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The map label for this gene is uraA [H]

Identifier: 39996035

GI number: 39996035

Start: 1001567

End: 1002817

Strand: Reverse

Name: uraA [H]

Synonym: GSU0932

Alternate gene names: 39996035

Gene position: 1002817-1001567 (Counterclockwise)

Preceding gene: 39996036

Following gene: 39996034

Centisome position: 26.29

GC content: 66.27

Gene sequence:

>1251_bases
ATGACCCACCACCAGGAACCGGTCTGGCGCCAGGCCATCGCCGGCGCGCAGATACTCTTCGTCGCCTTCGGCGCCCTCGT
GCTGGTGCCGATCCTCACCGGGCTCAACCCGAGCATGGCCCTGCTGGGCGCCGGCATCGGCACCCTGATCTTCCAGGCGT
GCACCGGGCGCAAGGTCCCCATCTTCCTTGGCTCCTCCTTCGCGTTCATCGCGCCGATCATCTACAGCGTCCAGACCTGG
GGCATCCCGGCCACCCTGTCGGGGCTCTTCGCCTCCGGCGCGCTCTATCTGATGCTGGCGCTGCTCATCAAGATGCGGGG
CGTCGCATTCATCCACCGGATCATGCCCCCCGTGGTGGTGGGCCCCATCATCATGCTCATCGGCCTGGGGCTCGCCGGCG
TGGCGGTCAACCTGGCCATGGGCAAGACCGGCGACGGCAAGGCAGTGCTGGTCGATTACCAGACGGCCCTCCTGGTGGCC
GGCGTATCCCTTGCCACCACCGTGGTCATTGCCCTCAAGGCAAAGGGCATCTTCCGGCTCATACCGATCCTTGCGGGGGT
TACAGTGGGCTACAGCCTCTCGGCGTTTCTGGGGCTGGTGAACTTCAGCACCATCGCCGCGGCCCCCTGGTTCGCCATGC
CCCCCTTCGTGGCACCCCAGTGGAGCTGGCCGGCGGTCTTCTTCATGATCCCTGTGGCGCTGGCCCCGGCCATCGAGCAT
GTGGGCGACATCATCGCCATCGGGGCCGTTACGGGGCGCGACTACACCGCCCGGCCGGGGCTCCACCGTACCATGCTCGG
CGACGGGCTGGCGGTCTGCGTGGCCGGACTCATCGGTGGTCCGCCGGTGACCACCTATTCCGAGGTGACCGGCGCGGTCA
TGATCACCCGCAACCACAACCCCGTCATCATGACCTGGGCCGCCTGCATCGCCATCCTCATGGCCTTTTTCGGCAAGTTC
AACGCCCTGCTCCAGTCCATTCCCACCCCGGTCATGGGAGGGATCATGATCCTGCTGTTCGGCAGCATTGCCGCCGTGGG
CCTCAATACCCTCATCCATGCCCGGGTCGACATGCACCGCCCCCGCAACCTGGTAATCGTGTCGCTGGTGCTTGTATTCG
GCATCGGCGGCCTGACCCTCCAGGCCGGCTGGGTGACTCTCCAGGGGGTGAGCCTCTGCGGCATCACCGCCGTGCTCCTG
AACCTCTTCCTGCCCAAGGAGAAAAGAGACAGCGCCCAGCAGGCATTCTGA

Upstream 100 bases:

>100_bases
CATTGACCGCTGCCTCAACGAACACGGCTACATCCTCCCCGGTCTCGGCGACGCGGGGGACAAGATCTTCGGCACTAAAT
AACTTCCCGCGGAGCATGCC

Downstream 100 bases:

>100_bases
GCACGCCTTGACGAGCACTCCCTCCGTGGTAGCATCTAGCCATCACCCAACCAAAGTGAGGGGCGCGACATGGCAGACGC
CACCATCGACAGGGAAGAGC

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTHHQEPVWRQAIAGAQILFVAFGALVLVPILTGLNPSMALLGAGIGTLIFQACTGRKVPIFLGSSFAFIAPIIYSVQTW
GIPATLSGLFASGALYLMLALLIKMRGVAFIHRIMPPVVVGPIIMLIGLGLAGVAVNLAMGKTGDGKAVLVDYQTALLVA
GVSLATTVVIALKAKGIFRLIPILAGVTVGYSLSAFLGLVNFSTIAAAPWFAMPPFVAPQWSWPAVFFMIPVALAPAIEH
VGDIIAIGAVTGRDYTARPGLHRTMLGDGLAVCVAGLIGGPPVTTYSEVTGAVMITRNHNPVIMTWAACIAILMAFFGKF
NALLQSIPTPVMGGIMILLFGSIAAVGLNTLIHARVDMHRPRNLVIVSLVLVFGIGGLTLQAGWVTLQGVSLCGITAVLL
NLFLPKEKRDSAQQAF

Sequences:

>Translated_416_residues
MTHHQEPVWRQAIAGAQILFVAFGALVLVPILTGLNPSMALLGAGIGTLIFQACTGRKVPIFLGSSFAFIAPIIYSVQTW
GIPATLSGLFASGALYLMLALLIKMRGVAFIHRIMPPVVVGPIIMLIGLGLAGVAVNLAMGKTGDGKAVLVDYQTALLVA
GVSLATTVVIALKAKGIFRLIPILAGVTVGYSLSAFLGLVNFSTIAAAPWFAMPPFVAPQWSWPAVFFMIPVALAPAIEH
VGDIIAIGAVTGRDYTARPGLHRTMLGDGLAVCVAGLIGGPPVTTYSEVTGAVMITRNHNPVIMTWAACIAILMAFFGKF
NALLQSIPTPVMGGIMILLFGSIAAVGLNTLIHARVDMHRPRNLVIVSLVLVFGIGGLTLQAGWVTLQGVSLCGITAVLL
NLFLPKEKRDSAQQAF
>Mature_415_residues
THHQEPVWRQAIAGAQILFVAFGALVLVPILTGLNPSMALLGAGIGTLIFQACTGRKVPIFLGSSFAFIAPIIYSVQTWG
IPATLSGLFASGALYLMLALLIKMRGVAFIHRIMPPVVVGPIIMLIGLGLAGVAVNLAMGKTGDGKAVLVDYQTALLVAG
VSLATTVVIALKAKGIFRLIPILAGVTVGYSLSAFLGLVNFSTIAAAPWFAMPPFVAPQWSWPAVFFMIPVALAPAIEHV
GDIIAIGAVTGRDYTARPGLHRTMLGDGLAVCVAGLIGGPPVTTYSEVTGAVMITRNHNPVIMTWAACIAILMAFFGKFN
ALLQSIPTPVMGGIMILLFGSIAAVGLNTLIHARVDMHRPRNLVIVSLVLVFGIGGLTLQAGWVTLQGVSLCGITAVLLN
LFLPKEKRDSAQQAF

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=385, Percent_Identity=25.974025974026, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI44680143, Length=388, Percent_Identity=26.0309278350515, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI44680148, Length=388, Percent_Identity=26.0309278350515, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40316845, Length=388, Percent_Identity=26.0309278350515, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788843, Length=424, Percent_Identity=36.0849056603774, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87081818, Length=421, Percent_Identity=35.1543942992874, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082181, Length=425, Percent_Identity=27.7647058823529, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790087, Length=402, Percent_Identity=27.363184079602, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI87082178, Length=322, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=203, Percent_Identity=27.0935960591133, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=174, Percent_Identity=29.3103448275862, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=376, Percent_Identity=22.3404255319149, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71993493, Length=174, Percent_Identity=28.1609195402299, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356175, Length=435, Percent_Identity=25.5172413793103, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43563; Mature: 43432

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHHQEPVWRQAIAGAQILFVAFGALVLVPILTGLNPSMALLGAGIGTLIFQACTGRKVP
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCE
IFLGSSFAFIAPIIYSVQTWGIPATLSGLFASGALYLMLALLIKMRGVAFIHRIMPPVVV
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GPIIMLIGLGLAGVAVNLAMGKTGDGKAVLVDYQTALLVAGVSLATTVVIALKAKGIFRL
HHHHHHHHCCHHHHHHHHEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IPILAGVTVGYSLSAFLGLVNFSTIAAAPWFAMPPFVAPQWSWPAVFFMIPVALAPAIEH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VGDIIAIGAVTGRDYTARPGLHRTMLGDGLAVCVAGLIGGPPVTTYSEVTGAVMITRNHN
HCCEEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCC
PVIMTWAACIAILMAFFGKFNALLQSIPTPVMGGIMILLFGSIAAVGLNTLIHARVDMHR
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRNLVIVSLVLVFGIGGLTLQAGWVTLQGVSLCGITAVLLNLFLPKEKRDSAQQAF
CCHHHHHHHHHHHCCCCCEEEECEEEECCCHHHHHHHHHHHHHCCCHHCCHHHCCC
>Mature Secondary Structure 
THHQEPVWRQAIAGAQILFVAFGALVLVPILTGLNPSMALLGAGIGTLIFQACTGRKVP
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCE
IFLGSSFAFIAPIIYSVQTWGIPATLSGLFASGALYLMLALLIKMRGVAFIHRIMPPVVV
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GPIIMLIGLGLAGVAVNLAMGKTGDGKAVLVDYQTALLVAGVSLATTVVIALKAKGIFRL
HHHHHHHHCCHHHHHHHHEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IPILAGVTVGYSLSAFLGLVNFSTIAAAPWFAMPPFVAPQWSWPAVFFMIPVALAPAIEH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VGDIIAIGAVTGRDYTARPGLHRTMLGDGLAVCVAGLIGGPPVTTYSEVTGAVMITRNHN
HCCEEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCC
PVIMTWAACIAILMAFFGKFNALLQSIPTPVMGGIMILLFGSIAAVGLNTLIHARVDMHR
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRNLVIVSLVLVFGIGGLTLQAGWVTLQGVSLCGITAVLLNLFLPKEKRDSAQQAF
CCHHHHHHHHHHHCCCCCEEEECEEEECCCHHHHHHHHHHHHHCCCHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]