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The map label for this gene is hpt [H]

Identifier: 39996120

GI number: 39996120

Start: 1098815

End: 1099372

Strand: Direct

Name: hpt [H]

Synonym: GSU1017

Alternate gene names: 39996120

Gene position: 1098815-1099372 (Clockwise)

Preceding gene: 39996119

Following gene: 39996122

Centisome position: 28.81

GC content: 62.19

Gene sequence:

>558_bases
ATGTCCGTAACTCTCGATGAAATCAAACAAGTCTACCAAGAGGCCGACTGTCTCTTTTCCGAAGCAGAGGTGGAGGCCGC
CATCGGCCGGCTTGCCACCGCGGTCACCGAACGTCTGGCCGAGGCCAATCCCCTGGTCTTCTGCGTCATGAACGGCGGGC
TCATCGTCACCGGCAAGCTGCTGCCCCGGCTCGGATTCCCCCTGGAGATCGAATACCTGCACGCCACGCGCTATGGGCAC
CACATCTTCGGCAAATCCCTCGACTGGCGGGTGCGTCCCACTGTGGACCTGAGAGGACGGACGGTACTGATTGTGGATGA
CATACTGGACGAGGGGGCGACGCTCGACGCCATTACCGAATGGTGCCTGCAGGAGGGGGCGGCGAAGGTCTTCACCGCCG
TGCTCGTGGACAAGGAGCATGACCGGAAGGCCCGGCCGGGGTTGAAGGCCGACTTCACGGGGCTTGTGTCCCCGGACCGG
TTCCTCTTCGGCTACGGAATGGATTACAAGGGATACTGGCGCAACGCGCCGGGGATCTATGCGGTGAAGGGGTATTAG

Upstream 100 bases:

>100_bases
GTGGTGAAATGGTTTGGTTGTTTTCATGTCAACCTGCTTGTCAATGCGAGCGCCTTGGGCTACTGTAACCTGCGATCACC
ATTTTTCCGCGAGGTCTTTC

Downstream 100 bases:

>100_bases
CCGTTCAGGGCGGGCCGGGGAACGGCTCGGGTTCGCCCTGAACGGCTCGGGCACCGCTTAGGGCTGCTTCCATACGTAGG
TTTTGCTGATGCTTGCGGCG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSVTLDEIKQVYQEADCLFSEAEVEAAIGRLATAVTERLAEANPLVFCVMNGGLIVTGKLLPRLGFPLEIEYLHATRYGH
HIFGKSLDWRVRPTVDLRGRTVLIVDDILDEGATLDAITEWCLQEGAAKVFTAVLVDKEHDRKARPGLKADFTGLVSPDR
FLFGYGMDYKGYWRNAPGIYAVKGY

Sequences:

>Translated_185_residues
MSVTLDEIKQVYQEADCLFSEAEVEAAIGRLATAVTERLAEANPLVFCVMNGGLIVTGKLLPRLGFPLEIEYLHATRYGH
HIFGKSLDWRVRPTVDLRGRTVLIVDDILDEGATLDAITEWCLQEGAAKVFTAVLVDKEHDRKARPGLKADFTGLVSPDR
FLFGYGMDYKGYWRNAPGIYAVKGY
>Mature_184_residues
SVTLDEIKQVYQEADCLFSEAEVEAAIGRLATAVTERLAEANPLVFCVMNGGLIVTGKLLPRLGFPLEIEYLHATRYGHH
IFGKSLDWRVRPTVDLRGRTVLIVDDILDEGATLDAITEWCLQEGAAKVFTAVLVDKEHDRKARPGLKADFTGLVSPDRF
LFGYGMDYKGYWRNAPGIYAVKGY

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=27.810650887574, Blast_Score=77, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20611; Mature: 20480

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLDEIKQVYQEADCLFSEAEVEAAIGRLATAVTERLAEANPLVFCVMNGGLIVTGKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEH
LPRLGFPLEIEYLHATRYGHHIFGKSLDWRVRPTVDLRGRTVLIVDDILDEGATLDAITE
HHHCCCCEEEEEEEEECCCCHHCCCCCCEEECCCEEECCCEEEEEEHHHCCCCCHHHHHH
WCLQEGAAKVFTAVLVDKEHDRKARPGLKADFTGLVSPDRFLFGYGMDYKGYWRNAPGIY
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEE
AVKGY
EEECC
>Mature Secondary Structure 
SVTLDEIKQVYQEADCLFSEAEVEAAIGRLATAVTERLAEANPLVFCVMNGGLIVTGKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEH
LPRLGFPLEIEYLHATRYGHHIFGKSLDWRVRPTVDLRGRTVLIVDDILDEGATLDAITE
HHHCCCCEEEEEEEEECCCCHHCCCCCCEEECCCEEECCCEEEEEEHHHCCCCCHHHHHH
WCLQEGAAKVFTAVLVDKEHDRKARPGLKADFTGLVSPDRFLFGYGMDYKGYWRNAPGIY
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEE
AVKGY
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]