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The map label for this gene is phoR [H]

Identifier: 39995121

GI number: 39995121

Start: 17115

End: 19298

Strand: Direct

Name: phoR [H]

Synonym: GSU0010

Alternate gene names: 39995121

Gene position: 17115-19298 (Clockwise)

Preceding gene: 39995120

Following gene: 39995122

Centisome position: 0.45

GC content: 61.77

Gene sequence:

>2184_bases
ATGACCGAAAAGAAACTGCGACTGCTTCTCGTGGAGGATAGCGAGGACGATGCCCTGCTGCTCCTGAACGACCTGAAGCG
CGGCGGCTACAGCGTGGAGCACGAGCGGGTCGAGACTGCCGCCGCCATGCGCGAGGCACTGGTGAAGCGGGAGTGGGACA
TTGTCATTTCCGACTACCGCCTGCCCCAGTTCACCGCGCCGGCAGCGCTTCAAATCCTCAAGCGCAGCGGTCTCGATCTA
CCCTTCATCATCGTGTCGGGGAAGATCGGTGAGGACATGCTTGTGGACGCCATGCGCGCCGGTGCCCACGATTACCTCAT
GAAAGGAAACCTCTCCCGCCTCATTCCGGCCGTGGACCGGGAAATCCGCGAGGCATCGGAGCGGCGGACCCGTCGCCGGG
CCGAACGCTCCATCCGCCAAGGCAAGATCGAGTGGGAAGCGGCCTTTGACGCCGTGTCGGACATCGTGGTCCTGACCGAT
CCCACCGGTACCATCATCCGCTGCAACAGCAAGCTGATTCAGTACTTCGATACCACCTACAACGATGTGATCGGCACAAA
CATCACTGAGCTCTTTTACGGCAACGATCCCGCCGGTGAAAGCATCTTCGGCCTCTGCGCCGATCTCAAGGCGGACGAAG
ACGATGTCCGCTTTCCCCGGCTGCCCGGGTGGTACAACGCTGCCTGCTACCCGATGCACCCCACCGAAAATGAGCATGGC
TACGTCTACGTGATCAAGGACATCACCAAACGCAAGCGGATGGAGGAAGAGAAAAAGCTCACGGACCGGGAGCTCCTCAC
CCTCTACGCCGTGGCCTTTCGCCTCAACTCCCAGCGGGGCTCCAAGCGGATCATGGTTGATCTCCTCTCCCAGCTGCACC
AGATGCTCCAGATCGACTGGTCCTGCATTCATCTCATGGAGAAAGGAAGTCTGAACCTCAGCGCCTGGCTGGGGCTGTCG
CGGGAGTTTGCCGAGTCCTTCGGCTCCCTGTCGCGCAGCCTCCCCTGGGTCAAGGATGTGCTCGACGGCAAAAGCTTCAA
GGCTGCCGAGATCGCCGGTCATTTCGGCCCGGAGGCGGAAGCGGCCGCGGAAGCCATGGGTATGGGAGCCTGGTGCGCCC
TCCCCCTCAAGATCGGCTCCGGCGTCCTGGGCACCCTGTTCGTGGCCCATCGCCCCAACCGGGAATACACTGACCGGGAG
GTGTTCCTTCTCAACTCCATCGCCAATCAGATGGCGGTCCTCATCGAGAATCACACCCTCTACGATCGGATGAAGGAGAA
GAACGAGGAGCTTGTCCGTAGCCGCAAGGCCCTCAAGGAGAACCTGGAGGAGGTGAAGCGGGCGAACATCGAACTGGGGC
GCCTGAATGCCTCCAAAAACAGCTTTATCGGTATGGCTTCCCATGAGCTGAAGACGCCGCTCACTTCCATCATCGGTGGG
TTGCAGTTCCTCCTCTTCTACAGCGACATTCCCATGACCCCCGAGCAGAAGGAGATGATGCAGTCGGTATACGAGGGGGT
GACCCAGCTCAAGGGAATCGTCGACGATCTCCTCTCCATCTCACGGATAGAGGCCAAGGGGTTCGCCGTCCATACCCGTC
CCGTGAAGCTGTCGGATCTCTGTCAGGAGGTACGGCAGACCCTGCTGCTCCCCCTGTCCGAGCGGGACATCCGCCTGGAA
ATCGCCGACGATCCCTGCCGCGTGCCGGCGGACGAGGGTTTTTGCCGCCTCGCGGTCCGCAACCTGACGGAAAACGCCAT
CAAGTTTACCCCTGACGGCGGACGGATTGCCATTACCGGCCGGCTGGTCACCATGGAGGAACTCACGGCGGACGAGGAGC
TGCTGCGCCCGTTCTACCGGGATTTCCCCGCCAATATCGCGGGGCATCCCGGGTTCTACCGCTTGGACGTGGCCGATACG
GGGATCGGAATCCCTCCCGATGAGGCGGTGCGGATCTTCGAGAAATTCTACGGCGTCGGCGACATCGAGTACCACTCCTC
CGGCAAGACCGGCTTCATGTCCAAGGGGTCGGGGCTCGGCCTTTCCATCGTCAAGGGGATCATGGACGCCCACGGCGGCA
TGGTCTGGGTGACGTCGGGCGAGGGAGGCGGCGGGAGCGTCTTTTCCCTCCTGTTCCCCATGGATAACACGTGCGTCGTT
CCCCTCCGGGGCGAAGCGAGGTAG

Upstream 100 bases:

>100_bases
GGGTCGAGGCAGCCCCGGATCACGGTGCCACATTCTACTTCACCCTGGGCGAGGAAGAGCACCTCGCCCGGAATTCCGAC
AAAGAGGACGGAACAACCCA

Downstream 100 bases:

>100_bases
CGAGCGCGTGCCGGCCGCCCTCTCACTGCACGAGCTGACCAAGCACTACGGCACCCTCACGGCCGTGGATCGCTTTTCCC
TGAAGGTCGACCGAGGTACC

Product: sensory box histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MTEKKLRLLLVEDSEDDALLLLNDLKRGGYSVEHERVETAAAMREALVKREWDIVISDYRLPQFTAPAALQILKRSGLDL
PFIIVSGKIGEDMLVDAMRAGAHDYLMKGNLSRLIPAVDREIREASERRTRRRAERSIRQGKIEWEAAFDAVSDIVVLTD
PTGTIIRCNSKLIQYFDTTYNDVIGTNITELFYGNDPAGESIFGLCADLKADEDDVRFPRLPGWYNAACYPMHPTENEHG
YVYVIKDITKRKRMEEEKKLTDRELLTLYAVAFRLNSQRGSKRIMVDLLSQLHQMLQIDWSCIHLMEKGSLNLSAWLGLS
REFAESFGSLSRSLPWVKDVLDGKSFKAAEIAGHFGPEAEAAAEAMGMGAWCALPLKIGSGVLGTLFVAHRPNREYTDRE
VFLLNSIANQMAVLIENHTLYDRMKEKNEELVRSRKALKENLEEVKRANIELGRLNASKNSFIGMASHELKTPLTSIIGG
LQFLLFYSDIPMTPEQKEMMQSVYEGVTQLKGIVDDLLSISRIEAKGFAVHTRPVKLSDLCQEVRQTLLLPLSERDIRLE
IADDPCRVPADEGFCRLAVRNLTENAIKFTPDGGRIAITGRLVTMEELTADEELLRPFYRDFPANIAGHPGFYRLDVADT
GIGIPPDEAVRIFEKFYGVGDIEYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVTSGEGGGGSVFSLLFPMDNTCVV
PLRGEAR

Sequences:

>Translated_727_residues
MTEKKLRLLLVEDSEDDALLLLNDLKRGGYSVEHERVETAAAMREALVKREWDIVISDYRLPQFTAPAALQILKRSGLDL
PFIIVSGKIGEDMLVDAMRAGAHDYLMKGNLSRLIPAVDREIREASERRTRRRAERSIRQGKIEWEAAFDAVSDIVVLTD
PTGTIIRCNSKLIQYFDTTYNDVIGTNITELFYGNDPAGESIFGLCADLKADEDDVRFPRLPGWYNAACYPMHPTENEHG
YVYVIKDITKRKRMEEEKKLTDRELLTLYAVAFRLNSQRGSKRIMVDLLSQLHQMLQIDWSCIHLMEKGSLNLSAWLGLS
REFAESFGSLSRSLPWVKDVLDGKSFKAAEIAGHFGPEAEAAAEAMGMGAWCALPLKIGSGVLGTLFVAHRPNREYTDRE
VFLLNSIANQMAVLIENHTLYDRMKEKNEELVRSRKALKENLEEVKRANIELGRLNASKNSFIGMASHELKTPLTSIIGG
LQFLLFYSDIPMTPEQKEMMQSVYEGVTQLKGIVDDLLSISRIEAKGFAVHTRPVKLSDLCQEVRQTLLLPLSERDIRLE
IADDPCRVPADEGFCRLAVRNLTENAIKFTPDGGRIAITGRLVTMEELTADEELLRPFYRDFPANIAGHPGFYRLDVADT
GIGIPPDEAVRIFEKFYGVGDIEYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVTSGEGGGGSVFSLLFPMDNTCVV
PLRGEAR
>Mature_726_residues
TEKKLRLLLVEDSEDDALLLLNDLKRGGYSVEHERVETAAAMREALVKREWDIVISDYRLPQFTAPAALQILKRSGLDLP
FIIVSGKIGEDMLVDAMRAGAHDYLMKGNLSRLIPAVDREIREASERRTRRRAERSIRQGKIEWEAAFDAVSDIVVLTDP
TGTIIRCNSKLIQYFDTTYNDVIGTNITELFYGNDPAGESIFGLCADLKADEDDVRFPRLPGWYNAACYPMHPTENEHGY
VYVIKDITKRKRMEEEKKLTDRELLTLYAVAFRLNSQRGSKRIMVDLLSQLHQMLQIDWSCIHLMEKGSLNLSAWLGLSR
EFAESFGSLSRSLPWVKDVLDGKSFKAAEIAGHFGPEAEAAAEAMGMGAWCALPLKIGSGVLGTLFVAHRPNREYTDREV
FLLNSIANQMAVLIENHTLYDRMKEKNEELVRSRKALKENLEEVKRANIELGRLNASKNSFIGMASHELKTPLTSIIGGL
QFLLFYSDIPMTPEQKEMMQSVYEGVTQLKGIVDDLLSISRIEAKGFAVHTRPVKLSDLCQEVRQTLLLPLSERDIRLEI
ADDPCRVPADEGFCRLAVRNLTENAIKFTPDGGRIAITGRLVTMEELTADEELLRPFYRDFPANIAGHPGFYRLDVADTG
IGIPPDEAVRIFEKFYGVGDIEYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVTSGEGGGGSVFSLLFPMDNTCVVP
LRGEAR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=273, Percent_Identity=29.3040293040293, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87081816, Length=317, Percent_Identity=30.5993690851735, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693157, Length=335, Percent_Identity=27.7611940298507, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=271, Percent_Identity=27.3062730627306, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=27.0175438596491, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1789149, Length=322, Percent_Identity=25.776397515528, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=262, Percent_Identity=26.3358778625954, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786912, Length=310, Percent_Identity=24.5161290322581, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=27.1604938271605, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=266, Percent_Identity=23.3082706766917, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=245, Percent_Identity=26.9387755102041, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 81295; Mature: 81164

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKLRLLLVEDSEDDALLLLNDLKRGGYSVEHERVETAAAMREALVKREWDIVISDYR
CCCCCEEEEEEECCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCC
LPQFTAPAALQILKRSGLDLPFIIVSGKIGEDMLVDAMRAGAHDYLMKGNLSRLIPAVDR
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHH
EIREASERRTRRRAERSIRQGKIEWEAAFDAVSDIVVLTDPTGTIIRCNSKLIQYFDTTY
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCCEEEECHHHHHHHHCHH
NDVIGTNITELFYGNDPAGESIFGLCADLKADEDDVRFPRLPGWYNAACYPMHPTENEHG
HHHHCCCHHEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
YVYVIKDITKRKRMEEEKKLTDRELLTLYAVAFRLNSQRGSKRIMVDLLSQLHQMLQIDW
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SCIHLMEKGSLNLSAWLGLSREFAESFGSLSRSLPWVKDVLDGKSFKAAEIAGHFGPEAE
HHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCCHH
AAAEAMGMGAWCALPLKIGSGVLGTLFVAHRPNREYTDREVFLLNSIANQMAVLIENHTL
HHHHHHCCCCCEEEEHHHCCCHHHHHHEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCHH
YDRMKEKNEELVRSRKALKENLEEVKRANIELGRLNASKNSFIGMASHELKTPLTSIIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECHHHHHCHHHHHHHH
LQFLLFYSDIPMTPEQKEMMQSVYEGVTQLKGIVDDLLSISRIEAKGFAVHTRPVKLSDL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
CQEVRQTLLLPLSERDIRLEIADDPCRVPADEGFCRLAVRNLTENAIKFTPDGGRIAITG
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCEEEEEE
RLVTMEELTADEELLRPFYRDFPANIAGHPGFYRLDVADTGIGIPPDEAVRIFEKFYGVG
EEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCC
DIEYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVTSGEGGGGSVFSLLFPMDNTCVV
CEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCEEEE
PLRGEAR
ECCCCCC
>Mature Secondary Structure 
TEKKLRLLLVEDSEDDALLLLNDLKRGGYSVEHERVETAAAMREALVKREWDIVISDYR
CCCCEEEEEEECCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCC
LPQFTAPAALQILKRSGLDLPFIIVSGKIGEDMLVDAMRAGAHDYLMKGNLSRLIPAVDR
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHH
EIREASERRTRRRAERSIRQGKIEWEAAFDAVSDIVVLTDPTGTIIRCNSKLIQYFDTTY
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCCEEEECHHHHHHHHCHH
NDVIGTNITELFYGNDPAGESIFGLCADLKADEDDVRFPRLPGWYNAACYPMHPTENEHG
HHHHCCCHHEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
YVYVIKDITKRKRMEEEKKLTDRELLTLYAVAFRLNSQRGSKRIMVDLLSQLHQMLQIDW
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SCIHLMEKGSLNLSAWLGLSREFAESFGSLSRSLPWVKDVLDGKSFKAAEIAGHFGPEAE
HHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCCHH
AAAEAMGMGAWCALPLKIGSGVLGTLFVAHRPNREYTDREVFLLNSIANQMAVLIENHTL
HHHHHHCCCCCEEEEHHHCCCHHHHHHEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCHH
YDRMKEKNEELVRSRKALKENLEEVKRANIELGRLNASKNSFIGMASHELKTPLTSIIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECHHHHHCHHHHHHHH
LQFLLFYSDIPMTPEQKEMMQSVYEGVTQLKGIVDDLLSISRIEAKGFAVHTRPVKLSDL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
CQEVRQTLLLPLSERDIRLEIADDPCRVPADEGFCRLAVRNLTENAIKFTPDGGRIAITG
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCEEEEEE
RLVTMEELTADEELLRPFYRDFPANIAGHPGFYRLDVADTGIGIPPDEAVRIFEKFYGVG
EEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCC
DIEYHSSGKTGFMSKGSGLGLSIVKGIMDAHGGMVWVTSGEGGGGSVFSLLFPMDNTCVV
CEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCEEEE
PLRGEAR
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]