Click here to switch to the map view.

The map label for this gene is srrB [H]

Identifier: 39995260

GI number: 39995260

Start: 166459

End: 167574

Strand: Direct

Name: srrB [H]

Synonym: GSU0149

Alternate gene names: 39995260

Gene position: 166459-167574 (Clockwise)

Preceding gene: 39995259

Following gene: 39995261

Centisome position: 4.36

GC content: 60.93

Gene sequence:

>1116_bases
ATGGATATCGTGACCAAGATGCAGTCTGAGCGCGGTCTCAAGTCGATTCTCGTCGTGGATGACGAATCGGTGATCCGCGA
CCTGTGCGCCAAGGCCCTCAAGGGGTACCGGGTCCTTCAGGCCGGCGACGGCGAAGAGGCCCTGCGCCTGTTCGAGCGGG
GGGGGATCGACGTTATCCTCACCGACGTAATGATGCCGAAGCTGAACGGCATCGAGCTCCTGCGGCGCCTCAAGGAGATG
GAGCCGACGCTCGTAGTCATCGTTATGACCGGTTACGCCGAAAAGGATATCATCCTCAATGCGCTCAAGGCGGACGCCGA
CGACTTCATCACCAAACCCCTGAACCTGCTGCAGCTCAAGACGGCAGTGGACCGCGCCTTGGACAAGAAGGTCCTCAAGG
AGGAGATCGCCAATCTCAAGAGCATGGACCGGCTCAAGAGCAACTTTCTGTCGCTCATCTCCCACAAGTTCCGGACGCCG
CTCACCGCCATCTCGCTCTTTCTCCAGAATCTCGCGTGCGGCGTCTACGACCCCGAGGACCCTGAATCCCGCAGGAACCT
GGAGCTCATCTTCGGCCAGTCCCGCTACCTGGAAAGCCTGGTGAGCGAACTCCTCGCCTTCAGTCGCTTCATGGACGCCG
AGGCGGGCCTCCAACTAGAGCCGTGCCTGCTGCAGGACCTGATTCCCAAGCTCGTCACGTCCTCCCGTGAGGCGGTCGCC
AAGCCCGGCATCGTCACCTCCTTCGACCTGGCCCCGCTGCCTCCCATCTCCCTGGACCGTGAGAAGATTACCTTCGCCAT
CGGCCAGATCATCGACAACGCCTACAAGTTTTCCCGGGAGAGAGGCAAGATCACCATCACTCTCAGGGAGTCGGGCGACG
AGTACCTGCTGGCCGTCGAGGACACGGGCGTGGGCATCCCCCGTGATGAAATACCCAAAATTTTCGAGAAGTTCTACCAA
GTGGACCCCGAAGGTACCGGTCAGATCCGCGGTTTCGGCCTCGGCCTTTTCTACGCGCGCGAGTTCGTCAAGCTCCACGA
TGGCACCATCTCTATCGAGAGCGAAGCCGGAGCTGGAACCCGGGTCACCATTGCCCTCCCCAGCGCAGCCACCTGA

Upstream 100 bases:

>100_bases
GAGCTGGCCCAGGCGGGCGGAACCCTGCCGGACAAGCTCGGCGAGGCCCTCGGCAAGGTGTGTGAACTCGTCCCCTGACC
GGGGAAACGGCAGGAACACC

Downstream 100 bases:

>100_bases
GATCGGCGTCATCCGCCCGGCTACGCGCGCTGTGAGCCCCTTTCACGGTTGATTATTTCCCTCGTTCTGCTATAGTTACA
CCTTTCTTGCGACCGTCCCC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MDIVTKMQSERGLKSILVVDDESVIRDLCAKALKGYRVLQAGDGEEALRLFERGGIDVILTDVMMPKLNGIELLRRLKEM
EPTLVVIVMTGYAEKDIILNALKADADDFITKPLNLLQLKTAVDRALDKKVLKEEIANLKSMDRLKSNFLSLISHKFRTP
LTAISLFLQNLACGVYDPEDPESRRNLELIFGQSRYLESLVSELLAFSRFMDAEAGLQLEPCLLQDLIPKLVTSSREAVA
KPGIVTSFDLAPLPPISLDREKITFAIGQIIDNAYKFSRERGKITITLRESGDEYLLAVEDTGVGIPRDEIPKIFEKFYQ
VDPEGTGQIRGFGLGLFYAREFVKLHDGTISIESEAGAGTRVTIALPSAAT

Sequences:

>Translated_371_residues
MDIVTKMQSERGLKSILVVDDESVIRDLCAKALKGYRVLQAGDGEEALRLFERGGIDVILTDVMMPKLNGIELLRRLKEM
EPTLVVIVMTGYAEKDIILNALKADADDFITKPLNLLQLKTAVDRALDKKVLKEEIANLKSMDRLKSNFLSLISHKFRTP
LTAISLFLQNLACGVYDPEDPESRRNLELIFGQSRYLESLVSELLAFSRFMDAEAGLQLEPCLLQDLIPKLVTSSREAVA
KPGIVTSFDLAPLPPISLDREKITFAIGQIIDNAYKFSRERGKITITLRESGDEYLLAVEDTGVGIPRDEIPKIFEKFYQ
VDPEGTGQIRGFGLGLFYAREFVKLHDGTISIESEAGAGTRVTIALPSAAT
>Mature_371_residues
MDIVTKMQSERGLKSILVVDDESVIRDLCAKALKGYRVLQAGDGEEALRLFERGGIDVILTDVMMPKLNGIELLRRLKEM
EPTLVVIVMTGYAEKDIILNALKADADDFITKPLNLLQLKTAVDRALDKKVLKEEIANLKSMDRLKSNFLSLISHKFRTP
LTAISLFLQNLACGVYDPEDPESRRNLELIFGQSRYLESLVSELLAFSRFMDAEAGLQLEPCLLQDLIPKLVTSSREAVA
KPGIVTSFDLAPLPPISLDREKITFAIGQIIDNAYKFSRERGKITITLRESGDEYLLAVEDTGVGIPRDEIPKIFEKFYQ
VDPEGTGQIRGFGLGLFYAREFVKLHDGTISIESEAGAGTRVTIALPSAAT

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=272, Percent_Identity=27.2058823529412, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=30.7053941908714, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=32.618025751073, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=132, Percent_Identity=37.8787878787879, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=27.3109243697479, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=29.6137339055794, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=28.1632653061224, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786912, Length=258, Percent_Identity=28.2945736434109, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=26.0683760683761, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=26.3392857142857, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790299, Length=133, Percent_Identity=30.8270676691729, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=26.2172284644195, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=34.2105263157895, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=29.2576419213974, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=26.0089686098655, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=103, Percent_Identity=30.0970873786408, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41194; Mature: 41194

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVTKMQSERGLKSILVVDDESVIRDLCAKALKGYRVLQAGDGEEALRLFERGGIDVIL
CCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCEEEE
TDVMMPKLNGIELLRRLKEMEPTLVVIVMTGYAEKDIILNALKADADDFITKPLNLLQLK
ECHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCHHHHHHCCHHHHHHH
TAVDRALDKKVLKEEIANLKSMDRLKSNFLSLISHKFRTPLTAISLFLQNLACGVYDPED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
PESRRNLELIFGQSRYLESLVSELLAFSRFMDAEAGLQLEPCLLQDLIPKLVTSSREAVA
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHC
KPGIVTSFDLAPLPPISLDREKITFAIGQIIDNAYKFSRERGKITITLRESGDEYLLAVE
CCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEE
DTGVGIPRDEIPKIFEKFYQVDPEGTGQIRGFGLGLFYAREFVKLHDGTISIESEAGAGT
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCEEEEECCCCCCC
RVTIALPSAAT
EEEEECCCCCC
>Mature Secondary Structure
MDIVTKMQSERGLKSILVVDDESVIRDLCAKALKGYRVLQAGDGEEALRLFERGGIDVIL
CCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCEEEE
TDVMMPKLNGIELLRRLKEMEPTLVVIVMTGYAEKDIILNALKADADDFITKPLNLLQLK
ECHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCHHHHHHCCHHHHHHH
TAVDRALDKKVLKEEIANLKSMDRLKSNFLSLISHKFRTPLTAISLFLQNLACGVYDPED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
PESRRNLELIFGQSRYLESLVSELLAFSRFMDAEAGLQLEPCLLQDLIPKLVTSSREAVA
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHC
KPGIVTSFDLAPLPPISLDREKITFAIGQIIDNAYKFSRERGKITITLRESGDEYLLAVE
CCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEE
DTGVGIPRDEIPKIFEKFYQVDPEGTGQIRGFGLGLFYAREFVKLHDGTISIESEAGAGT
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCEEEEECCCCCCC
RVTIALPSAAT
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA