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The map label for this gene is clpP [H]

Identifier: 39996891

GI number: 39996891

Start: 1957709

End: 1958308

Strand: Reverse

Name: clpP [H]

Synonym: GSU1792

Alternate gene names: 39996891

Gene position: 1958308-1957709 (Counterclockwise)

Preceding gene: 39996892

Following gene: 39996890

Centisome position: 51.34

GC content: 51.17

Gene sequence:

>600_bases
ATGCTTGTACCGATAGTGGTCGAACAAACGGGTAGGGGTGAACGTTCCTACGATATTTATTCGAGGCTCCTGAAGGATCG
CATTATCTTTCTTGGCGGCCCCGTTGACGACCACGTTGCGAATCTGGTCATAGCCCAGATGCTTTTTCTCGAGGCCGAGG
ATCCGGACAAGGATATCCATCTGTACATCAACTCGCCGGGCGGCGTTGTAACATCGGGTATGGCCATCTACGACACCATG
CAGTACATAAAAGCACCCGTGTCGACAATTTGCGTGGGGCAGGCCGCTTCAATGGGGGCGTTGCTTTTGTCGGGCGGGGA
GAAGGGAAAGCGTTTCAGCTTGAAGCATTCCCGGATTATGATCCATCAGCCTTTAGGTGGATTCCAGGGTCAGGCAACGG
ATATTCATATTCATGCCCAGGAAATTCTGAAGCTTAAAAAACGGCTGAACGAGATTCTTGCCGAAAATACAGGGCAGCAA
CTGGCCAAGGTTGAAGCCGATACCGAGCGCGACTATTTTATGTCTGGAGCGGAGGCGAAGGACTATGGTATCATTGATAA
CATAATTGAGCGCAATACTCCCAGCGGAGGTACTCGGTGA

Upstream 100 bases:

>100_bases
TGTAGCGCACTTGGCCGAGGAGAAGGTCATGTCGTTTCTTCTGGGTAGCGCAGTAATCAGCGAGAAGACGAAAGAGTAAC
CTGTGGAGCGAGGAGGCAAC

Downstream 100 bases:

>100_bases
GTAGGAGAAACGACGGCAGCGACAATCTCACCTGCTCCTTTTGTGGTAAGAGCCAGGATGAAGTAAAAAAGCTCATTGCC
GGACCAACGGTATATATTTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPVDDHVANLVIAQMLFLEAEDPDKDIHLYINSPGGVVTSGMAIYDTM
QYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLKHSRIMIHQPLGGFQGQATDIHIHAQEILKLKKRLNEILAENTGQQ
LAKVEADTERDYFMSGAEAKDYGIIDNIIERNTPSGGTR

Sequences:

>Translated_199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPVDDHVANLVIAQMLFLEAEDPDKDIHLYINSPGGVVTSGMAIYDTM
QYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLKHSRIMIHQPLGGFQGQATDIHIHAQEILKLKKRLNEILAENTGQQ
LAKVEADTERDYFMSGAEAKDYGIIDNIIERNTPSGGTR
>Mature_199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPVDDHVANLVIAQMLFLEAEDPDKDIHLYINSPGGVVTSGMAIYDTM
QYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLKHSRIMIHQPLGGFQGQATDIHIHAQEILKLKKRLNEILAENTGQQ
LAKVEADTERDYFMSGAEAKDYGIIDNIIERNTPSGGTR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=64.3617021276596, Blast_Score=256, Evalue=8e-69,
Organism=Escherichia coli, GI1786641, Length=188, Percent_Identity=70.7446808510638, Blast_Score=293, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=56.8421052631579, Blast_Score=229, Evalue=8e-61,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=59.7883597883598, Blast_Score=245, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21869; Mature: 21869

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPVDDHVANLVIAQMLFLEAEDPDKDIH
CEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTSGMAIYDTMQYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLKHSRIM
EEECCCCCEEECCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCEEEECCCEEE
IHQPLGGFQGQATDIHIHAQEILKLKKRLNEILAENTGQQLAKVEADTERDYFMSGAEAK
EECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHCCCCCC
DYGIIDNIIERNTPSGGTR
CCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPVDDHVANLVIAQMLFLEAEDPDKDIH
CEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTSGMAIYDTMQYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLKHSRIM
EEECCCCCEEECCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCEEEECCCEEE
IHQPLGGFQGQATDIHIHAQEILKLKKRLNEILAENTGQQLAKVEADTERDYFMSGAEAK
EECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHCCCCCC
DYGIIDNIIERNTPSGGTR
CCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA