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The map label for this gene is pcM [H]

Identifier: 39996624

GI number: 39996624

Start: 1670581

End: 1671231

Strand: Direct

Name: pcM [H]

Synonym: GSU1524

Alternate gene names: 39996624

Gene position: 1670581-1671231 (Clockwise)

Preceding gene: 39996623

Following gene: 39996625

Centisome position: 43.8

GC content: 60.22

Gene sequence:

>651_bases
ATGAACTTTGAAATTGCACGCAAACGGATGGTCGAATCCCAGATCATCGCGCGAGGCGTCTCGGACCGGCGGGTGATCGA
GGCGATGCTGAAAGTGCCCCGCCACGTCTTTGTAGAAGAGGCCATGGCCGCCCAGGCCTACAGCGACACACCGCTGCCCA
TCGGCGAAAAACAGACCATCTCCCAGCCTTACATGGTCGCCCTGATGACCGAACTCCTGGAGTTGAAAGGGAAGGAAAAG
GTTCTGGAAATCGGTACCGGCTCAGGGTACCAGGCCGCTATCCTGGCAGTCATGGCCGACCGGGTCTACACGGTGGAGCG
CATTCGTCCGCTTGCGTTGCGGGCGCGCAAGGCCCTCGACAGCCTGGGCCTACTCAATGTCAATATCAAGATGTCCGACG
GCACGGTTGGCTGGGAAGACGAGGCTCCCTTCGACGCCATCATTGTGACCGCCGGAGCCCCGGATATCCCGCAACAGTAC
ATCGACCAGCTCAAGCCCGGCGGGAGGCTTGTCATCCCGGTGGGGACCCAGTTCGAACAGGTGCTCGTCAGGGTGGTCAA
GCAGGAGGACGGTTCGGTCGAGCGGGAGAACATCACGGGATGCAGGTTCGTCAAACTGGTGGGCAAATTCGGTTGGAGCA
GCGATGACTAA

Upstream 100 bases:

>100_bases
CTCGATTTTGCAGTCGTGGGACCTTTCGGCATGCCGCCCGGAGGCTGGACAGCCGTCGGGAGCTCTGCTATAGTCGCGTT
TCCACCAACAGGGGCATGTT

Downstream 100 bases:

>100_bases
GCGCCGCCGGGCGCTTTGCGACGGAGATCTCCATGAGCGACATGAACGAACTGGATGAGAAAGAGCTGGATGCTCCGGAT
GAGCCCGGCGAGGACTTCAT

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNFEIARKRMVESQIIARGVSDRRVIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTISQPYMVALMTELLELKGKEK
VLEIGTGSGYQAAILAVMADRVYTVERIRPLALRARKALDSLGLLNVNIKMSDGTVGWEDEAPFDAIIVTAGAPDIPQQY
IDQLKPGGRLVIPVGTQFEQVLVRVVKQEDGSVERENITGCRFVKLVGKFGWSSDD

Sequences:

>Translated_216_residues
MNFEIARKRMVESQIIARGVSDRRVIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTISQPYMVALMTELLELKGKEK
VLEIGTGSGYQAAILAVMADRVYTVERIRPLALRARKALDSLGLLNVNIKMSDGTVGWEDEAPFDAIIVTAGAPDIPQQY
IDQLKPGGRLVIPVGTQFEQVLVRVVKQEDGSVERENITGCRFVKLVGKFGWSSDD
>Mature_216_residues
MNFEIARKRMVESQIIARGVSDRRVIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTISQPYMVALMTELLELKGKEK
VLEIGTGSGYQAAILAVMADRVYTVERIRPLALRARKALDSLGLLNVNIKMSDGTVGWEDEAPFDAIIVTAGAPDIPQQY
IDQLKPGGRLVIPVGTQFEQVLVRVVKQEDGSVERENITGCRFVKLVGKFGWSSDD

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=197, Percent_Identity=37.5634517766497, Blast_Score=107, Evalue=9e-24,
Organism=Escherichia coli, GI1789100, Length=194, Percent_Identity=50, Blast_Score=181, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71983477, Length=203, Percent_Identity=32.0197044334975, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193207222, Length=201, Percent_Identity=30.8457711442786, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17981723, Length=180, Percent_Identity=37.7777777777778, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23902; Mature: 23902

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEIARKRMVESQIIARGVSDRRVIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SQPYMVALMTELLELKGKEKVLEIGTGSGYQAAILAVMADRVYTVERIRPLALRARKALD
CCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLLNVNIKMSDGTVGWEDEAPFDAIIVTAGAPDIPQQYIDQLKPGGRLVIPVGTQFEQ
HCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCHHH
VLVRVVKQEDGSVERENITGCRFVKLVGKFGWSSDD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNFEIARKRMVESQIIARGVSDRRVIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SQPYMVALMTELLELKGKEKVLEIGTGSGYQAAILAVMADRVYTVERIRPLALRARKALD
CCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLLNVNIKMSDGTVGWEDEAPFDAIIVTAGAPDIPQQYIDQLKPGGRLVIPVGTQFEQ
HCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCHHH
VLVRVVKQEDGSVERENITGCRFVKLVGKFGWSSDD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA