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The map label for this gene is zraR [H]

Identifier: 39997601

GI number: 39997601

Start: 2762042

End: 2763736

Strand: Reverse

Name: zraR [H]

Synonym: GSU2506

Alternate gene names: 39997601

Gene position: 2763736-2762042 (Counterclockwise)

Preceding gene: 39997602

Following gene: 39997600

Centisome position: 72.46

GC content: 62.54

Gene sequence:

>1695_bases
ATGGCCAGAAGGGTTCTGATAGTAGAGGATGAGGACACGCTGCGGTTCACGTTCGAGCACTTCCTCGCGGCCGAGGGCTA
TGCCGTCGATACGGCGGCCGATTTCGCGGAGGCGATCGGCAAGGTCGAATCCGCCGACTATGACCTTGTTTTCACCGACA
TCATCCTGGGCAACGATAACGGCATCGATGTCCTGCGCGAAGTCAAGGAGCGCCAGCCCTCCATCCCCGTAGTGATGATC
ACCGGCTATCCCAACGTGGAGACGGCGTCCGACGCCGTCCGGCTCGGGGCCTTCGACTATCTCCCCAAGCCGGTCAAGCG
CGACGCCCTGCTGCGGGTGGCTCGCATGGCCCTCGAACACAAGGACCTCATGGAGGAGCGGGAGAAATACCGGACCAACC
TGGAGGCCATCTTCCAGAGCGTGGACGATGCCATCCTCACCGTGGATCTGGACATGAACGTGGTGGCCTACAACGAGTCC
GGGAAATACTTCTTCAGCCTCGCCGCCGAATCCATCGGCAGGCGCTACGTGCCGGGAGAGGGGAACGGCGCGTTCCTCCA
CGCGCTCACGGAAACCCTCAAGACCAAGCGGCCGGTGGAGACCCAGCGGACCGAATGCGTGGTCGGGGGGAGCGAAAAGC
GCGTGGTGAGCCTCAAGACCTCCCCCCTGGTGGACCGGACCGGCACCTTCTCCGGGGCCGTCATGGTGGTGCGCGACGAA
ACGCGCCTGGATGATCTGGAAAAGAGTTTCGAGGGGCGGGAGACGTTCCACAACCTGGTGGGAAGCAGCCCCCGCATGAA
GGAGATTTACGCCTTTGTCGAGTCCCTGGCCGATGTCCCCACTACCGTGCTGGTGACCGGCGAGAGCGGCACCGGCAAGG
AGCTCGTGGCGGCGGCCCTGCACTACAAGGGGGGGCGGAGCACCAAGCCCTTCGTCAAGGTCAACTGTTCCGCCCTGGCG
GAACCGCTGCTGGAGAGCGAGCTGTTCGGCCACGTGAAAGGGGCCTTCACCGGCGCCATCAAGGACAAGATGGGCCGTTT
CCAGAAAGCGGACGGCGGCACGATCTTCCTGGACGAGATCGGCGACATCTCGCCGGGGATGCAGGTGCGGCTGCTGCGGG
TCCTGCAGGAGAGGGAATTCGAGCGGGTGGGCGACTCCACCCCCATCAAGGTGGATGTACGGGTCATTGCCGCCACCAAC
GTCGACCTGGCGGAAAAGGTGCGGATCGGCCAGTTCCGGGAAGACCTCTTCTACCGCCTGAAGGTCGTCCGGATCCACAT
CCCGCCGCTGCGGGAACGGCGCGAGGATATCCCCATGCTCGTGGAACACTTCCTGGCCAAATTCCGCGGCAAGTTCAAAA
AGGACGTCAGCGCGGTTTCCGACGAGGTCATGAAGGTGTTCATGTCCTATCCCTGGCCGGGCAATGTCCGCGAACTGGAA
CACGTGCTCGAACACTCGTGCATCGTCTGCACTTCCGGCCTGATCACCCTGGAACACCTTCCCTCGGATTTCATGGAACA
CCATGAGATCCACGGCAACGAACCGGCCACCGAGCGGGAGACCACCCTGCAGGCGATCCGGAAAGCCCTGGAAAAATCCG
GCGGCAACAAGGCCAAGGCGGCGCGCCTGCTCGGCATCAGCCGTATCACCTTGTACCGAAAACTCAATGAATTAAAGATT
GTTCACGACGAGTAG

Upstream 100 bases:

>100_bases
CTGATCTCGGACCATGGAGGGCGACTGAAGGTTGAAAGCGTCGAGGGAGAGTTCACCCGTGTAATGATTGATTTGCCCGT
AATGACCTGGGAGGACGAGT

Downstream 100 bases:

>100_bases
CCGATTAGGGTGTATCATGTAACACATTTGTTCCTTAACATCTGTGTTACATGATACACTTTTTCAATGAACGGCCGGTC
GGAAACGATAAGTGAAATAG

Product: sensory box protein/sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MARRVLIVEDEDTLRFTFEHFLAAEGYAVDTAADFAEAIGKVESADYDLVFTDIILGNDNGIDVLREVKERQPSIPVVMI
TGYPNVETASDAVRLGAFDYLPKPVKRDALLRVARMALEHKDLMEEREKYRTNLEAIFQSVDDAILTVDLDMNVVAYNES
GKYFFSLAAESIGRRYVPGEGNGAFLHALTETLKTKRPVETQRTECVVGGSEKRVVSLKTSPLVDRTGTFSGAVMVVRDE
TRLDDLEKSFEGRETFHNLVGSSPRMKEIYAFVESLADVPTTVLVTGESGTGKELVAAALHYKGGRSTKPFVKVNCSALA
EPLLESELFGHVKGAFTGAIKDKMGRFQKADGGTIFLDEIGDISPGMQVRLLRVLQEREFERVGDSTPIKVDVRVIAATN
VDLAEKVRIGQFREDLFYRLKVVRIHIPPLRERREDIPMLVEHFLAKFRGKFKKDVSAVSDEVMKVFMSYPWPGNVRELE
HVLEHSCIVCTSGLITLEHLPSDFMEHHEIHGNEPATERETTLQAIRKALEKSGGNKAKAARLLGISRITLYRKLNELKI
VHDE

Sequences:

>Translated_564_residues
MARRVLIVEDEDTLRFTFEHFLAAEGYAVDTAADFAEAIGKVESADYDLVFTDIILGNDNGIDVLREVKERQPSIPVVMI
TGYPNVETASDAVRLGAFDYLPKPVKRDALLRVARMALEHKDLMEEREKYRTNLEAIFQSVDDAILTVDLDMNVVAYNES
GKYFFSLAAESIGRRYVPGEGNGAFLHALTETLKTKRPVETQRTECVVGGSEKRVVSLKTSPLVDRTGTFSGAVMVVRDE
TRLDDLEKSFEGRETFHNLVGSSPRMKEIYAFVESLADVPTTVLVTGESGTGKELVAAALHYKGGRSTKPFVKVNCSALA
EPLLESELFGHVKGAFTGAIKDKMGRFQKADGGTIFLDEIGDISPGMQVRLLRVLQEREFERVGDSTPIKVDVRVIAATN
VDLAEKVRIGQFREDLFYRLKVVRIHIPPLRERREDIPMLVEHFLAKFRGKFKKDVSAVSDEVMKVFMSYPWPGNVRELE
HVLEHSCIVCTSGLITLEHLPSDFMEHHEIHGNEPATERETTLQAIRKALEKSGGNKAKAARLLGISRITLYRKLNELKI
VHDE
>Mature_563_residues
ARRVLIVEDEDTLRFTFEHFLAAEGYAVDTAADFAEAIGKVESADYDLVFTDIILGNDNGIDVLREVKERQPSIPVVMIT
GYPNVETASDAVRLGAFDYLPKPVKRDALLRVARMALEHKDLMEEREKYRTNLEAIFQSVDDAILTVDLDMNVVAYNESG
KYFFSLAAESIGRRYVPGEGNGAFLHALTETLKTKRPVETQRTECVVGGSEKRVVSLKTSPLVDRTGTFSGAVMVVRDET
RLDDLEKSFEGRETFHNLVGSSPRMKEIYAFVESLADVPTTVLVTGESGTGKELVAAALHYKGGRSTKPFVKVNCSALAE
PLLESELFGHVKGAFTGAIKDKMGRFQKADGGTIFLDEIGDISPGMQVRLLRVLQEREFERVGDSTPIKVDVRVIAATNV
DLAEKVRIGQFREDLFYRLKVVRIHIPPLRERREDIPMLVEHFLAKFRGKFKKDVSAVSDEVMKVFMSYPWPGNVRELEH
VLEHSCIVCTSGLITLEHLPSDFMEHHEIHGNEPATERETTLQAIRKALEKSGGNKAKAARLLGISRITLYRKLNELKIV
HDE

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=52.6490066225166, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1788550, Length=325, Percent_Identity=44.3076923076923, Blast_Score=278, Evalue=9e-76,
Organism=Escherichia coli, GI1790299, Length=332, Percent_Identity=42.4698795180723, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87082117, Length=320, Percent_Identity=44.0625, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788905, Length=358, Percent_Identity=40.5027932960894, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1789087, Length=310, Percent_Identity=43.2258064516129, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=43.2098765432099, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1786524, Length=338, Percent_Identity=40.5325443786982, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI87082152, Length=314, Percent_Identity=41.0828025477707, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI87081872, Length=306, Percent_Identity=39.5424836601307, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1787583, Length=256, Percent_Identity=39.84375, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87081858, Length=448, Percent_Identity=28.5714285714286, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1789828, Length=225, Percent_Identity=35.1111111111111, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787487, Length=127, Percent_Identity=29.9212598425197, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1786784, Length=147, Percent_Identity=31.2925170068027, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 63129; Mature: 62998

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRVLIVEDEDTLRFTFEHFLAAEGYAVDTAADFAEAIGKVESADYDLVFTDIILGNDN
CCCEEEEEECCCCHHHHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCCEEEEEEEEECCC
GIDVLREVKERQPSIPVVMITGYPNVETASDAVRLGAFDYLPKPVKRDALLRVARMALEH
CHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHH
KDLMEEREKYRTNLEAIFQSVDDAILTVDLDMNVVAYNESGKYFFSLAAESIGRRYVPGE
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCEEEEEEHHHHCCEECCCC
GNGAFLHALTETLKTKRPVETQRTECVVGGSEKRVVSLKTSPLVDRTGTFSGAVMVVRDE
CCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEECC
TRLDDLEKSFEGRETFHNLVGSSPRMKEIYAFVESLADVPTTVLVTGESGTGKELVAAAL
HHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
HYKGGRSTKPFVKVNCSALAEPLLESELFGHVKGAFTGAIKDKMGRFQKADGGTIFLDEI
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GDISPGMQVRLLRVLQEREFERVGDSTPIKVDVRVIAATNVDLAEKVRIGQFREDLFYRL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHEE
KVVRIHIPPLRERREDIPMLVEHFLAKFRGKFKKDVSAVSDEVMKVFMSYPWPGNVRELE
EEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
HVLEHSCIVCTSGLITLEHLPSDFMEHHEIHGNEPATERETTLQAIRKALEKSGGNKAKA
HHHHCCCEEECCCCEEHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
ARLLGISRITLYRKLNELKIVHDE
HHHHHHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure 
ARRVLIVEDEDTLRFTFEHFLAAEGYAVDTAADFAEAIGKVESADYDLVFTDIILGNDN
CCEEEEEECCCCHHHHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCCEEEEEEEEECCC
GIDVLREVKERQPSIPVVMITGYPNVETASDAVRLGAFDYLPKPVKRDALLRVARMALEH
CHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHH
KDLMEEREKYRTNLEAIFQSVDDAILTVDLDMNVVAYNESGKYFFSLAAESIGRRYVPGE
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCEEEEEEHHHHCCEECCCC
GNGAFLHALTETLKTKRPVETQRTECVVGGSEKRVVSLKTSPLVDRTGTFSGAVMVVRDE
CCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEECC
TRLDDLEKSFEGRETFHNLVGSSPRMKEIYAFVESLADVPTTVLVTGESGTGKELVAAAL
HHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
HYKGGRSTKPFVKVNCSALAEPLLESELFGHVKGAFTGAIKDKMGRFQKADGGTIFLDEI
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GDISPGMQVRLLRVLQEREFERVGDSTPIKVDVRVIAATNVDLAEKVRIGQFREDLFYRL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHEE
KVVRIHIPPLRERREDIPMLVEHFLAKFRGKFKKDVSAVSDEVMKVFMSYPWPGNVRELE
EEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
HVLEHSCIVCTSGLITLEHLPSDFMEHHEIHGNEPATERETTLQAIRKALEKSGGNKAKA
HHHHCCCEEECCCCEEHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
ARLLGISRITLYRKLNELKIVHDE
HHHHHHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]