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The map label for this gene is xseA

Identifier: 39996866

GI number: 39996866

Start: 1929198

End: 1930541

Strand: Reverse

Name: xseA

Synonym: GSU1767

Alternate gene names: 39996866

Gene position: 1930541-1929198 (Counterclockwise)

Preceding gene: 39996868

Following gene: 39996865

Centisome position: 50.62

GC content: 62.13

Gene sequence:

>1344_bases
GTGGATATCTTTTCTGAAAAACGAATCCTGACCGTGTCCCAGCTCACCTCGCTGATTCGCGGGGTGCTTGAGGAAAACTT
CGAGCACGTGTGGGTGGAAGGGGAGGTGTCGAACCTGGCCACGCCGGCCTCCGGCCACCTCTACTTCACGCTGAAGGACG
GAGCGGCCCAGATCCGTTGCGTCATGTTCAGGGCATCATCCAGGGCACTGAAATTTCGTCCCCGCGACGGGATGGGCCTC
ATCGTCCGCGGGAGAGTCACGGTGTACGATCAGCGGGGTGAGTACCAACTGCTGGTGGAATACCTCGAGCCCCGCGGGAT
CGGAGCCTTGCAACTGGCCTTCATTCAGCTGAAGGAGCAATTGGCCCGGGAAGGGCTGTTCGCTGACGAGCACAAGAAAC
CTATTCCACCGTTGCCTCAGAAGATTGGAGTGGTCACCTCGGCCACGGGGGCGGCAATTCACGACATCCTTACCGTGCTG
AACCGCCGCTTCGCCAACGTGGAGATCCTCATCCGGCCGGTAAAAGTCCAGGGTGAGGGGGCTGCGGAGGAAATCGCCGC
GGCGATTGACGACTTCAACCGCTACGGCGTCATCGACGTGATGATCGTCGGGCGGGGGGGCGGATCGCTCGAGGATCTAT
GGGCATTCAACGAGGAAATGGTTGCTCGGGCAATCCATCGTTCGCGCATCCCGGTGATTTCTGCTGTTGGGCACGAAGTG
GACTTCACCATTGCTGATTTTGTTGCCGACCTGCGGGCTCCTACGCCGTCGGCAGCGGCCGAACTGGTGGTGAAGAGCAA
AGAGGAACTAGCCGCCCGTCTTGAATTTCTCAGGCATCGGCTGGTTCAGGGGGGACGGCAGGTCCTGGCCGAGAGGAGGG
GCGAGCTCGACAGTCTCAACCGTTCCCTTCGTGATCCGTCCATGCTGGTGGGGCACCTGTCACAGCGGGTCGATGACCTC
TCGGCCCGGTTGGAGCGAGGGACAGCGAACAGTGTCCGACGTCATCGCGGTAGCCTTGATCTGCTGACCACCAATTTGCG
CCTTACCAATCCCGCCGTCAGGCTCGAGCGAGCCAGGGAAAGGGTCATAGCCCTTGCCGGGCGCAACGAGACGCTGCTCC
GCCGTTTCCTGGACCACCTCAGAGAGAAAACGCTCGTGGCCGCAGCGCGGCTCGATACGCTTTCGCCGCTGGCCACCATG
GCCCGGGGATACAGCATCGTGCTGAAGCTTCCCGAGCGGTGTCTCGTTACCGACAGCGCCCGACTCGCGCCGGGAGACCG
GGTGGAGTTGTGCCTTCGTCGCGGCCGGGCCGGCTGTTGCGTGGAATCCAGCAGCGACACGTGA

Upstream 100 bases:

>100_bases
ATACTACACTGTCCGCCTGACAGCGGTCAACCCGGTTTGACAGGCCGTTGCCCCTGAATTATATCTATTTGATACTAAAT
AACTTTAACCCGGGGTTCCC

Downstream 100 bases:

>100_bases
CAAACCTTGACTCACCCTGTCCGGGCGCTATAATGACCCCTTCATTTTCATATTCGGGATAAATCTATGGCTGTTGAAAA
ATTTGAAACCGCACTGAAAA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDIFSEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLATPASGHLYFTLKDGAAQIRCVMFRASSRALKFRPRDGMGL
IVRGRVTVYDQRGEYQLLVEYLEPRGIGALQLAFIQLKEQLAREGLFADEHKKPIPPLPQKIGVVTSATGAAIHDILTVL
NRRFANVEILIRPVKVQGEGAAEEIAAAIDDFNRYGVIDVMIVGRGGGSLEDLWAFNEEMVARAIHRSRIPVISAVGHEV
DFTIADFVADLRAPTPSAAAELVVKSKEELAARLEFLRHRLVQGGRQVLAERRGELDSLNRSLRDPSMLVGHLSQRVDDL
SARLERGTANSVRRHRGSLDLLTTNLRLTNPAVRLERARERVIALAGRNETLLRRFLDHLREKTLVAAARLDTLSPLATM
ARGYSIVLKLPERCLVTDSARLAPGDRVELCLRRGRAGCCVESSSDT

Sequences:

>Translated_447_residues
MDIFSEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLATPASGHLYFTLKDGAAQIRCVMFRASSRALKFRPRDGMGL
IVRGRVTVYDQRGEYQLLVEYLEPRGIGALQLAFIQLKEQLAREGLFADEHKKPIPPLPQKIGVVTSATGAAIHDILTVL
NRRFANVEILIRPVKVQGEGAAEEIAAAIDDFNRYGVIDVMIVGRGGGSLEDLWAFNEEMVARAIHRSRIPVISAVGHEV
DFTIADFVADLRAPTPSAAAELVVKSKEELAARLEFLRHRLVQGGRQVLAERRGELDSLNRSLRDPSMLVGHLSQRVDDL
SARLERGTANSVRRHRGSLDLLTTNLRLTNPAVRLERARERVIALAGRNETLLRRFLDHLREKTLVAAARLDTLSPLATM
ARGYSIVLKLPERCLVTDSARLAPGDRVELCLRRGRAGCCVESSSDT
>Mature_447_residues
MDIFSEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLATPASGHLYFTLKDGAAQIRCVMFRASSRALKFRPRDGMGL
IVRGRVTVYDQRGEYQLLVEYLEPRGIGALQLAFIQLKEQLAREGLFADEHKKPIPPLPQKIGVVTSATGAAIHDILTVL
NRRFANVEILIRPVKVQGEGAAEEIAAAIDDFNRYGVIDVMIVGRGGGSLEDLWAFNEEMVARAIHRSRIPVISAVGHEV
DFTIADFVADLRAPTPSAAAELVVKSKEELAARLEFLRHRLVQGGRQVLAERRGELDSLNRSLRDPSMLVGHLSQRVDDL
SARLERGTANSVRRHRGSLDLLTTNLRLTNPAVRLERARERVIALAGRNETLLRRFLDHLREKTLVAAARLDTLSPLATM
ARGYSIVLKLPERCLVTDSARLAPGDRVELCLRRGRAGCCVESSSDT

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=401, Percent_Identity=46.3840399002494, Blast_Score=352, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_GEOSL (Q74CA7)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952817.1
- GeneID:   2686679
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1767
- NMPDR:   fig|243231.1.peg.1755
- TIGR:   GSU1767
- HOGENOM:   HBG634411
- OMA:   ILERGFV
- ProtClustDB:   PRK00286
- BioCyc:   GSUL243231:GSU_1767-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49594; Mature: 49594

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFSEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLATPASGHLYFTLKDGAAQIRC
CCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCEEEEEEECCCCEEEE
VMFRASSRALKFRPRDGMGLIVRGRVTVYDQRGEYQLLVEYLEPRGIGALQLAFIQLKEQ
EEEECCCCCEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
LAREGLFADEHKKPIPPLPQKIGVVTSATGAAIHDILTVLNRRFANVEILIRPVKVQGEG
HHHCCCCCCCCCCCCCCCCHHHCEEECCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCC
AAEEIAAAIDDFNRYGVIDVMIVGRGGGSLEDLWAFNEEMVARAIHRSRIPVISAVGHEV
HHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEECCCCCC
DFTIADFVADLRAPTPSAAAELVVKSKEELAARLEFLRHRLVQGGRQVLAERRGELDSLN
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RSLRDPSMLVGHLSQRVDDLSARLERGTANSVRRHRGSLDLLTTNLRLTNPAVRLERARE
HHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECEEECCHHHHHHHHHH
RVIALAGRNETLLRRFLDHLREKTLVAAARLDTLSPLATMARGYSIVLKLPERCLVTDSA
HEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHEECCCC
RLAPGDRVELCLRRGRAGCCVESSSDT
CCCCCHHHHHHHHCCCCCEEECCCCCC
>Mature Secondary Structure
MDIFSEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLATPASGHLYFTLKDGAAQIRC
CCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCEEEEEEECCCCEEEE
VMFRASSRALKFRPRDGMGLIVRGRVTVYDQRGEYQLLVEYLEPRGIGALQLAFIQLKEQ
EEEECCCCCEEECCCCCCEEEEEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
LAREGLFADEHKKPIPPLPQKIGVVTSATGAAIHDILTVLNRRFANVEILIRPVKVQGEG
HHHCCCCCCCCCCCCCCCCHHHCEEECCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCC
AAEEIAAAIDDFNRYGVIDVMIVGRGGGSLEDLWAFNEEMVARAIHRSRIPVISAVGHEV
HHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEECCCCCC
DFTIADFVADLRAPTPSAAAELVVKSKEELAARLEFLRHRLVQGGRQVLAERRGELDSLN
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RSLRDPSMLVGHLSQRVDDLSARLERGTANSVRRHRGSLDLLTTNLRLTNPAVRLERARE
HHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECEEECCHHHHHHHHHH
RVIALAGRNETLLRRFLDHLREKTLVAAARLDTLSPLATMARGYSIVLKLPERCLVTDSA
HEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHEECCCC
RLAPGDRVELCLRRGRAGCCVESSSDT
CCCCCHHHHHHHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA