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The map label for this gene is ubiB [H]

Identifier: 39996190

GI number: 39996190

Start: 1172658

End: 1174343

Strand: Direct

Name: ubiB [H]

Synonym: GSU1088

Alternate gene names: 39996190

Gene position: 1172658-1174343 (Clockwise)

Preceding gene: 39996189

Following gene: 39996192

Centisome position: 30.75

GC content: 63.76

Gene sequence:

>1686_bases
ATGCTGAGCGTTTTCCAGCTCAATCGCAACATCCGGAGCCTGCGCCGCTATCGACAGATCGTGCGGGTATTGGTCAAGTA
TGGCTTCGAGCACGCCCTGTCGCTCATGGGGCTGTCCCGGTTCGTTGCCCGGGGACGCCGGCTGTTCCGCAAGCCCGAAC
CGGAACTGGCCCGGCTCTCGCCCGCGGAGCGGATGAGGCTTGCCCTTGAAGAACTGGGCCCCACGTTTGTCAAGCTGGGC
CAGATCCTCTCTACCCGCCCGGACGTGATCCCCCGCAGTTTCGTGCTGGAGTTCGCCCGGCTCCAGGATCAGGTGCCGTC
GTTCCCCTTCGAGGACGCCCTGGACCAGATCCGCCGCGAGCTTGGTCGCGATCCGGAGGAGCGTTTTTCCTTCATCGACC
CCGAGCCCCTTGCGGCAGCCTCCATCGCTCAGGTCCACCGGGCCCGGCTCGTTTCCGGCGAAGAGGTGGTGATCAAGGTC
CGTCGTCCCGGCGTGGTGGAGGCCGTGGAGACCGACATCGACGCCATGATGGGATTGGCGGTCCTGGCCGAGCGTCACCT
TCCCCGCAGCGACATCTACGACCCGGTGGGGCTCGTGAAGGAGTTCGCCCGGACGATCCGCCGCGAGATGGACTTCGCGC
GGGAAGGGCATACCATCGAGCGCTTTGCCGAGAACTTCGCGGGGGACCCGACCCTCTACTTCCCCACGGTCCACTGGGAC
TGTACCGCCCGGGGGCTCCTGACCATGGAGTTCATCAACGGGATCAAGGTGTCGGACACGGCGGCCTTGGAACGCGCGGG
CATGGACCGTCGGCTCATCGCCCGACGCGGCGCCGATGCCTTCCTCAAGATGGTCCTCACCCACGGCTTCTTCCATGGCG
ATCCCCATCCCGGCAATGTCCTTATCCTGCCGGACAACGTCATCTGTCTGCTGGACTACGGCATGGTGGGGCGGCTCGAC
GCCCAGCTCAAGGGGTATCTCACCGACATCCTGCTGGCCATCGTCCAGCGGGACGTGGACGAGGTGATCTCGCTGCTGCT
CTACTCGGGGGAGATTGCCGACACCTTGGATACCCGGGCTCTCAAGCGGGACCTGACCGGTCTGATCGACAACTACTACG
AGACCCCGCTCCAGGAGATCGAGGTGGGACGGGTGCTGCTGGAGTTTCTGGAGGTGATTACCACCTATCACATCAAGTTC
CAGCCCGACCTCATGCTGTTGGCCAAGGCCCTGGTGGCCATCGAGGGGATGGGGCGGGAGCTGGACCCCGCCTTCGACAT
GGTGGAGCACCTGCGCCCCTTCATGAAGCAGGCCGTGCGCGACCGCTTCTCTCCCCGCCAGCTGATCAGGGAGATGAACT
CGAACCTTCTCTCCTACTTCACCCTTGCCCGCAACCTGCCGCGGGACCTGAAGGAACTCCTCAACCGAATCAACCGGAAC
AAATTCAAGATCGACCTGGAACACCGGGGTCTCGACCGGGCCATGCGGGAGTTCGACAAGTCCGTGAACCGCCTTTCCTC
CAGCCTGATCATTGCCGCCCTGATCGTTGGCTCGTCCATTGTCATGCAGACCGACAAGGGTCCGAAGTTCCTCGATTTTC
CCGTGTTCGCCTTCATGGGCTACACCATCGCCGGCTTCATCGGCCTCTGGTGGGTCGTGGCGATCATCCGGTCGGGGCGG
CTGTAA

Upstream 100 bases:

>100_bases
TGGACCGACTTGGGCTCGTTCCCCGTGAGGAGTACGACCGGCTCGTCAAGCGGGTTGAGGCCCTTGAGGCCAAAGCCGGC
GTCGGAGACCCGAGCACCGA

Downstream 100 bases:

>100_bases
CGAAACCTCAGATTCTCACCAGATCATACTCGCGCGTCCCCATGCCGATCTTCTCGGCATGCTCCAGCTGAATCTCCCAA
TCGATGTCCGGGTGAACCCC

Product: ubiquinone biosynthesis protein AarF

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MLSVFQLNRNIRSLRRYRQIVRVLVKYGFEHALSLMGLSRFVARGRRLFRKPEPELARLSPAERMRLALEELGPTFVKLG
QILSTRPDVIPRSFVLEFARLQDQVPSFPFEDALDQIRRELGRDPEERFSFIDPEPLAAASIAQVHRARLVSGEEVVIKV
RRPGVVEAVETDIDAMMGLAVLAERHLPRSDIYDPVGLVKEFARTIRREMDFAREGHTIERFAENFAGDPTLYFPTVHWD
CTARGLLTMEFINGIKVSDTAALERAGMDRRLIARRGADAFLKMVLTHGFFHGDPHPGNVLILPDNVICLLDYGMVGRLD
AQLKGYLTDILLAIVQRDVDEVISLLLYSGEIADTLDTRALKRDLTGLIDNYYETPLQEIEVGRVLLEFLEVITTYHIKF
QPDLMLLAKALVAIEGMGRELDPAFDMVEHLRPFMKQAVRDRFSPRQLIREMNSNLLSYFTLARNLPRDLKELLNRINRN
KFKIDLEHRGLDRAMREFDKSVNRLSSSLIIAALIVGSSIVMQTDKGPKFLDFPVFAFMGYTIAGFIGLWWVVAIIRSGR
L

Sequences:

>Translated_561_residues
MLSVFQLNRNIRSLRRYRQIVRVLVKYGFEHALSLMGLSRFVARGRRLFRKPEPELARLSPAERMRLALEELGPTFVKLG
QILSTRPDVIPRSFVLEFARLQDQVPSFPFEDALDQIRRELGRDPEERFSFIDPEPLAAASIAQVHRARLVSGEEVVIKV
RRPGVVEAVETDIDAMMGLAVLAERHLPRSDIYDPVGLVKEFARTIRREMDFAREGHTIERFAENFAGDPTLYFPTVHWD
CTARGLLTMEFINGIKVSDTAALERAGMDRRLIARRGADAFLKMVLTHGFFHGDPHPGNVLILPDNVICLLDYGMVGRLD
AQLKGYLTDILLAIVQRDVDEVISLLLYSGEIADTLDTRALKRDLTGLIDNYYETPLQEIEVGRVLLEFLEVITTYHIKF
QPDLMLLAKALVAIEGMGRELDPAFDMVEHLRPFMKQAVRDRFSPRQLIREMNSNLLSYFTLARNLPRDLKELLNRINRN
KFKIDLEHRGLDRAMREFDKSVNRLSSSLIIAALIVGSSIVMQTDKGPKFLDFPVFAFMGYTIAGFIGLWWVVAIIRSGR
L
>Mature_561_residues
MLSVFQLNRNIRSLRRYRQIVRVLVKYGFEHALSLMGLSRFVARGRRLFRKPEPELARLSPAERMRLALEELGPTFVKLG
QILSTRPDVIPRSFVLEFARLQDQVPSFPFEDALDQIRRELGRDPEERFSFIDPEPLAAASIAQVHRARLVSGEEVVIKV
RRPGVVEAVETDIDAMMGLAVLAERHLPRSDIYDPVGLVKEFARTIRREMDFAREGHTIERFAENFAGDPTLYFPTVHWD
CTARGLLTMEFINGIKVSDTAALERAGMDRRLIARRGADAFLKMVLTHGFFHGDPHPGNVLILPDNVICLLDYGMVGRLD
AQLKGYLTDILLAIVQRDVDEVISLLLYSGEIADTLDTRALKRDLTGLIDNYYETPLQEIEVGRVLLEFLEVITTYHIKF
QPDLMLLAKALVAIEGMGRELDPAFDMVEHLRPFMKQAVRDRFSPRQLIREMNSNLLSYFTLARNLPRDLKELLNRINRN
KFKIDLEHRGLDRAMREFDKSVNRLSSSLIIAALIVGSSIVMQTDKGPKFLDFPVFAFMGYTIAGFIGLWWVVAIIRSGR
L

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=273, Percent_Identity=30.4029304029304, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=32.962962962963, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI217035081, Length=219, Percent_Identity=31.5068493150685, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI32261307, Length=387, Percent_Identity=26.0981912144703, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI34147522, Length=283, Percent_Identity=26.1484098939929, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI27363457, Length=290, Percent_Identity=26.8965517241379, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI217416386, Length=253, Percent_Identity=26.8774703557312, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI2367309, Length=545, Percent_Identity=33.5779816513761, Blast_Score=270, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17559152, Length=275, Percent_Identity=31.2727272727273, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17555620, Length=472, Percent_Identity=23.0932203389831, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=319, Percent_Identity=27.8996865203762, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=437, Percent_Identity=22.1967963386728, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321319, Length=241, Percent_Identity=28.6307053941909, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=243, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI22024280, Length=268, Percent_Identity=33.955223880597, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24662575, Length=288, Percent_Identity=29.1666666666667, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI18859849, Length=265, Percent_Identity=32.0754716981132, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 64091; Mature: 64091

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVFQLNRNIRSLRRYRQIVRVLVKYGFEHALSLMGLSRFVARGRRLFRKPEPELARLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
PAERMRLALEELGPTFVKLGQILSTRPDVIPRSFVLEFARLQDQVPSFPFEDALDQIRRE
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LGRDPEERFSFIDPEPLAAASIAQVHRARLVSGEEVVIKVRRPGVVEAVETDIDAMMGLA
HCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
VLAERHLPRSDIYDPVGLVKEFARTIRREMDFAREGHTIERFAENFAGDPTLYFPTVHWD
HHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCEEEC
CTARGLLTMEFINGIKVSDTAALERAGMDRRLIARRGADAFLKMVLTHGFFHGDPHPGNV
CCCCCHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEE
LILPDNVICLLDYGMVGRLDAQLKGYLTDILLAIVQRDVDEVISLLLYSGEIADTLDTRA
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LKRDLTGLIDNYYETPLQEIEVGRVLLEFLEVITTYHIKFQPDLMLLAKALVAIEGMGRE
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCEECCHHHHHHHHHHHHHHCCCC
LDPAFDMVEHLRPFMKQAVRDRFSPRQLIREMNSNLLSYFTLARNLPRDLKELLNRINRN
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
KFKIDLEHRGLDRAMREFDKSVNRLSSSLIIAALIVGSSIVMQTDKGPKFLDFPVFAFMG
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHHHH
YTIAGFIGLWWVVAIIRSGRL
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLSVFQLNRNIRSLRRYRQIVRVLVKYGFEHALSLMGLSRFVARGRRLFRKPEPELARLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
PAERMRLALEELGPTFVKLGQILSTRPDVIPRSFVLEFARLQDQVPSFPFEDALDQIRRE
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LGRDPEERFSFIDPEPLAAASIAQVHRARLVSGEEVVIKVRRPGVVEAVETDIDAMMGLA
HCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
VLAERHLPRSDIYDPVGLVKEFARTIRREMDFAREGHTIERFAENFAGDPTLYFPTVHWD
HHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCEEEC
CTARGLLTMEFINGIKVSDTAALERAGMDRRLIARRGADAFLKMVLTHGFFHGDPHPGNV
CCCCCHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEE
LILPDNVICLLDYGMVGRLDAQLKGYLTDILLAIVQRDVDEVISLLLYSGEIADTLDTRA
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LKRDLTGLIDNYYETPLQEIEVGRVLLEFLEVITTYHIKFQPDLMLLAKALVAIEGMGRE
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCEECCHHHHHHHHHHHHHHCCCC
LDPAFDMVEHLRPFMKQAVRDRFSPRQLIREMNSNLLSYFTLARNLPRDLKELLNRINRN
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
KFKIDLEHRGLDRAMREFDKSVNRLSSSLIIAALIVGSSIVMQTDKGPKFLDFPVFAFMG
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHHHH
YTIAGFIGLWWVVAIIRSGRL
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA