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The map label for this gene is lysC [H]

Identifier: 39996898

GI number: 39996898

Start: 1965367

End: 1966584

Strand: Reverse

Name: lysC [H]

Synonym: GSU1799

Alternate gene names: 39996898

Gene position: 1966584-1965367 (Counterclockwise)

Preceding gene: 39996899

Following gene: 39996897

Centisome position: 51.56

GC content: 53.04

Gene sequence:

>1218_bases
ATGGCACTGGTGGTCCAGAAATACGGCGGCACCTCGATGGGGTCCATCGAGCGCATCCGCAATGTTGCCAAACGGGTCGC
CAAGACCTATGACGCCGGAAACGATATGGTTGTTGTCGTTTCCGCCATGTCGGGAGAAACCAACAAGCTCGTGGCCCTCG
CCAATGAGATTTGCGAATTCCCGGATACCCGCGAATATGATGTGCTGGTGGCGTCGGGCGAGCAGGTCTCCATAGCTCTC
CTTGCCATGTGCCTCAAGTCGATGGGCTACAAGGCCAAGTCATATCATGGCTGGCAGATACCCATTATCACTGACAGCGC
TTTCAGCAAGGCTCGAATCGAGAGCATCGACGACACCAAGGTGCGCGCTGACCTTAAAGACGGCTCCATTGTCATTGTCG
CCGGTTTCCAGGGCGTCGACAAAGATGGCAATATCACTACTCTGGGCCGTGGTGGCTCCGATACCTCGGCGGTTGCCGTA
GCTGCCGCCTTCAAAGCGGATGTGTGCGAGATTTTCACCGACGTGGACGGCGTTTATACCACTGATCCGAATATTTGCCA
GGATGCCCGGAAAATTGAGAAGGTATCCTATGATGAGATGCTGGAACTCGCCTCGCTCGGGGCGAAGGTTCTTCAGATCC
GTTCCGTAGAATTTGCGAAGAAGTACAATGTGGACGTTCATGTCCGCTCCAGCTTCAATGAAAATCCAGGGACCATGGTT
ACCAAGGAGGATAAGGATATGGAAGCAGTTCTCGTTTCGGGAATCGCCTACGACAAGAACGAAGCAAAAATTGCCGTGAT
GGGGGTACCCGACAAACCGGGAATCGCCGCCAAAATTCTGTCGCCCCTTTCCGACGCCAATATATCGGTCGATATGATTG
TCCAGAATGTAAGCGGGGGTGACCTGACCGATTTCACCTTCACTGTTACCAAGGCAGATTTCAAGAAAGCCCTCGCCATC
ACCAAGGAAGTGGCCAAGGAGATCAGTGCCAAAGAGGTGGCAGAGGACGAAAACATTTCAAAAATATCCATCGTTGGTGT
CGGCATGCGGAGCCATGCGGGGGTTGCCACCAAAATGTTCCAGACCCTTGCCAAGGAAGGGATCAACATCCAGATGATCT
CCACTTCTGAAATCAAGGTTTCGGTCATTGTTGACGCAAAATACACCGAACTGGCCGTTCGGGTGCTTCACGAAGCGTTC
GGACTCTCCGGCAAATAA

Upstream 100 bases:

>100_bases
CACTGGTCTGATTCCTGCTATTAAGTGACGACCTGCGGTCGTGTCCTGTATACAAACTGCAGTATGACACATATGATCCA
GAGCAAAGGAGGAACGGTAG

Downstream 100 bases:

>100_bases
AGAAACTTCCAGAGCGGAAGCGCGGAATTTCGAAGGCGCGGGGGAGAAAATCGATCATTTGATTTTTTCTTCCGCGCTTT
CGTACATGCGCCTCGCCGTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEICEFPDTREYDVLVASGEQVSIAL
LAMCLKSMGYKAKSYHGWQIPIITDSAFSKARIESIDDTKVRADLKDGSIVIVAGFQGVDKDGNITTLGRGGSDTSAVAV
AAAFKADVCEIFTDVDGVYTTDPNICQDARKIEKVSYDEMLELASLGAKVLQIRSVEFAKKYNVDVHVRSSFNENPGTMV
TKEDKDMEAVLVSGIAYDKNEAKIAVMGVPDKPGIAAKILSPLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAI
TKEVAKEISAKEVAEDENISKISIVGVGMRSHAGVATKMFQTLAKEGINIQMISTSEIKVSVIVDAKYTELAVRVLHEAF
GLSGK

Sequences:

>Translated_405_residues
MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEICEFPDTREYDVLVASGEQVSIAL
LAMCLKSMGYKAKSYHGWQIPIITDSAFSKARIESIDDTKVRADLKDGSIVIVAGFQGVDKDGNITTLGRGGSDTSAVAV
AAAFKADVCEIFTDVDGVYTTDPNICQDARKIEKVSYDEMLELASLGAKVLQIRSVEFAKKYNVDVHVRSSFNENPGTMV
TKEDKDMEAVLVSGIAYDKNEAKIAVMGVPDKPGIAAKILSPLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAI
TKEVAKEISAKEVAEDENISKISIVGVGMRSHAGVATKMFQTLAKEGINIQMISTSEIKVSVIVDAKYTELAVRVLHEAF
GLSGK
>Mature_404_residues
ALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEICEFPDTREYDVLVASGEQVSIALL
AMCLKSMGYKAKSYHGWQIPIITDSAFSKARIESIDDTKVRADLKDGSIVIVAGFQGVDKDGNITTLGRGGSDTSAVAVA
AAFKADVCEIFTDVDGVYTTDPNICQDARKIEKVSYDEMLELASLGAKVLQIRSVEFAKKYNVDVHVRSSFNENPGTMVT
KEDKDMEAVLVSGIAYDKNEAKIAVMGVPDKPGIAAKILSPLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAIT
KEVAKEISAKEVAEDENISKISIVGVGMRSHAGVATKMFQTLAKEGINIQMISTSEIKVSVIVDAKYTELAVRVLHEAFG
LSGK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=347, Percent_Identity=34.2939481268012, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790455, Length=456, Percent_Identity=28.2894736842105, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790376, Length=286, Percent_Identity=24.4755244755245, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=494, Percent_Identity=23.8866396761134, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43436; Mature: 43305

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEICEF
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCC
PDTREYDVLVASGEQVSIALLAMCLKSMGYKAKSYHGWQIPIITDSAFSKARIESIDDTK
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHCCCCCCE
VRADLKDGSIVIVAGFQGVDKDGNITTLGRGGSDTSAVAVAAAFKADVCEIFTDVDGVYT
EEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICQDARKIEKVSYDEMLELASLGAKVLQIRSVEFAKKYNVDVHVRSSFNENPGTMV
CCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEE
TKEDKDMEAVLVSGIAYDKNEAKIAVMGVPDKPGIAAKILSPLSDANISVDMIVQNVSGG
ECCCCCHHHHEEECEEECCCCCEEEEEECCCCCCHHHHHHCCCCCCCCEEEEEEEECCCC
DLTDFTFTVTKADFKKALAITKEVAKEISAKEVAEDENISKISIVGVGMRSHAGVATKMF
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHH
QTLAKEGINIQMISTSEIKVSVIVDAKYTELAVRVLHEAFGLSGK
HHHHHCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEICEF
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCC
PDTREYDVLVASGEQVSIALLAMCLKSMGYKAKSYHGWQIPIITDSAFSKARIESIDDTK
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHCCCCCCE
VRADLKDGSIVIVAGFQGVDKDGNITTLGRGGSDTSAVAVAAAFKADVCEIFTDVDGVYT
EEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICQDARKIEKVSYDEMLELASLGAKVLQIRSVEFAKKYNVDVHVRSSFNENPGTMV
CCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEE
TKEDKDMEAVLVSGIAYDKNEAKIAVMGVPDKPGIAAKILSPLSDANISVDMIVQNVSGG
ECCCCCHHHHEEECEEECCCCCEEEEEECCCCCCHHHHHHCCCCCCCCEEEEEEEECCCC
DLTDFTFTVTKADFKKALAITKEVAKEISAKEVAEDENISKISIVGVGMRSHAGVATKMF
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHH
QTLAKEGINIQMISTSEIKVSVIVDAKYTELAVRVLHEAFGLSGK
HHHHHCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]