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The map label for this gene is cysK [H]

Identifier: 39995642

GI number: 39995642

Start: 567299

End: 568222

Strand: Direct

Name: cysK [H]

Synonym: GSU0535

Alternate gene names: 39995642

Gene position: 567299-568222 (Clockwise)

Preceding gene: 39995641

Following gene: 39995643

Centisome position: 14.87

GC content: 65.04

Gene sequence:

>924_bases
ATGCCGCTACTAACCAACGACAAGGTAATCGAGCAGATCGGCAATACCCCTCTCCTGAGACTGGCAAAGCTTGAGCGAAA
GGGTTCGGCAGCCGTATTCGGCAAGGCGGAGTTCTTCAACCCCGGCGGCAGCATCAAGGATCGTATCTGCCTCGCCATGA
TCGAGGCCGCCGAGCGTGACGGCACCCTCAAGCCCGGCGCCACGGTGGTGGAGCCCACCAGCGGCAATACGGGCATCGGC
CTGTCCATGATCTGCGCGGTCAAGGGGTACAAGCTCATCCTGACCATGCCCGATACCATGACTGTGGAGCGGCGGCGGCT
GCTGGCGGCGTACGGCGCCGAACTGATCCTCACCCCCGGCGCCCAGGGGATGCGCGGGGCCGTTATGAAGGCGGAGGAAC
TGGCGGCCCAGCCGGGGCACGTGATGATGCACCAGTTCAAGAACCCGGCAAACCCGGATATCCATCGCCGGACCACGGGG
CCGGAGATCGTGGAAACCCTGTCCGGCACGACCATCGACGCCTTCGTGGCGGGGGTGGGCACCGGCGGCACCATCACCGG
CGTCGGCGAGGTGCTCAGGACGCACAACTCCTCGGTGCGGGTCGTGGCGGTGGAGCCGGCTGATTCGCCGGTCCTCTCGG
GAGGCCAGCCCGGTCCCCACAAGATCCAGGGAATCGGAGCCGGCTTCGTTCCCGATGTGCTCAATACCAAGGTGTATGAC
GAGATCATCACCGTTTCCAACGACGATGCCTATGCCACCGTGCGCGACTTGGCCCGCGAGGAGGGCATCCTCGTCGGCAT
CTCCTCAGGTGCCAACGTCTTCGCCGCCCTTCAGGTGGCTGCCAAGCTCGGGCCGGGCAAGAACGTGGTAACGATCCTGT
GCGACACCGGCGAGCGGTACCTTTCCACCGGGGTGTTCGACTGA

Upstream 100 bases:

>100_bases
CGGTCAAGGATCTGTGCGACCGGGGACAGCAGATGGGGGTCAAGCGGGAGCAGGATCACCGGTTCATGTACTTTATCTGA
CATGCGGGAAGGAGACATTC

Downstream 100 bases:

>100_bases
TCGCCGCTCCTCGTCCGATTCAACCGCAACGCCCCTCACGGGGCGTTTTTTTTGAGGTGTCCGATGGAACAAACGCATCT
GAAATATGAACAACTCAAGG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPLLTNDKVIEQIGNTPLLRLAKLERKGSAAVFGKAEFFNPGGSIKDRICLAMIEAAERDGTLKPGATVVEPTSGNTGIG
LSMICAVKGYKLILTMPDTMTVERRRLLAAYGAELILTPGAQGMRGAVMKAEELAAQPGHVMMHQFKNPANPDIHRRTTG
PEIVETLSGTTIDAFVAGVGTGGTITGVGEVLRTHNSSVRVVAVEPADSPVLSGGQPGPHKIQGIGAGFVPDVLNTKVYD
EIITVSNDDAYATVRDLAREEGILVGISSGANVFAALQVAAKLGPGKNVVTILCDTGERYLSTGVFD

Sequences:

>Translated_307_residues
MPLLTNDKVIEQIGNTPLLRLAKLERKGSAAVFGKAEFFNPGGSIKDRICLAMIEAAERDGTLKPGATVVEPTSGNTGIG
LSMICAVKGYKLILTMPDTMTVERRRLLAAYGAELILTPGAQGMRGAVMKAEELAAQPGHVMMHQFKNPANPDIHRRTTG
PEIVETLSGTTIDAFVAGVGTGGTITGVGEVLRTHNSSVRVVAVEPADSPVLSGGQPGPHKIQGIGAGFVPDVLNTKVYD
EIITVSNDDAYATVRDLAREEGILVGISSGANVFAALQVAAKLGPGKNVVTILCDTGERYLSTGVFD
>Mature_306_residues
PLLTNDKVIEQIGNTPLLRLAKLERKGSAAVFGKAEFFNPGGSIKDRICLAMIEAAERDGTLKPGATVVEPTSGNTGIGL
SMICAVKGYKLILTMPDTMTVERRRLLAAYGAELILTPGAQGMRGAVMKAEELAAQPGHVMMHQFKNPANPDIHRRTTGP
EIVETLSGTTIDAFVAGVGTGGTITGVGEVLRTHNSSVRVVAVEPADSPVLSGGQPGPHKIQGIGAGFVPDVLNTKVYDE
IITVSNDDAYATVRDLAREEGILVGISSGANVFAALQVAAKLGPGKNVVTILCDTGERYLSTGVFD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=39.3548387096774, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=39.3548387096774, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=39.3548387096774, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI11345492, Length=297, Percent_Identity=24.9158249158249, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=52.4590163934426, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=45.6375838926174, Blast_Score=243, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=50.8361204013378, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=53.8720538720539, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=48.494983277592, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=49.3197278911565, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=46.4882943143813, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=48.8262910798122, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=323, Percent_Identity=38.0804953560372, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=37.1069182389937, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=44.8275862068966, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=297, Percent_Identity=27.6094276094276, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=38.0503144654088, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=36.280487804878, Blast_Score=146, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=38.3870967741935, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=38.3870967741935, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32117; Mature: 31986

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLTNDKVIEQIGNTPLLRLAKLERKGSAAVFGKAEFFNPGGSIKDRICLAMIEAAERD
CCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHCC
GTLKPGATVVEPTSGNTGIGLSMICAVKGYKLILTMPDTMTVERRRLLAAYGAELILTPG
CCCCCCCEEEECCCCCCCCCHHEEEEECCCEEEEECCCCHHHHHHHHHHHCCCEEEECCC
AQGMRGAVMKAEELAAQPGHVMMHQFKNPANPDIHRRTTGPEIVETLSGTTIDAFVAGVG
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEHHHEECC
TGGTITGVGEVLRTHNSSVRVVAVEPADSPVLSGGQPGPHKIQGIGAGFVPDVLNTKVYD
CCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHCHHHHH
EIITVSNDDAYATVRDLAREEGILVGISSGANVFAALQVAAKLGPGKNVVTILCDTGERY
HEEEECCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHH
LSTGVFD
HHCCCCC
>Mature Secondary Structure 
PLLTNDKVIEQIGNTPLLRLAKLERKGSAAVFGKAEFFNPGGSIKDRICLAMIEAAERD
CCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHCC
GTLKPGATVVEPTSGNTGIGLSMICAVKGYKLILTMPDTMTVERRRLLAAYGAELILTPG
CCCCCCCEEEECCCCCCCCCHHEEEEECCCEEEEECCCCHHHHHHHHHHHCCCEEEECCC
AQGMRGAVMKAEELAAQPGHVMMHQFKNPANPDIHRRTTGPEIVETLSGTTIDAFVAGVG
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEHHHEECC
TGGTITGVGEVLRTHNSSVRVVAVEPADSPVLSGGQPGPHKIQGIGAGFVPDVLNTKVYD
CCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHCHHHHH
EIITVSNDDAYATVRDLAREEGILVGISSGANVFAALQVAAKLGPGKNVVTILCDTGERY
HEEEECCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHH
LSTGVFD
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA