Click here to switch to the map view.

The map label for this gene is shc-1 [H]

Identifier: 39995794

GI number: 39995794

Start: 725430

End: 727469

Strand: Reverse

Name: shc-1 [H]

Synonym: GSU0688

Alternate gene names: 39995794

Gene position: 727469-725430 (Counterclockwise)

Preceding gene: 39995797

Following gene: 39995793

Centisome position: 19.07

GC content: 62.01

Gene sequence:

>2040_bases
ATGAAAATCTCAAAAAATCCCATTTCGCACGCACTCACTTCGTTCAATGATGCGGCACGGGAAACAGCTGACAATAGTGC
CGCACGCAAGTCGGGGAAAATCCACCACCTCCCCGCCACCATTTGGAAAAAAAAGGAATCGACGGTATCGAGCCCTCTCG
ATATAGCTATCGAGCGGACCCAGGAATTCTTTTTCCGCGAGCAGCTCCCCGCCGGCTACTGGTGGGCCGAGCTGGAATCC
AACGCTACTATAACCGCCGAATACATCATGCTGTTCCACTTCATGGGGCTGGTTAACCGTGAAAAAGAGCGGAAGATGGC
CAATTACCTTCTCCGCCAGCAGACTACGGAGGGCTACTGGACCATCTGGCACGGCGGTCCCGGCGACCTTTCCACCACAA
TCGAGGCCTATTTCGCCCTGAAGCTCGCCGGCTACCCGGCCGATCATCCGTCCATGAGCAAGGCCCGGGCGTTCATCCTA
GAGCACGGCGGCATCCTCAAGGCGCGGGTCTTCACCAAGATATTCCTTGCCCTGTTCGGGGAGTTCTCCTGGCTGGGGGT
TCCCTCCATGCCCATCGAGATGATGCTGCTCCCCGCCGGCTTCACCTTCAACATGTACGAGTTTTCCAGCTGGTCACGGG
CAACGATCATCCCCCTCTCCATCGTCATGGCGGAGCGGCCGGTGCGCAAGCTGCCCCCCTGGGCCCGGGTGCAGGAGCTT
TACGTGCGCCCCCCGCGGCCCACGGACTATACCTTCACCAAGGAAGACGGTATCCTCACCTGGAAGAACATCTTCATCGG
CATCGACCACGTACTGAAGGTGTACGAGGCGAGCCCCATCCGGCCGGGCAGGAAGAAAGCCATGGCCATCGCCGAGAAGT
GGGTGCTCGAGCACCAGGAGCCCACCGGCGACTGGGGGGGCATCCAGCCCGCCATGCTCAACTCGGTGCTGGCGCTCCAC
GTACTCGGTTACGCCAACGACCATCCGGCCGTGGCCAAGGGGCTGCAGGCCCTGGCCAACTTCTGCATCGAGGGTGAGGA
CGAACTGGTCCTCCAGTCCTGCGTCTCGCCGGTATGGGATACGGCCCTGGGCCTCATGGCCATGGTCGACTCGGGAGTCC
CCACCGATCACCCTTCCCTCTCCAAGGCGGCCCAATGGCTTCTGGACCGTGAAGTCCGCAGGCCGGGCGACTGGAAGATC
AAGTGTCCCGATCTGGAGCCCGGCGGCTGGGCCTTCGAGTTCATGAACGACTGGTATCCCGATGTGGACGACTCGGGTAT
CGTCATGATGGCCATCAAAAACGTGAAGGTTAAGGACCAGCGGGCCAAAGAGGACACCATCACCCGCGGCATCGCCTGGT
GCCTGGGCATGCAGAGCAAGAACGGCGGCTGGGGGGCCTTTGACAAGGACAACACCAAGCACATCCTCAACAAGATCCCC
TTCGCCGACCTGGAGGCCCTCATCGACCCCCCCACGGCGGATCTGACCGGCCGCATGCTGGAGCTCATGGGGACCTACGG
TTATCCCAAGGACCACCCAGCGGCGGTCAGGGCGCTGAAGTTCATCCGTGAGACCCAGGAACCCGACGGTCCCTGGTGGG
GACGGTGGGGGGTAAATTACATCTACGGCACTTGGTCGGTCATGTCCGGACTTGCCGCCTTTGGCGAAGACATGAGCCAG
CCTTGGATCCGCAAGGCCGTGGACTGGCTCGTGGAGCACCAGAACGAAGACGGCGGCTGGGGCGAGTGTTGCGAGTCGTA
CGCCGATCCCCGGCTGGCCGGCGTCGGGCCCAGCACGGCGTCTCAGACAGGATGGGCCCTTCTCACGCTCCTTGCCGCCG
GCGAGGTGGCAAGCTCGTCCGTGGTGCGGGGAGTCCAGTATCTCCTCGACACCCAGAAGCCCGACGGGACCTGGGACGAG
GACGCCTTCACCGGCACGGGCTTCCCGAAATTTTTCATGATCAAGTACCACATCTACCGGAACTGCTTCCCTCTCATGGC
GCTGGGACGCTACCGGACGCTTGCGGGCAAAGGGCTCTGA

Upstream 100 bases:

>100_bases
TCTTTTTTGTTAAATCTGTGATATTAAACACCGATTGCTGTTGGCTGCCCACGGTTGGCGGGCCGATATTCAGATGCATT
GTCCAAGGAGCAGAGCCGAG

Downstream 100 bases:

>100_bases
CAGCCTCGACAAGTAAGTGGATTACGCGTAGGGGCGGTTCACCAACCGCCCCTACATCAGTTTTGAAGGCACTATGAAGG
TTTTTGTCACCGGCGCGACC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKISKNPISHALTSFNDAARETADNSAARKSGKIHHLPATIWKKKESTVSSPLDIAIERTQEFFFREQLPAGYWWAELES
NATITAEYIMLFHFMGLVNREKERKMANYLLRQQTTEGYWTIWHGGPGDLSTTIEAYFALKLAGYPADHPSMSKARAFIL
EHGGILKARVFTKIFLALFGEFSWLGVPSMPIEMMLLPAGFTFNMYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
YVRPPRPTDYTFTKEDGILTWKNIFIGIDHVLKVYEASPIRPGRKKAMAIAEKWVLEHQEPTGDWGGIQPAMLNSVLALH
VLGYANDHPAVAKGLQALANFCIEGEDELVLQSCVSPVWDTALGLMAMVDSGVPTDHPSLSKAAQWLLDREVRRPGDWKI
KCPDLEPGGWAFEFMNDWYPDVDDSGIVMMAIKNVKVKDQRAKEDTITRGIAWCLGMQSKNGGWGAFDKDNTKHILNKIP
FADLEALIDPPTADLTGRMLELMGTYGYPKDHPAAVRALKFIRETQEPDGPWWGRWGVNYIYGTWSVMSGLAAFGEDMSQ
PWIRKAVDWLVEHQNEDGGWGECCESYADPRLAGVGPSTASQTGWALLTLLAAGEVASSSVVRGVQYLLDTQKPDGTWDE
DAFTGTGFPKFFMIKYHIYRNCFPLMALGRYRTLAGKGL

Sequences:

>Translated_679_residues
MKISKNPISHALTSFNDAARETADNSAARKSGKIHHLPATIWKKKESTVSSPLDIAIERTQEFFFREQLPAGYWWAELES
NATITAEYIMLFHFMGLVNREKERKMANYLLRQQTTEGYWTIWHGGPGDLSTTIEAYFALKLAGYPADHPSMSKARAFIL
EHGGILKARVFTKIFLALFGEFSWLGVPSMPIEMMLLPAGFTFNMYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
YVRPPRPTDYTFTKEDGILTWKNIFIGIDHVLKVYEASPIRPGRKKAMAIAEKWVLEHQEPTGDWGGIQPAMLNSVLALH
VLGYANDHPAVAKGLQALANFCIEGEDELVLQSCVSPVWDTALGLMAMVDSGVPTDHPSLSKAAQWLLDREVRRPGDWKI
KCPDLEPGGWAFEFMNDWYPDVDDSGIVMMAIKNVKVKDQRAKEDTITRGIAWCLGMQSKNGGWGAFDKDNTKHILNKIP
FADLEALIDPPTADLTGRMLELMGTYGYPKDHPAAVRALKFIRETQEPDGPWWGRWGVNYIYGTWSVMSGLAAFGEDMSQ
PWIRKAVDWLVEHQNEDGGWGECCESYADPRLAGVGPSTASQTGWALLTLLAAGEVASSSVVRGVQYLLDTQKPDGTWDE
DAFTGTGFPKFFMIKYHIYRNCFPLMALGRYRTLAGKGL
>Mature_679_residues
MKISKNPISHALTSFNDAARETADNSAARKSGKIHHLPATIWKKKESTVSSPLDIAIERTQEFFFREQLPAGYWWAELES
NATITAEYIMLFHFMGLVNREKERKMANYLLRQQTTEGYWTIWHGGPGDLSTTIEAYFALKLAGYPADHPSMSKARAFIL
EHGGILKARVFTKIFLALFGEFSWLGVPSMPIEMMLLPAGFTFNMYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
YVRPPRPTDYTFTKEDGILTWKNIFIGIDHVLKVYEASPIRPGRKKAMAIAEKWVLEHQEPTGDWGGIQPAMLNSVLALH
VLGYANDHPAVAKGLQALANFCIEGEDELVLQSCVSPVWDTALGLMAMVDSGVPTDHPSLSKAAQWLLDREVRRPGDWKI
KCPDLEPGGWAFEFMNDWYPDVDDSGIVMMAIKNVKVKDQRAKEDTITRGIAWCLGMQSKNGGWGAFDKDNTKHILNKIP
FADLEALIDPPTADLTGRMLELMGTYGYPKDHPAAVRALKFIRETQEPDGPWWGRWGVNYIYGTWSVMSGLAAFGEDMSQ
PWIRKAVDWLVEHQNEDGGWGECCESYADPRLAGVGPSTASQTGWALLTLLAAGEVASSSVVRGVQYLLDTQKPDGTWDE
DAFTGTGFPKFFMIKYHIYRNCFPLMALGRYRTLAGKGL

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=600, Percent_Identity=25, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI47933397, Length=600, Percent_Identity=25, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI224177558, Length=600, Percent_Identity=25, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI224177556, Length=568, Percent_Identity=25.3521126760563, Blast_Score=166, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6321863, Length=668, Percent_Identity=23.6526946107784, Blast_Score=141, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 76204; Mature: 76204

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISKNPISHALTSFNDAARETADNSAARKSGKIHHLPATIWKKKESTVSSPLDIAIERT
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCHHHHHCCHHHCCCCHHHHHHHH
QEFFFREQLPAGYWWAELESNATITAEYIMLFHFMGLVNREKERKMANYLLRQQTTEGYW
HHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
TIWHGGPGDLSTTIEAYFALKLAGYPADHPSMSKARAFILEHGGILKARVFTKIFLALFG
EEEECCCCCHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
EFSWLGVPSMPIEMMLLPAGFTFNMYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCEEEEHHHHHHHCCCHHHCCCHHHHHHH
YVRPPRPTDYTFTKEDGILTWKNIFIGIDHVLKVYEASPIRPGRKKAMAIAEKWVLEHQE
HCCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
PTGDWGGIQPAMLNSVLALHVLGYANDHPAVAKGLQALANFCIEGEDELVLQSCVSPVWD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TALGLMAMVDSGVPTDHPSLSKAAQWLLDREVRRPGDWKIKCPDLEPGGWAFEFMNDWYP
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEHHHHHCCCC
DVDDSGIVMMAIKNVKVKDQRAKEDTITRGIAWCLGMQSKNGGWGAFDKDNTKHILNKIP
CCCCCCEEEEEEECCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
FADLEALIDPPTADLTGRMLELMGTYGYPKDHPAAVRALKFIRETQEPDGPWWGRWGVNY
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCE
IYGTWSVMSGLAAFGEDMSQPWIRKAVDWLVEHQNEDGGWGECCESYADPRLAGVGPSTA
EEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEECCCCCCC
SQTGWALLTLLAAGEVASSSVVRGVQYLLDTQKPDGTWDEDAFTGTGFPKFFMIKYHIYR
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHH
NCFPLMALGRYRTLAGKGL
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKISKNPISHALTSFNDAARETADNSAARKSGKIHHLPATIWKKKESTVSSPLDIAIERT
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCHHHHHCCHHHCCCCHHHHHHHH
QEFFFREQLPAGYWWAELESNATITAEYIMLFHFMGLVNREKERKMANYLLRQQTTEGYW
HHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
TIWHGGPGDLSTTIEAYFALKLAGYPADHPSMSKARAFILEHGGILKARVFTKIFLALFG
EEEECCCCCHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
EFSWLGVPSMPIEMMLLPAGFTFNMYEFSSWSRATIIPLSIVMAERPVRKLPPWARVQEL
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCEEEEHHHHHHHCCCHHHCCCHHHHHHH
YVRPPRPTDYTFTKEDGILTWKNIFIGIDHVLKVYEASPIRPGRKKAMAIAEKWVLEHQE
HCCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
PTGDWGGIQPAMLNSVLALHVLGYANDHPAVAKGLQALANFCIEGEDELVLQSCVSPVWD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TALGLMAMVDSGVPTDHPSLSKAAQWLLDREVRRPGDWKIKCPDLEPGGWAFEFMNDWYP
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEHHHHHCCCC
DVDDSGIVMMAIKNVKVKDQRAKEDTITRGIAWCLGMQSKNGGWGAFDKDNTKHILNKIP
CCCCCCEEEEEEECCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
FADLEALIDPPTADLTGRMLELMGTYGYPKDHPAAVRALKFIRETQEPDGPWWGRWGVNY
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCE
IYGTWSVMSGLAAFGEDMSQPWIRKAVDWLVEHQNEDGGWGECCESYADPRLAGVGPSTA
EEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEECCCCCCC
SQTGWALLTLLAAGEVASSSVVRGVQYLLDTQKPDGTWDEDAFTGTGFPKFFMIKYHIYR
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHH
NCFPLMALGRYRTLAGKGL
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]