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The map label for this gene is hemG [H]

Identifier: 39995123

GI number: 39995123

Start: 20296

End: 21705

Strand: Reverse

Name: hemG [H]

Synonym: GSU0012

Alternate gene names: 39995123

Gene position: 21705-20296 (Counterclockwise)

Preceding gene: 39995124

Following gene: NA

Centisome position: 0.57

GC content: 64.54

Gene sequence:

>1410_bases
ATGAAAAAGGCGATTGTGGCCGGCGGCGGCATCTCAGGGCTCGCCACCGCGTACCTGCTGAAAACCCGGGCCGCGGAGGA
AGGACTTGAGCTCGACGTGACCCTGGTGGAGCGGGAGGAACGCCTGGGGGGCAAAATCTGGAGCATCAAGGAGGAGGGGT
ATCTCTGCGAGTGGGGCCCCAACGGTTTTCTGGACTCCAAACCCCAGACCCTCGACCTCTGCCGGGAACTGGGCGCGTCT
GACCTGCTCCTGCGGAGCAACGACAACGCCCGCAAGCGGTTCATCTACACCGGCGGGGCGCTGAACCGCCTACCCGAGAA
CGGACCCATGTTTCTCAAAAGCGGTCTCATCTCCTGGCCGGGCAAGCTGCGGCTCGCCATGGAACCGTTCATTCCGAAAA
AAGCGGGCGACGAGGACGAAACCCTGGCGGCCTTCGGCCGGCGCCGCCTGGGGGACGAAGCGCTGCGCAAGCTGATTGCG
CCCATGGTGTCGGGGATTTTTGCCGGCAATCCGGAAACCATGTCCCTGCGGTCGTGCTTTCCCCGCATCGCCGAGTTGGA
GGATGAATACGGCAGCTTGGTGCGGGCCATGATCCGTCTGGCGAAAAAGAAGAAGCAGGAGGTCGCTCAAGGAAAGGCGG
TGGCCAGCGCCGCCGGACCGGGCGGGGTGCTCACCTCGTTCCGGGACGGCATCCAGGCCCTCACCGATATCCTGGCCGAG
CGTCTCGGTCCGGACACTATCGTATCGGGCCAGGAAGTGCTGGAAGTTTCGCGGGGCGGAAGCCTCCCCTGGCGGGTGCG
GACCGGAAGCATCGATATGGACGCCGATCTGGTGATCCTGGCGACCCCCGCCTATGCCACCGCCTCCATCATTCAGGGAG
TGGACTCCGACATGGCCGGCATTCTCCGGCAGATCCCCTACGCCACCATGACCGTTGTCTGCTTCGGATATGACCGGGAG
CGGATCGCCCACGATCTGAACGGCTTCGGCTATCTCATTCCAAAGGAGGAGGGGATGAATACCCTGGGCACGCTCTGGGA
TTCGAGCATCTTCGAGAACCGGGCGCCGGAAGGTCAGGTCCTCCTGCGCAGCATGATGGGGGGGGCCTGCTTCCCCGAAT
ACGTCAACCTGACCGACGAGGAGGTCACTGGGCGGGTGAAGAACGACCTCGCCACCATCATGGGCATCACGGCGCCTCCT
TCGTTCGTCCGCATCTTCCGCCATCACCAGGCCATCCCCCAGTACACCGTGGGGCACTCCACACGCGTAGCCGCTCTGGA
GCAGAGAGCCGCCTCCCTGCCGGGACTTTTCCTCACCGGCAACTCTTACCGGGGTATCGGCCTCAACGACTGCGTGGCCG
CCGCCAACCGCACCGCCGGCGAGGCCATCGCCCAGCTCACATCCCGCTGA

Upstream 100 bases:

>100_bases
AGGAACGCCTCGCCACCGCTTTCGAGACCATTGCGGACGTTCTCGGCAAACTCGAATAACCGTACAAAGACAGTTTATCC
ACAGCGGAAGGAGAGAGAAC

Downstream 100 bases:

>100_bases
ACAGACAGAAAAGGGGGGCGCCATGCCCCCCTTCCATATTTCCTGCCGTTGCCCCGCCCGATCTCATTCCCGCACGTCAC
GACCCGTCAGTTCGATGAAA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKKAIVAGGGISGLATAYLLKTRAAEEGLELDVTLVEREERLGGKIWSIKEEGYLCEWGPNGFLDSKPQTLDLCRELGAS
DLLLRSNDNARKRFIYTGGALNRLPENGPMFLKSGLISWPGKLRLAMEPFIPKKAGDEDETLAAFGRRRLGDEALRKLIA
PMVSGIFAGNPETMSLRSCFPRIAELEDEYGSLVRAMIRLAKKKKQEVAQGKAVASAAGPGGVLTSFRDGIQALTDILAE
RLGPDTIVSGQEVLEVSRGGSLPWRVRTGSIDMDADLVILATPAYATASIIQGVDSDMAGILRQIPYATMTVVCFGYDRE
RIAHDLNGFGYLIPKEEGMNTLGTLWDSSIFENRAPEGQVLLRSMMGGACFPEYVNLTDEEVTGRVKNDLATIMGITAPP
SFVRIFRHHQAIPQYTVGHSTRVAALEQRAASLPGLFLTGNSYRGIGLNDCVAAANRTAGEAIAQLTSR

Sequences:

>Translated_469_residues
MKKAIVAGGGISGLATAYLLKTRAAEEGLELDVTLVEREERLGGKIWSIKEEGYLCEWGPNGFLDSKPQTLDLCRELGAS
DLLLRSNDNARKRFIYTGGALNRLPENGPMFLKSGLISWPGKLRLAMEPFIPKKAGDEDETLAAFGRRRLGDEALRKLIA
PMVSGIFAGNPETMSLRSCFPRIAELEDEYGSLVRAMIRLAKKKKQEVAQGKAVASAAGPGGVLTSFRDGIQALTDILAE
RLGPDTIVSGQEVLEVSRGGSLPWRVRTGSIDMDADLVILATPAYATASIIQGVDSDMAGILRQIPYATMTVVCFGYDRE
RIAHDLNGFGYLIPKEEGMNTLGTLWDSSIFENRAPEGQVLLRSMMGGACFPEYVNLTDEEVTGRVKNDLATIMGITAPP
SFVRIFRHHQAIPQYTVGHSTRVAALEQRAASLPGLFLTGNSYRGIGLNDCVAAANRTAGEAIAQLTSR
>Mature_469_residues
MKKAIVAGGGISGLATAYLLKTRAAEEGLELDVTLVEREERLGGKIWSIKEEGYLCEWGPNGFLDSKPQTLDLCRELGAS
DLLLRSNDNARKRFIYTGGALNRLPENGPMFLKSGLISWPGKLRLAMEPFIPKKAGDEDETLAAFGRRRLGDEALRKLIA
PMVSGIFAGNPETMSLRSCFPRIAELEDEYGSLVRAMIRLAKKKKQEVAQGKAVASAAGPGGVLTSFRDGIQALTDILAE
RLGPDTIVSGQEVLEVSRGGSLPWRVRTGSIDMDADLVILATPAYATASIIQGVDSDMAGILRQIPYATMTVVCFGYDRE
RIAHDLNGFGYLIPKEEGMNTLGTLWDSSIFENRAPEGQVLLRSMMGGACFPEYVNLTDEEVTGRVKNDLATIMGITAPP
SFVRIFRHHQAIPQYTVGHSTRVAALEQRAASLPGLFLTGNSYRGIGLNDCVAAANRTAGEAIAQLTSR

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=482, Percent_Identity=31.1203319502075, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4506001, Length=482, Percent_Identity=31.1203319502075, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24649745, Length=454, Percent_Identity=28.4140969162996, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 50767; Mature: 50767

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAIVAGGGISGLATAYLLKTRAAEEGLELDVTLVEREERLGGKIWSIKEEGYLCEWGP
CCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCEEEEEECCCEEEEECC
NGFLDSKPQTLDLCRELGASDLLLRSNDNARKRFIYTGGALNRLPENGPMFLKSGLISWP
CCCCCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEECCHHHCCCCCCCCHHHCCCCCCC
GKLRLAMEPFIPKKAGDEDETLAAFGRRRLGDEALRKLIAPMVSGIFAGNPETMSLRSCF
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
PRIAELEDEYGSLVRAMIRLAKKKKQEVAQGKAVASAAGPGGVLTSFRDGIQALTDILAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RLGPDTIVSGQEVLEVSRGGSLPWRVRTGSIDMDADLVILATPAYATASIIQGVDSDMAG
HCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCHHHHH
ILRQIPYATMTVVCFGYDRERIAHDLNGFGYLIPKEEGMNTLGTLWDSSIFENRAPEGQV
HHHHCCHHEEEEEEECCCHHHHHHHCCCCEEEEECHHCCHHHHHHHHHHHHHCCCCHHHH
LLRSMMGGACFPEYVNLTDEEVTGRVKNDLATIMGITAPPSFVRIFRHHQAIPQYTVGHS
HHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC
TRVAALEQRAASLPGLFLTGNSYRGIGLNDCVAAANRTAGEAIAQLTSR
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKAIVAGGGISGLATAYLLKTRAAEEGLELDVTLVEREERLGGKIWSIKEEGYLCEWGP
CCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCEEEEEECCCEEEEECC
NGFLDSKPQTLDLCRELGASDLLLRSNDNARKRFIYTGGALNRLPENGPMFLKSGLISWP
CCCCCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEECCHHHCCCCCCCCHHHCCCCCCC
GKLRLAMEPFIPKKAGDEDETLAAFGRRRLGDEALRKLIAPMVSGIFAGNPETMSLRSCF
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
PRIAELEDEYGSLVRAMIRLAKKKKQEVAQGKAVASAAGPGGVLTSFRDGIQALTDILAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RLGPDTIVSGQEVLEVSRGGSLPWRVRTGSIDMDADLVILATPAYATASIIQGVDSDMAG
HCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCHHHHH
ILRQIPYATMTVVCFGYDRERIAHDLNGFGYLIPKEEGMNTLGTLWDSSIFENRAPEGQV
HHHHCCHHEEEEEEECCCHHHHHHHCCCCEEEEECHHCCHHHHHHHHHHHHHCCCCHHHH
LLRSMMGGACFPEYVNLTDEEVTGRVKNDLATIMGITAPPSFVRIFRHHQAIPQYTVGHS
HHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC
TRVAALEQRAASLPGLFLTGNSYRGIGLNDCVAAANRTAGEAIAQLTSR
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]