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The map label for this gene is tcp [H]

Identifier: 39996402

GI number: 39996402

Start: 1421178

End: 1422869

Strand: Direct

Name: tcp [H]

Synonym: GSU1300

Alternate gene names: 39996402

Gene position: 1421178-1422869 (Clockwise)

Preceding gene: 39996401

Following gene: 39996403

Centisome position: 37.26

GC content: 57.86

Gene sequence:

>1692_bases
ATGCGTATCGGTGATCTCAAAATTGGCGTACGGCTTGGTATTGGATTTGGTGTTTTGCTCGTCCTACTGGGTGTCGTTAC
CGTGGTCGGCATCAATGGTATGAAGGAGATTAACTCAAAGCTGGATCGCATTCTCAAGGTCAACTATGGGAAGATCAAGA
ATGCCAATGAAGTCTCTATGGTCGTTGGCGATTTGATGGGCAAGATCAATGAAATAATGCTCAAGGACGTGAATGAGCGG
CCTGCAATCAAACAGGAAATTGAAAAATTGCGGAGCGATTACCGCTCTGCCCTGGAGAGGCTTGAACAACTGGAGCAGAC
GGATCAGGGCAAACAATTGATCGCCGGTGCCAAATCCGCTATTGATAATGCCAAAAAGGCCAATAACGACATCATCGAGC
TGAGTCTTGCCGGGAAAACCGATCAGGCTCTGATAGTTTACAACAAGGAAGGCGCCCCCCTATCGCAAAAGATCGTGACG
GCATTCAAGAATATCGTGAAGTATCAGGAAGAGCGGATGGAGCTGCGCTACGCTGAAGCGCTGAAAGCCTACGGCACCTC
CCGGGCCGTTGCACTCGGTGTTGCTTTCTGCGCAGCGATCATCGGCATTCTTATCAGCCTGTTTGCGACCAGGAGCATTA
CGCGTCCCCTCGACAAAGCCGTATCGGTATCCAATGAACTGGCAGAGGGGAACCTGACCGTAACGATCGAAGCGACGAGC
AAGGACGAGACGGGTCAGCTGCTTGCGGCGATGCACAACATGGTAGAGAAGCTGAAGGGCGTGGTAGCTGACGTGAAGAG
CGCGGCGGACAACGTTGCCGCCGGCAGCCAGGAGCTCTCCTCCAGCTCCGAGGAGATGAGCCAGGGAGCCACCGAGCAGG
CGGCCGCGGCCGAAGAGGCCTCCAGCTCCATGGAGCAGATGAGCTCCAACATCCGGCAGAACGCTGACAACGCCACCCAG
ACCGAGAAGATCGCCCTGAAGAGCGCCACGGATGCCCGCGAGGGTGGCAAGGCTGTTGCCGGCACGGTGAGTGCCATGAA
GGAAATCGCCTCCAAGATCTCGATCATCGAGGAGATAGCCCGTCAGACGAACCTGCTGGCGTTGAACGCAGCCATCGAAG
CGGCGCGTGCCGGTGAGCACGGCAAAGGGTTCGCGGTGGTAGCGGCCGAGGTCAGAAAGCTTGCCGAACGGAGCCAGAAG
GCAGCGGGCGAGATCAGCGAGCTGTCTGCCTCCAGCGTTCAGGTAGCGGAAGAAGCCGGCGAGATGCTGACGCGAATCGT
GCCGGACATCCAGCGTACCGCGGAACTGGTGCAGGAGATCAGCGCCGCGTGCAAGGAGCAGGACACGGGAGCGGAGCAGA
TCAACAAAGCTATCCAGCAGCTTGACCAGGTGATCCAGCAGAACGCCAGCGCCAGCGAAGAGATGGCGTCCACCAGCGAA
GAGCTGGCCAGTCAGGCCGAACAGCTGCAGGCCACCATTTCATTCTTCCGGACCGATGATCGTGGCGCGTCAAGCCGGAG
CGCGGTCCATCGTCCCGTTGCCAAGAAAAAGGCAGCGATCCCTCATCTGGGTCACGGCACGTCCAACGGCTACCACGCCG
AACCCGCGACGTCGCGGAAAGTGGCGGTGGGCGGCGGGGTAAACCTGAACCTGGACAGCGATCACCTTGACGACCAGTTC
GAGAAATTCTAG

Upstream 100 bases:

>100_bases
GTTATTGGAAAATGGTCTGACAACGGTATATATCAAATCGTTTTCAGGTCGACAGCGGTAGAAGTGCAATATGTTGCTTC
ACTTATCCAAGGAGGATGGT

Downstream 100 bases:

>100_bases
GAGGGAGCGATGGCACACGCAGACGCAACGGAAACGCGGCAGTACCTGACCTTCACTCTTGCCGGGGAAGTCTTTGGGGT
GGACGTGGCCAAGGTCCGTG

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: Citrate chemoreceptor protein [H]

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MRIGDLKIGVRLGIGFGVLLVLLGVVTVVGINGMKEINSKLDRILKVNYGKIKNANEVSMVVGDLMGKINEIMLKDVNER
PAIKQEIEKLRSDYRSALERLEQLEQTDQGKQLIAGAKSAIDNAKKANNDIIELSLAGKTDQALIVYNKEGAPLSQKIVT
AFKNIVKYQEERMELRYAEALKAYGTSRAVALGVAFCAAIIGILISLFATRSITRPLDKAVSVSNELAEGNLTVTIEATS
KDETGQLLAAMHNMVEKLKGVVADVKSAADNVAAGSQELSSSSEEMSQGATEQAAAAEEASSSMEQMSSNIRQNADNATQ
TEKIALKSATDAREGGKAVAGTVSAMKEIASKISIIEEIARQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAERSQK
AAGEISELSASSVQVAEEAGEMLTRIVPDIQRTAELVQEISAACKEQDTGAEQINKAIQQLDQVIQQNASASEEMASTSE
ELASQAEQLQATISFFRTDDRGASSRSAVHRPVAKKKAAIPHLGHGTSNGYHAEPATSRKVAVGGGVNLNLDSDHLDDQF
EKF

Sequences:

>Translated_563_residues
MRIGDLKIGVRLGIGFGVLLVLLGVVTVVGINGMKEINSKLDRILKVNYGKIKNANEVSMVVGDLMGKINEIMLKDVNER
PAIKQEIEKLRSDYRSALERLEQLEQTDQGKQLIAGAKSAIDNAKKANNDIIELSLAGKTDQALIVYNKEGAPLSQKIVT
AFKNIVKYQEERMELRYAEALKAYGTSRAVALGVAFCAAIIGILISLFATRSITRPLDKAVSVSNELAEGNLTVTIEATS
KDETGQLLAAMHNMVEKLKGVVADVKSAADNVAAGSQELSSSSEEMSQGATEQAAAAEEASSSMEQMSSNIRQNADNATQ
TEKIALKSATDAREGGKAVAGTVSAMKEIASKISIIEEIARQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAERSQK
AAGEISELSASSVQVAEEAGEMLTRIVPDIQRTAELVQEISAACKEQDTGAEQINKAIQQLDQVIQQNASASEEMASTSE
ELASQAEQLQATISFFRTDDRGASSRSAVHRPVAKKKAAIPHLGHGTSNGYHAEPATSRKVAVGGGVNLNLDSDHLDDQF
EKF
>Mature_563_residues
MRIGDLKIGVRLGIGFGVLLVLLGVVTVVGINGMKEINSKLDRILKVNYGKIKNANEVSMVVGDLMGKINEIMLKDVNER
PAIKQEIEKLRSDYRSALERLEQLEQTDQGKQLIAGAKSAIDNAKKANNDIIELSLAGKTDQALIVYNKEGAPLSQKIVT
AFKNIVKYQEERMELRYAEALKAYGTSRAVALGVAFCAAIIGILISLFATRSITRPLDKAVSVSNELAEGNLTVTIEATS
KDETGQLLAAMHNMVEKLKGVVADVKSAADNVAAGSQELSSSSEEMSQGATEQAAAAEEASSSMEQMSSNIRQNADNATQ
TEKIALKSATDAREGGKAVAGTVSAMKEIASKISIIEEIARQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAERSQK
AAGEISELSASSVQVAEEAGEMLTRIVPDIQRTAELVQEISAACKEQDTGAEQINKAIQQLDQVIQQNASASEEMASTSE
ELASQAEQLQATISFFRTDDRGASSRSAVHRPVAKKKAAIPHLGHGTSNGYHAEPATSRKVAVGGGVNLNLDSDHLDDQF
EKF

Specific function: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=326, Percent_Identity=38.6503067484663, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788194, Length=370, Percent_Identity=35.9459459459459, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788195, Length=330, Percent_Identity=39.3939393939394, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI2367378, Length=360, Percent_Identity=36.9444444444444, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789453, Length=316, Percent_Identity=31.6455696202532, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 60028; Mature: 60028

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGDLKIGVRLGIGFGVLLVLLGVVTVVGINGMKEINSKLDRILKVNYGKIKNANEVSM
CCCCCEEEHHEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
VVGDLMGKINEIMLKDVNERPAIKQEIEKLRSDYRSALERLEQLEQTDQGKQLIAGAKSA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IDNAKKANNDIIELSLAGKTDQALIVYNKEGAPLSQKIVTAFKNIVKYQEERMELRYAEA
HHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAYGTSRAVALGVAFCAAIIGILISLFATRSITRPLDKAVSVSNELAEGNLTVTIEATS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
KDETGQLLAAMHNMVEKLKGVVADVKSAADNVAAGSQELSSSSEEMSQGATEQAAAAEEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHCCCHHHHHHHHHH
SSSMEQMSSNIRQNADNATQTEKIALKSATDAREGGKAVAGTVSAMKEIASKISIIEEIA
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAERSQKAAGEISELSASSVQVAEEAG
HHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
EMLTRIVPDIQRTAELVQEISAACKEQDTGAEQINKAIQQLDQVIQQNASASEEMASTSE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELASQAEQLQATISFFRTDDRGASSRSAVHRPVAKKKAAIPHLGHGTSNGYHAEPATSRK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
VAVGGGVNLNLDSDHLDDQFEKF
EEECCCEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MRIGDLKIGVRLGIGFGVLLVLLGVVTVVGINGMKEINSKLDRILKVNYGKIKNANEVSM
CCCCCEEEHHEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
VVGDLMGKINEIMLKDVNERPAIKQEIEKLRSDYRSALERLEQLEQTDQGKQLIAGAKSA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IDNAKKANNDIIELSLAGKTDQALIVYNKEGAPLSQKIVTAFKNIVKYQEERMELRYAEA
HHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAYGTSRAVALGVAFCAAIIGILISLFATRSITRPLDKAVSVSNELAEGNLTVTIEATS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
KDETGQLLAAMHNMVEKLKGVVADVKSAADNVAAGSQELSSSSEEMSQGATEQAAAAEEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHCCCHHHHHHHHHH
SSSMEQMSSNIRQNADNATQTEKIALKSATDAREGGKAVAGTVSAMKEIASKISIIEEIA
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RQTNLLALNAAIEAARAGEHGKGFAVVAAEVRKLAERSQKAAGEISELSASSVQVAEEAG
HHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
EMLTRIVPDIQRTAELVQEISAACKEQDTGAEQINKAIQQLDQVIQQNASASEEMASTSE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELASQAEQLQATISFFRTDDRGASSRSAVHRPVAKKKAAIPHLGHGTSNGYHAEPATSRK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
VAVGGGVNLNLDSDHLDDQFEKF
EEECCCEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8419927; 11677609 [H]