Click here to switch to the map view.

The map label for this gene is pfs [H]

Identifier: 39995561

GI number: 39995561

Start: 483145

End: 483876

Strand: Direct

Name: pfs [H]

Synonym: GSU0453

Alternate gene names: 39995561

Gene position: 483145-483876 (Clockwise)

Preceding gene: 39995560

Following gene: 39995562

Centisome position: 12.67

GC content: 64.89

Gene sequence:

>732_bases
ATGGAACCGATTCTTGTTGTTGCCGCAACCCGGCAGGAGCTGACGCTGCTGATCCGAAGTCTCGGCGCCCGGGAGCGTGG
AGGCGCCGGTCGCCGTCCCAGCTGGCTCGGCAAGGTGGGGTTGCTGCCGGTGGTCCTGGCCGAGACCGGCATCGGCAAAG
TCAATACCGCGGCTGCCCTTGCCGCGCTGTTCGAGAACTTCATCCCCCGACTGGTGATCAATACCGGCTGCGCCGGCGCG
TACACCGCGAGCGGTCTTCGGGTCGGCGACCTGGCCGTTGCCTCAGCCGAAATTTCCGGCGATGAGGGGGTCCTCACCCC
CCAAGGGTGGGAAGGCCTCGATCTTATCGGTATCCCCGCCTTGGAGCGTAAAGGGGTGCGCTACTTCAACGAGTTTCCAC
TTTCTCTCCATCCCGCCGAGCAGGCGGTCCAACTGGCCACGGCCCTCGGCATCCCGCTCCGCCGGGGGAAGTTCGTCACC
GTCTCGACCTGCAGCGGCATCACGGCCCGCGGCGACGAACTGGCCAGCCGCTTCGATGCAATCTGCGAAAACATGGAGGG
GGCCGCCATGGCCCAGGTCGCCTTGGACTACGGTGTCGACTGCCTGGAGGTACGGGGGGTCAGCAACATGGTGGAAGACC
GTGACCTCTCCCGCTGGAACCTGCCCCTGGCCGTGGAAAAGGCCCAGCGTTTCATTATCAAATATCTCGAAACCTGCGGG
GAGGAGCAGTGA

Upstream 100 bases:

>100_bases
TCGTGGAGGCTCATGGCGGACGCATTGAGGTGGTGAGCGAAGCGGGCAAGGGGAGCATCTTCACGGTCCTGCTGCCGCGG
GTCGTCGCAGGATGATCCCC

Downstream 100 bases:

>100_bases
TGGACGCGCTCTCGCTCGGCTTTTCGCCCTGTCCCAACGATACGTTCATCTTCTATGGCCTGATCCACGGACGTGTGCCG
ACCAGCGGACTTACCTTCCG

Product: MTA/SAH nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MEPILVVAATRQELTLLIRSLGARERGGAGRRPSWLGKVGLLPVVLAETGIGKVNTAAALAALFENFIPRLVINTGCAGA
YTASGLRVGDLAVASAEISGDEGVLTPQGWEGLDLIGIPALERKGVRYFNEFPLSLHPAEQAVQLATALGIPLRRGKFVT
VSTCSGITARGDELASRFDAICENMEGAAMAQVALDYGVDCLEVRGVSNMVEDRDLSRWNLPLAVEKAQRFIIKYLETCG
EEQ

Sequences:

>Translated_243_residues
MEPILVVAATRQELTLLIRSLGARERGGAGRRPSWLGKVGLLPVVLAETGIGKVNTAAALAALFENFIPRLVINTGCAGA
YTASGLRVGDLAVASAEISGDEGVLTPQGWEGLDLIGIPALERKGVRYFNEFPLSLHPAEQAVQLATALGIPLRRGKFVT
VSTCSGITARGDELASRFDAICENMEGAAMAQVALDYGVDCLEVRGVSNMVEDRDLSRWNLPLAVEKAQRFIIKYLETCG
EEQ
>Mature_243_residues
MEPILVVAATRQELTLLIRSLGARERGGAGRRPSWLGKVGLLPVVLAETGIGKVNTAAALAALFENFIPRLVINTGCAGA
YTASGLRVGDLAVASAEISGDEGVLTPQGWEGLDLIGIPALERKGVRYFNEFPLSLHPAEQAVQLATALGIPLRRGKFVT
VSTCSGITARGDELASRFDAICENMEGAAMAQVALDYGVDCLEVRGVSNMVEDRDLSRWNLPLAVEKAQRFIIKYLETCG
EEQ

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively [H]

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =3.2.2.9 [H]

Molecular weight: Translated: 25938; Mature: 25938

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPILVVAATRQELTLLIRSLGARERGGAGRRPSWLGKVGLLPVVLAETGIGKVNTAAAL
CCCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AALFENFIPRLVINTGCAGAYTASGLRVGDLAVASAEISGDEGVLTPQGWEGLDLIGIPA
HHHHHHHHHHHHHCCCCCCCHHCCCCEECCEEEEEEECCCCCCCCCCCCCCCCEEECCCC
LERKGVRYFNEFPLSLHPAEQAVQLATALGIPLRRGKFVTVSTCSGITARGDELASRFDA
HHHCCCHHHHCCCCEECCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHH
ICENMEGAAMAQVALDYGVDCLEVRGVSNMVEDRDLSRWNLPLAVEKAQRFIIKYLETCG
HHHCCCCHHHHHHHHHHCCCCEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
EEQ
CCC
>Mature Secondary Structure
MEPILVVAATRQELTLLIRSLGARERGGAGRRPSWLGKVGLLPVVLAETGIGKVNTAAAL
CCCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AALFENFIPRLVINTGCAGAYTASGLRVGDLAVASAEISGDEGVLTPQGWEGLDLIGIPA
HHHHHHHHHHHHHCCCCCCCHHCCCCEECCEEEEEEECCCCCCCCCCCCCCCCEEECCCC
LERKGVRYFNEFPLSLHPAEQAVQLATALGIPLRRGKFVTVSTCSGITARGDELASRFDA
HHHCCCHHHHCCCCEECCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHH
ICENMEGAAMAQVALDYGVDCLEVRGVSNMVEDRDLSRWNLPLAVEKAQRFIIKYLETCG
HHHCCCCHHHHHHHHHHCCCCEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
EEQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA