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The map label for this gene is frdA [H]

Identifier: 39996279

GI number: 39996279

Start: 1282525

End: 1284438

Strand: Direct

Name: frdA [H]

Synonym: GSU1177

Alternate gene names: 39996279

Gene position: 1282525-1284438 (Clockwise)

Preceding gene: 39996278

Following gene: 39996280

Centisome position: 33.63

GC content: 59.35

Gene sequence:

>1914_bases
GTGATACTCGACGGAAAATGTCCGACAGGGCCAATTGAGAAAACGTGGGACAAGCACCGCTTCGACATGAAGCTGGTCAA
CCCCGCCAACAAGCGCAAGTACAAGATTCTCGTCGTCGGAACCGGTCTTGCCGGTGGTGCAGCCGCTGCATCGCTGGGTG
AACTCGGTTACAACGTTGAGGCGTTCTGTTATCAGGACAGCCCGCGGCGCGCGCACTCCATTGCCGCCCAGGGCGGTATC
AACGCAGCCAAGAACTACCCGAACGACGGCGACAGCATCTACCGTCTCTTCTATGACACCATCAAGGGCGGCGACTTCCG
CGCCCGTGAAGCCGATGTCTGGCGCCTCGCTCAGGTGTCCAATAATATCATCGATCAGTGCGTAGCTCAGGGTGTACCCT
TTGCCCGTGACTATGCCGGCTACCTGGACAACCGCTCCTTTGGCGGCGCCCAGGTTTCCCGTACCTTCTATGCCCGGGGG
CAGACGGGGCAACAGCTGCTGCTGGGCGCCTATTCCGCTCTTGCTCGCCAGATCAAGGCCGGTACCGTCAAGATGTTCCC
TCGCACCGAAATGCTTGATCTTGTTGTTGTAGACGGCGAGGCCAAAGGGATCACGATTCGCGATCTGGTCACCGGCGAGA
TCCGCACCCATGTGGGCGATGCGGTTGTTCTTTGCACCGGCGGCTACGTAAACGTCTTCTACCTCTCCACCAACGCAATG
GGGTGCAGCGTTACCGCAGCCTGGAAGGCCCACAAGAAAGGCGCCTTCTTCGCCAACCCCTGTTACACCCAGATTCACCC
GACCTGCATTCCGCAGCATGGTGACAAGCAATCCAAGCTCACCCTCATGTCCGAGTCGCTCCGTAACGACGGCCGCTGCT
GGGTGCCCAAGAAGCAGGGGGACAACCGTGCACCGGGCCAGATTCCCGACGAGGACCGCGACTACTACCTGGAGCGGAAG
TACCCCTCCTTCGGAAACCTTGCTCCCCGTGACATCGCGTCCCGCGCCGCCAAGGAACAGTGCGACGACAACCGTGGCGT
CGGACCGGGCGGACGTGGCGTCTATCTTGACTTCGCCTCCTCCATTCAGCGCCTTGGTGAGAGCACCATCCGTGAGCGTT
ACGGCAACCTCTTCGAAATGTATGAGAAGATCACCGACGAGAACGCCTATAAGGTTCCGATGCGGATCTATCCGGCTCCG
CACTACTCCATGGGCGGTCTCTGGGTCGATTACAACTGCATGAGCAACGTGCCGGGCCTCTTCGTTCTGGGTGAAGCCAA
CTTCTCGGTGCATGGAGCGAACCGTCTCGGCGCCAGCGCACTCATGCAGGGGCTTGCCGACGGCTACTTCGTCATCCCCT
ACACTATCGCCGACTACCTTGCCCGTATTACCCCGGGCAAAGTCAAGGCGGATCATCCGGAGTGCAAGAAATCGGTTGAG
GATGTTAATAACGACCTCAAGAAGTTCGTGTCGATCAACGGCAAGAAGACGGTCACCGAGTTCCACCGCGAACTGGGCAA
GATCATGTGGAACAACGTCGGTATGGCCCGGAGCGAGGAGAGCTGCAAGGAGGCACTCAAGGTAATCCCGCAGATCCGTG
AGGAGTTCTGGAAGAACGTGAAGGTTAGCGGCTCCGGTGCTGAGTTCAACCAGCAGCTTGAGAACGCTGGCCGCGTAGCC
GACTTCCTGGAGTTTGCCGAGCTCATGACGCTGGATGCCCTCCATCGCAACGAGTCCTGCGGCGGGCACTTCCGGGTCGA
GCACCAGATGCCCGACGGCGAGGCCAAGCGGGACGACGAGAACTACTGCTATGCCGCCGCCTGGGAGTTCAAGGGTGTCG
GCAAAGAGCCCGAGCTTCACAAGGAGCCGCTGAAGTTTGAAAACGTCCACCTTGCTATAAGGAGCTACAAATAA

Upstream 100 bases:

>100_bases
AGCAAAATCGGCATGATTGCCGCCGTGGTTCTGCTCCTCGGCTATGCGACCATCCCGTTCGTCATCGTCACCGGCATTCT
GAAAGGTTAGGGGGTTCATA

Downstream 100 bases:

>100_bases
TGAGCCATCACGACAAGAATATGACTCTTACCCTTCATGTCTGGCGCCAGAAGGGACCGAAGGACCCGGGGAAATTCGAG
GTCTACGAGGCGAAAGACGT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MILDGKCPTGPIEKTWDKHRFDMKLVNPANKRKYKILVVGTGLAGGAAAASLGELGYNVEAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALARQIKAGTVKMFPRTEMLDLVVVDGEAKGITIRDLVTGEIRTHVGDAVVLCTGGYVNVFYLSTNAM
GCSVTAAWKAHKKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWVPKKQGDNRAPGQIPDEDRDYYLERK
YPSFGNLAPRDIASRAAKEQCDDNRGVGPGGRGVYLDFASSIQRLGESTIRERYGNLFEMYEKITDENAYKVPMRIYPAP
HYSMGGLWVDYNCMSNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIADYLARITPGKVKADHPECKKSVE
DVNNDLKKFVSINGKKTVTEFHRELGKIMWNNVGMARSEESCKEALKVIPQIREEFWKNVKVSGSGAEFNQQLENAGRVA
DFLEFAELMTLDALHRNESCGGHFRVEHQMPDGEAKRDDENYCYAAAWEFKGVGKEPELHKEPLKFENVHLAIRSYK

Sequences:

>Translated_637_residues
MILDGKCPTGPIEKTWDKHRFDMKLVNPANKRKYKILVVGTGLAGGAAAASLGELGYNVEAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALARQIKAGTVKMFPRTEMLDLVVVDGEAKGITIRDLVTGEIRTHVGDAVVLCTGGYVNVFYLSTNAM
GCSVTAAWKAHKKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWVPKKQGDNRAPGQIPDEDRDYYLERK
YPSFGNLAPRDIASRAAKEQCDDNRGVGPGGRGVYLDFASSIQRLGESTIRERYGNLFEMYEKITDENAYKVPMRIYPAP
HYSMGGLWVDYNCMSNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIADYLARITPGKVKADHPECKKSVE
DVNNDLKKFVSINGKKTVTEFHRELGKIMWNNVGMARSEESCKEALKVIPQIREEFWKNVKVSGSGAEFNQQLENAGRVA
DFLEFAELMTLDALHRNESCGGHFRVEHQMPDGEAKRDDENYCYAAAWEFKGVGKEPELHKEPLKFENVHLAIRSYK
>Mature_637_residues
MILDGKCPTGPIEKTWDKHRFDMKLVNPANKRKYKILVVGTGLAGGAAAASLGELGYNVEAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALARQIKAGTVKMFPRTEMLDLVVVDGEAKGITIRDLVTGEIRTHVGDAVVLCTGGYVNVFYLSTNAM
GCSVTAAWKAHKKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWVPKKQGDNRAPGQIPDEDRDYYLERK
YPSFGNLAPRDIASRAAKEQCDDNRGVGPGGRGVYLDFASSIQRLGESTIRERYGNLFEMYEKITDENAYKVPMRIYPAP
HYSMGGLWVDYNCMSNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIADYLARITPGKVKADHPECKKSVE
DVNNDLKKFVSINGKKTVTEFHRELGKIMWNNVGMARSEESCKEALKVIPQIREEFWKNVKVSGSGAEFNQQLENAGRVA
DFLEFAELMTLDALHRNESCGGHFRVEHQMPDGEAKRDDENYCYAAAWEFKGVGKEPELHKEPLKFENVHLAIRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=558, Percent_Identity=26.8817204301075, Blast_Score=147, Evalue=4e-35,
Organism=Escherichia coli, GI1790597, Length=542, Percent_Identity=27.4907749077491, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1786942, Length=579, Percent_Identity=26.4248704663212, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI1788928, Length=585, Percent_Identity=25.8119658119658, Blast_Score=128, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17505833, Length=542, Percent_Identity=26.9372693726937, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=537, Percent_Identity=27.56052141527, Blast_Score=164, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322701, Length=598, Percent_Identity=27.4247491638796, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=600, Percent_Identity=27.1666666666667, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17137288, Length=547, Percent_Identity=26.691042047532, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24655642, Length=547, Percent_Identity=26.691042047532, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24655647, Length=547, Percent_Identity=26.691042047532, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24663005, Length=573, Percent_Identity=24.956369982548, Blast_Score=141, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70834; Mature: 70834

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDGKCPTGPIEKTWDKHRFDMKLVNPANKRKYKILVVGTGLAGGAAAASLGELGYNVE
CEECCCCCCCCCHHCCCHHCCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEE
AFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALARQIKA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHC
GTVKMFPRTEMLDLVVVDGEAKGITIRDLVTGEIRTHVGDAVVLCTGGYVNVFYLSTNAM
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
GCSVTAAWKAHKKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWVPKKQG
CCEEEEHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCC
DNRAPGQIPDEDRDYYLERKYPSFGNLAPRDIASRAAKEQCDDNRGVGPGGRGVYLDFAS
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
SIQRLGESTIRERYGNLFEMYEKITDENAYKVPMRIYPAPHYSMGGLWVDYNCMSNVPGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEECCCCCCCCCEEEECHHHCCCCCE
FVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIADYLARITPGKVKADHPECKKSVE
EEEECCCEEEECCHHCCHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHH
DVNNDLKKFVSINGKKTVTEFHRELGKIMWNNVGMARSEESCKEALKVIPQIREEFWKNV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCE
KVSGSGAEFNQQLENAGRVADFLEFAELMTLDALHRNESCGGHFRVEHQMPDGEAKRDDE
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
NYCYAAAWEFKGVGKEPELHKEPLKFENVHLAIRSYK
CEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MILDGKCPTGPIEKTWDKHRFDMKLVNPANKRKYKILVVGTGLAGGAAAASLGELGYNVE
CEECCCCCCCCCHHCCCHHCCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEE
AFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALARQIKA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHC
GTVKMFPRTEMLDLVVVDGEAKGITIRDLVTGEIRTHVGDAVVLCTGGYVNVFYLSTNAM
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
GCSVTAAWKAHKKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWVPKKQG
CCEEEEHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCC
DNRAPGQIPDEDRDYYLERKYPSFGNLAPRDIASRAAKEQCDDNRGVGPGGRGVYLDFAS
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
SIQRLGESTIRERYGNLFEMYEKITDENAYKVPMRIYPAPHYSMGGLWVDYNCMSNVPGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEECCCCCCCCCEEEECHHHCCCCCE
FVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIADYLARITPGKVKADHPECKKSVE
EEEECCCEEEECCHHCCHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHH
DVNNDLKKFVSINGKKTVTEFHRELGKIMWNNVGMARSEESCKEALKVIPQIREEFWKNV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCE
KVSGSGAEFNQQLENAGRVADFLEFAELMTLDALHRNESCGGHFRVEHQMPDGEAKRDDE
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
NYCYAAAWEFKGVGKEPELHKEPLKFENVHLAIRSYK
CEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]