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The map label for this gene is atoC [H]

Identifier: 39996753

GI number: 39996753

Start: 1810491

End: 1811927

Strand: Direct

Name: atoC [H]

Synonym: GSU1653

Alternate gene names: 39996753

Gene position: 1810491-1811927 (Clockwise)

Preceding gene: 39996752

Following gene: 39996757

Centisome position: 47.47

GC content: 59.01

Gene sequence:

>1437_bases
ATGGGGACCAAACTTCTGGTACTCGACGACGATTCGGTGGTTCTTGAACAACTGAAGCAGGTCTTCGGCGCCGAAGGCTA
TGAAGTCTTTACCGTCAGCCAGGATCGGGAGGCCTATCGCATCATCGCTGCTGAACATCCGAACGTGGCCATCATCGATC
TGAACCTTGAGGGCGCCTCGGGGCTCGATGTGCTGCGTGAGGCGAAACGGCTCGACCATGCCCTCGCCGTAATCATCACC
ACCGGCTCCCGGGCCACCCGCAATGCCATAGAGGCCATGCGGCAGGGAGCCTACGATTACATTATCAAGCCGTTCAACCT
GCCGGCTCTGACCGAGACGGTCCGCAAGGCCGTCGAATGCAACCTCATGACCCGGACGGTCCGCTTCACCGGTGGCGGCG
GCGGTATCGACGACGATGTCGATTATGAAGACGTGATGATCGGGTCTTCGCCGGAGATGCTCGAAGTCTGGAAGATGGTC
GGGAGGGTCGCCGATTCGGATGCATCGGTGCTGATTCAGGGGGAGAGCGGTACCGGCAAGGAGCTTCTCGCCCGAGCCAT
TTACCACTATTCACGTCGGCGCCACCGTCCGTTTCTTGCGGTCAACTGTGCGGCTCTGCCCGAAACGCTGCTTGAAAGCG
AACTGTTCGGCCACGAAAAGGGTGCCTTCACCGATGCCCACTCGCGTCGCATCGGCAAGTTCGAACAGTGCAACGGCGGA
ACGATTTTTCTCGATGAAGTGGCGGAGATGAGCCTCGCCAACCAGGGGAAGCTCCTGCGGGTGCTTGAGAACCAGGAGTT
CGAGAGGGTGGGGGGGAACGAGACGGTTCGGGTCGACGTGCGCGTGCTCACTGCCACTAATCGCAGCCTAGTGCAGGCCG
TGAAGGAAAAAGCCTTCCGTCTCGACCTCCTCTATCGTCTGCGCGTGGTCTCGTTCTACCTGCCGCCCCTGCGGGAGCGG
GTCGAGGACGTCCCCCTTCTGACTGATTTGTTCATCAAGACCTTTTCCCGGAAACACGGCAAGAAGATCAAAGGAATCGC
CCCCAGGGCACTGGAGATGCTGAAGGTGGGACATTGGGAAGGAAACATCCGCGAGCTGAAAAATGTCATCAATTCGGCAA
CTGTCCTCTGCAAGGGAGACTTTCTCATGCCCGAGGACTTCGCGCCACTACTGCCCGCTGCCGTGTTGCCGCGAAAGGTC
GAGGGAGGTGTGGGTGACGATTACTTCGGATTTTTCAGGAAGGTTCTAGAGCCGGAGTTTGATACCCTGTGCCGGAAGAG
CAAAGGGGCCGTGTTCGAAACCGTCAGCAGTAGTCTGCAGGGAGCATTGATCCGGCTGGCCCTTGAACGATGCGGCAACA
ATCAGGTAGTGGCGGCCCGCCTTCTCGGCATAAGTAGAAATACCCTACGCGACCGATTGGCCCGCTCGGAAGGGTGA

Upstream 100 bases:

>100_bases
TCGGAGGCCCCTTTTTTAGTGGCCGCGTGCAACTTCTTGTAATTGTTGAATATTGTAATTAAGTGATAAATGCGGATCCA
ATGCATTGTATGGAGGGAGT

Downstream 100 bases:

>100_bases
CAGCCGGTATCGCCGGTGGTTGGTCACGAGTCGTACGGGCGGTCCGTTGCGCTAAGGGGCTCGCGTTGCAGGTTCCGGGA
TGATCTGGGACTATGCGGGA

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MGTKLLVLDDDSVVLEQLKQVFGAEGYEVFTVSQDREAYRIIAAEHPNVAIIDLNLEGASGLDVLREAKRLDHALAVIIT
TGSRATRNAIEAMRQGAYDYIIKPFNLPALTETVRKAVECNLMTRTVRFTGGGGGIDDDVDYEDVMIGSSPEMLEVWKMV
GRVADSDASVLIQGESGTGKELLARAIYHYSRRRHRPFLAVNCAALPETLLESELFGHEKGAFTDAHSRRIGKFEQCNGG
TIFLDEVAEMSLANQGKLLRVLENQEFERVGGNETVRVDVRVLTATNRSLVQAVKEKAFRLDLLYRLRVVSFYLPPLRER
VEDVPLLTDLFIKTFSRKHGKKIKGIAPRALEMLKVGHWEGNIRELKNVINSATVLCKGDFLMPEDFAPLLPAAVLPRKV
EGGVGDDYFGFFRKVLEPEFDTLCRKSKGAVFETVSSSLQGALIRLALERCGNNQVVAARLLGISRNTLRDRLARSEG

Sequences:

>Translated_478_residues
MGTKLLVLDDDSVVLEQLKQVFGAEGYEVFTVSQDREAYRIIAAEHPNVAIIDLNLEGASGLDVLREAKRLDHALAVIIT
TGSRATRNAIEAMRQGAYDYIIKPFNLPALTETVRKAVECNLMTRTVRFTGGGGGIDDDVDYEDVMIGSSPEMLEVWKMV
GRVADSDASVLIQGESGTGKELLARAIYHYSRRRHRPFLAVNCAALPETLLESELFGHEKGAFTDAHSRRIGKFEQCNGG
TIFLDEVAEMSLANQGKLLRVLENQEFERVGGNETVRVDVRVLTATNRSLVQAVKEKAFRLDLLYRLRVVSFYLPPLRER
VEDVPLLTDLFIKTFSRKHGKKIKGIAPRALEMLKVGHWEGNIRELKNVINSATVLCKGDFLMPEDFAPLLPAAVLPRKV
EGGVGDDYFGFFRKVLEPEFDTLCRKSKGAVFETVSSSLQGALIRLALERCGNNQVVAARLLGISRNTLRDRLARSEG
>Mature_477_residues
GTKLLVLDDDSVVLEQLKQVFGAEGYEVFTVSQDREAYRIIAAEHPNVAIIDLNLEGASGLDVLREAKRLDHALAVIITT
GSRATRNAIEAMRQGAYDYIIKPFNLPALTETVRKAVECNLMTRTVRFTGGGGGIDDDVDYEDVMIGSSPEMLEVWKMVG
RVADSDASVLIQGESGTGKELLARAIYHYSRRRHRPFLAVNCAALPETLLESELFGHEKGAFTDAHSRRIGKFEQCNGGT
IFLDEVAEMSLANQGKLLRVLENQEFERVGGNETVRVDVRVLTATNRSLVQAVKEKAFRLDLLYRLRVVSFYLPPLRERV
EDVPLLTDLFIKTFSRKHGKKIKGIAPRALEMLKVGHWEGNIRELKNVINSATVLCKGDFLMPEDFAPLLPAAVLPRKVE
GGVGDDYFGFFRKVLEPEFDTLCRKSKGAVFETVSSSLQGALIRLALERCGNNQVVAARLLGISRNTLRDRLARSEG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=387, Percent_Identity=44.1860465116279, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1790437, Length=473, Percent_Identity=37.6321353065539, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=37.5266524520256, Blast_Score=304, Evalue=9e-84,
Organism=Escherichia coli, GI1788905, Length=398, Percent_Identity=36.4321608040201, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI1789087, Length=332, Percent_Identity=43.9759036144578, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082117, Length=237, Percent_Identity=50.6329113924051, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789233, Length=233, Percent_Identity=46.3519313304721, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI87082152, Length=256, Percent_Identity=48.046875, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI87081872, Length=338, Percent_Identity=39.0532544378698, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1786524, Length=341, Percent_Identity=39.5894428152493, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1787583, Length=284, Percent_Identity=40.8450704225352, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=35, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081858, Length=211, Percent_Identity=31.2796208530806, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1790863, Length=123, Percent_Identity=36.5853658536585, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53109; Mature: 52978

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKLLVLDDDSVVLEQLKQVFGAEGYEVFTVSQDREAYRIIAAEHPNVAIIDLNLEGAS
CCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEECCCCC
GLDVLREAKRLDHALAVIITTGSRATRNAIEAMRQGAYDYIIKPFNLPALTETVRKAVEC
CHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHH
NLMTRTVRFTGGGGGIDDDVDYEDVMIGSSPEMLEVWKMVGRVADSDASVLIQGESGTGK
CEEEEEEEEECCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHH
ELLARAIYHYSRRRHRPFLAVNCAALPETLLESELFGHEKGAFTDAHSRRIGKFEQCNGG
HHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCC
TIFLDEVAEMSLANQGKLLRVLENQEFERVGGNETVRVDVRVLTATNRSLVQAVKEKAFR
EEEHHHHHHHHHCCCCCEEEHHCCCHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHH
LDLLYRLRVVSFYLPPLRERVEDVPLLTDLFIKTFSRKHGKKIKGIAPRALEMLKVGHWE
HHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
GNIRELKNVINSATVLCKGDFLMPEDFAPLLPAAVLPRKVEGGVGDDYFGFFRKVLEPEF
CCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHCCCH
DTLCRKSKGAVFETVSSSLQGALIRLALERCGNNQVVAARLLGISRNTLRDRLARSEG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
GTKLLVLDDDSVVLEQLKQVFGAEGYEVFTVSQDREAYRIIAAEHPNVAIIDLNLEGAS
CCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEECCCCC
GLDVLREAKRLDHALAVIITTGSRATRNAIEAMRQGAYDYIIKPFNLPALTETVRKAVEC
CHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHH
NLMTRTVRFTGGGGGIDDDVDYEDVMIGSSPEMLEVWKMVGRVADSDASVLIQGESGTGK
CEEEEEEEEECCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHH
ELLARAIYHYSRRRHRPFLAVNCAALPETLLESELFGHEKGAFTDAHSRRIGKFEQCNGG
HHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCC
TIFLDEVAEMSLANQGKLLRVLENQEFERVGGNETVRVDVRVLTATNRSLVQAVKEKAFR
EEEHHHHHHHHHCCCCCEEEHHCCCHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHH
LDLLYRLRVVSFYLPPLRERVEDVPLLTDLFIKTFSRKHGKKIKGIAPRALEMLKVGHWE
HHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
GNIRELKNVINSATVLCKGDFLMPEDFAPLLPAAVLPRKVEGGVGDDYFGFFRKVLEPEF
CCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHCCCH
DTLCRKSKGAVFETVSSSLQGALIRLALERCGNNQVVAARLLGISRNTLRDRLARSEG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]