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The map label for this gene is pdxA [H]

Identifier: 39995226

GI number: 39995226

Start: 129587

End: 130600

Strand: Direct

Name: pdxA [H]

Synonym: GSU0115

Alternate gene names: 39995226

Gene position: 129587-130600 (Clockwise)

Preceding gene: 39995225

Following gene: 39995227

Centisome position: 3.4

GC content: 60.26

Gene sequence:

>1014_bases
ATGAAAAAACCTCGCATTGTTATCACGATGGGTGATCCGACCGGCGTCGGCCCCGAGATCATAGCGAAAGCCCTGGCCGA
TCCGGCGGTGAGAGAGTGCTGTCGACACCTTGTGGTCGGCGACGAGTTCGCCATGAGCCGGGGAATTGCTCTGACCGGAA
CCGGTTTCAGAATAGAGACGTCAGAGAGCGTTCCCTTTGAGGAACCTGCCGACGGAGTCATTACGCTGCGCAAGGTTACG
TCCCTCTCCGCCGAAGACCTTTGCTATGGTCAACCGACGATCGCCAGCGGTGATGCAGTCTTTCGCTCCATCTGTCATGC
AGCAGACCTCTGTCTCAAGGGTGAGGCTGACGGTATGGCAACGGCACCGATCAACAAAGGGGCTCTCAACCGGGCGGGAC
ACCGGTATCCCGGCCACACGGAGCTTCTTGCCGAGCTTACCGGAGCAGATCGCGTCGTCATGATGCTGGCAGGGGCACGG
CTGCGGGTAGCGCTGGTAACCATTCATGAGGCCCTGGTGCGGGTCCCCGCACTGGTGACATTCGAACAAGTCCTTGAAAC
CATTCGTATCACGCACCGGGACGTGCACCGCTACTTTACACGCAATCCCCGCATCGCGGTGCTTGCCCTCAACCCCCACT
GCGGCGAGGGCGGTATGTTCGGGGACGAAGAGTCTCGGATCATTGCTCCAGCTGTCCAGGCGGCACGGCAGGAAGGTATT
GACGCGACAGGCCCTCTATCCGCAGATACCCTCTTTCACTTTGCCGTGCACGGAGCCTATGATGCGGTTGTCTGCATGTA
CCACGACCAGGGGCTCATTCCCCTGAAGCTCCTCCATTTTGACGATGGTGTGAACGTTACCCTGGGACTCCCCATTATTC
GGACCTCAGTGGACCACGGTACCGCCTACGACCTGGCGGGCACAGGGAAGGCTTCTGCCGAGAGTATGAAGGCCGCCATC
ATGATGGCCGCGGCAATGGCCGGGAGCAGGCGAGAGGAGAGCGGAGCGCCGTGA

Upstream 100 bases:

>100_bases
GAAAATAACCACCATCGACAACATGCTGAAAAGAGCGGCTCTGCCGCTCTTTTTTTTTCACCGGGATGCGCTTGAAACCT
GCTATGATTCCGCCATGCAG

Downstream 100 bases:

>100_bases
GGATGAAGAAACTGCTGTATCTGGCCATAGGTGCCGTGGTTGCGTATGGGATCTATATCGCCATATCGCTCATGTTTCTC
CCGTCGGTTGCAGAACTGAA

Product: pyridoxal phosphate biosynthetic protein PdxA

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKKPRIVITMGDPTGVGPEIIAKALADPAVRECCRHLVVGDEFAMSRGIALTGTGFRIETSESVPFEEPADGVITLRKVT
SLSAEDLCYGQPTIASGDAVFRSICHAADLCLKGEADGMATAPINKGALNRAGHRYPGHTELLAELTGADRVVMMLAGAR
LRVALVTIHEALVRVPALVTFEQVLETIRITHRDVHRYFTRNPRIAVLALNPHCGEGGMFGDEESRIIAPAVQAARQEGI
DATGPLSADTLFHFAVHGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGKASAESMKAAI
MMAAAMAGSRREESGAP

Sequences:

>Translated_337_residues
MKKPRIVITMGDPTGVGPEIIAKALADPAVRECCRHLVVGDEFAMSRGIALTGTGFRIETSESVPFEEPADGVITLRKVT
SLSAEDLCYGQPTIASGDAVFRSICHAADLCLKGEADGMATAPINKGALNRAGHRYPGHTELLAELTGADRVVMMLAGAR
LRVALVTIHEALVRVPALVTFEQVLETIRITHRDVHRYFTRNPRIAVLALNPHCGEGGMFGDEESRIIAPAVQAARQEGI
DATGPLSADTLFHFAVHGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGKASAESMKAAI
MMAAAMAGSRREESGAP
>Mature_337_residues
MKKPRIVITMGDPTGVGPEIIAKALADPAVRECCRHLVVGDEFAMSRGIALTGTGFRIETSESVPFEEPADGVITLRKVT
SLSAEDLCYGQPTIASGDAVFRSICHAADLCLKGEADGMATAPINKGALNRAGHRYPGHTELLAELTGADRVVMMLAGAR
LRVALVTIHEALVRVPALVTFEQVLETIRITHRDVHRYFTRNPRIAVLALNPHCGEGGMFGDEESRIIAPAVQAARQEGI
DATGPLSADTLFHFAVHGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGKASAESMKAAI
MMAAAMAGSRREESGAP

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=42.2492401215805, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35829; Mature: 35829

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPRIVITMGDPTGVGPEIIAKALADPAVRECCRHLVVGDEFAMSRGIALTGTGFRIET
CCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHCCEEEECCCEEEEC
SESVPFEEPADGVITLRKVTSLSAEDLCYGQPTIASGDAVFRSICHAADLCLKGEADGMA
CCCCCCCCCCCCEEEEEHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCEE
TAPINKGALNRAGHRYPGHTELLAELTGADRVVMMLAGARLRVALVTIHEALVRVPALVT
ECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHH
FEQVLETIRITHRDVHRYFTRNPRIAVLALNPHCGEGGMFGDEESRIIAPAVQAARQEGI
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCCC
DATGPLSADTLFHFAVHGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHG
CCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEECCCCEEEECCEEEEEECCCC
TAYDLAGTGKASAESMKAAIMMAAAMAGSRREESGAP
CEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKPRIVITMGDPTGVGPEIIAKALADPAVRECCRHLVVGDEFAMSRGIALTGTGFRIET
CCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHCCEEEECCCEEEEC
SESVPFEEPADGVITLRKVTSLSAEDLCYGQPTIASGDAVFRSICHAADLCLKGEADGMA
CCCCCCCCCCCCEEEEEHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCEE
TAPINKGALNRAGHRYPGHTELLAELTGADRVVMMLAGARLRVALVTIHEALVRVPALVT
ECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHH
FEQVLETIRITHRDVHRYFTRNPRIAVLALNPHCGEGGMFGDEESRIIAPAVQAARQEGI
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCCC
DATGPLSADTLFHFAVHGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHG
CCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEECCCCEEEECCEEEEEECCCC
TAYDLAGTGKASAESMKAAIMMAAAMAGSRREESGAP
CEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA