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The map label for this gene is accC [H]

Identifier: 39997117

GI number: 39997117

Start: 2212199

End: 2213539

Strand: Reverse

Name: accC [H]

Synonym: GSU2019

Alternate gene names: 39997117

Gene position: 2213539-2212199 (Counterclockwise)

Preceding gene: 39997118

Following gene: 39997116

Centisome position: 58.04

GC content: 57.49

Gene sequence:

>1341_bases
ATGTTTCATAAAGTTCTGATTGCAAATCGTGGCGAAATCGCCCTGAGGGTCATCCGGGCCTGCAAAGAGCTGGGAATCAA
GACCGTTGCCGTCTACTCGACAGCGGACAGGGATTCGCTCCATGTGAAGCTCGCGGATGAGAGTGTCTGCATCGGTCCCG
CGCCGAGCCTGCAGAGCTATCTTAATATTAACGCCATCATTTCGGCTGCCGAATTGACCGATGCCGAGGCAATCCACCCC
GGCTACGGTTTTCTGTCGGAAAATGCCGCTTTTGCCGAAATCTGTGAAAACTGCGGTATAACCTTCATCGGCCCCTCTTC
ACAAAGCATGCGCATCATGGGCGACAAGATCAGCGCCCGGCAGGCGGTGATCAAGGAAAATGTGCCGATCCTGCCCGGCA
CCAAGGAGGGGGTTAACGACGTCAACGAGGCGGTGAAGATCGCCAAGAAGATCGGCTTCCCCGTCATCATCAAGGCGACT
GCCGGAGGCGGTGGCCGGGGGATGAAGATCGTGCACTCCCCGGCGGCCCTCCCCAACGCCTTTGCCACGGCTCGCGCCGA
GGCTCAGGCCGGTTTCGGCAACCCTGAGGTCTACATTGAGAAGTATTGCGAGAAGCCGCGCCACGTTGAGATCCAGGTCA
TGGCCGACAAGCACGGTAACGTGATTCACCTGGGTGAGCGGGACTGCTCCATCCAGCGTCGCCACCAGAAGATCATCGAG
GAGTCGCCGTGCCCGGTCATGACTCCTGCACTCCGCAAGGCCATGGGTGATGCGGCTGTTCGCGCGTCCAAGGCAGTGGG
GTACGACAGTGTCGGCACCGTTGAGTTCCTGGTGGACAAGGACCTCAACTTCTATTTCATGGAAATGAATACCCGGGTGC
AGGTTGAGCATCCGGTGACCGAAATGGTGACCGGCATCGACATCGTCCGGGAGCAGATCCGTTCTGCAGCCGGTCTCAAG
CTTCGTTACAAGCAAAGCGACATTAAACTGCACGGTCACGCTATTGAATGCCGTATCAATGCTGAAGATCCGGTGAAGTT
CACCCCGTCGCCGGGCAAGATCGTCGGTTACCATACCCCGGGAGGTCTGGGTGTGCGGATCGATTCTTTCGTCTATGATC
AGTATTCCGTGGTCCCCCACTACGACTCGCTCATAGCGAAGCTGATCGTCCACGCAGAGACCAGGGAAGACGCCATCCGC
CGCATGGCCCGCGCCCTTGACGAGTACATCATTGAGGGCATCAAGACCACAATCCCCTTCCATAAGAGGATCATGGACAA
CAAAGACTTTATGGAGGGGAATGTCGACACCGGCTTCCTCGAGCGAATCGTGCTGGAGTAG

Upstream 100 bases:

>100_bases
CCAGATCTGCAAGGAGAACGCCCAGCCGGTGGAGTTCGGGGAGCCCCTCTTCATCGTGGAGCCGATGTAGTCGTCCCGGC
CGTCATTGGAGAAATCATAC

Downstream 100 bases:

>100_bases
GGCATGGATTTTCCTGAAGAGCTCAAGTACAGCAAGGAACACGTTTGGGTCAGGGAAGAGGGGGATCGGGCGGTCATCGG
GCTGACCGATTATGCCCAGG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFHKVLIANRGEIALRVIRACKELGIKTVAVYSTADRDSLHVKLADESVCIGPAPSLQSYLNINAIISAAELTDAEAIHP
GYGFLSENAAFAEICENCGITFIGPSSQSMRIMGDKISARQAVIKENVPILPGTKEGVNDVNEAVKIAKKIGFPVIIKAT
AGGGGRGMKIVHSPAALPNAFATARAEAQAGFGNPEVYIEKYCEKPRHVEIQVMADKHGNVIHLGERDCSIQRRHQKIIE
ESPCPVMTPALRKAMGDAAVRASKAVGYDSVGTVEFLVDKDLNFYFMEMNTRVQVEHPVTEMVTGIDIVREQIRSAAGLK
LRYKQSDIKLHGHAIECRINAEDPVKFTPSPGKIVGYHTPGGLGVRIDSFVYDQYSVVPHYDSLIAKLIVHAETREDAIR
RMARALDEYIIEGIKTTIPFHKRIMDNKDFMEGNVDTGFLERIVLE

Sequences:

>Translated_446_residues
MFHKVLIANRGEIALRVIRACKELGIKTVAVYSTADRDSLHVKLADESVCIGPAPSLQSYLNINAIISAAELTDAEAIHP
GYGFLSENAAFAEICENCGITFIGPSSQSMRIMGDKISARQAVIKENVPILPGTKEGVNDVNEAVKIAKKIGFPVIIKAT
AGGGGRGMKIVHSPAALPNAFATARAEAQAGFGNPEVYIEKYCEKPRHVEIQVMADKHGNVIHLGERDCSIQRRHQKIIE
ESPCPVMTPALRKAMGDAAVRASKAVGYDSVGTVEFLVDKDLNFYFMEMNTRVQVEHPVTEMVTGIDIVREQIRSAAGLK
LRYKQSDIKLHGHAIECRINAEDPVKFTPSPGKIVGYHTPGGLGVRIDSFVYDQYSVVPHYDSLIAKLIVHAETREDAIR
RMARALDEYIIEGIKTTIPFHKRIMDNKDFMEGNVDTGFLERIVLE
>Mature_446_residues
MFHKVLIANRGEIALRVIRACKELGIKTVAVYSTADRDSLHVKLADESVCIGPAPSLQSYLNINAIISAAELTDAEAIHP
GYGFLSENAAFAEICENCGITFIGPSSQSMRIMGDKISARQAVIKENVPILPGTKEGVNDVNEAVKIAKKIGFPVIIKAT
AGGGGRGMKIVHSPAALPNAFATARAEAQAGFGNPEVYIEKYCEKPRHVEIQVMADKHGNVIHLGERDCSIQRRHQKIIE
ESPCPVMTPALRKAMGDAAVRASKAVGYDSVGTVEFLVDKDLNFYFMEMNTRVQVEHPVTEMVTGIDIVREQIRSAAGLK
LRYKQSDIKLHGHAIECRINAEDPVKFTPSPGKIVGYHTPGGLGVRIDSFVYDQYSVVPHYDSLIAKLIVHAETREDAIR
RMARALDEYIIEGIKTTIPFHKRIMDNKDFMEGNVDTGFLERIVLE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=50.1123595505618, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=50.1123595505618, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=50.1123595505618, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=50.6818181818182, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=46.9662921348315, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=46.9662921348315, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=46.9662921348315, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=33.4637964774951, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=33.4637964774951, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=33.4637964774951, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=33.4637964774951, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=33.4637964774951, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=32.03125, Blast_Score=262, Evalue=4e-70,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=58.4650112866817, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=47.9910714285714, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=50.1133786848073, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=46.4125560538117, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=29.3650793650794, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=29.3650793650794, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=485, Percent_Identity=28.8659793814433, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=45.2488687782805, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.7427293064877, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.0850111856823, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323863, Length=465, Percent_Identity=33.9784946236559, Blast_Score=249, Evalue=8e-67,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=31.9148936170213, Blast_Score=242, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=49.3212669683258, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281363050, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652212, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=443, Percent_Identity=48.5327313769752, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=48.2758620689655, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=31.8271119842829, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=31.8271119842829, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=31.8271119842829, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=31.8271119842829, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49004; Mature: 49004

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHKVLIANRGEIALRVIRACKELGIKTVAVYSTADRDSLHVKLADESVCIGPAPSLQSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCHHHH
LNINAIISAAELTDAEAIHPGYGFLSENAAFAEICENCGITFIGPSSQSMRIMGDKISAR
HCHHHEEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCCEEEECCHHHHH
QAVIKENVPILPGTKEGVNDVNEAVKIAKKIGFPVIIKATAGGGGRGMKIVHSPAALPNA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCH
FATARAEAQAGFGNPEVYIEKYCEKPRHVEIQVMADKHGNVIHLGERDCSIQRRHQKIIE
HHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPCPVMTPALRKAMGDAAVRASKAVGYDSVGTVEFLVDKDLNFYFMEMNTRVQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMVTGIDIVREQIRSAAGLKLRYKQSDIKLHGHAIECRINAEDPVKFTPSPGKIVGYHTP
HHHHHHHHHHHHHHHHCCCEEEEECCCEEEECEEEEEEECCCCCEEECCCCCCEEEEECC
GGLGVRIDSFVYDQYSVVPHYDSLIAKLIVHAETREDAIRRMARALDEYIIEGIKTTIPF
CCCEEEEEEEEECCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
HKRIMDNKDFMEGNVDTGFLERIVLE
HHHHCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MFHKVLIANRGEIALRVIRACKELGIKTVAVYSTADRDSLHVKLADESVCIGPAPSLQSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCHHHH
LNINAIISAAELTDAEAIHPGYGFLSENAAFAEICENCGITFIGPSSQSMRIMGDKISAR
HCHHHEEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCCEEEECCHHHHH
QAVIKENVPILPGTKEGVNDVNEAVKIAKKIGFPVIIKATAGGGGRGMKIVHSPAALPNA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCH
FATARAEAQAGFGNPEVYIEKYCEKPRHVEIQVMADKHGNVIHLGERDCSIQRRHQKIIE
HHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPCPVMTPALRKAMGDAAVRASKAVGYDSVGTVEFLVDKDLNFYFMEMNTRVQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMVTGIDIVREQIRSAAGLKLRYKQSDIKLHGHAIECRINAEDPVKFTPSPGKIVGYHTP
HHHHHHHHHHHHHHHHCCCEEEEECCCEEEECEEEEEEECCCCCEEECCCCCCEEEEECC
GGLGVRIDSFVYDQYSVVPHYDSLIAKLIVHAETREDAIRRMARALDEYIIEGIKTTIPF
CCCEEEEEEEEECCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
HKRIMDNKDFMEGNVDTGFLERIVLE
HHHHCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]