTCATGGCCATGCGGGGGGAGGGGTACGGATCGGTCCACCGTTACGAGGTGCTCCGGTCG
GAGGTGGTGCATCTGCTGGCCATGCTCTCCCGCAAGGACCTCAAGGCCCGCCGGGAGGTGCCGGGGCTCAACCCGGACCG
GGCCGACATCATCACTGCCGGTGTCACTGTGGTGGACGAGCTCATGAGGTTCTTCGACGTGAACCTCTTGCGGGTCAATG
AGCGGGGAATCCGGGAAGGGCTCATCATCAAGGCCCTGCGGACCCACGGCCTGATTCCCGGCATGGAAACTCCCCTCACC
TGGCGCGAGTCGGTGCTGGAGTTCGCCCGTTCATGCCATGCGGACGAAGAGCATGCCCTCCAGGTGGCGCGGCTTTCCCT
GGAGATATTCGATTCCCTGGAGCCGGTCTATGGCATGGGCGAGGGAGCCCGCCGGATACTGGAGGCGGCGGCCATCCTCC
ACGACGTGGGCTACTTCATCAACTATTCAAGCCACCACAAGCATTCATACCATTTGATCCGCCACGCGGACCTCTTCGGC
TTCACCCCCCGGGAGCGGGAGCTGATCGCCTCAGCGGCCCGCTACCACCGCAAGGCCCTTCCCAAGAAGAAGCACGAGTC
GTACATGCGTCTGGCGGAGCCGGACCGGCTCCTGGTGGCGCGCCTGGGCGGCATCCTGCGGCTCGCCGACGGCCTCGACC
GTCGCCGCAACAGCCTGGTCTCCGGCCTTACCTGTTCCCTTTCCGACGGCACCTTCATCCTTACCCTTGCCAGTCGCGGA
GAAATCTCCGTGGAGCTCTTCGGCGGCAAGATCAAGGGAGATCTCTTCGAGGAGGCCTTCAGTAAGCGCCTCCTGCTGGT
GGCCGAAAGCGCCCTCGCCTGA

Upstream 100 bases:

>100_bases
ACCACATCGCGGGGGAGCGGCACCGGCAGTTCGCGCTGTTTGCCGGGCTCCTGGCCGAGACCCCCTTCGAAGCCATCGGC
GAACAGGTGAGGAGAGCGCT

Downstream 100 bases:

>100_bases
GCCTGTCCCCTCCGTATTTTCGTAATTGTGTGCGTACCGTAACGAAATCGAAGTGTTGAACGTCTAAAGTGGGATCATGA
CACGTCAGGAGGTTCAACGA

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTHNRLAAIDIGTNSIRCIVVEVTRNGKFRVLDDEKATVRLGEGMAASGTISPAAWERAVTALGRMKKIVDGYGVKVVEA
VATSAVRRAANGEEFIRTVEETVGVRVAVISGEEEAELAALSVRNHFDMEGVRYAMVDIGGGSLEIVTALGTHIEDIHSL
ELGAVVLTERFVRSDPPRQADLDRLRKHVRASLKESLGAEWGHLQSLVGSGGTITSIAAMVMAMRGEGYGSVHRYEVLRS
EVVHLLAMLSRKDLKARREVPGLNPDRADIITAGVTVVDELMRFFDVNLLRVNERGIREGLIIKALRTHGLIPGMETPLT
WRESVLEFARSCHADEEHALQVARLSLEIFDSLEPVYGMGEGARRILEAAAILHDVGYFINYSSHHKHSYHLIRHADLFG
FTPRERELIASAARYHRKALPKKKHESYMRLAEPDRLLVARLGGILRLADGLDRRRNSLVSGLTCSLSDGTFILTLASRG
EISVELFGGKIKGDLFEEAFSKRLLLVAESALA

Sequences:

>Translated_513_residues
MTHNRLAAIDIGTNSIRCIVVEVTRNGKFRVLDDEKATVRLGEGMAASGTISPAAWERAVTALGRMKKIVDGYGVKVVEA
VATSAVRRAANGEEFIRTVEETVGVRVAVISGEEEAELAALSVRNHFDMEGVRYAMVDIGGGSLEIVTALGTHIEDIHSL
ELGAVVLTERFVRSDPPRQADLDRLRKHVRASLKESLGAEWGHLQSLVGSGGTITSIAAMVMAMRGEGYGSVHRYEVLRS
EVVHLLAMLSRKDLKARREVPGLNPDRADIITAGVTVVDELMRFFDVNLLRVNERGIREGLIIKALRTHGLIPGMETPLT
WRESVLEFARSCHADEEHALQVARLSLEIFDSLEPVYGMGEGARRILEAAAILHDVGYFINYSSHHKHSYHLIRHADLFG
FTPRERELIASAARYHRKALPKKKHESYMRLAEPDRLLVARLGGILRLADGLDRRRNSLVSGLTCSLSDGTFILTLASRG
EISVELFGGKIKGDLFEEAFSKRLLLVAESALA
>Mature_512_residues
THNRLAAIDIGTNSIRCIVVEVTRNGKFRVLDDEKATVRLGEGMAASGTISPAAWERAVTALGRMKKIVDGYGVKVVEAV
ATSAVRRAANGEEFIRTVEETVGVRVAVISGEEEAELAALSVRNHFDMEGVRYAMVDIGGGSLEIVTALGTHIEDIHSLE
LGAVVLTERFVRSDPPRQADLDRLRKHVRASLKESLGAEWGHLQSLVGSGGTITSIAAMVMAMRGEGYGSVHRYEVLRSE
VVHLLAMLSRKDLKARREVPGLNPDRADIITAGVTVVDELMRFFDVNLLRVNERGIREGLIIKALRTHGLIPGMETPLTW
RESVLEFARSCHADEEHALQVARLSLEIFDSLEPVYGMGEGARRILEAAAILHDVGYFINYSSHHKHSYHLIRHADLFGF
TPRERELIASAARYHRKALPKKKHESYMRLAEPDRLLVARLGGILRLADGLDRRRNSLVSGLTCSLSDGTFILTLASRGE
ISVELFGGKIKGDLFEEAFSKRLLLVAESALA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=493, Percent_Identity=27.3833671399594, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788848, Length=428, Percent_Identity=26.4018691588785, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56473; Mature: 56342

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHNRLAAIDIGTNSIRCIVVEVTRNGKFRVLDDEKATVRLGEGMAASGTISPAAWERAV
CCCCEEEEEEECCCCEEEEEEEEECCCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHH
TALGRMKKIVDGYGVKVVEAVATSAVRRAANGEEFIRTVEETVGVRVAVISGEEEAELAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEEECCCCCHHHHH
LSVRNHFDMEGVRYAMVDIGGGSLEIVTALGTHIEDIHSLELGAVVLTERFVRSDPPRQA
HHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLDRLRKHVRASLKESLGAEWGHLQSLVGSGGTITSIAAMVMAMRGEGYGSVHRYEVLRS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EVVHLLAMLSRKDLKARREVPGLNPDRADIITAGVTVVDELMRFFDVNLLRVNERGIREG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHH
LIIKALRTHGLIPGMETPLTWRESVLEFARSCHADEEHALQVARLSLEIFDSLEPVYGMG
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHCCC
EGARRILEAAAILHDVGYFINYSSHHKHSYHLIRHADLFGFTPRERELIASAARYHRKAL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECHHCCCCCHHHHHHHHHHHHHHHHC
PKKKHESYMRLAEPDRLLVARLGGILRLADGLDRRRNSLVSGLTCSLSDGTFILTLASRG
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEECCC
EISVELFGGKIKGDLFEEAFSKRLLLVAESALA
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THNRLAAIDIGTNSIRCIVVEVTRNGKFRVLDDEKATVRLGEGMAASGTISPAAWERAV
CCCEEEEEEECCCCEEEEEEEEECCCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHH
TALGRMKKIVDGYGVKVVEAVATSAVRRAANGEEFIRTVEETVGVRVAVISGEEEAELAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEEECCCCCHHHHH
LSVRNHFDMEGVRYAMVDIGGGSLEIVTALGTHIEDIHSLELGAVVLTERFVRSDPPRQA
HHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLDRLRKHVRASLKESLGAEWGHLQSLVGSGGTITSIAAMVMAMRGEGYGSVHRYEVLRS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EVVHLLAMLSRKDLKARREVPGLNPDRADIITAGVTVVDELMRFFDVNLLRVNERGIREG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHH
LIIKALRTHGLIPGMETPLTWRESVLEFARSCHADEEHALQVARLSLEIFDSLEPVYGMG
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHCCC
EGARRILEAAAILHDVGYFINYSSHHKHSYHLIRHADLFGFTPRERELIASAARYHRKAL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECHHCCCCCHHHHHHHHHHHHHHHHC
PKKKHESYMRLAEPDRLLVARLGGILRLADGLDRRRNSLVSGLTCSLSDGTFILTLASRG
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEECCC
EISVELFGGKIKGDLFEEAFSKRLLLVAESALA
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]