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Identifier: 39996036

GI number: 39996036

Start: 1002836

End: 1003465

Strand: Reverse

Name: upp

Synonym: GSU0933

Alternate gene names: 39996036

Gene position: 1003465-1002836 (Counterclockwise)

Preceding gene: 39996038

Following gene: 39996035

Centisome position: 26.31

GC content: 64.13

Gene sequence:

>630_bases
ATGGGCGTTCACGAGCTTACCCACCCGTTAGTCAGGCACAAGATCGGCCTCATGCGCGAGGCGGATATCAGCACCAAGAA
ATTTCGGGAACTTGCCGCCGAGCTGGCGCGGTTGCTGGCCTACGAGGCGTGCGGCGACTTCCCCCTGGAGGTCCGGACCA
TCACCGGCTGGGACGGCAACCCGGTGGAGATCGAACAGATCAAGGGGAAGAAGGTGACGGTGGTGCCCATCCTGCGGGCC
GGCATCGGCATGCTCGACGGGGTCCTCGACATGATCCCCAACGCCAAGGTGAGCGTGGTGGGACTCGCCCGCAACGAGGA
GACCCTCGAAGCACACACCTATCTGGAGAAGTTCGTGGACAAGCTTGACGAACGGCTGGCCGTCATCCTCGACCCGATGC
TCGCCACGGGCGGCTCCATGGAGGCAACCATCAGCATGCTCAAGCGCAACGGTTGCCGCCAGATCAGGGTCCTGGCGCTG
GTGGCGGCACCCGAGGGGCTCGCCCGGGTCACTGCCGCCCATCCCGATGTGGACATCTACGTGGCGGCCATTGACCGCTG
CCTCAACGAACACGGCTACATCCTCCCCGGTCTCGGCGACGCGGGGGACAAGATCTTCGGCACTAAATAA

Upstream 100 bases:

>100_bases
CACGCGGCGCATCGTCGCCGCCGACGCGCCCTTTTCAGATGACTTGTCTGACAAATTCGGGTAATCTTCCGGCCGGCGAA
TTACCACAACGGAGGCATCC

Downstream 100 bases:

>100_bases
CTTCCCGCGGAGCATGCCATGACCCACCACCAGGAACCGGTCTGGCGCCAGGCCATCGCCGGCGCGCAGATACTCTTCGT
CGCCTTCGGCGCCCTCGTGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGVHELTHPLVRHKIGLMREADISTKKFRELAAELARLLAYEACGDFPLEVRTITGWDGNPVEIEQIKGKKVTVVPILRA
GIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYLEKFVDKLDERLAVILDPMLATGGSMEATISMLKRNGCRQIRVLAL
VAAPEGLARVTAAHPDVDIYVAAIDRCLNEHGYILPGLGDAGDKIFGTK

Sequences:

>Translated_209_residues
MGVHELTHPLVRHKIGLMREADISTKKFRELAAELARLLAYEACGDFPLEVRTITGWDGNPVEIEQIKGKKVTVVPILRA
GIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYLEKFVDKLDERLAVILDPMLATGGSMEATISMLKRNGCRQIRVLAL
VAAPEGLARVTAAHPDVDIYVAAIDRCLNEHGYILPGLGDAGDKIFGTK
>Mature_208_residues
GVHELTHPLVRHKIGLMREADISTKKFRELAAELARLLAYEACGDFPLEVRTITGWDGNPVEIEQIKGKKVTVVPILRAG
IGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYLEKFVDKLDERLAVILDPMLATGGSMEATISMLKRNGCRQIRVLALV
AAPEGLARVTAAHPDVDIYVAAIDRCLNEHGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=25.7425742574257, Blast_Score=71, Evalue=5e-13,
Organism=Escherichia coli, GI87082118, Length=209, Percent_Identity=66.5071770334928, Blast_Score=293, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=22.7722772277228, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=22.7722772277228, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=196, Percent_Identity=32.6530612244898, Blast_Score=101, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=25.615763546798, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=25.615763546798, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=25.615763546798, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=25.615763546798, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_GEOSL (Q74EM9)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951987.1
- ProteinModelPortal:   Q74EM9
- SMR:   Q74EM9
- GeneID:   2687088
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0933
- NMPDR:   fig|243231.1.peg.925
- TIGR:   GSU0933
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- BioCyc:   GSUL243231:GSU_0933-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22747; Mature: 22616

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVHELTHPLVRHKIGLMREADISTKKFRELAAELARLLAYEACGDFPLEVRTITGWDGN
CCHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
PVEIEQIKGKKVTVVPILRAGIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYLEKFVD
CEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
KLDERLAVILDPMLATGGSMEATISMLKRNGCRQIRVLALVAAPEGLARVTAAHPDVDIY
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHCCCCCCHHH
VAAIDRCLNEHGYILPGLGDAGDKIFGTK
HHHHHHHHHCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GVHELTHPLVRHKIGLMREADISTKKFRELAAELARLLAYEACGDFPLEVRTITGWDGN
CHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
PVEIEQIKGKKVTVVPILRAGIGMLDGVLDMIPNAKVSVVGLARNEETLEAHTYLEKFVD
CEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
KLDERLAVILDPMLATGGSMEATISMLKRNGCRQIRVLALVAAPEGLARVTAAHPDVDIY
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHCCCCCCHHH
VAAIDRCLNEHGYILPGLGDAGDKIFGTK
HHHHHHHHHCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA