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The map label for this gene is mutL

Identifier: 39997099

GI number: 39997099

Start: 2192669

End: 2194489

Strand: Reverse

Name: mutL

Synonym: GSU2001

Alternate gene names: 39997099

Gene position: 2194489-2192669 (Counterclockwise)

Preceding gene: 39997100

Following gene: 39997098

Centisome position: 57.54

GC content: 65.51

Gene sequence:

>1821_bases
ATGCCACACCGGATCAGGATACTGCCCGAGATACTCACCAACAAGATCGCTGCCGGCGAGGTGGTGGAACGCCCCGCATC
GGTGGTGAAGGAACTGGTGGAGAACGCCCTGGATGCCGGCTGCGGCGAGATAATCGTAGAGATCGAGGGGGGAGGGCGGC
GCCTCATCCGGATCACCGACGACGGCTGCGGCATGTCGCGGGAAGACGCCCTCATGGCCCTTGAGCGTCACGCCACCAGC
AAGATCGCCACGGACGACGACCTGTTCTCCCTGGCCACGCTCGGCTTCCGCGGAGAGGCGCTCCCCTCCGTGGCCTCGGT
CTCCCGCTTCACCCTCGCCACCCGCGAGCGGGGGAGCATCGAAGGAACCGAGATTTACGCCGAAGGGGGAAAGATCCGCG
AGGTGAAGGCCTGCGGCATGGCCGAGGGGACCGTGGTCTCGGTCCGCAATCTCTTCTTCAATACTCCGGCCCGTCTCAAG
TTCATGAAGAGTGTTGAGACCGAGGGGGGCCACGTGGCAGACCTGGTCACCCGGCTGGCCCTTTCCCGCCCGGAGGTTCG
CTTCACCTGCGTGAGCGACGGCAAGACCCTGTTCCGGGCCCTGGACGGCACCCTGCTGGACCGGGTGGCCGCACTTCTGG
GCAAGACCGTTGCCTCAGCCCTCCACCCCGTGGATCTGGCCACCGAGGGGGTGCGGGTGACCGGACTCGTGGCTCGCCCC
GATGTGAGCCGTTCCGCGGCATCGCACCTCTACACCTACATCAATGGTCGTTTCATCCGCGACCGCGTCGTGCAGCACGC
CATACTCCAGGCCTATCGCAACTTCCTGGAGCGGGGGCGCTACCCGGTGGTGGTTCTCTTTATCGAGGTTTCTCCCGGCG
AAGTAGACGTGAACGTCCATCCTACCAAGCACGAGGTCCGCTTCAGGCAGCAGGGGATCGTGCACGATGTGATCCAGGGG
GCCGTGGAGGAGACGCTCCGGCTCACGCCCTGGATTCGCCGCTCCGAGTCACCCGTTGCTGCGCCGCTGGCGGTGCCCCG
GCCGCAACAATACGTTCAGGGCACGGGTGCTCGTCAGGTGGAAGAAGTGCGGGAGCTTCTGGAAAACTACCGTCCCGCCG
TGGCTCCCCATCGGCCGCTCTTCGCGCCACAACCCGCACCGCAGCCGGATCGGGAGCCGCCTTTGCCCGATTCTGGCAGC
CGGATGCTGGACGACACGGCCGTGCGTCGTCACGGGGGCTATTTCTCTTCCCTTGCCGTCATCGGCCAGTACAACGCATC
CTACATCCTGTGCCAGGATGGCTCTGATCTGGTCATCATCGACCAGCATGCGGCCCACGAGCGGGTCGCCTTCGAGCGCC
TCAAGACGCAGTTCGCTGCCGGCCGGGTCGAGGGGCAGGGGCTTCTTTTCCCCGAGACCGTGGAGCTGTCTCACCGGGAA
TCGGCGGTGGTGCGGGAACACGGCGGCGAACTGGGCCGGCTCGGTTTCGATCTAGAGGATTTCGGGGGTACTACCTGGAT
CGTAAAGGGGATTCCGCGCCTGCTGGCAGGCACCGACTACCTGCGCCTGCTACGCGACACCCTTGAGGAGCTCCAGTCCC
TCGGAGCCAGCCGCAGCATCGCCGATGCCGTGGAGGATATCCTGACCCGCGTCGCCTGCCACAGCGTTGTGCGGGGCGAG
CACCCCCTGACCACCGGCGAGATTGAGGCCCTCTTCGCCCATATGGACGCCACCGACTTTTCCACCAATTGCCCCCATGG
CAGGCCCGTCCTCCAGCGACTTACGCTGGGGGAGGTGGAGAAGATGTTCAAGAGAGTGTGA

Upstream 100 bases:

>100_bases
GCGGCGGCAGCATCCAGGAGGAGAAGCATCCCAACCTGATCTACACCGCAATCAACGATGCCTTCCACGTAGTGGAAGCC
GTCAAGAGGAAGCTTGCCTG

Downstream 100 bases:

>100_bases
CCGCTATCATGGGCAATCAGGCCGGGTCAAAGACAAAACTCGTCATAATCCAGGGGCCGACTGCATCGGGCAAGTCAGAA
CTTGCGGTCCGGCTGGCGGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MPHRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITDDGCGMSREDALMALERHATS
KIATDDDLFSLATLGFRGEALPSVASVSRFTLATRERGSIEGTEIYAEGGKIREVKACGMAEGTVVSVRNLFFNTPARLK
FMKSVETEGGHVADLVTRLALSRPEVRFTCVSDGKTLFRALDGTLLDRVAALLGKTVASALHPVDLATEGVRVTGLVARP
DVSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVHPTKHEVRFRQQGIVHDVIQG
AVEETLRLTPWIRRSESPVAAPLAVPRPQQYVQGTGARQVEEVRELLENYRPAVAPHRPLFAPQPAPQPDREPPLPDSGS
RMLDDTAVRRHGGYFSSLAVIGQYNASYILCQDGSDLVIIDQHAAHERVAFERLKTQFAAGRVEGQGLLFPETVELSHRE
SAVVREHGGELGRLGFDLEDFGGTTWIVKGIPRLLAGTDYLRLLRDTLEELQSLGASRSIADAVEDILTRVACHSVVRGE
HPLTTGEIEALFAHMDATDFSTNCPHGRPVLQRLTLGEVEKMFKRV

Sequences:

>Translated_606_residues
MPHRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITDDGCGMSREDALMALERHATS
KIATDDDLFSLATLGFRGEALPSVASVSRFTLATRERGSIEGTEIYAEGGKIREVKACGMAEGTVVSVRNLFFNTPARLK
FMKSVETEGGHVADLVTRLALSRPEVRFTCVSDGKTLFRALDGTLLDRVAALLGKTVASALHPVDLATEGVRVTGLVARP
DVSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVHPTKHEVRFRQQGIVHDVIQG
AVEETLRLTPWIRRSESPVAAPLAVPRPQQYVQGTGARQVEEVRELLENYRPAVAPHRPLFAPQPAPQPDREPPLPDSGS
RMLDDTAVRRHGGYFSSLAVIGQYNASYILCQDGSDLVIIDQHAAHERVAFERLKTQFAAGRVEGQGLLFPETVELSHRE
SAVVREHGGELGRLGFDLEDFGGTTWIVKGIPRLLAGTDYLRLLRDTLEELQSLGASRSIADAVEDILTRVACHSVVRGE
HPLTTGEIEALFAHMDATDFSTNCPHGRPVLQRLTLGEVEKMFKRV
>Mature_605_residues
PHRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITDDGCGMSREDALMALERHATSK
IATDDDLFSLATLGFRGEALPSVASVSRFTLATRERGSIEGTEIYAEGGKIREVKACGMAEGTVVSVRNLFFNTPARLKF
MKSVETEGGHVADLVTRLALSRPEVRFTCVSDGKTLFRALDGTLLDRVAALLGKTVASALHPVDLATEGVRVTGLVARPD
VSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVHPTKHEVRFRQQGIVHDVIQGA
VEETLRLTPWIRRSESPVAAPLAVPRPQQYVQGTGARQVEEVRELLENYRPAVAPHRPLFAPQPAPQPDREPPLPDSGSR
MLDDTAVRRHGGYFSSLAVIGQYNASYILCQDGSDLVIIDQHAAHERVAFERLKTQFAAGRVEGQGLLFPETVELSHRES
AVVREHGGELGRLGFDLEDFGGTTWIVKGIPRLLAGTDYLRLLRDTLEELQSLGASRSIADAVEDILTRVACHSVVRGEH
PLTTGEIEALFAHMDATDFSTNCPHGRPVLQRLTLGEVEKMFKRV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=34.1463414634146, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=28.4403669724771, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI189458898, Length=324, Percent_Identity=28.3950617283951, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4505913, Length=337, Percent_Identity=27.5964391691395, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128478, Length=337, Percent_Identity=27.5964391691395, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI189458896, Length=322, Percent_Identity=27.0186335403727, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=28.2051282051282, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=25.752508361204, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI91992162, Length=361, Percent_Identity=22.9916897506925, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI91992160, Length=361, Percent_Identity=22.9916897506925, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790612, Length=519, Percent_Identity=36.8015414258189, Blast_Score=279, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71991825, Length=317, Percent_Identity=34.384858044164, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=26.4623955431755, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=363, Percent_Identity=32.7823691460055, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=376, Percent_Identity=23.6702127659574, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=719, Percent_Identity=21.4186369958275, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=33.433734939759, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17136970, Length=392, Percent_Identity=23.469387755102, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_GEOSL (Q74BP0)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953050.1
- HSSP:   P23367
- ProteinModelPortal:   Q74BP0
- SMR:   Q74BP0
- GeneID:   2688110
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2001
- NMPDR:   fig|243231.1.peg.1988
- TIGR:   GSU2001
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   GSUL243231:GSU_2001-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 66599; Mature: 66468

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITD
CCCCEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEC
DGCGMSREDALMALERHATSKIATDDDLFSLATLGFRGEALPSVASVSRFTLATRERGSI
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
EGTEIYAEGGKIREVKACGMAEGTVVSVRNLFFNTPARLKFMKSVETEGGHVADLVTRLA
CCCEEEECCCCEEEEHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
LSRPEVRFTCVSDGKTLFRALDGTLLDRVAALLGKTVASALHPVDLATEGVRVTGLVARP
HCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEECC
DVSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVH
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEC
PTKHEVRFRQQGIVHDVIQGAVEETLRLTPWIRRSESPVAAPLAVPRPQQYVQGTGARQV
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHCCCCHHHH
EEVRELLENYRPAVAPHRPLFAPQPAPQPDREPPLPDSGSRMLDDTAVRRHGGYFSSLAV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHH
IGQYNASYILCQDGSDLVIIDQHAAHERVAFERLKTQFAAGRVEGQGLLFPETVELSHRE
EEECCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCHH
SAVVREHGGELGRLGFDLEDFGGTTWIVKGIPRLLAGTDYLRLLRDTLEELQSLGASRSI
HHHHHHCCCCHHHCCCCHHHCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
ADAVEDILTRVACHSVVRGEHPLTTGEIEALFAHMDATDFSTNCPHGRPVLQRLTLGEVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
KMFKRV
HHHHCC
>Mature Secondary Structure 
PHRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITD
CCCEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEC
DGCGMSREDALMALERHATSKIATDDDLFSLATLGFRGEALPSVASVSRFTLATRERGSI
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
EGTEIYAEGGKIREVKACGMAEGTVVSVRNLFFNTPARLKFMKSVETEGGHVADLVTRLA
CCCEEEECCCCEEEEHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
LSRPEVRFTCVSDGKTLFRALDGTLLDRVAALLGKTVASALHPVDLATEGVRVTGLVARP
HCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEECC
DVSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVH
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEC
PTKHEVRFRQQGIVHDVIQGAVEETLRLTPWIRRSESPVAAPLAVPRPQQYVQGTGARQV
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHCCCCHHHH
EEVRELLENYRPAVAPHRPLFAPQPAPQPDREPPLPDSGSRMLDDTAVRRHGGYFSSLAV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHH
IGQYNASYILCQDGSDLVIIDQHAAHERVAFERLKTQFAAGRVEGQGLLFPETVELSHRE
EEECCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCHH
SAVVREHGGELGRLGFDLEDFGGTTWIVKGIPRLLAGTDYLRLLRDTLEELQSLGASRSI
HHHHHHCCCCHHHCCCCHHHCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
ADAVEDILTRVACHSVVRGEHPLTTGEIEALFAHMDATDFSTNCPHGRPVLQRLTLGEVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
KMFKRV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA