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The map label for this gene is capL [H]

Identifier: 39997040

GI number: 39997040

Start: 2126686

End: 2127972

Strand: Reverse

Name: capL [H]

Synonym: GSU1942

Alternate gene names: 39997040

Gene position: 2127972-2126686 (Counterclockwise)

Preceding gene: 39997041

Following gene: 39997039

Centisome position: 55.79

GC content: 60.92

Gene sequence:

>1287_bases
ATGACCGCTGACCGCACCATTTCCGTTATCGGACTCGGCTACGTGGGACTCCCCGTGGCGGTTGCCTTCGGCCGTGTCCG
TCGGACTGTCGGATTCGACATCAATGCCGGCCGCATCGCCGAGCTCAAGCAGGGGATCGATCGAACCGGCGAGGTGACTG
CTGAGGCCCTGGCCGCAGCGAACATCCTTTTCACCGACCGCATCGAGGAACTCCGTCTGGCGGATTTTCACATCGTGGCG
GTGCCGACTCCCATCGATGAAGCGAATCAGCCCGACCTTACCCTGATGCTGAAGGCGTCGGAAACGGTGGGTAAGGCCCT
GAAGCAGGGCGACATCGTGGTGTACGAGTCCACAGTGTATCCCGGTGTCACTGAGGACGAGTGCGTGCCGATCCTGGAAC
GGGTGTCGGGACTGCGCTGCGGCACCGATTTCACCGTGGGCTACAGCCCTGAGCGGATCAATCCGGGCGACAGGGAGCAT
ACTTTCACGAAGATCACCAAAGTAGTGTCGGGGCAGGATGCTGCGACACTCGACGTAGTTGCCCGAGTGTATGAATCAGT
GGTGACGGCGGGGGTTCACCGGGCGTCGAGCATCAAGGTGGCCGAAGCGGCCAAGGTGATTGAGAACACACAACGGGACC
TGAACATCGCCCTCATGAACGAGTTGGCCCTGATTTTCGACCGGCTGGGCATCGACACTAGCGAGGTGCTGGAGGCGGCC
GGAACCAAGTGGAACTTCCTCAGGTTCAAGCCGGGGCTCGTGGGAGGGCATTGCATCGGTGTGGATCCGTACTATCTGAC
CCACAAGGCGGAGAAGATCGGTTACATCCCCCAGGTGATCCTGGCGGGCCGCAGGATCAACGACGGTATGGGCAAATTCG
TGGCCCAGAAGACGGTGAAAGAGATGATCCTGGCCGGACACCCGGTTCTGGGAGCCAGGGTGACGGTGCTCGGCCTCACC
TTCAAGGAGGATTGCCCTGACCTGCGCAATTCCCGAGTGATCGACATTATCCGCGAACTTGAGGAGTATGGTGTGAAGGT
TCAGGTCTACGACCCCTTGGCCGACCCCAACGAGGCCCTGCATGAATACGGGGTGACGCTTGTGCCGGCAGATGGTCTGG
AGCCTGCAGCTGCGGTGGTTGCCGCTGTGGCACACCGTCAGTTCCGGTCCCTGGCCGGGGATGACTTGCTTCGATTGATG
GGGCACCCCCCGGTTCTCATGGACGTTAAGGGTATGTACGACCAGAACATGCTGCGGCAGGCGGGAATCCGCTTCTGGAG
GCTCTGA

Upstream 100 bases:

>100_bases
TTGTGCCTGCACAAGATTTGGTGTAAATTTTATCGACAGTTGGTAGAAGATAACCTTGGAACTGCACGTGATTCATGGGA
TCGAGCAAAAGGAGCGCTCA

Downstream 100 bases:

>100_bases
GCCGGTCATGATGCAGTTGGTCCTTTCAGCGGCGGCGGTACTGCTCTCCCTGGCCGTAATCGGAGTCACCATCCGCCGTC
AGGGGCTTACCCTTTCAGTC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTADRTISVIGLGYVGLPVAVAFGRVRRTVGFDINAGRIAELKQGIDRTGEVTAEALAAANILFTDRIEELRLADFHIVA
VPTPIDEANQPDLTLMLKASETVGKALKQGDIVVYESTVYPGVTEDECVPILERVSGLRCGTDFTVGYSPERINPGDREH
TFTKITKVVSGQDAATLDVVARVYESVVTAGVHRASSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLEAA
GTKWNFLRFKPGLVGGHCIGVDPYYLTHKAEKIGYIPQVILAGRRINDGMGKFVAQKTVKEMILAGHPVLGARVTVLGLT
FKEDCPDLRNSRVIDIIRELEEYGVKVQVYDPLADPNEALHEYGVTLVPADGLEPAAAVVAAVAHRQFRSLAGDDLLRLM
GHPPVLMDVKGMYDQNMLRQAGIRFWRL

Sequences:

>Translated_428_residues
MTADRTISVIGLGYVGLPVAVAFGRVRRTVGFDINAGRIAELKQGIDRTGEVTAEALAAANILFTDRIEELRLADFHIVA
VPTPIDEANQPDLTLMLKASETVGKALKQGDIVVYESTVYPGVTEDECVPILERVSGLRCGTDFTVGYSPERINPGDREH
TFTKITKVVSGQDAATLDVVARVYESVVTAGVHRASSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLEAA
GTKWNFLRFKPGLVGGHCIGVDPYYLTHKAEKIGYIPQVILAGRRINDGMGKFVAQKTVKEMILAGHPVLGARVTVLGLT
FKEDCPDLRNSRVIDIIRELEEYGVKVQVYDPLADPNEALHEYGVTLVPADGLEPAAAVVAAVAHRQFRSLAGDDLLRLM
GHPPVLMDVKGMYDQNMLRQAGIRFWRL
>Mature_427_residues
TADRTISVIGLGYVGLPVAVAFGRVRRTVGFDINAGRIAELKQGIDRTGEVTAEALAAANILFTDRIEELRLADFHIVAV
PTPIDEANQPDLTLMLKASETVGKALKQGDIVVYESTVYPGVTEDECVPILERVSGLRCGTDFTVGYSPERINPGDREHT
FTKITKVVSGQDAATLDVVARVYESVVTAGVHRASSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLEAAG
TKWNFLRFKPGLVGGHCIGVDPYYLTHKAEKIGYIPQVILAGRRINDGMGKFVAQKTVKEMILAGHPVLGARVTVLGLTF
KEDCPDLRNSRVIDIIRELEEYGVKVQVYDPLADPNEALHEYGVTLVPADGLEPAAAVVAAVAHRQFRSLAGDDLLRLMG
HPPVLMDVKGMYDQNMLRQAGIRFWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=434, Percent_Identity=29.2626728110599, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=24.9457700650759, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=21.1663066954644, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46696; Mature: 46565

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADRTISVIGLGYVGLPVAVAFGRVRRTVGFDINAGRIAELKQGIDRTGEVTAEALAAA
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
NILFTDRIEELRLADFHIVAVPTPIDEANQPDLTLMLKASETVGKALKQGDIVVYESTVY
HHHHHHHHHHHEECCEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCCEEEEECCCC
PGVTEDECVPILERVSGLRCGTDFTVGYSPERINPGDREHTFTKITKVVSGQDAATLDVV
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
ARVYESVVTAGVHRASSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLEAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GTKWNFLRFKPGLVGGHCIGVDPYYLTHKAEKIGYIPQVILAGRRINDGMGKFVAQKTVK
CCCEEEEEECCCCCCCEEECCCCHHEECCHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHH
EMILAGHPVLGARVTVLGLTFKEDCPDLRNSRVIDIIRELEEYGVKVQVYDPLADPNEAL
HHHHCCCCCCCCEEEEEEEEEHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHH
HEYGVTLVPADGLEPAAAVVAAVAHRQFRSLAGDDLLRLMGHPPVLMDVKGMYDQNMLRQ
HHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
AGIRFWRL
HCCCCCCC
>Mature Secondary Structure 
TADRTISVIGLGYVGLPVAVAFGRVRRTVGFDINAGRIAELKQGIDRTGEVTAEALAAA
CCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
NILFTDRIEELRLADFHIVAVPTPIDEANQPDLTLMLKASETVGKALKQGDIVVYESTVY
HHHHHHHHHHHEECCEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCCEEEEECCCC
PGVTEDECVPILERVSGLRCGTDFTVGYSPERINPGDREHTFTKITKVVSGQDAATLDVV
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
ARVYESVVTAGVHRASSIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTSEVLEAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GTKWNFLRFKPGLVGGHCIGVDPYYLTHKAEKIGYIPQVILAGRRINDGMGKFVAQKTVK
CCCEEEEEECCCCCCCEEECCCCHHEECCHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHH
EMILAGHPVLGARVTVLGLTFKEDCPDLRNSRVIDIIRELEEYGVKVQVYDPLADPNEAL
HHHHCCCCCCCCEEEEEEEEEHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHH
HEYGVTLVPADGLEPAAAVVAAVAHRQFRSLAGDDLLRLMGHPPVLMDVKGMYDQNMLRQ
HHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
AGIRFWRL
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]