Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 39996707

GI number: 39996707

Start: 1757872

End: 1759119

Strand: Direct

Name: glyA [H]

Synonym: GSU1607

Alternate gene names: 39996707

Gene position: 1757872-1759119 (Clockwise)

Preceding gene: 39996706

Following gene: 39996708

Centisome position: 46.09

GC content: 58.01

Gene sequence:

>1248_bases
ATGTCGATTCTCGAAACCTTTGACCCGCAGGTAGCTGAGGCGATCCGCCATGAAACCGAACGGCAGGAGTACAACCTGGA
GTTGATCGCTTCCGAAAACTTTGTTTCCGAGGCGGTACTGGAAGCCCAGGGCTCGGTGATGACCAATAAGTATGCCGAGG
GATACCCCGGTAAGCGCTACTATGGTGGATGCCACCATGTGGACGTGGTGGAAAATCTCGCTATTGAGCGGGCCAAGGAG
CTTTTCGGTGCCGATCATGCCAACGTCCAGCCCCATTCGGGCTCCCAGGCAAATATGGCGGTCTATTTTTCGGTGCTCAA
GCCCGGCGACACCATTCTTGGGATGAATCTGTCCCACGGCGGCCACCTGACCCACGGCAGCCCCGTGAACTTCTCCGGCC
GTTTCTTCAACGTGGTTCCCTACGGCGTGTCCCAGGAGACCGAAACGATCGACTTCAATGAGGTGGAGCGTCTTGCCCTT
GAGCATAAGCCGAAGATGATAGTTGTGGGGGCAAGCGCCTATCCCCGAACCATCGATTTTGCCGCCTTCCGCATCATTGC
CGATAAGGTCGGCGCGGTTATCATGGTTGATATGGCTCACATTGCGGGCCTGGTTGCGGCCGGTCTCCATCCGAGCCCTG
TTCCCTACGCTGAATTCGTGACCACCACTACCCATAAGACCCTCAGAGGTCCCCGCGGCGGGATGATCCTGTGCCGTGAG
GAGTACGCCAAGACGCTCAATTCCAACATCTTCCCCGGTATCCAGGGGGGGCCGCTCATGCATGTCATCGCGGCCAAGGC
CGTTGCCCTCAAGGAGGCCCTCCAGCCCGAGTTCAAAGCGTATCAGGCCCAGATCGTGAAAAATGCCAAGGCCCTTGCCG
ACGAGCTGGTAAAGCGCGGGTTCCGGCTTGTGTCCGGCGGCACCGATAACCATCTGATGCTGGTTAACCTAACCGGCACC
GAACTGACCGGCAAGGTGGCGGAAGAGTCTCTGGATAAGGCCGGCATCACGGTGAACAAGAACACGGTGCCTTTCGAGAC
CCGTTCACCCTTTGTCACCTCCGGTTTCCGGATCGGCACTCCCGCAGCCACTACCCACGGTCTCAAGGAAGCTGAAATGG
CCGACGTGGCGGGCTTTATCGCAGAGGCCCTGGCCAACGTGGACAATGATGCCAAACTCGCCGAGATTAAGGGGAGGGTC
AATGTGCTTATGAAACGCTTCCCCCTCTATGCTCACCGTCTTTCATAA

Upstream 100 bases:

>100_bases
TGAAGTAGACATCGTGCCTGATCGGCGGTTACATGAAGTTTGATACGGGACTGGATACGGTCCCGTTTTCCTTTTTCCCA
CTTTTACAAGGAGACCTGAC

Downstream 100 bases:

>100_bases
GAGTATTGATCCGATTCGTCTGAAAAGGGATCCGTACGGCATCCCCCCTTTTTCTTTGCTATGATTCTATGGTTGTGCAG
TCGAATGGGGCGCGGACCCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSILETFDPQVAEAIRHETERQEYNLELIASENFVSEAVLEAQGSVMTNKYAEGYPGKRYYGGCHHVDVVENLAIERAKE
LFGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLAL
EHKPKMIVVGASAYPRTIDFAAFRIIADKVGAVIMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCRE
EYAKTLNSNIFPGIQGGPLMHVIAAKAVALKEALQPEFKAYQAQIVKNAKALADELVKRGFRLVSGGTDNHLMLVNLTGT
ELTGKVAEESLDKAGITVNKNTVPFETRSPFVTSGFRIGTPAATTHGLKEAEMADVAGFIAEALANVDNDAKLAEIKGRV
NVLMKRFPLYAHRLS

Sequences:

>Translated_415_residues
MSILETFDPQVAEAIRHETERQEYNLELIASENFVSEAVLEAQGSVMTNKYAEGYPGKRYYGGCHHVDVVENLAIERAKE
LFGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLAL
EHKPKMIVVGASAYPRTIDFAAFRIIADKVGAVIMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCRE
EYAKTLNSNIFPGIQGGPLMHVIAAKAVALKEALQPEFKAYQAQIVKNAKALADELVKRGFRLVSGGTDNHLMLVNLTGT
ELTGKVAEESLDKAGITVNKNTVPFETRSPFVTSGFRIGTPAATTHGLKEAEMADVAGFIAEALANVDNDAKLAEIKGRV
NVLMKRFPLYAHRLS
>Mature_414_residues
SILETFDPQVAEAIRHETERQEYNLELIASENFVSEAVLEAQGSVMTNKYAEGYPGKRYYGGCHHVDVVENLAIERAKEL
FGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLALE
HKPKMIVVGASAYPRTIDFAAFRIIADKVGAVIMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCREE
YAKTLNSNIFPGIQGGPLMHVIAAKAVALKEALQPEFKAYQAQIVKNAKALADELVKRGFRLVSGGTDNHLMLVNLTGTE
LTGKVAEESLDKAGITVNKNTVPFETRSPFVTSGFRIGTPAATTHGLKEAEMADVAGFIAEALANVDNDAKLAEIKGRVN
VLMKRFPLYAHRLS

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=451, Percent_Identity=44.1241685144124, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=451, Percent_Identity=44.1241685144124, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=451, Percent_Identity=44.1241685144124, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=451, Percent_Identity=44.1241685144124, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=451, Percent_Identity=43.4589800443459, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=45.3271028037383, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=44.3099273607748, Blast_Score=304, Evalue=8e-83,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=61.3138686131387, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=47.2772277227723, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=47.2772277227723, Blast_Score=358, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6319739, Length=428, Percent_Identity=45.5607476635514, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323087, Length=426, Percent_Identity=44.3661971830986, Blast_Score=350, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24640005, Length=448, Percent_Identity=46.4285714285714, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221329721, Length=448, Percent_Identity=46.4285714285714, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45013; Mature: 44882

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILETFDPQVAEAIRHETERQEYNLELIASENFVSEAVLEAQGSVMTNKYAEGYPGKRY
CCCHHHCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCHHCCCCCCCCC
YGGCHHVDVVENLAIERAKELFGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEECCC
GHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLALEHKPKMIVVGASAYPRTIDF
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHH
AAFRIIADKVGAVIMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCRE
HHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHH
EYAKTLNSNIFPGIQGGPLMHVIAAKAVALKEALQPEFKAYQAQIVKNAKALADELVKRG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
FRLVSGGTDNHLMLVNLTGTELTGKVAEESLDKAGITVNKNTVPFETRSPFVTSGFRIGT
CEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEECCEEECC
PAATTHGLKEAEMADVAGFIAEALANVDNDAKLAEIKGRVNVLMKRFPLYAHRLS
CCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure 
SILETFDPQVAEAIRHETERQEYNLELIASENFVSEAVLEAQGSVMTNKYAEGYPGKRY
CCHHHCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCHHCCCCCCCCC
YGGCHHVDVVENLAIERAKELFGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEECCC
GHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLALEHKPKMIVVGASAYPRTIDF
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHH
AAFRIIADKVGAVIMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCRE
HHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHH
EYAKTLNSNIFPGIQGGPLMHVIAAKAVALKEALQPEFKAYQAQIVKNAKALADELVKRG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
FRLVSGGTDNHLMLVNLTGTELTGKVAEESLDKAGITVNKNTVPFETRSPFVTSGFRIGT
CEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEECCEEECC
PAATTHGLKEAEMADVAGFIAEALANVDNDAKLAEIKGRVNVLMKRFPLYAHRLS
CCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA