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The map label for this gene is trpF

Identifier: 39997473

GI number: 39997473

Start: 2606832

End: 2607443

Strand: Reverse

Name: trpF

Synonym: GSU2378

Alternate gene names: 39997473

Gene position: 2607443-2606832 (Counterclockwise)

Preceding gene: 39997474

Following gene: 39997472

Centisome position: 68.36

GC content: 68.63

Gene sequence:

>612_bases
ATGGTCCGCGTCAAGATCTGCGGCATAACATCCCTTGAGGATGCCCTCGTGGCGGTGGAGGCCGGGGCCGACGCCCTCGG
CTTCGTCTTTCACGACGAATCGCCCCGCCACGTGACGCCCGAACAGGCCGCCGGCATCATCGCCGGGCTCCCGCCGTTTA
TCCAGACCGTGGGGCTTTTCGTGAACCGTCCCCCGGCATTCGTCAACGACACGGCCACCCGCTGCCGCCTCGATCTGGTC
CAGCTCCACGGCGACGAGCCGCCCGAGTTCTGCGACGCCGTGGAGCGCCGGGTGATCAAGGCCTTCAGGGTGAAGGACAT
CAGCAGCCTCGACCCGATCCGGCACTACCGCGTGGCGGCCCACCTGCTGGACGCCTACTCCCCCAAGGCCTACGGCGGCA
CCGGCCTTACCTTCAACTGGGACATCGCAGCTGCGGCAAAGGCGTTCGGCCCGCTCATCCTCGCCGGGGGACTCACCCCC
GACAACGTGCGGGAAGCGGTGGAAACGGTGAAGCCCTATGCCGTGGACGTCTCGGGCGGCGTGGAAAGCGCGCCCGGCCG
GAAGGACGCAGCCAGGGTGCGGGAGTTCATCCGGCGGGCCAAGGGGTGGTGA

Upstream 100 bases:

>100_bases
TACGACGCCTACCTCTCCGGCGGCCTGGAAGACGTCGAATACCCCGAGGAGATGATCCGGGAGTCCCTGGCCAAACTGCC
CAAGGTGGAACTGTGAACGG

Downstream 100 bases:

>100_bases
GACCGGAGGCAGACCATGGAAGTACCCCTCTCAGTCCCCCCTACCCTGTAGGGGGGAAGCGAGCACCGCGAGCAGGGGGG
TGAGCAGTGGGAACTTTTAT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MVRVKICGITSLEDALVAVEAGADALGFVFHDESPRHVTPEQAAGIIAGLPPFIQTVGLFVNRPPAFVNDTATRCRLDLV
QLHGDEPPEFCDAVERRVIKAFRVKDISSLDPIRHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKAFGPLILAGGLTP
DNVREAVETVKPYAVDVSGGVESAPGRKDAARVREFIRRAKGW

Sequences:

>Translated_203_residues
MVRVKICGITSLEDALVAVEAGADALGFVFHDESPRHVTPEQAAGIIAGLPPFIQTVGLFVNRPPAFVNDTATRCRLDLV
QLHGDEPPEFCDAVERRVIKAFRVKDISSLDPIRHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKAFGPLILAGGLTP
DNVREAVETVKPYAVDVSGGVESAPGRKDAARVREFIRRAKGW
>Mature_203_residues
MVRVKICGITSLEDALVAVEAGADALGFVFHDESPRHVTPEQAAGIIAGLPPFIQTVGLFVNRPPAFVNDTATRCRLDLV
QLHGDEPPEFCDAVERRVIKAFRVKDISSLDPIRHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKAFGPLILAGGLTP
DNVREAVETVKPYAVDVSGGVESAPGRKDAARVREFIRRAKGW

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=190, Percent_Identity=35.7894736842105, Blast_Score=97, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_GEOSL (Q74AH7)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953424.1
- HSSP:   Q56320
- ProteinModelPortal:   Q74AH7
- SMR:   Q74AH7
- GeneID:   2688046
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2378
- NMPDR:   fig|243231.1.peg.2362
- TIGR:   GSU2378
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- BioCyc:   GSUL243231:GSU_2378-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 21901; Mature: 21901

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVKICGITSLEDALVAVEAGADALGFVFHDESPRHVTPEQAAGIIAGLPPFIQTVGLF
CEEEEEECCCCHHHHHEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHH
VNRPPAFVNDTATRCRLDLVQLHGDEPPEFCDAVERRVIKAFRVKDISSLDPIRHYRVAA
HCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
HLLDAYSPKAYGGTGLTFNWDIAAAAKAFGPLILAGGLTPDNVREAVETVKPYAVDVSGG
HHHHHCCCCCCCCCCCEEECHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCEEEEECCC
VESAPGRKDAARVREFIRRAKGW
CCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVRVKICGITSLEDALVAVEAGADALGFVFHDESPRHVTPEQAAGIIAGLPPFIQTVGLF
CEEEEEECCCCHHHHHEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHH
VNRPPAFVNDTATRCRLDLVQLHGDEPPEFCDAVERRVIKAFRVKDISSLDPIRHYRVAA
HCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
HLLDAYSPKAYGGTGLTFNWDIAAAAKAFGPLILAGGLTPDNVREAVETVKPYAVDVSGG
HHHHHCCCCCCCCCCCEEECHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCEEEEECCC
VESAPGRKDAARVREFIRRAKGW
CCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA