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The map label for this gene is fabF-2 [H]

Identifier: 39996705

GI number: 39996705

Start: 1756090

End: 1757322

Strand: Direct

Name: fabF-2 [H]

Synonym: GSU1605

Alternate gene names: 39996705

Gene position: 1756090-1757322 (Clockwise)

Preceding gene: 39996704

Following gene: 39996706

Centisome position: 46.04

GC content: 58.07

Gene sequence:

>1233_bases
ATGAGAAGAGTAGTGGTGACGGGAGTCGGCGCCGTATCTCCGCTCGGAGTCGGCAACGCCGCCAACTGGGACGCGCTCGT
TTCAGGCACGTCGGGCATTGGGCACATAACCCGCTTTGACGCCTCCGACCTGCCGGTGAGGATCGCCGGTGAGGTTAAGG
GCTTTGATCCCGAGCAGTACATCGACAAGAAAGAGGTCAAGAAGATGGACCTCTTCATCCAGTACGCCATGGCAGCTGCC
CATTACGCCATGGAAGATTCCGGCCTCCAGATCACCGAGGAGAACGCGGAGCGTACGGGTGTCCTGGTCGGCGCGGGACT
GGGCGGTTTGCCGACCATCGAAAAGTATCATGCCGCCATGCTCGAAGGCGGGCACAAGAAAATTTCCCCCTTCTTCATTC
CGATGCTGATCATCAATCTGGCACCCGGCCACATTTCAATCAAGTATGGGGCCAAGGGACCCAATCTGTCGTCGGTATCC
GCCTGCGCCACCGGTACACATTCCATCGGTGATGCGTACCATATGATCAAGCGCGGCGATGCGGACGCCATGATTGCTGG
TGGTACCGAGTCCACGGTGACTCCCCTCGGAATTGGCGGTTTTGCGGTCATGAAGGCTCTCTCCACGCGTAACGACGATC
CGACCGCTGCGTCGCGTCCCTTTGAAAAGAATCGCGATGGTTTCGTTCTCGCTGAGGGTGCGGGTATCGTCGTTCTTGAG
GAGTATGAGGCTGCCAAGAAACGCGGGGCCAAAATTTATGCCGAGATCGTCGGCTATGGTCTCACGGGCGACGCCTACCA
TCTCACCGCTCCGGCACCGGAGGGAGAAGGTGCAGCGCGGTGTATGAAAATGGCTCTCAACAACGCCGGGGTCCGTCCGG
AGGAAGTGGACTACATCAACGCTCATGGCACGTCCACGCCCTTCAATGACTACTACGAGACCCTTGCCGTCAAGAGCGTG
TTCGGTGACTACGCGAAAAAGGTTATGGTGTCCTCCACCAAGTCCATGACCGGGCACCTGCTCGGCGCAGCCGGCGGTGT
TGAAGCTGTCTTTACCCTCATGGCCATGGACAAGGGTGTGATTCCGCCGACCATCAACTATCAGGAGCAGGACCCCGAGT
GCGATCTTGATTATGTTCCCAATGCCGCCCGGGAGAAGTCGATCACGTACGCCCTCAGCAATAACTTCGGTTTTGGGGGC
ACGAACGCGACGCTGCTCTTTAAGAAAGTATAG

Upstream 100 bases:

>100_bases
GCACGCGGCCTTCGGGCCGCGTCCGCGTGCATCCGTATGCGAGCTTCAGCGGCTTCATGGCGGATGCGTTCAGATTCACG
ACCATCGGGAGCACATATCT

Downstream 100 bases:

>100_bases
GGGGCACGCAGTGATAGTCGTCGGTAGCGATCACGGTGGTCTGGAACTGAAGGAAGCGGTTAAGCGGCTCCTTGCCGAGC
GGGGGGAAACCTTCGAAGAC

Product: 3-oxoacyl-ACP synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRRVVVTGVGAVSPLGVGNAANWDALVSGTSGIGHITRFDASDLPVRIAGEVKGFDPEQYIDKKEVKKMDLFIQYAMAAA
HYAMEDSGLQITEENAERTGVLVGAGLGGLPTIEKYHAAMLEGGHKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVS
ACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPTAASRPFEKNRDGFVLAEGAGIVVLE
EYEAAKKRGAKIYAEIVGYGLTGDAYHLTAPAPEGEGAARCMKMALNNAGVRPEEVDYINAHGTSTPFNDYYETLAVKSV
FGDYAKKVMVSSTKSMTGHLLGAAGGVEAVFTLMAMDKGVIPPTINYQEQDPECDLDYVPNAAREKSITYALSNNFGFGG
TNATLLFKKV

Sequences:

>Translated_410_residues
MRRVVVTGVGAVSPLGVGNAANWDALVSGTSGIGHITRFDASDLPVRIAGEVKGFDPEQYIDKKEVKKMDLFIQYAMAAA
HYAMEDSGLQITEENAERTGVLVGAGLGGLPTIEKYHAAMLEGGHKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVS
ACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPTAASRPFEKNRDGFVLAEGAGIVVLE
EYEAAKKRGAKIYAEIVGYGLTGDAYHLTAPAPEGEGAARCMKMALNNAGVRPEEVDYINAHGTSTPFNDYYETLAVKSV
FGDYAKKVMVSSTKSMTGHLLGAAGGVEAVFTLMAMDKGVIPPTINYQEQDPECDLDYVPNAAREKSITYALSNNFGFGG
TNATLLFKKV
>Mature_410_residues
MRRVVVTGVGAVSPLGVGNAANWDALVSGTSGIGHITRFDASDLPVRIAGEVKGFDPEQYIDKKEVKKMDLFIQYAMAAA
HYAMEDSGLQITEENAERTGVLVGAGLGGLPTIEKYHAAMLEGGHKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVS
ACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPTAASRPFEKNRDGFVLAEGAGIVVLE
EYEAAKKRGAKIYAEIVGYGLTGDAYHLTAPAPEGEGAARCMKMALNNAGVRPEEVDYINAHGTSTPFNDYYETLAVKSV
FGDYAKKVMVSSTKSMTGHLLGAAGGVEAVFTLMAMDKGVIPPTINYQEQDPECDLDYVPNAAREKSITYALSNNFGFGG
TNATLLFKKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=48.5576923076923, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=57.4324324324324, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=24.2352941176471, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=55.609756097561, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=40.3381642512077, Blast_Score=271, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=37.2596153846154, Blast_Score=277, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=42.6356589147287, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI212642053, Length=383, Percent_Identity=25.8485639686684, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=362, Percent_Identity=23.2044198895028, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=37.3601789709172, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=45.6730769230769, Blast_Score=357, Evalue=6e-99,
Organism=Drosophila melanogaster, GI19920632, Length=381, Percent_Identity=24.9343832020997, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI221330659, Length=381, Percent_Identity=24.9343832020997, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24581345, Length=380, Percent_Identity=24.2105263157895, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43344; Mature: 43344

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGVGAVSPLGVGNAANWDALVSGTSGIGHITRFDASDLPVRIAGEVKGFDPEQY
CCEEEEECCCCCCCCCCCCCCCCHHEEECCCCCCCEEEECCCCCCEEEECCCCCCCHHHH
IDKKEVKKMDLFIQYAMAAAHYAMEDSGLQITEENAERTGVLVGAGLGGLPTIEKYHAAM
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHHH
LEGGHKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVSACATGTHSIGDAYHMIKRGD
HCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHCCC
ADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPTAASRPFEKNRDGFVLAEGAGIVVLE
CCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEC
EYEAAKKRGAKIYAEIVGYGLTGDAYHLTAPAPEGEGAARCMKMALNNAGVRPEEVDYIN
CHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEE
AHGTSTPFNDYYETLAVKSVFGDYAKKVMVSSTKSMTGHLLGAAGGVEAVFTLMAMDKGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCHHHHHHHHHHCCCC
IPPTINYQEQDPECDLDYVPNAAREKSITYALSNNFGFGGTNATLLFKKV
CCCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEECCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MRRVVVTGVGAVSPLGVGNAANWDALVSGTSGIGHITRFDASDLPVRIAGEVKGFDPEQY
CCEEEEECCCCCCCCCCCCCCCCHHEEECCCCCCCEEEECCCCCCEEEECCCCCCCHHHH
IDKKEVKKMDLFIQYAMAAAHYAMEDSGLQITEENAERTGVLVGAGLGGLPTIEKYHAAM
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHHH
LEGGHKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVSACATGTHSIGDAYHMIKRGD
HCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHCCC
ADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPTAASRPFEKNRDGFVLAEGAGIVVLE
CCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEC
EYEAAKKRGAKIYAEIVGYGLTGDAYHLTAPAPEGEGAARCMKMALNNAGVRPEEVDYIN
CHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEE
AHGTSTPFNDYYETLAVKSVFGDYAKKVMVSSTKSMTGHLLGAAGGVEAVFTLMAMDKGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCHHHHHHHHHHCCCC
IPPTINYQEQDPECDLDYVPNAAREKSITYALSNNFGFGGTNATLLFKKV
CCCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEECCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]