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The map label for this gene is folP [H]

Identifier: 39996907

GI number: 39996907

Start: 1972864

End: 1973775

Strand: Reverse

Name: folP [H]

Synonym: GSU1808

Alternate gene names: 39996907

Gene position: 1973775-1972864 (Counterclockwise)

Preceding gene: 39996908

Following gene: 39996906

Centisome position: 51.75

GC content: 61.4

Gene sequence:

>912_bases
ATGACTCCATTGACTGCCCAATGCTCCGGAACCTTACTTTGCGCGGAGCACGCCACCGGACAGCACCATGCCGGGGTATG
GCGACTGCGTAGCCGGCGCATTGACCTTACATCCCGTCCTTGTATCATGGGGGTCCTTAACGTGACCCCCGATTCATTTT
CTGACGGCAATTGCTACCTGGACCCCGCTGCGGCGGAAGATCGGGCTCTTGCCATGGTGGCTGAAGGGGCAGATATTGTT
GATATCGGCGGTGAAAGCACCCGCCCAGGTGCACCTTCGGTCAGCGAAGCTGAAGAAATGCAACGGGTGGTGCCTCTTGT
GGAGCGCCTTGCCGCAAAACTGCCGGTTCCTCTTTCCGTCGATACCTACAAGGCTGCTGTAGCCCGCGAGGCTCTTGCCG
CCGGCGCAGAGGTCATCAACGATATCAGCGGCCTGACCTTTGACCCGGGCATGGCGACCACCGTGGCCGAGGCCCGGGCG
GGACTCGTGGTCATGCACACACGCGGCACCCCGGCGATGATGCAGCGCGATACGGCCTATGACGATCTGATTGCCGAAGT
GCTCGGATCGCTGCGCTACTCTATGGGTCGCGCACAGGCGGCGGGAATCCCCAATGAGCAGATCGTAGTGGATCCGGGCA
TCGGTTTCGGCAAAAGCGTTGACGGGAATCTGGAAATTCTCCGGCGTCTTGCGGAGTTTGCCAGCCTGGGACGGCCCATA
CTCGTCGGTACTTCCCGCAAGTCGTTCATAGGCGCCGTTCTTGACAGGGAGGTAGCAGATCGCCTGTTCGGAACCGCCGC
CACGGTGGCGGTGGCCGTGGCAAACGGCGCCTCCATACTGAGAGTTCATGATGTTCGGGCCATGCGGGATGTGGCCCTGA
TGACCCGGGCGATTCTTGCTCCGCGACGCTGA

Upstream 100 bases:

>100_bases
TTATCGAGAAAGAGAACCTGACCGGCGACGAAGTTGACCGGATCATCAAGGATGACTGCGCGGCCAGCCGCGCTGCAGTC
GAAGAGGCCCCCGTGGCTCC

Downstream 100 bases:

>100_bases
TCACACCCCATTTACCGTACTGATTCAGCCCACCCCTGTCAGGTGACGACGATGACCGAGCCACTCCAGATCTTCGGTTG
GCGCGACGCAATCGATATCG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTPLTAQCSGTLLCAEHATGQHHAGVWRLRSRRIDLTSRPCIMGVLNVTPDSFSDGNCYLDPAAAEDRALAMVAEGADIV
DIGGESTRPGAPSVSEAEEMQRVVPLVERLAAKLPVPLSVDTYKAAVAREALAAGAEVINDISGLTFDPGMATTVAEARA
GLVVMHTRGTPAMMQRDTAYDDLIAEVLGSLRYSMGRAQAAGIPNEQIVVDPGIGFGKSVDGNLEILRRLAEFASLGRPI
LVGTSRKSFIGAVLDREVADRLFGTAATVAVAVANGASILRVHDVRAMRDVALMTRAILAPRR

Sequences:

>Translated_303_residues
MTPLTAQCSGTLLCAEHATGQHHAGVWRLRSRRIDLTSRPCIMGVLNVTPDSFSDGNCYLDPAAAEDRALAMVAEGADIV
DIGGESTRPGAPSVSEAEEMQRVVPLVERLAAKLPVPLSVDTYKAAVAREALAAGAEVINDISGLTFDPGMATTVAEARA
GLVVMHTRGTPAMMQRDTAYDDLIAEVLGSLRYSMGRAQAAGIPNEQIVVDPGIGFGKSVDGNLEILRRLAEFASLGRPI
LVGTSRKSFIGAVLDREVADRLFGTAATVAVAVANGASILRVHDVRAMRDVALMTRAILAPRR
>Mature_302_residues
TPLTAQCSGTLLCAEHATGQHHAGVWRLRSRRIDLTSRPCIMGVLNVTPDSFSDGNCYLDPAAAEDRALAMVAEGADIVD
IGGESTRPGAPSVSEAEEMQRVVPLVERLAAKLPVPLSVDTYKAAVAREALAAGAEVINDISGLTFDPGMATTVAEARAG
LVVMHTRGTPAMMQRDTAYDDLIAEVLGSLRYSMGRAQAAGIPNEQIVVDPGIGFGKSVDGNLEILRRLAEFASLGRPIL
VGTSRKSFIGAVLDREVADRLFGTAATVAVAVANGASILRVHDVRAMRDVALMTRAILAPRR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=270, Percent_Identity=44.8148148148148, Blast_Score=225, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324073, Length=302, Percent_Identity=32.4503311258278, Blast_Score=149, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31968; Mature: 31837

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLTAQCSGTLLCAEHATGQHHAGVWRLRSRRIDLTSRPCIMGVLNVTPDSFSDGNCYL
CCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEE
DPAAAEDRALAMVAEGADIVDIGGESTRPGAPSVSEAEEMQRVVPLVERLAAKLPVPLSV
CCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
DTYKAAVAREALAAGAEVINDISGLTFDPGMATTVAEARAGLVVMHTRGTPAMMQRDTAY
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCEEEEEECCCHHHHHCCCHH
DDLIAEVLGSLRYSMGRAQAAGIPNEQIVVDPGIGFGKSVDGNLEILRRLAEFASLGRPI
HHHHHHHHHHHHHHHCHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
LVGTSRKSFIGAVLDREVADRLFGTAATVAVAVANGASILRVHDVRAMRDVALMTRAILA
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHC
PRR
CCC
>Mature Secondary Structure 
TPLTAQCSGTLLCAEHATGQHHAGVWRLRSRRIDLTSRPCIMGVLNVTPDSFSDGNCYL
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEE
DPAAAEDRALAMVAEGADIVDIGGESTRPGAPSVSEAEEMQRVVPLVERLAAKLPVPLSV
CCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
DTYKAAVAREALAAGAEVINDISGLTFDPGMATTVAEARAGLVVMHTRGTPAMMQRDTAY
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCEEEEEECCCHHHHHCCCHH
DDLIAEVLGSLRYSMGRAQAAGIPNEQIVVDPGIGFGKSVDGNLEILRRLAEFASLGRPI
HHHHHHHHHHHHHHHCHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
LVGTSRKSFIGAVLDREVADRLFGTAATVAVAVANGASILRVHDVRAMRDVALMTRAILA
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHC
PRR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]