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The map label for this gene is gcvT [H]

Identifier: 39995483

GI number: 39995483

Start: 409470

End: 410558

Strand: Direct

Name: gcvT [H]

Synonym: GSU0375

Alternate gene names: 39995483

Gene position: 409470-410558 (Clockwise)

Preceding gene: 39995482

Following gene: 39995484

Centisome position: 10.74

GC content: 65.38

Gene sequence:

>1089_bases
ATGGATACCCTCGCAAGCACCCCGTTGCGCATCGAGCACGAACGCCTCAACGCCCTCATGGCCCCCTTCGGCGGCTGGAA
CATGCCGATCCAGTACGAAGGGATCATCGCCGAGCACCGGTGGTGCCGGGAGAAGGCCTCCCTGTTCGACATCTGCCACA
TGGGGGAATTCCTCTTCACGGGCGATATCATCGCCGACGGACTGGAAGACGTCTTCACGTTTTCGGTGGCCTCCATCCCG
GTGGGGCGGTCCCGCTACGGCTTCCTCCTGAACGGAGACGGCGGCATCATGGACGATCTGATCGTCTTCCGCCTGGCGCA
GAACGAGGCCATGGTGGTGGTGAACGCGGCCACCATAGGCAAGGATTTCGCTGCCATCTCCGCCCGTCTCGGCGGCGGCG
GGTTTCAGGACATCTCCGCCGCAACCGCCAAGCTCGATCTCCAGGGCCCCCTCTCCCGGGAAGTACTTGTGGAGGTCATC
GGCCCGGAAATCGCGGCAATTCCCTATTTCAAATTCATCCGGACCAAGGTTCTCGGCGCCGATGCCATCGTGAGCCGCAC
CGGCTATACCGGAGAACTCGGCTATGAGATCTTCCTTCCGTCGGACCGCGTGGTGGAACTCTGGCAGCGGCTGTTGGCCG
ATCCCCGCGTCAGACCCGCCGGCCTCGGCGCCCGGGACGTGCTCCGGCTGGAGGTGGGCTACAGCCTCTACGGCAGCGAT
ATCGACGAGTCTACCACTCCCCTGGAGGCGGGGCTCGAGTCCTTCGTGTCCTTTGACAAGTCCTTCGTGGGCAAAGATGC
GCTCCTGGCCCAGCGGGCGGAAGGGGTGATGCGTCGCCGGGTGGCCTTTCAGGTCGCTTCCCGCCGTTCTCCCCGCCACG
ACTACGAGATTTTGTTCCAGGGCGAGCAGGTCGGCGCCGTCACCAGCGGTGTCTTTTCCCCCATGCTCGGCTGCGGCCTC
GGCCTCGGCTATGTGACTCCCGGCACGGCCGTCCCCGGCGCCCCGCTCACGATCCGGCACGAGCGGGTCAGCATGGATGC
GACGGTGGTGGACGCCCCTTTCTATCGGGGAGGGTCCCTGCGCGCCTGA

Upstream 100 bases:

>100_bases
TGGCAACGTCGGTTTCCTGCGGTAAAATCGTTTACAAACCCCCGGTCATCATTTACAGTTGTGGCCCCGCCCACAGCCAT
CCCCCCTTCGGGAGACCCCC

Downstream 100 bases:

>100_bases
TTTGCCGGCAGATAATCCATTCAGTTCGTCATACATCCACAAGGAGGCAACAGTCATGGAAACCTATTTCACCAAAGAGC
ACGAGTGGGTCAAGGTCAAG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MDTLASTPLRIEHERLNALMAPFGGWNMPIQYEGIIAEHRWCREKASLFDICHMGEFLFTGDIIADGLEDVFTFSVASIP
VGRSRYGFLLNGDGGIMDDLIVFRLAQNEAMVVVNAATIGKDFAAISARLGGGGFQDISAATAKLDLQGPLSREVLVEVI
GPEIAAIPYFKFIRTKVLGADAIVSRTGYTGELGYEIFLPSDRVVELWQRLLADPRVRPAGLGARDVLRLEVGYSLYGSD
IDESTTPLEAGLESFVSFDKSFVGKDALLAQRAEGVMRRRVAFQVASRRSPRHDYEILFQGEQVGAVTSGVFSPMLGCGL
GLGYVTPGTAVPGAPLTIRHERVSMDATVVDAPFYRGGSLRA

Sequences:

>Translated_362_residues
MDTLASTPLRIEHERLNALMAPFGGWNMPIQYEGIIAEHRWCREKASLFDICHMGEFLFTGDIIADGLEDVFTFSVASIP
VGRSRYGFLLNGDGGIMDDLIVFRLAQNEAMVVVNAATIGKDFAAISARLGGGGFQDISAATAKLDLQGPLSREVLVEVI
GPEIAAIPYFKFIRTKVLGADAIVSRTGYTGELGYEIFLPSDRVVELWQRLLADPRVRPAGLGARDVLRLEVGYSLYGSD
IDESTTPLEAGLESFVSFDKSFVGKDALLAQRAEGVMRRRVAFQVASRRSPRHDYEILFQGEQVGAVTSGVFSPMLGCGL
GLGYVTPGTAVPGAPLTIRHERVSMDATVVDAPFYRGGSLRA
>Mature_362_residues
MDTLASTPLRIEHERLNALMAPFGGWNMPIQYEGIIAEHRWCREKASLFDICHMGEFLFTGDIIADGLEDVFTFSVASIP
VGRSRYGFLLNGDGGIMDDLIVFRLAQNEAMVVVNAATIGKDFAAISARLGGGGFQDISAATAKLDLQGPLSREVLVEVI
GPEIAAIPYFKFIRTKVLGADAIVSRTGYTGELGYEIFLPSDRVVELWQRLLADPRVRPAGLGARDVLRLEVGYSLYGSD
IDESTTPLEAGLESFVSFDKSFVGKDALLAQRAEGVMRRRVAFQVASRRSPRHDYEILFQGEQVGAVTSGVFSPMLGCGL
GLGYVTPGTAVPGAPLTIRHERVSMDATVVDAPFYRGGSLRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=364, Percent_Identity=32.6923076923077, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI257796258, Length=348, Percent_Identity=32.7586206896552, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI257796256, Length=297, Percent_Identity=32.996632996633, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI257796254, Length=359, Percent_Identity=30.08356545961, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI24797151, Length=307, Percent_Identity=27.3615635179153, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI197927446, Length=323, Percent_Identity=28.4829721362229, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI21361378, Length=323, Percent_Identity=28.4829721362229, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194306651, Length=347, Percent_Identity=24.7838616714697, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=32.8804347826087, Blast_Score=174, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=360, Percent_Identity=32.2222222222222, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32563613, Length=318, Percent_Identity=28.9308176100629, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71994052, Length=330, Percent_Identity=23.6363636363636, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=330, Percent_Identity=23.6363636363636, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=364, Percent_Identity=32.6923076923077, Blast_Score=159, Evalue=5e-40,
Organism=Drosophila melanogaster, GI20129441, Length=363, Percent_Identity=35.8126721763085, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28571104, Length=284, Percent_Identity=27.8169014084507, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130091, Length=359, Percent_Identity=25.0696378830084, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39257; Mature: 39257

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLASTPLRIEHERLNALMAPFGGWNMPIQYEGIIAEHRWCREKASLFDICHMGEFLFT
CCCCCCCCCEEEHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHEE
GDIIADGLEDVFTFSVASIPVGRSRYGFLLNGDGGIMDDLIVFRLAQNEAMVVVNAATIG
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHEECCCCEEEEEEEHHHC
KDFAAISARLGGGGFQDISAATAKLDLQGPLSREVLVEVIGPEIAAIPYFKFIRTKVLGA
CHHHHHHHHCCCCCCCHHHHHHEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
DAIVSRTGYTGELGYEIFLPSDRVVELWQRLLADPRVRPAGLGARDVLRLEVGYSLYGSD
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEECCEEECCC
IDESTTPLEAGLESFVSFDKSFVGKDALLAQRAEGVMRRRVAFQVASRRSPRHDYEILFQ
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
GEQVGAVTSGVFSPMLGCGLGLGYVTPGTAVPGAPLTIRHERVSMDATVVDAPFYRGGSL
CCHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCCCCCCC
RA
CC
>Mature Secondary Structure
MDTLASTPLRIEHERLNALMAPFGGWNMPIQYEGIIAEHRWCREKASLFDICHMGEFLFT
CCCCCCCCCEEEHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHEE
GDIIADGLEDVFTFSVASIPVGRSRYGFLLNGDGGIMDDLIVFRLAQNEAMVVVNAATIG
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHEECCCCEEEEEEEHHHC
KDFAAISARLGGGGFQDISAATAKLDLQGPLSREVLVEVIGPEIAAIPYFKFIRTKVLGA
CHHHHHHHHCCCCCCCHHHHHHEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
DAIVSRTGYTGELGYEIFLPSDRVVELWQRLLADPRVRPAGLGARDVLRLEVGYSLYGSD
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEECCEEECCC
IDESTTPLEAGLESFVSFDKSFVGKDALLAQRAEGVMRRRVAFQVASRRSPRHDYEILFQ
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
GEQVGAVTSGVFSPMLGCGLGLGYVTPGTAVPGAPLTIRHERVSMDATVVDAPFYRGGSL
CCHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCCCCCCC
RA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA