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The map label for this gene is moeZ [H]

Identifier: 39996452

GI number: 39996452

Start: 1476972

End: 1477766

Strand: Direct

Name: moeZ [H]

Synonym: GSU1350

Alternate gene names: 39996452

Gene position: 1476972-1477766 (Clockwise)

Preceding gene: 39996451

Following gene: 39996453

Centisome position: 38.72

GC content: 67.17

Gene sequence:

>795_bases
ATGTTCACCGACCAACAGATCGAGCGCTATTCCCGCCACATCATCCTGAAGGAGGTGGGGGGCAAGGGGCAGAAGAAGCT
CCTGGACGGGAAGGTGATGGTGATCGGCGCCGGCGGGCTCGGGGCCCCCATCGCCCTCTACCTGGCCGCGGCCGGGGTCG
GCACCATCGGCATTGCCGACGCCGACGTGGTGGACCTCTCCAACCTCCAGCGGCAGGTGATCCACTTCACCCCCGACGTG
GGCAAGCCCAAGGTGGAATCGGCCCGGGAGAAGATGGAGGCCATCAACCCCGATGTGAGGGTGCGGACCTACCAGGAGTG
GATCTCCGCCGCCAACATCGCCCGGATCATTGCCGACTACGACTTCGTCATCGACGGCACCGACAACTTCGCCGCCAAGT
TCCTCGTCAACGACGCCTGCGTCCTGGCCGGCACGCCGTACTCCCACGGCGGCATCCTCCAGTTCGACGGCCAGACCCTG
ACCGTGAAGCCGGGGGAATCCCCCTGCTACCGCTGCATCTTCCCGGCCCCGCCGCCAAAGGACGCCATCCCCACCTGCGC
CCGGGCCGGGGTCATTGGCGTGCTCCCGGGCGTGCTCGGCACCATCCAGGCCACCGAGGCGATCAAGTACCTGCTCGGCC
AGGGAGACCTCCTCACCGGCCGGCTCCTCACCTACAACGCCCTGCGGATGCGCTTCCGCGAAGTGCCGGTGAAGAAGAGC
GCCCGGTGCCCGGTCTGCGGCGACAATCCCACCATCACGGAACTGGTGGACGAGCTCGACATCGAGACCTCCTGA

Upstream 100 bases:

>100_bases
GGCGAAACGGTCTATGCCCGGCCGCGCAGGATTCAGACCTTTGTGGAGGATTATCAGATATGATGTTCTGCCCGGCGTTT
CCGCACGGAGTTGCATAACC

Downstream 100 bases:

>100_bases
TGGATTGTATCTCTGTGATTTCCTCCATGTCTCTGTGGCGGATGTTCCGTTGTTGAAAAGGAAAAGATCAATGTCCGAGG
AGAAGAATACCGCCATCGAC

Product: thiF family protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MFTDQQIERYSRHIILKEVGGKGQKKLLDGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDV
GKPKVESAREKMEAINPDVRVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLVNDACVLAGTPYSHGGILQFDGQTL
TVKPGESPCYRCIFPAPPPKDAIPTCARAGVIGVLPGVLGTIQATEAIKYLLGQGDLLTGRLLTYNALRMRFREVPVKKS
ARCPVCGDNPTITELVDELDIETS

Sequences:

>Translated_264_residues
MFTDQQIERYSRHIILKEVGGKGQKKLLDGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDV
GKPKVESAREKMEAINPDVRVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLVNDACVLAGTPYSHGGILQFDGQTL
TVKPGESPCYRCIFPAPPPKDAIPTCARAGVIGVLPGVLGTIQATEAIKYLLGQGDLLTGRLLTYNALRMRFREVPVKKS
ARCPVCGDNPTITELVDELDIETS
>Mature_264_residues
MFTDQQIERYSRHIILKEVGGKGQKKLLDGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDV
GKPKVESAREKMEAINPDVRVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLVNDACVLAGTPYSHGGILQFDGQTL
TVKPGESPCYRCIFPAPPPKDAIPTCARAGVIGVLPGVLGTIQATEAIKYLLGQGDLLTGRLLTYNALRMRFREVPVKKS
ARCPVCGDNPTITELVDELDIETS

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=257, Percent_Identity=43.1906614785992, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4885649, Length=158, Percent_Identity=31.6455696202532, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38045942, Length=178, Percent_Identity=30.3370786516854, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI38045944, Length=178, Percent_Identity=30.3370786516854, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI13376212, Length=258, Percent_Identity=29.8449612403101, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38327032, Length=222, Percent_Identity=29.2792792792793, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI23510338, Length=192, Percent_Identity=28.6458333333333, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI23510340, Length=192, Percent_Identity=28.6458333333333, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787048, Length=248, Percent_Identity=41.1290322580645, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87082356, Length=247, Percent_Identity=40.080971659919, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1789177, Length=111, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=251, Percent_Identity=40.2390438247012, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193203301, Length=197, Percent_Identity=27.4111675126904, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI86565433, Length=217, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI86565431, Length=217, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71984476, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508819, Length=228, Percent_Identity=25.8771929824561, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=256, Percent_Identity=39.453125, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320598, Length=176, Percent_Identity=27.8409090909091, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325323, Length=173, Percent_Identity=28.9017341040462, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322639, Length=190, Percent_Identity=30.5263157894737, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24582879, Length=257, Percent_Identity=42.0233463035019, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24660640, Length=167, Percent_Identity=34.1317365269461, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI28573937, Length=186, Percent_Identity=29.5698924731183, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641311, Length=258, Percent_Identity=29.8449612403101, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20129973, Length=174, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 28397; Mature: 28397

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTDQQIERYSRHIILKEVGGKGQKKLLDGKVMVIGAGGLGAPIALYLAAAGVGTIGIAD
CCCHHHHHHHHHEEEEECCCCCCCCEEECCEEEEEECCCCCHHHHHHHHHHCCCEEECCC
ADVVDLSNLQRQVIHFTPDVGKPKVESAREKMEAINPDVRVRTYQEWISAANIARIIADY
CCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCC
DFVIDGTDNFAAKFLVNDACVLAGTPYSHGGILQFDGQTLTVKPGESPCYRCIFPAPPPK
EEEEECCCCCEEHHEECCCEEEECCCCCCCCEEEECCEEEEECCCCCCCEEEECCCCCCC
DAIPTCARAGVIGVLPGVLGTIQATEAIKYLLGQGDLLTGRLLTYNALRMRFREVPVKKS
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCC
ARCPVCGDNPTITELVDELDIETS
CCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MFTDQQIERYSRHIILKEVGGKGQKKLLDGKVMVIGAGGLGAPIALYLAAAGVGTIGIAD
CCCHHHHHHHHHEEEEECCCCCCCCEEECCEEEEEECCCCCHHHHHHHHHHCCCEEECCC
ADVVDLSNLQRQVIHFTPDVGKPKVESAREKMEAINPDVRVRTYQEWISAANIARIIADY
CCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCC
DFVIDGTDNFAAKFLVNDACVLAGTPYSHGGILQFDGQTLTVKPGESPCYRCIFPAPPPK
EEEEECCCCCEEHHEECCCEEEECCCCCCCCEEEECCEEEEECCCCCCCEEEECCCCCCC
DAIPTCARAGVIGVLPGVLGTIQATEAIKYLLGQGDLLTGRLLTYNALRMRFREVPVKKS
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCC
ARCPVCGDNPTITELVDELDIETS
CCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]