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The map label for this gene is gmhA

Identifier: 39997185

GI number: 39997185

Start: 2293102

End: 2293671

Strand: Reverse

Name: gmhA

Synonym: GSU2087

Alternate gene names: 39997185

Gene position: 2293671-2293102 (Counterclockwise)

Preceding gene: 39997186

Following gene: 39997184

Centisome position: 60.14

GC content: 64.21

Gene sequence:

>570_bases
GTGATAGACGACATTACGGCACAACTGCGCGCCGGCCGACAGGTCCTGGAGGCGCTCGAACGGGAACTGGCAGGCCGCAT
CGCATCGTTCGCGGAGCTCCTTGCCGATTCTCTGGCAGGGGGGCGCAAGCTCCTCGTCATGGGGAACGGCGGCTCGGCTG
CCGATGCCCAGCATTTCGCGGCGGAGATCGTCGGGCGCTTCAAGCTCGAGCGCCGGGGACTGCCGGCCGTGGCGCTTACC
ACCGATACCTCCATTCTCACCGCCATCGGCAACGACTATGGGTTCGACGCCATATTCCGCCGCCAGGTGGAAGCCCTGGC
CGACGAAGGGGATGTGGTGGTGGGTATTTCCACCAGCGGCAACTCCCGCAACGTTCAGGAAGCCCTGCTCCTGGCCCGTG
AGCGCGGCTGTCGTACCATCGGACTCCTGGGCCGGGACGGTGGTTCCATCCGCGATATCGTGGACCTGGATCTCACCGTG
CCGAGTGCCGATACCCCCCGCATCCAGGAGGGGCACATAACCATTATTCACATCGTCTGCGACTTGGTCGAAAAGAGGCT
GTTCCCATGA

Upstream 100 bases:

>100_bases
GCGAAGGGGAGCAAAATCCGGTGACAGCCCCGGCCGATTGCGTTACAGTAGCAATTTCCGACGGAACCCGCCAGGGGGAT
GAGCGGAAGGAGGTGGCCCA

Downstream 100 bases:

>100_bases
AATACCGTCCCGTGGACCTTTCCGGAGTCACCACCTATCCCCTTGCCGAACGGAAGAACAAGGTGAGCATCCGGCGCGAT
TTTGCCGGATCGGTCACGTC

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MIDDITAQLRAGRQVLEALERELAGRIASFAELLADSLAGGRKLLVMGNGGSAADAQHFAAEIVGRFKLERRGLPAVALT
TDTSILTAIGNDYGFDAIFRRQVEALADEGDVVVGISTSGNSRNVQEALLLARERGCRTIGLLGRDGGSIRDIVDLDLTV
PSADTPRIQEGHITIIHIVCDLVEKRLFP

Sequences:

>Translated_189_residues
MIDDITAQLRAGRQVLEALERELAGRIASFAELLADSLAGGRKLLVMGNGGSAADAQHFAAEIVGRFKLERRGLPAVALT
TDTSILTAIGNDYGFDAIFRRQVEALADEGDVVVGISTSGNSRNVQEALLLARERGCRTIGLLGRDGGSIRDIVDLDLTV
PSADTPRIQEGHITIIHIVCDLVEKRLFP
>Mature_189_residues
MIDDITAQLRAGRQVLEALERELAGRIASFAELLADSLAGGRKLLVMGNGGSAADAQHFAAEIVGRFKLERRGLPAVALT
TDTSILTAIGNDYGFDAIFRRQVEALADEGDVVVGISTSGNSRNVQEALLLARERGCRTIGLLGRDGGSIRDIVDLDLTV
PSADTPRIQEGHITIIHIVCDLVEKRLFP

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=158, Percent_Identity=50.6329113924051, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789539, Length=192, Percent_Identity=41.6666666666667, Blast_Score=145, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_GEOSL (Q74BF4)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953136.1
- HSSP:   Q9PNE6
- ProteinModelPortal:   Q74BF4
- SMR:   Q74BF4
- GeneID:   2687876
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2087
- NMPDR:   fig|243231.1.peg.2074
- TIGR:   GSU2087
- HOGENOM:   HBG671955
- OMA:   QEMHILI
- ProtClustDB:   PRK13937
- BioCyc:   GSUL243231:GSU_2087-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20231; Mature: 20231

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS51464 SIS

Important sites: BINDING 62-62 BINDING 122-122 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDITAQLRAGRQVLEALERELAGRIASFAELLADSLAGGRKLLVMGNGGSAADAQHFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AEIVGRFKLERRGLPAVALTTDTSILTAIGNDYGFDAIFRRQVEALADEGDVVVGISTSG
HHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
NSRNVQEALLLARERGCRTIGLLGRDGGSIRDIVDLDLTVPSADTPRIQEGHITIIHIVC
CCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCEEHHHHHH
DLVEKRLFP
HHHHHHCCC
>Mature Secondary Structure
MIDDITAQLRAGRQVLEALERELAGRIASFAELLADSLAGGRKLLVMGNGGSAADAQHFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AEIVGRFKLERRGLPAVALTTDTSILTAIGNDYGFDAIFRRQVEALADEGDVVVGISTSG
HHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
NSRNVQEALLLARERGCRTIGLLGRDGGSIRDIVDLDLTVPSADTPRIQEGHITIIHIVC
CCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCEEHHHHHH
DLVEKRLFP
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA