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The map label for this gene is der

Identifier: 39997323

GI number: 39997323

Start: 2440825

End: 2442141

Strand: Reverse

Name: der

Synonym: GSU2225

Alternate gene names: 39997323

Gene position: 2442141-2440825 (Counterclockwise)

Preceding gene: 39997324

Following gene: 39997322

Centisome position: 64.03

GC content: 60.29

Gene sequence:

>1317_bases
ATGATACTGCCGATCGTTGCCATAGTAGGTCGCCCCAATGTGGGCAAGTCGACCCTTTTCAACCGTCTCGTGGGGCGCCG
CAAGGCGATAGTTGACGATATGCCCGGCGTAACCCGGGACCGCAATTACGAAACGGTCACCCGTTTCGACGTCCCCTTCA
TCCTGATCGACACCGGCGGGTTCGAGCCAGAGAGTTCCGACCGGCTCCTCCAGCAGATGCGTGAGCAGTCCCGGCTCGCC
ATGGAAGAGGCTGACGTGATCCTCTTCCTTATGGACGGCCGTGCCGGGCTCAACCCCGCCGATGTGGAGGTGGTGGAGAT
GCTCCGGCGGGTGGACAAGCCGGTCTTCTTCGTGGTCAACAAGGTGGATGGCGAAACCCTTGAGGTGGCGGCATCCGAGT
TCTACTCCCTGGGAGTCGACAATCTGCTTACCATTTCAGCGGAGCACAACCGCGGCGTGCGCGACCTGATGGACGAGGTG
GTGGCGGCCCTGCCCCAGCGGACCACCAGCCCCGAGGAGCGCAATGCGACCAAGATTGCCGTTGTGGGCCGCCCCAATGT
GGGCAAGTCCTCCCTGGTCAACCGGCTGCTGGGATACGAGCGGGTGGTGGCCAATCCGACTCCCGGCACCACCCGGGATT
CCGTGGACACTTGGTTCACCTGCAACAAGAAGCGCTACCTCCTCATCGATACCGCGGGCATCCGGCGCAAGGGGAAGACC
ACCCAGAAGATCGAAAAATACAGCGTGGTGGACTCCCTGCGCAGCATCGAGCGGGCCGACGTGGTCCTCATCGTGCTCAA
TGCCGAGGAGGGGGTGACCGAGCAGGACGAACGGATTGCCGGCTATGCCTTCGAGGCGGGCAAGGCCTGTATCTTCGTGG
TCAACAAGTGGGACGCCATTGAGAAGGACAACAGCTCCGTGGGGCGCTTCGTGGATAAGATCAGGACTGAATTCAAGTAT
CTCGCCTTTGTGCCGATAGTATTTGTGTCGGCTAAAACAGGCCAGCGGCTCAACCGGATCATGGAAGAGGTGGAAAAGGT
CATGGCCCAGTACGTGAAACGGGTCACCACCTCGGAGCTCAACCGGATCTTTTCGGCAGCGGTGGAGAGTCATCACCATC
CGCTCGTCATGGGGCGGCGGGTCAAGTTCTACTTCGCCACCCAAGTGGGGACCAGGCCCCCCACCTTTGTCATTTTCACC
AATCGGCCGGATGGGATGCACTTTTCCTATGAACGGTACCTTGTCAATAAATTCCGCGAGGCGTTCGATTTTACCGGAAC
GCCTTTGCGTCTCCTGTTCAGGGGACGGGAGCGCTAG

Upstream 100 bases:

>100_bases
TCGAGCGGTTGCTCGACACGAAGGTGTTTCTGGAACTCTTCGTGCGGGTCCGCAGGGACTGGAGCGAAAACCCGAATATA
CTCAAGGAGCTCGGATACCG

Downstream 100 bases:

>100_bases
CCCTCCGAACGAGCGTAAACGGCGGCTGGACGGCCTCTCGCGGGGAGCCGTAACCACTTTACTTGCATGGGTCGATGGTT
TATGATGGGCGCCGCTTCCA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MILPIVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFDVPFILIDTGGFEPESSDRLLQQMREQSRLA
MEEADVILFLMDGRAGLNPADVEVVEMLRRVDKPVFFVVNKVDGETLEVAASEFYSLGVDNLLTISAEHNRGVRDLMDEV
VAALPQRTTSPEERNATKIAVVGRPNVGKSSLVNRLLGYERVVANPTPGTTRDSVDTWFTCNKKRYLLIDTAGIRRKGKT
TQKIEKYSVVDSLRSIERADVVLIVLNAEEGVTEQDERIAGYAFEAGKACIFVVNKWDAIEKDNSSVGRFVDKIRTEFKY
LAFVPIVFVSAKTGQRLNRIMEEVEKVMAQYVKRVTTSELNRIFSAAVESHHHPLVMGRRVKFYFATQVGTRPPTFVIFT
NRPDGMHFSYERYLVNKFREAFDFTGTPLRLLFRGRER

Sequences:

>Translated_438_residues
MILPIVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFDVPFILIDTGGFEPESSDRLLQQMREQSRLA
MEEADVILFLMDGRAGLNPADVEVVEMLRRVDKPVFFVVNKVDGETLEVAASEFYSLGVDNLLTISAEHNRGVRDLMDEV
VAALPQRTTSPEERNATKIAVVGRPNVGKSSLVNRLLGYERVVANPTPGTTRDSVDTWFTCNKKRYLLIDTAGIRRKGKT
TQKIEKYSVVDSLRSIERADVVLIVLNAEEGVTEQDERIAGYAFEAGKACIFVVNKWDAIEKDNSSVGRFVDKIRTEFKY
LAFVPIVFVSAKTGQRLNRIMEEVEKVMAQYVKRVTTSELNRIFSAAVESHHHPLVMGRRVKFYFATQVGTRPPTFVIFT
NRPDGMHFSYERYLVNKFREAFDFTGTPLRLLFRGRER
>Mature_438_residues
MILPIVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFDVPFILIDTGGFEPESSDRLLQQMREQSRLA
MEEADVILFLMDGRAGLNPADVEVVEMLRRVDKPVFFVVNKVDGETLEVAASEFYSLGVDNLLTISAEHNRGVRDLMDEV
VAALPQRTTSPEERNATKIAVVGRPNVGKSSLVNRLLGYERVVANPTPGTTRDSVDTWFTCNKKRYLLIDTAGIRRKGKT
TQKIEKYSVVDSLRSIERADVVLIVLNAEEGVTEQDERIAGYAFEAGKACIFVVNKWDAIEKDNSSVGRFVDKIRTEFKY
LAFVPIVFVSAKTGQRLNRIMEEVEKVMAQYVKRVTTSELNRIFSAAVESHHHPLVMGRRVKFYFATQVGTRPPTFVIFT
NRPDGMHFSYERYLVNKFREAFDFTGTPLRLLFRGRER

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=461, Percent_Identity=41.648590021692, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI2367268, Length=153, Percent_Identity=37.2549019607843, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788919, Length=177, Percent_Identity=31.638418079096, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507259, Length=122, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=200, Percent_Identity=30.5, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_GEOSL (Q74AX4)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953274.1
- HSSP:   Q9X1F8
- ProteinModelPortal:   Q74AX4
- SMR:   Q74AX4
- GeneID:   2687605
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2225
- NMPDR:   fig|243231.1.peg.2212
- TIGR:   GSU2225
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   GSUL243231:GSU_2225-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49685; Mature: 49685

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPIVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFDVPFILIDTGG
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCC
FEPESSDRLLQQMREQSRLAMEEADVILFLMDGRAGLNPADVEVVEMLRRVDKPVFFVVN
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEE
KVDGETLEVAASEFYSLGVDNLLTISAEHNRGVRDLMDEVVAALPQRTTSPEERNATKIA
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VVGRPNVGKSSLVNRLLGYERVVANPTPGTTRDSVDTWFTCNKKRYLLIDTAGIRRKGKT
EEECCCCCHHHHHHHHHCHHHHCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCC
TQKIEKYSVVDSLRSIERADVVLIVLNAEEGVTEQDERIAGYAFEAGKACIFVVNKWDAI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHEEEEEECCCEEEEEEECCCCC
EKDNSSVGRFVDKIRTEFKYLAFVPIVFVSAKTGQRLNRIMEEVEKVMAQYVKRVTTSEL
CCCCCHHHHHHHHHHHHHHHHHEEHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRIFSAAVESHHHPLVMGRRVKFYFATQVGTRPPTFVIFTNRPDGMHFSYERYLVNKFRE
HHHHHHHHHCCCCCEEECCEEEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
AFDFTGTPLRLLFRGRER
HHCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MILPIVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFDVPFILIDTGG
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCC
FEPESSDRLLQQMREQSRLAMEEADVILFLMDGRAGLNPADVEVVEMLRRVDKPVFFVVN
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEE
KVDGETLEVAASEFYSLGVDNLLTISAEHNRGVRDLMDEVVAALPQRTTSPEERNATKIA
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VVGRPNVGKSSLVNRLLGYERVVANPTPGTTRDSVDTWFTCNKKRYLLIDTAGIRRKGKT
EEECCCCCHHHHHHHHHCHHHHCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCC
TQKIEKYSVVDSLRSIERADVVLIVLNAEEGVTEQDERIAGYAFEAGKACIFVVNKWDAI
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHEEEEEECCCEEEEEEECCCCC
EKDNSSVGRFVDKIRTEFKYLAFVPIVFVSAKTGQRLNRIMEEVEKVMAQYVKRVTTSEL
CCCCCHHHHHHHHHHHHHHHHHEEHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRIFSAAVESHHHPLVMGRRVKFYFATQVGTRPPTFVIFTNRPDGMHFSYERYLVNKFRE
HHHHHHHHHCCCCCEEECCEEEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
AFDFTGTPLRLLFRGRER
HHCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA